International Journal of Urology最新文献

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The first detailed annual record on the National Clinical Database Urology Division in Japan: A report on five surgical procedures. 日本首个国家临床数据库泌尿科年度详细记录:关于五项外科手术的报告
IF 1.8 3区 医学
International Journal of Urology Pub Date : 2024-08-18 DOI: 10.1111/iju.15561
Eiji Kikuchi, Hiroyuki Yamamoto, Takahiro Yasui, Shingo Hatakeyama, Ryuichi Mizuno, Shinichi Sakamoto, Kentaro Mizuno, Shuichi Morizane, Nozomi Hayakawa, Takashi Kobayashi, Toshiyuki Kamoto, Masatoshi Eto
{"title":"The first detailed annual record on the National Clinical Database Urology Division in Japan: A report on five surgical procedures.","authors":"Eiji Kikuchi, Hiroyuki Yamamoto, Takahiro Yasui, Shingo Hatakeyama, Ryuichi Mizuno, Shinichi Sakamoto, Kentaro Mizuno, Shuichi Morizane, Nozomi Hayakawa, Takashi Kobayashi, Toshiyuki Kamoto, Masatoshi Eto","doi":"10.1111/iju.15561","DOIUrl":"https://doi.org/10.1111/iju.15561","url":null,"abstract":"<p><strong>Objectives: </strong>The National Clinical Database (NCD) Urology Division commenced registration in April 2018 in Japan. This is the first report to focus on five surgeries for which detailed information is registered.</p><p><strong>Methods: </strong>We herein describe annual trends in and the complication grades of the following five surgeries: partial nephrectomy, radical nephrectomy, radical cystectomy, radical prostatectomy, and pyeloplasty, using the NCD. A total of 149 417 patients treated with the five types of surgeries based on NCD data were enrolled in this report.</p><p><strong>Results: </strong>The number of patients was 55 630 for partial/radical nephrectomy from April 2018 to December 2021, 83 653 for radical prostatectomy from April 2018 to December 2021, and 9342 for radical cystectomy from January 2020 to December 2021. In 2021, partial nephrectomy was performed on 7416 cases, radical nephrectomy on 7739 cases, radical prostatectomy on 22 692 cases, radical cystectomy on 4677 cases, and pyeloplasty on 792 cases.</p><p><strong>Conclusions: </strong>The results obtained showed that a robot-assisted or laparoscopic procedure has replaced open surgery as the common approach for all five surgeries. An analysis of NCD data may be useful for understanding trends in surgical procedures across the major field of urology.</p>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141999908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial Comment on Japanese clinical practice guidelines for prostate cancer 2023 对《日本前列腺癌临床实践指南 2023》的编辑评论。
IF 1.8 3区 医学
International Journal of Urology Pub Date : 2024-08-14 DOI: 10.1111/iju.15562
Yusuke Goto MD, PhD
{"title":"Editorial Comment on Japanese clinical practice guidelines for prostate cancer 2023","authors":"Yusuke Goto MD, PhD","doi":"10.1111/iju.15562","DOIUrl":"10.1111/iju.15562","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"31 11","pages":"1222"},"PeriodicalIF":1.8,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Can the Briganti 2019 nomogram be modified to predict lymph node metastasis risk in patients with prostate cancer detected with in-bore biopsy? 能否修改布里甘蒂 2019 提名图,以预测通过腔内活检发现的前列腺癌患者的淋巴结转移风险?
IF 1.8 3区 医学
International Journal of Urology Pub Date : 2024-08-14 DOI: 10.1111/iju.15553
Serdar Madendere, Mert Kılıç, Bengi Gürses, Metin Vural, Ayşe Armutlu, İbrahim Kulaç, Kayhan Tarım, Barış Esen, İbrahim Can Aykanat, Mert Veznikli, Abdullah Erdem Canda, Derya Balbay, Dilek Ertoy Baydar, Yakup Kordan, Tarık Esen
{"title":"Can the Briganti 2019 nomogram be modified to predict lymph node metastasis risk in patients with prostate cancer detected with in-bore biopsy?","authors":"Serdar Madendere,&nbsp;Mert Kılıç,&nbsp;Bengi Gürses,&nbsp;Metin Vural,&nbsp;Ayşe Armutlu,&nbsp;İbrahim Kulaç,&nbsp;Kayhan Tarım,&nbsp;Barış Esen,&nbsp;İbrahim Can Aykanat,&nbsp;Mert Veznikli,&nbsp;Abdullah Erdem Canda,&nbsp;Derya Balbay,&nbsp;Dilek Ertoy Baydar,&nbsp;Yakup Kordan,&nbsp;Tarık Esen","doi":"10.1111/iju.15553","DOIUrl":"10.1111/iju.15553","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>We aimed to modify the Briganti 2019 nomogram and to test whether it is valid for patients who were diagnosed with prostate cancer through in-bore prostate biopsies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data for 204 patients with positive multiparametric prostate MRI and prostate cancer identified either by mpMRI-cognitive/software fusion or in-bore biopsy and who underwent robot-assisted radical prostatectomy and extended pelvic lymph node dissection between 2012 and 2023 were retrospectively analyzed. The Briganti 2019 nomogram was applied to the mpMRI-cognitive/software fusion biopsy group (142 patients) in the original form, and then, two modifications were tested for the targeted component. Original and modified scores were compared. These modifications were adapted for the in-bore biopsy group (62 patients). The final histopathologic stage was regarded as the gold standard.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Nodal metastases were identified in 18/142 (12.6%) of mpMRI-cognitive/software fusion biopsy patients and 8/62 (12.9%) of the in-bore biopsy patients. In the mpMRI-cognitive/software fusion biopsy group, tumor size/core size (%) of targeted biopsy cores and positive core percentage on systematic biopsy were significant parameters for lymph node metastasis based on univariate logistic regression analyses (<i>p</i> &lt; 0.05). With the modifications of these parameters for the in-bore biopsy group, V1 modification of the Briganti 2019 nomogram provided 100% sensitivity and 31.5% specificity (AUC:0.627), while V2 modification provided 75% sensitivity and 46.3% specificity (AUC:0.645).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Briganti 2019 nomogram may be modified by utilizing tumor size/core size (%) for targeted biopsy cores instead of positive core percentage on systematic biopsy or by not taking both parameters into consideration to detect node metastasis risk of patients diagnosed with in-bore biopsies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"31 11","pages":"1269-1277"},"PeriodicalIF":1.8,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preoperative risk stratification models after radical cystectomy for bladder cancer: A multi-center study 膀胱癌根治性切除术后术前风险分层模型:一项多中心研究。
IF 1.8 3区 医学
International Journal of Urology Pub Date : 2024-08-14 DOI: 10.1111/iju.15560
Hiroshi Yamane, Shuichi Morizane, Masashi Honda, Kuniyasu Muraoka, Hirofumi Oono, Tadahiro Isoyama, Koji Ono, Takehiro Sejima, Hiroyuki Kadowaki, Atsushi Takenaka
{"title":"Preoperative risk stratification models after radical cystectomy for bladder cancer: A multi-center study","authors":"Hiroshi Yamane,&nbsp;Shuichi Morizane,&nbsp;Masashi Honda,&nbsp;Kuniyasu Muraoka,&nbsp;Hirofumi Oono,&nbsp;Tadahiro Isoyama,&nbsp;Koji Ono,&nbsp;Takehiro Sejima,&nbsp;Hiroyuki Kadowaki,&nbsp;Atsushi Takenaka","doi":"10.1111/iju.15560","DOIUrl":"10.1111/iju.15560","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>We investigated preoperative patient factors associated with prognosis in 263 bladder cancer (BC) patients undergoing radical cystectomy (RC). We also developed new risk stratification models for prognosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study included patients treated at Tottori University Hospital and affiliated hospitals between January 2010 and December 2019. The relationship between preoperative patient factors and overall recurrence-free and cancer-specific survival (CSS) was analyzed. The modified Glasgow prognosis score (mGPS) was calculated using serum albumin and C-reactive protein (CRP) levels. Statistical analyses included the log-rank test and Cox proportional hazards regression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Eastern Cooperative Oncology Group performance status (ECOG-PS), mGPS, and clinical tumor stage independently predicted CSS in multivariate analysis. A new risk stratification model included ECOG-PS ≥2, clinical tumor stage ≥3, serum albumin &lt;3.5 g/dL, and serum CRP &gt;0.5 mg/dL. Risk groups were defined as 0 factors (low risk), 1–2 factors (intermediate risk), and 3–4 factors (high risk). High-risk patients showed significantly poorer 3-year cancer-free survival: 86.9% (low risk), 76.7% (intermediate risk), and 50.0% (high risk).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>ECOG-PS, clinical tumor stage, and mGPS are predictive of poor cancer-free survival post-RC for BC. Our model offers the potential for prognostic prediction in these patients.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"31 11","pages":"1278-1287"},"PeriodicalIF":1.8,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Considerations on perioperative hemodynamic instability in pheochromocytoma 嗜铬细胞瘤围术期血流动力学不稳定的考虑因素。
IF 1.8 3区 医学
International Journal of Urology Pub Date : 2024-08-12 DOI: 10.1111/iju.15559
Fumihiko Urabe MD, PhD, Shoji Kimura MD, PhD, Takahiro Kimura MD, PhD
{"title":"Considerations on perioperative hemodynamic instability in pheochromocytoma","authors":"Fumihiko Urabe MD, PhD,&nbsp;Shoji Kimura MD, PhD,&nbsp;Takahiro Kimura MD, PhD","doi":"10.1111/iju.15559","DOIUrl":"10.1111/iju.15559","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"31 10","pages":"1174"},"PeriodicalIF":1.8,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141916679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel clipping procedure for preventing post-operative inguinal hernia in robot-assisted radical prostatectomy 预防机器人辅助前列腺癌根治术术后腹股沟疝的新型剪切术。
IF 1.8 3区 医学
International Journal of Urology Pub Date : 2024-08-09 DOI: 10.1111/iju.15544
Yuji Hakozaki, Yuta Yamada, Tetsuya Fujimura, Naoki Kimura, Kenichi Sasaki, Kazuki Maki, Kazuma Sugimoto, Taro Izumi, Jun Kaneko, Fumihiko Urabe, Mayuko Tokunaga, Yoichi Fujii, Jun Kamei, Taketo Kawai, Satoru Taguchi, Yoshiyuki Akiyama, Daisuke Yamada, Haruki Kume
{"title":"Novel clipping procedure for preventing post-operative inguinal hernia in robot-assisted radical prostatectomy","authors":"Yuji Hakozaki,&nbsp;Yuta Yamada,&nbsp;Tetsuya Fujimura,&nbsp;Naoki Kimura,&nbsp;Kenichi Sasaki,&nbsp;Kazuki Maki,&nbsp;Kazuma Sugimoto,&nbsp;Taro Izumi,&nbsp;Jun Kaneko,&nbsp;Fumihiko Urabe,&nbsp;Mayuko Tokunaga,&nbsp;Yoichi Fujii,&nbsp;Jun Kamei,&nbsp;Taketo Kawai,&nbsp;Satoru Taguchi,&nbsp;Yoshiyuki Akiyama,&nbsp;Daisuke Yamada,&nbsp;Haruki Kume","doi":"10.1111/iju.15544","DOIUrl":"10.1111/iju.15544","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Inguinal hernia (IH) is a common postoperative complication after robot-assisted radical prostatectomy (RARP). We developed a novel clipping technique for the prevention of IH developing after RARP.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This cohort included 759 consecutive patients who underwent RARP for prostate cancer at the University of Tokyo Hospital between January 2011 and December 2018. We reviewed clinical parameters and identified the risk factors of postoperative IH. The prophylactic preventive procedure of IH development was performed by clipping the peritoneum and underlying tissue around the internal inguinal ring using Hem-o-Lok clip to prevent the prolapse of the intestine through the internal inguinal ring.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In total, 236 patients received the clipping procedure. The median follow-up time was 50 months. The incidence rate of IH was 10.8% (78/720). The median time to the diagnosis of IH was 10 months. Univariate analysis revealed that patients with higher age (age ≥ 63), low BMI (BMI &lt; 25 kg/m<sup>2</sup>), and lower number of surgical experiences (Surgical experience &lt; 40) showed a significantly higher odds ratio of developing IH. Multivariate analysis showed that “BMI &lt; 25 kg/m<sup>2</sup>” and “Surgical experience &lt; 40” were independent predictive factors of IH. Among the patients with a high risk of IH due to receiving surgery from inexperienced surgeons, there was a statistically significant preventive effect for the patients with “BMI ≥ 25 kg/m<sup>2</sup>” by the novel clipping procedure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The novel clipping procedure reduced the risk of post-operative IH in obese patients when the RARP was performed by inexperienced surgeons.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"31 11","pages":"1241-1247"},"PeriodicalIF":1.8,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/iju.15544","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141906548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial Comment to: “Survival of stage III non-seminoma testis cancer patients versus simulated controls, according to race/ethnicity” 编辑评论:"根据种族/人种,III期非精索瘤睾丸癌患者与模拟对照组的生存率"。
IF 1.8 3区 医学
International Journal of Urology Pub Date : 2024-08-06 DOI: 10.1111/iju.15557
Christoph Würnschimmel MD, Luca Afferi MD, Mike Wenzel MD, BSc
{"title":"Editorial Comment to: “Survival of stage III non-seminoma testis cancer patients versus simulated controls, according to race/ethnicity”","authors":"Christoph Würnschimmel MD,&nbsp;Luca Afferi MD,&nbsp;Mike Wenzel MD, BSc","doi":"10.1111/iju.15557","DOIUrl":"10.1111/iju.15557","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"31 10","pages":"1143-1144"},"PeriodicalIF":1.8,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Annual record on the number of general urological surgeries registered in the National Clinical Database system between April 2018 and December 2021 in Japan 2018 年 4 月至 2021 年 12 月期间,日本在国家临床数据库系统中登记的普通泌尿外科手术数量的年度记录。
IF 1.8 3区 医学
International Journal of Urology Pub Date : 2024-08-06 DOI: 10.1111/iju.15551
Takahiro Yasui, Eiji Kikuchi, Hiroyuki Yamamoto, Daisuke Ishii, Ryuichi Mizuno, Shingo Hatakeyama, Takashi Kobayashi, Junji Uchida, Masayuki Takahashi, Shinichi Sakamoto, Shuichi Morizane, Toshiyuki Kamoto, Masatoshi Eto
{"title":"Annual record on the number of general urological surgeries registered in the National Clinical Database system between April 2018 and December 2021 in Japan","authors":"Takahiro Yasui,&nbsp;Eiji Kikuchi,&nbsp;Hiroyuki Yamamoto,&nbsp;Daisuke Ishii,&nbsp;Ryuichi Mizuno,&nbsp;Shingo Hatakeyama,&nbsp;Takashi Kobayashi,&nbsp;Junji Uchida,&nbsp;Masayuki Takahashi,&nbsp;Shinichi Sakamoto,&nbsp;Shuichi Morizane,&nbsp;Toshiyuki Kamoto,&nbsp;Masatoshi Eto","doi":"10.1111/iju.15551","DOIUrl":"10.1111/iju.15551","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The Japanese National Clinical Database (NCD) is a large-scale, nationwide, web-based data entry system that covers the majority of surgical cases performed in Japan. An NCD specializing in urological surgery was launched based on the NCD system in 2018.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>All urological surgeries performed at more than 1000 institutions were registered from 2018. We herein report the number of surgeries conducted as stipulated in the “Certified Urology Surgeon Training Curriculum” between April 2018 and December 2021.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 1 377 677 cases were registered from 1185 facilities nationwide under the initiative of the Japanese Urological Association. We examined the number of procedures performed every year for each of the 10 categories.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The NCD system sustainably provides important information relating to the preoperative status, operational outcome, and best practice for urological surgery in Japan.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"31 11","pages":"1256-1262"},"PeriodicalIF":1.8,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Location-specific diagnostic efficiency of photodynamic diagnosis-guided biopsy in bladder mapping biopsies 光动力诊断引导下膀胱图谱活检的特定位置诊断效率。
IF 1.8 3区 医学
International Journal of Urology Pub Date : 2024-08-02 DOI: 10.1111/iju.15552
Yuki Nakamura, Yudai Ishikawa, Masaki Kobayashi, Motohiro Fujiwara, Bo Fan, Shohei Fukuda, Yuma Waseda, Hajime Tanaka, Soichiro Yoshida, Yasuhisa Fujii
{"title":"Location-specific diagnostic efficiency of photodynamic diagnosis-guided biopsy in bladder mapping biopsies","authors":"Yuki Nakamura,&nbsp;Yudai Ishikawa,&nbsp;Masaki Kobayashi,&nbsp;Motohiro Fujiwara,&nbsp;Bo Fan,&nbsp;Shohei Fukuda,&nbsp;Yuma Waseda,&nbsp;Hajime Tanaka,&nbsp;Soichiro Yoshida,&nbsp;Yasuhisa Fujii","doi":"10.1111/iju.15552","DOIUrl":"10.1111/iju.15552","url":null,"abstract":"<div>\u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Photodynamic diagnosis (PDD)-assisted transurethral resection of bladder tumors (TURBT) has emerged as a promising complementary tool to white light (WL) cystoscopy, potentially improving cancer detection and replacing conventional mapping biopsies. This study aimed to investigate the diagnostic accuracy of PDD by anatomical locations in mapping biopsies through lesion-based analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>PDD and WL findings were prospectively recorded in 102 patients undergoing mapping biopsies and PDD-assisted TURBT using oral 5-aminolevulinic acid. We evaluated 673 specimens collected from flat tumor or normal-looking lesions on WL cystoscopy, after excluding 98 specimens collected from papillary or nodular tumors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among the 673 lesions, cancer was detected in 110 (16%) by lesion-based analysis. PDD demonstrated significantly higher sensitivity (65.5% vs. 46.4%, <i>p</i> &lt; 0.001) and negative predictive value (92.5% vs. 89.5%, <i>p</i> &lt; 0.001) compared to WL. The sensitivity of PDD findings varied by location: posterior (100%), right (78.6%), dome (73.3%), left (70.6%), trigone (58.8%), bladder neck (41.7%), anterior (40.0%), and prostatic urethra (25.0%). Incorporating targeted biopsies of specific locations (bladder neck, anterior, and prostatic urethra) into the PDD-guided biopsies, regardless of PDD findings, significantly increased the overall sensitivity from 65.5% to 82.7% (<i>p</i> = 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study first demonstrated the detection rate of location-specific mapping biopsies using PDD, revealing difficulties in accuracy assessment in areas susceptible to tangential fluorescence. While PDD-guided biopsy improves cancer detection compared to WL cystoscopy even for flat tumors or normal-looking lesions, more careful decisions, including mapping biopsies, may be beneficial for an assessment in these tangential areas.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"31 11","pages":"1263-1268"},"PeriodicalIF":1.8,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141874782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is meta-analysis effective in evaluating local treatment benefits for oligometastatic prostate cancer? 荟萃分析是否能有效评估少转移性前列腺癌的局部治疗效果?
IF 1.8 3区 医学
International Journal of Urology Pub Date : 2024-08-01 DOI: 10.1111/iju.15555
Fumihiko Urabe MD, PhD, Shoji Kimura MD, PhD, Kojiro Tashiro MD, PhD
{"title":"Is meta-analysis effective in evaluating local treatment benefits for oligometastatic prostate cancer?","authors":"Fumihiko Urabe MD, PhD,&nbsp;Shoji Kimura MD, PhD,&nbsp;Kojiro Tashiro MD, PhD","doi":"10.1111/iju.15555","DOIUrl":"10.1111/iju.15555","url":null,"abstract":"","PeriodicalId":14323,"journal":{"name":"International Journal of Urology","volume":"31 11","pages":"1293"},"PeriodicalIF":1.8,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141874781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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