Physical and rehabilitation medicine, medical rehabilitation最新文献

{"title":"REMOTE REHABILITATION: ROLE AND OPPORTUNITIES","authors":"I. Borisov, V. A. Bondar, M. Kanarsky, Y. Y. Nekrasova, N. V. Reutova, Natalya P. Borisova, S. Matafonova, Marina P. Yurasova, Vitaliy V. Yevstifeyev","doi":"10.36425/rehab80253","DOIUrl":"https://doi.org/10.36425/rehab80253","url":null,"abstract":"Medical rehabilitation is a complex, long-term and financially costly process of restoring the physiological functions of the body after injuries and the consequences of past diseases. The need for an individual approach to each life situation necessitates the search and development of new technologies in the method of providing rehabilitation assistance. One of the principles of a successful rehabilitation process is continuity, which, in most cases, is disrupted after the transfer of patients to the outpatient stage. The 21st century, in contrast to the previous one, is distinguished by more accessible technologies for everyday and individual use. A separate category of patients are patients with the consequences of brain damage, socialization and the return of the ability to self-serve for whom is one of the most difficult in rehabilitation practice. One of these technologies is distance rehabilitation, which provides the principle of continuity, social and informational support for relatives who provide care for patients on an outpatient basis.","PeriodicalId":142894,"journal":{"name":"Physical and rehabilitation medicine, medical rehabilitation","volume":"117 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116208055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HLA AND CANCER","authors":"Aleksandr S. Golota","doi":"10.36425/rehab79387","DOIUrl":"https://doi.org/10.36425/rehab79387","url":null,"abstract":"This review provides updated information on HLA class I and II antigens in cancer. The expression of HLA antigens in normal and tumor tissues, the physiological organization of the components of HLA antigen-processing machinery, the expression patterns of HLA antigens associated with the molecular and regulatory defects identified to date, as well as their functional and clinical significance, are described. This review summarizes clinical and experimental data on the complexity of immune escape mechanisms used by tumour cells to avoid T and natural killer cell responses. The variety of class I HLA phenotypes that can be produced by tumor cells during this process is presented. We also discuss here the potential capacity of metastatic lesions to recover MHC/HLA class I expression after immunotherapy, which depends on the reversible/ soft or irreversible/hard nature of the molecular mechanism responsible for the altered HLA class I phenotypes, and which determines the progression or regression of metastatic lesions in response to treatment. HLA сlass II genes play key roles in connecting innate and adaptive immunity in tumor rejection and when the escape route via HLA-I is already established. Antigens сlass II HLA expression in tumor cells and gives tumor cells the ability to present antigens, becoming less aggressive, and improves prognosis. Malignant tumors, as a genetic disease, are caused by structural alterations of the genome which can give rise to the expression of tumor-associated antigens in the form of either structurally altered molecules or of overexpressed normal molecules. Tumor associated antigens recognized by the immune system and induce a T-cell-mediated immune response. Outgrowing cancers use different strategies to evade destruction by the immune system. Immune evasion mechanisms affecting the expression and/or function of HLA-antigens are of special interest to tumor immunologists, since these molecules play a crucial role in the interaction of malignant cells with immune cells. This review describes the potential role of immunity control points in immunosuppression and therapeutic strategies for restoring the cytotoxicity of immune cells.","PeriodicalId":142894,"journal":{"name":"Physical and rehabilitation medicine, medical rehabilitation","volume":"28 4 Pt 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125689771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"METHODICAL ASPECTS OF THE DEPLOYMENT OF A MEDICAL REHABILITATION CENTER BASED ON THE MILITARY SPA ORGANIZATION","authors":"A. V. Shakula","doi":"10.36425/rehab77963","DOIUrl":"https://doi.org/10.36425/rehab77963","url":null,"abstract":"One of the areas of use of military sanatoriums in peacetime and wartime is the organization of medical rehabilitation centers (CMR) at their base. The medical staff of medical and preventive institutions at the stages of rehabilitation should have a clear understanding of the place and importance of medical measures in the overall task of protecting troops, effectively interact with other specialists in the tasks of providing military personnel, carrying out rehabilitation of the affected and sick for the rapid return of the reconvalescenes, medical rehabilitation of patients after routine operations, ensuring the observation regime and effective postcovid rehabilitation of patients.","PeriodicalId":142894,"journal":{"name":"Physical and rehabilitation medicine, medical rehabilitation","volume":"102 11-12","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120924802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CIRCADIAN RHYTHM AND CHRONIC DISORDERS OF CONSCIOUSNESS","authors":"M. Kanarskii, J. Nekrasova, Irina V. Vorob’eva, I. Borisov","doi":"10.36425/rehab63225","DOIUrl":"https://doi.org/10.36425/rehab63225","url":null,"abstract":"Among the possible points of therapeutic action and predicting the outcome in patients in a vegetative state and minimally conscious state, the analysis of circadian rhythms, such as the sleep-wake cycle, melatonin secretion, temperature trends, heart rate, and blood pressure, attracts more and more attention. In this review, we analyzed studies on circadian rhythms in patients with chronic disorders of consciousness, assessed the possible limitations of standard methods, proposed a concept for the development of an assessment of the sleep-wake cycle, and assessed the role of exogenous factors that are likely to be involved in the disturbance of circadian rhythms in intensive care units. Based on the results of the study, we came to the conclusion that for the full realization of the rehabilitation potential, it is necessary to develop methods for assessing circadian rhythms based on a multicomponent approach, including 24-hour monitoring using actigraphy for more accurate identification of the rest -activity cycle, video monitoring of the orofascial area to increase the reliability of oculographic assessment and revealing hidden patterns, analysis of the temperature curve, the level of melatonin, TSH, cortisol, as well as exogenous factors. It is necessary to use the information obtained for therapeutic, prognostic, diagnostic and rehabilitation purposes","PeriodicalId":142894,"journal":{"name":"Physical and rehabilitation medicine, medical rehabilitation","volume":"127 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132527734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of the quality of care in patients with coronary heart disease with chronic heart failure in medical and preventive institutions in the Moscow Region","authors":"V. A. Kosov, N. P. Trebina, Natalia V. Svist, A. Pavlov, D. V. Slivinsky, A. Shakula","doi":"10.36425/rehab70772","DOIUrl":"https://doi.org/10.36425/rehab70772","url":null,"abstract":"In the organization of systematic work on the examination and management of the quality of medical care taking into account the existing recommendations in each medical-preventive institution should constantly work clinical-expert commissions, including: the medical-control subcommittee, the subcommittee to study the death outcomes, the subcommittee of the examination of disability, the subcommittee of the study of surgical complications. The results of the expert study revealed that the indicators of the commission in the provision of medical and diagnostic care for patients with coronary heart disease in the Moscow region hospital are at an average level, compared to the rates of the commission for other types of medical care. Conducting a complex of medical rehabilitation on the basis of a spa organization for patients with chronic heart failure and acute myocardial infarction after coronary artery bypass grafting allows to significantly improve the level of medical and diagnostic care and improve the quality of life of patients.","PeriodicalId":142894,"journal":{"name":"Physical and rehabilitation medicine, medical rehabilitation","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122863571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms of low-temperature rehabilitation technologies. Extreme aerocriotherapy","authors":"O. Shevelev, M. Petrova, M. Yuriev, A. Smolensky, M. Zhdanova","doi":"10.36425/rehab80232","DOIUrl":"https://doi.org/10.36425/rehab80232","url":null,"abstract":"The mechanisms of increasing the resistance of cells to significant temperature and damaging effects are typical, and cellular tolerance, ensuring the effectiveness of systemic regulation, is an important part of increasing the adaptive and rehabilitative potential of the entire organism. The expression of early genes encoding a wide range of stress-protective proteins increases the resistance of cells not only to significant temperature stimuli, but also to ischemia, hypoxia, and other damaging factors, forming the effects of cross-adaptation. Even a small change in temperature is significant enough to trigger the processes of genomic reprogramming. It seems to us important to consider the mechanisms of low-temperature therapeutic and rehabilitation technologies from the standpoint of cellular response to temperature stimuli. Currently, a large number of low temperature technologies (HT) are used in medical rehabilitation, which can be divided into two groups: moderately low temperature effects (from 30C to +20C) and extremely low temperature effects (from 30C to 180C), which includes the technology of extreme aerocriotherapy (EACT). The purpose of the review is to analyze the systemic and local mechanisms of EACT implemented with the participation of the main known stress-protective proteins.","PeriodicalId":142894,"journal":{"name":"Physical and rehabilitation medicine, medical rehabilitation","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115324352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the structure of psycho-emotional disorders in patients with consequences of CVA who underwent rehabilitation at the FSCCRR in conditions of social and communicative deprivation","authors":"Milena V. Martynova, Margorita V. Petrovskaya, M. Stern, A. Kulikov, Elena V. Milovanova, M. Petrova","doi":"10.36425/rehab80122","DOIUrl":"https://doi.org/10.36425/rehab80122","url":null,"abstract":"Introduction: Patients of FRCC ICMRR undergo rehabilitation after \"cerebral accidents\" of acute cerebrovascular accident (ACVA), Traumatic Brain Injury (TBI), brain surgery. During the pandemic COVID-19 (20202021), the hard situation of patients dealing with the disease is made more difficult by the visits ban in the hospital. Patients are forced to stay a month or more of loneliness, away from family and loved ones, in conditions of \"isolation\". \u0000Aims: Was to identify the frequency of occurrence and severity of anxiety and depressive disorders among patients caused by a long stay in the hospital, limited communication with relatives due to the COVID-19 pandemic. \u0000Materials and methods: The study group consisted of 132 patients of the Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitation (FRCC ICMRR) who were hospitalized during the COVID-19 pandemic (from May 2020 to April 2021); the comparison group consisted of 104 patients who were treated in the FRCC ICMRR in 2019. After studying the medical documentation, 2 groups of patients were formed: the study group of 21 people and the comparison group of 24 people with an identical distribution by gender and age, by the severity of neurological deficit (mild and moderate severity of the lesion), localization of the process, criteria of social activity. The following methods were used in the study: organizational-comparative method; empirical-observation, conversation, questionnaire; psychodiagnostic methods-tests (ODS-2, HADS, STAI), the method of expert assessments, a qualitative method of data processing (differentiation of material by groups, its analysis). \u0000Results: The stress of hospitalisation and unvoluntary isolation makes patients mental health much worse, causes mental maladjustment, and often manifests itself in the development of anxiety-depressive pathopsychological symptoms: the frequency of occurrence of personal anxiety increased by 3 times; the severity of the symptoms of situational anxiety increased by 1.5 times, no cases of neurosis were detected among patients of both groups. \u0000Conclusions: To reduce the negative consequences of psycho-emotional stress from unvoluntary isolation, to prevent the formation of social-stress disorder, it is necessary to carry out a number of activities not only in a separate institution, but also at the global level.","PeriodicalId":142894,"journal":{"name":"Physical and rehabilitation medicine, medical rehabilitation","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126358494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progressive resistance power training for gait and balance rehabilitation in multiple sclerosis: a pilot single-arm study.","authors":"Kseniia V. Voinova, G. Makshakov, E. Evdoshenko","doi":"10.36425/rehab77932","DOIUrl":"https://doi.org/10.36425/rehab77932","url":null,"abstract":"Aims: \u0000The aim of the study was to evaluate the effectiveness of 4-weeks inpatient power training protocol on parameters of gait and balance in pwMS. \u0000 \u0000Materials and methods. \u000026 subjects aged 18 65 years and Expanded Disability Status Scale (EDSS) score 2.0 to 6.5 Receiving standard rehabilitation with PRT was applied for 30 minutes, 5 days a week for 4 weeks in addition to other rehabilitation methods. The primary endpoint was the time of 6-minute walking test (6MWT) at week 4 (W4) compared to week 1 (W1). Secondary outcomes included the time in Timed 25-foot walking test (T25FW), Timed Up-n-Go test (TUG), 5 times sit-to-stand test (5TSST), Expanded disability status scale score (EDSS), muscle strength. \u0000 \u0000Results. \u0000After the 4-week course of rehabilitation a significant improvement was reached in all tests. The most prominent was the improvement in the 6MWT with 20/25 (80%) patients showing the increase in the distance walked above the minimal clinically important difference (MCID). Changes in other tests were less manifest: 3/25 (12%) of patients improved above MCID in both TUG and 5TSST, 6/25 (24%) patients - in T25FW. After a 4-week course of rehabilitation, a significant improvement was acquired in the 6MWT. Changes in other tests were significantly less manifest. Muscle in hip flexors improved significantly on the left side (mean (SD) at W1 - 3,96 (0,67) vs W4 - 4,72 (0,46), p=0,04)) and showed the trend to significance of the right side: W1 - 3,68 (0,8); W4 - 4,52 (0,65), p=0,08. \u0000Conclusions: \u0000The most significant effect was achieved in the primary outcome that was the distance walked in 6MWT. Less disabled patients can show better improvement in further studies, as was defined by T25FW test. Regular exercise can improve daily activity using a program that patients can easily do at home on their own.","PeriodicalId":142894,"journal":{"name":"Physical and rehabilitation medicine, medical rehabilitation","volume":"48 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114479458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospects of using adaptive phagotherapy (Phage therapy) in the rehabilitation of post-Covid 19 patients (editorial).","authors":"Natalya V. Beloborodova, A. Grechko, A. Y. Zurabov, F. Zurabov, A. Kuzovlev, M. Petrova, E. Chernevskaya, A. Yakovlev","doi":"10.36425/rehab80658","DOIUrl":"https://doi.org/10.36425/rehab80658","url":null,"abstract":"The work is devoted to the organization of postcovid rehabilitation by developing a strategy of adative phage therapy, which is the production and application of a complex of bacteriophages for a specific medical institution/department based on an up-to-date collection of hospital bacterial strains isolated from the biomaterial of patients of the same institution. \u0000Bacteriophages were actively used in the world in the 20-40s of the twentieth century in various fields of medicine, but the rapid development of phage resistance in each individual case limited their use. The use of complex preparations of bacteriophages from the collection pure lines of bacteriophages of the SPC \"MikroMir\" a set of various phages aimed at restoring the human microbiome after a covid infection allowed to sharply reduce the number of antibiotics used in intensive care units and reduce antibiotic resistance with proven safety of phage therapy.","PeriodicalId":142894,"journal":{"name":"Physical and rehabilitation medicine, medical rehabilitation","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128939442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CEREBRAL PALSY BIOMARKER","authors":"Aleksandr S. Golota","doi":"10.36425/rehab79386","DOIUrl":"https://doi.org/10.36425/rehab79386","url":null,"abstract":"Cerebral palsy is a neurological disorder that is attributed to non-progressive injury or malformation that occurred in the developing fetal or infant brain. The motor disorders in cerebral palsy are often accompanied by disturbances of sensation, perception, cognition, communication, behaviour, and by epilepsy. Cerebral palsy is a complex disorder that is likely to be of multifactorial origin. Epidemiological studies have shown that the origins of most CP are prior to labor. A number of clinical risk factors for cerebral palsy have been described in the literature including preterm birth, low birth weight, inflammation, maternal infection during pregnancy and placenta pathology. Hypoxia at birth may be primary or secondary to preexisting pathology, but the currently known clinical risk factors do not explain the majority of cases. Many of these risk factors may have a genetic component. Several single nucleotide polymorphisms, DNA copy number variations and epigenetic patterns increase genetic susceptibility for cerebral palsy. Whole genome sequencing and gene expression studies may extend the percentage of cases with a genetic pathway. Clinical risk factors could act as triggers for CP where there is genetic susceptibility. These new findings should refocus research about the causes of these complex and varied neurodevelopmental disorders on the search for biomarkers of the risk of cerebral palsy. Genomics, proteomics and metabolomics have huge potential for deepening our understanding of many complex diseases by identifying diagnostic and prognostic panels of biomarkers, especially in various neurological disorders, including cerebral palsy.","PeriodicalId":142894,"journal":{"name":"Physical and rehabilitation medicine, medical rehabilitation","volume":"82 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125628242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}