International Journal of Research in Pharmaceutical Sciences最新文献

Change Control from Initiation to Implementation in the Pharmaceutical Industry: A Comprehensive Review 制药行业从启动到实施的变革控制：全面回顾

International Journal of Research in Pharmaceutical Sciences Pub Date : 2024-07-26 DOI: 10.26452/ijrps.v15i3.4681

Soaib Ahmed, Souvik Kundu, Rahul Patra, Jaydip Ray

{"title":"Change Control from Initiation to Implementation in the Pharmaceutical Industry: A Comprehensive Review","authors":"Soaib Ahmed, Souvik Kundu, Rahul Patra, Jaydip Ray","doi":"10.26452/ijrps.v15i3.4681","DOIUrl":"https://doi.org/10.26452/ijrps.v15i3.4681","url":null,"abstract":"Change control plays a role in cGMP, just as all aspects of quality management should continually strive for enhancement. It works with a prior mechanism that empowers designated personnel across fields to assess, as well as having permission to authorize proposing or doing modifications that would impact the status that was prevalidated for the process system, including facilities, systems, and equipment. Change management involves overseeing changes in staff, protocols, operations, and product standards. These changes can occur in areas such as manufacturing, quality control, quality assurance, engineering, research and development (R&D), and marketing. Depending on their significance, changes may be categorized as critical, major, or minor; they may also be classified as emergency, planned, or unplanned based on their nature. Effective change management encompasses the coordination of personnel resources along with protocols to ensure consistency in operations and product excellence. It is a component of GMP compliance, as regulatory bodies mandate companies to demonstrate proficiency in managing changes. The process entails initiating a change request, followed by evaluating its impact on the product before devising an action plan for implementation, ultimately culminating with the Change Control Board (CCB) making decisions regarding the proposed changes.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"22 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141799518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Study of Sublingual Misoprostol and Dinoprostone Gel in Labour Induction and Its Implication on Maternal and Neonatal Outcome 舌下含服米索前列醇和地诺前列酮凝胶引产的比较研究及其对产妇和新生儿结局的影响

International Journal of Research in Pharmaceutical Sciences Pub Date : 2024-07-24 DOI: 10.26452/ijrps.v15i2.4680

Subashree Ilangovan, Selvi A

引用次数: 0

GC-MS Analysis of Bioactive Phytochemicals in Kalanchoe lanceolata for Antimicrobial and Antidiabetic Activities GC-MS 分析 Kalanchoe lanceolata 中具有生物活性的植物化学物质的抗菌和抗糖尿病活性

International Journal of Research in Pharmaceutical Sciences Pub Date : 2024-07-17 DOI: 10.26452/ijrps.v15i3.4678

Sravanthi Suram, Lali Lingfa, Baloji Gugulothu, Srinivas Ankanagari

{"title":"GC-MS Analysis of Bioactive Phytochemicals in Kalanchoe lanceolata for Antimicrobial and Antidiabetic Activities","authors":"Sravanthi Suram, Lali Lingfa, Baloji Gugulothu, Srinivas Ankanagari","doi":"10.26452/ijrps.v15i3.4678","DOIUrl":"https://doi.org/10.26452/ijrps.v15i3.4678","url":null,"abstract":"The herb Kalanchoe lanceolata, which is widely used in traditional medicine, has showed promise in treating a range of ailments. Despite its widespread usage in traditional medicine, the phytochemical contents of K. lanceolata are not well studied, particularly in terms of its potential involvement in diabetes management. In this study, the objective was to identify the phytochemical constituents of K. lanceolata and determine how they can help with diabetes management. The whole plant methanolic, ethyl acetate, and petroleum ether extracts were analysed with GC-MS to identify bioactive components. In this study, 63 compounds were identified, 27 of which possess bioactive properties. Acorenone B, columbin, phytol, astaxanthin, β-sitosterol, 2,4-di-tert-butylphenol, and caryophyllene oxide are significant compounds found to be present in K. lanceolata. In silico molecular docking studies predicted the antidiabetic and antibacterial properties of phytochemical compounds. These compounds show potential as antibacterial, antifungal and antidiabetic agents. This study stresses the significance of K. lanceolata bioactive components and sheds light on the therapeutic potential in diabetes control.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":" 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141831139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutraceutical Muffins: Development and Sensory Evaluation 营养松饼：开发和感官评估

International Journal of Research in Pharmaceutical Sciences Pub Date : 2024-07-17 DOI: 10.26452/ijrps.v15i3.4679

Bhatt Mehul K, Goswami Dhruvi, Rajgor Hiral, Patel Devanshi, Vora Jahanavee, Talaviya Priti, Shah Nehal

引用次数: 0

Cention-N: A Review Cention-N：回顾

International Journal of Research in Pharmaceutical Sciences Pub Date : 2024-05-20 DOI: 10.26452/ijrps.v15i2.4676

Ashima Varshney, Sonal Gupta, Kumari Akancha, Neha Lal

{"title":"Cention-N: A Review","authors":"Ashima Varshney, Sonal Gupta, Kumari Akancha, Neha Lal","doi":"10.26452/ijrps.v15i2.4676","DOIUrl":"https://doi.org/10.26452/ijrps.v15i2.4676","url":null,"abstract":"An ideal material used for restoration should be adhesive, tooth coloured, resistant to wear, nontoxic and biocompatible with the tissue. Various direct filling materials are available in dentistry such as amalgam, glass ionomer cement (GIC) and esthetic composite material, each of them having its advantages and disadvantages hence proper selection of restorative materials will help for its clinical success. Cention-N is a new alkasite, bulk filling, basic tooth-coloured, radiopaque material introduced by Ivoclar Vivadent in 2016. It is a self-curing filling material with optimum light curing. It consists of an isofiller which reduces the polymerization shrinkage and utilizes an alkaline filler which is capable of releasing acid-neutralizing ions. It presents with good mechanical properties and long-term stability due to the cross-linking of methacrylates in the final restoration hence it can be used in load-bearing areas. Cention-N can be efficiently used in pediatric patients as it is moisture resistant and releases fluoride which helps in remineralizing teeth thus preventing secondary caries. The use of caution is restricted in the anterior tooth as it is available only in one shade.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"16 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141119893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Hypotensive Anaesthesia in Functional Endoscopic Sinus Surgeries: A Systematic Review 功能性内窥镜鼻窦手术中的降压麻醉：系统回顾

International Journal of Research in Pharmaceutical Sciences Pub Date : 2024-02-29 DOI: 10.26452/ijrps.v15i1.4664

Govindarajan A, Swetha Ns, Govind Shaji, P. S

{"title":"Hypotensive Anaesthesia in Functional Endoscopic Sinus Surgeries: A Systematic Review","authors":"Govindarajan A, Swetha Ns, Govind Shaji, P. S","doi":"10.26452/ijrps.v15i1.4664","DOIUrl":"https://doi.org/10.26452/ijrps.v15i1.4664","url":null,"abstract":"This systematic review comprehensively analyzes the literature on hypotensive anesthesia in Functional Endoscopic Sinus Surgeries (FESS), crucial for treating sinonasal disorders. The anesthesia technique choice significantly influences FESS outcomes. Hypotensive anesthesia, involving controlled blood pressure reduction during surgery, garners attention for potential benefits. A database search identified relevant studies examining its efficacy, safety, and impact on intraoperative visibility, surgical time, blood loss, and postoperative outcomes. Various drugs, including inhalational agents, hypocapnia, hypercapnia, local adrenaline, fentanyl, remifentanil, esmolol, dexmedetomidine, and nitroglycerine, have been employed to minimize bleeding and enhance operative conditions. Sevoflurane is a common inhalation agent. Dexmedetomidine, with lower bolus doses, proves advantageous for visibility and achieving a MAP of 60 mm Hg swiftly. Opioids have a lower hypotensive potential, nitroglycerine lacks analgesic effects, and beta-blockers provide favorable conditions. Dexmedetomidine's prolonged analgesia correlates with improved postoperative outcomes. Limited studies explore combined drugs' efficacy or side effects. Cognitive dysfunction is a concern, with hypotension approved up to a MAP of 60 mm Hg. The technique's application extends to children, but careful patient selection is crucial, considering contraindications and comorbidities.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140414571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative study of rubber band ligation versus surgical excision in the treatment of second-degree haemorrhoids 橡皮筋结扎与手术切除治疗二度痔疮的比较研究

International Journal of Research in Pharmaceutical Sciences Pub Date : 2024-02-12 DOI: 10.26452/ijrps.v15i1.4663

Kishore D, Debarath Das, Lakshmana R, Pravin Dhas, S. N, Malarmannan M

{"title":"Comparative study of rubber band ligation versus surgical excision in the treatment of second-degree haemorrhoids","authors":"Kishore D, Debarath Das, Lakshmana R, Pravin Dhas, S. N, Malarmannan M","doi":"10.26452/ijrps.v15i1.4663","DOIUrl":"https://doi.org/10.26452/ijrps.v15i1.4663","url":null,"abstract":"Our study focused on comparing the efficacy of Rubber Band Ligation (banding), a day-care and cost-effective procedure, with conventional haemorrhoidectomy in the treatment of haemorrhoids. The study included 120 patients diagnosed through proctoscopic examination, with 60 assigned to each group. Patients were randomly selected through simple alternation for banding or haemorrhoidectomy after receiving procedural explanations and providing consent. Banding, utilizing Barron's band applicator and Hemoband suction device under local anaesthesia, demonstrated notable advantages. Comparison parameters included bleeding, pain, prolapse, and overall relief during follow-ups. Banding showed significantly lower bleeding persistence at 4 weeks compared to haemorrhoidectomy (p < 0.001). Prolapse rates were comparable between the two groups (10%). Complete relief was observed in 1.66% of patients in both groups at the first follow-up (p = 0.929). Banding resulted in moderate pain levels compared to haemorrhoidectomy. Hospital stay duration favoured banding, with 71.66% discharged in 1-3 days, while haemorrhoidectomy had longer stays (3-6 days: 26.66%, >6 days: 1.66%). In conclusion, Rubber Band Ligation emerged as a more effective and preferable method for second-degree haemorrhoids, providing better outcomes, reduced bleeding, and shorter hospital stays compared to conventional haemorrhoidectomy.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"12 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139782917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative study of tissue culture and sensitivity versus swab culture and sensitivity of microorganisms in the healing of diabetic foot ulcers 糖尿病足溃疡愈合中微生物的组织培养和敏感性与拭子培养和敏感性的比较研究

International Journal of Research in Pharmaceutical Sciences Pub Date : 2024-02-12 DOI: 10.26452/ijrps.v15i1.4660

Debarath Das, Kishore D, Lakshmana R, Pravin Dhas, S. N, Malarmannan M

{"title":"Comparative study of tissue culture and sensitivity versus swab culture and sensitivity of microorganisms in the healing of diabetic foot ulcers","authors":"Debarath Das, Kishore D, Lakshmana R, Pravin Dhas, S. N, Malarmannan M","doi":"10.26452/ijrps.v15i1.4660","DOIUrl":"https://doi.org/10.26452/ijrps.v15i1.4660","url":null,"abstract":"This prospective observational study, conducted at the Department of General Surgery, SRM Medical College and Hospital, aimed to assess the effectiveness of tissue culture and sensitivity compared to swab culture and sensitivity in the healing of diabetic foot ulcers through antibiotic sensitivity of microorganisms. Between May 2016 and August 2017, 160 subjects with diabetic foot ulcers were randomly assigned treatment based on either swab or tissue culture findings. Patients were followed at 15-day intervals for up to 60 days. Results showed positive swab cultures in 76.88% and positive tissue cultures in 92.50% of the study population. The most prevalent organism in swab cultures was Proteus (14.38%), while Pseudomonas (16.88%) dominated in tissue cultures. The cumulative proportion of subjects developing granulation tissue was faster in the tissue culture group, reaching 57.50% at 15 to 30 days and 99% at 31 to 45 days. The swab culture group exhibited proportions of 48.80%, 75%, and 93.80% at the same intervals. In conclusion, diabetic foot ulcer treatment based on tissue culture showed slightly faster healing rates compared to swab culture. However, both groups achieved good ulcer healing within the 60-day follow-up period. These findings emphasize the importance of choosing an appropriate culture method for effective management of diabetic foot ulcers.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"100 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139784346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physicochemical and heavy metal analysis of Yavani-Sadav Churan – An Ayurvedic formulation Yavani-Sadav Churan（一种阿育吠陀配方）的理化和重金属分析

International Journal of Research in Pharmaceutical Sciences Pub Date : 2024-02-12 DOI: 10.26452/ijrps.v15i1.4661

Suman Lata, Sonia Dhiman, Mamta Rana

{"title":"Physicochemical and heavy metal analysis of Yavani-Sadav Churan – An Ayurvedic formulation","authors":"Suman Lata, Sonia Dhiman, Mamta Rana","doi":"10.26452/ijrps.v15i1.4661","DOIUrl":"https://doi.org/10.26452/ijrps.v15i1.4661","url":null,"abstract":"Ayurveda is the most ancient documented healing heritage of the world that describes health management through natural products. Bhaishjya Kalpana, a branch of Ayurveda, describes details of pharmaceutical preparations of different dosage forms. Chooran kalpana is one of the solid dosage forms considered the secondary Kalpana of Kalka kalpana. In a common language, it is known as powder medicine and is used extensively in Ayurvedic treatment. For promoting Ayurveda, traditional health management introduced the term Drug standardization in the manufacturing of Ayurvedic medicine to ensure good quality medicines for the satisfaction of customers in the international market. Drug standardization is the core issue not only for Bhaishjya Kalpana but also for the entire Ayurveda health care. In the present study, Yavani–Sadav Churan was prepared and the physicochemical and Heavy metal analysis of churan is the main aim of the study. In this study, different parameters for assessment of purity, quality, and safety of Yavanisadava chooran will be carried out like organoleptic characteristics, loss on drying, total ash, acid insoluble ash, water-soluble extractives, and Alcohol soluble extractives. pH, Bulk density, Tap density, Particle size, TLC and Heavy metal analysis by AAS method etc., which contribute to a great extent for standardization.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"20 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139782972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative study of rubber band ligation versus surgical excision in the treatment of second-degree haemorrhoids 橡皮筋结扎与手术切除治疗二度痔疮的比较研究

International Journal of Research in Pharmaceutical Sciences Pub Date : 2024-02-12 DOI: 10.26452/ijrps.v15i1.4663

Kishore D, Debarath Das, Lakshmana R, Pravin Dhas, S. N, Malarmannan M

{"title":"Comparative study of rubber band ligation versus surgical excision in the treatment of second-degree haemorrhoids","authors":"Kishore D, Debarath Das, Lakshmana R, Pravin Dhas, S. N, Malarmannan M","doi":"10.26452/ijrps.v15i1.4663","DOIUrl":"https://doi.org/10.26452/ijrps.v15i1.4663","url":null,"abstract":"Our study focused on comparing the efficacy of Rubber Band Ligation (banding), a day-care and cost-effective procedure, with conventional haemorrhoidectomy in the treatment of haemorrhoids. The study included 120 patients diagnosed through proctoscopic examination, with 60 assigned to each group. Patients were randomly selected through simple alternation for banding or haemorrhoidectomy after receiving procedural explanations and providing consent. Banding, utilizing Barron's band applicator and Hemoband suction device under local anaesthesia, demonstrated notable advantages. Comparison parameters included bleeding, pain, prolapse, and overall relief during follow-ups. Banding showed significantly lower bleeding persistence at 4 weeks compared to haemorrhoidectomy (p < 0.001). Prolapse rates were comparable between the two groups (10%). Complete relief was observed in 1.66% of patients in both groups at the first follow-up (p = 0.929). Banding resulted in moderate pain levels compared to haemorrhoidectomy. Hospital stay duration favoured banding, with 71.66% discharged in 1-3 days, while haemorrhoidectomy had longer stays (3-6 days: 26.66%, >6 days: 1.66%). In conclusion, Rubber Band Ligation emerged as a more effective and preferable method for second-degree haemorrhoids, providing better outcomes, reduced bleeding, and shorter hospital stays compared to conventional haemorrhoidectomy.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"128 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139842860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0