International Journal of Research in Pharmaceutical Sciences最新文献_第2页

Physicochemical and heavy metal analysis of Yavani-Sadav Churan – An Ayurvedic formulation Yavani-Sadav Churan（一种阿育吠陀配方）的理化和重金属分析

International Journal of Research in Pharmaceutical Sciences Pub Date : 2024-02-12 DOI: 10.26452/ijrps.v15i1.4661

Suman Lata, Sonia Dhiman, Mamta Rana

{"title":"Physicochemical and heavy metal analysis of Yavani-Sadav Churan – An Ayurvedic formulation","authors":"Suman Lata, Sonia Dhiman, Mamta Rana","doi":"10.26452/ijrps.v15i1.4661","DOIUrl":"https://doi.org/10.26452/ijrps.v15i1.4661","url":null,"abstract":"Ayurveda is the most ancient documented healing heritage of the world that describes health management through natural products. Bhaishjya Kalpana, a branch of Ayurveda, describes details of pharmaceutical preparations of different dosage forms. Chooran kalpana is one of the solid dosage forms considered the secondary Kalpana of Kalka kalpana. In a common language, it is known as powder medicine and is used extensively in Ayurvedic treatment. For promoting Ayurveda, traditional health management introduced the term Drug standardization in the manufacturing of Ayurvedic medicine to ensure good quality medicines for the satisfaction of customers in the international market. Drug standardization is the core issue not only for Bhaishjya Kalpana but also for the entire Ayurveda health care. In the present study, Yavani–Sadav Churan was prepared and the physicochemical and Heavy metal analysis of churan is the main aim of the study. In this study, different parameters for assessment of purity, quality, and safety of Yavanisadava chooran will be carried out like organoleptic characteristics, loss on drying, total ash, acid insoluble ash, water-soluble extractives, and Alcohol soluble extractives. pH, Bulk density, Tap density, Particle size, TLC and Heavy metal analysis by AAS method etc., which contribute to a great extent for standardization.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"139 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139842940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biodiversity and Healing: Exploring the medicinal potential of wild edible plants abundant in antioxidants 生物多样性与治疗：探索富含抗氧化剂的野生食用植物的药用潜力

International Journal of Research in Pharmaceutical Sciences Pub Date : 2024-02-12 DOI: 10.26452/ijrps.v15i1.4662

T. Seal, B. Pillai, K. Chaudhuri

{"title":"Biodiversity and Healing: Exploring the medicinal potential of wild edible plants abundant in antioxidants","authors":"T. Seal, B. Pillai, K. Chaudhuri","doi":"10.26452/ijrps.v15i1.4662","DOIUrl":"https://doi.org/10.26452/ijrps.v15i1.4662","url":null,"abstract":"Wild edible plants (WEPs) are rich in antioxidants with a history of traditional medicinal use. This study aimed to find the most efficient polyphenol extraction solvent from WEPs, including Lasia spinosa, Eriosema chinense, Nasturtium indicum, Begonia hatacoa, and Embelia floribunda, for pharmaceutical and drug industry applications. Polyphenols, crucial antioxidants, were meticulously analyzed via RP-HPLC. Total phenolic, flavonoid, and flavonol levels were measured with four solvents. 80% aqueous (aq.) ethanol proved the most effective, surpassing solvents of varying polarities. The plants exhibited high total phenolics and flavonols, notably gallic acid (30.78±1.67 µg/mg dry extract) and syringic acid (32.03±1.89 µg/mg dry extract) in 80% Aq. ethanol extract of E. floribunda. Correlation analyses revealed strong connections between parameters, with 80% Aq. ethanol and acetone showing the highest correlation values (r and R2), indicating their exceptional polyphenol extraction and antioxidant potential. The principal component analysis emphasized the pharmaceutical potential of WEPs, particularly E. floribunda's 80% Aq. ethanol extract due to its phenolic and polyphenolic content. In conclusion, 80% of ethanol extracts of these plants outperform synthetic derivatives in antioxidant activity, making them promising for pharmaceutical and drug product development with enhanced natural antioxidant properties.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"16 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139784171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biodiversity and Healing: Exploring the medicinal potential of wild edible plants abundant in antioxidants 生物多样性与治疗：探索富含抗氧化剂的野生食用植物的药用潜力

International Journal of Research in Pharmaceutical Sciences Pub Date : 2024-02-12 DOI: 10.26452/ijrps.v15i1.4662

T. Seal, B. Pillai, K. Chaudhuri

{"title":"Biodiversity and Healing: Exploring the medicinal potential of wild edible plants abundant in antioxidants","authors":"T. Seal, B. Pillai, K. Chaudhuri","doi":"10.26452/ijrps.v15i1.4662","DOIUrl":"https://doi.org/10.26452/ijrps.v15i1.4662","url":null,"abstract":"Wild edible plants (WEPs) are rich in antioxidants with a history of traditional medicinal use. This study aimed to find the most efficient polyphenol extraction solvent from WEPs, including Lasia spinosa, Eriosema chinense, Nasturtium indicum, Begonia hatacoa, and Embelia floribunda, for pharmaceutical and drug industry applications. Polyphenols, crucial antioxidants, were meticulously analyzed via RP-HPLC. Total phenolic, flavonoid, and flavonol levels were measured with four solvents. 80% aqueous (aq.) ethanol proved the most effective, surpassing solvents of varying polarities. The plants exhibited high total phenolics and flavonols, notably gallic acid (30.78±1.67 µg/mg dry extract) and syringic acid (32.03±1.89 µg/mg dry extract) in 80% Aq. ethanol extract of E. floribunda. Correlation analyses revealed strong connections between parameters, with 80% Aq. ethanol and acetone showing the highest correlation values (r and R2), indicating their exceptional polyphenol extraction and antioxidant potential. The principal component analysis emphasized the pharmaceutical potential of WEPs, particularly E. floribunda's 80% Aq. ethanol extract due to its phenolic and polyphenolic content. In conclusion, 80% of ethanol extracts of these plants outperform synthetic derivatives in antioxidant activity, making them promising for pharmaceutical and drug product development with enhanced natural antioxidant properties.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"68 46","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139844197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative study of tissue culture and sensitivity versus swab culture and sensitivity of microorganisms in the healing of diabetic foot ulcers 糖尿病足溃疡愈合中微生物的组织培养和敏感性与拭子培养和敏感性的比较研究

International Journal of Research in Pharmaceutical Sciences Pub Date : 2024-02-12 DOI: 10.26452/ijrps.v15i1.4660

Debarath Das, Kishore D, Lakshmana R, Pravin Dhas, S. N, Malarmannan M

{"title":"Comparative study of tissue culture and sensitivity versus swab culture and sensitivity of microorganisms in the healing of diabetic foot ulcers","authors":"Debarath Das, Kishore D, Lakshmana R, Pravin Dhas, S. N, Malarmannan M","doi":"10.26452/ijrps.v15i1.4660","DOIUrl":"https://doi.org/10.26452/ijrps.v15i1.4660","url":null,"abstract":"This prospective observational study, conducted at the Department of General Surgery, SRM Medical College and Hospital, aimed to assess the effectiveness of tissue culture and sensitivity compared to swab culture and sensitivity in the healing of diabetic foot ulcers through antibiotic sensitivity of microorganisms. Between May 2016 and August 2017, 160 subjects with diabetic foot ulcers were randomly assigned treatment based on either swab or tissue culture findings. Patients were followed at 15-day intervals for up to 60 days. Results showed positive swab cultures in 76.88% and positive tissue cultures in 92.50% of the study population. The most prevalent organism in swab cultures was Proteus (14.38%), while Pseudomonas (16.88%) dominated in tissue cultures. The cumulative proportion of subjects developing granulation tissue was faster in the tissue culture group, reaching 57.50% at 15 to 30 days and 99% at 31 to 45 days. The swab culture group exhibited proportions of 48.80%, 75%, and 93.80% at the same intervals. In conclusion, diabetic foot ulcer treatment based on tissue culture showed slightly faster healing rates compared to swab culture. However, both groups achieved good ulcer healing within the 60-day follow-up period. These findings emphasize the importance of choosing an appropriate culture method for effective management of diabetic foot ulcers.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"66 51","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139844287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Systematic Review of Solubility Enhancement Techniques Used for BCS Class II & IV 用于 BCS II 级和 IV 级的溶解度增强技术系统回顾

International Journal of Research in Pharmaceutical Sciences Pub Date : 2024-02-06 DOI: 10.26452/ijrps.v15i1.4658

Pavankumar Dhoble, Bharat Tekade, Vishal Bodke, Mohan Kale

{"title":"A Systematic Review of Solubility Enhancement Techniques Used for BCS Class II & IV","authors":"Pavankumar Dhoble, Bharat Tekade, Vishal Bodke, Mohan Kale","doi":"10.26452/ijrps.v15i1.4658","DOIUrl":"https://doi.org/10.26452/ijrps.v15i1.4658","url":null,"abstract":"Because of their low solubility, pharmaceutical researchers encounter tremendous difficulties in creating sustainable and more soluble drugs (BCS class II). About 40% of oral dosage forms have formulation and development problems due to water insolubility. The rate of dissolving, absorption, distribution, and excretion of an active medicinal substance is determined by its solubility parameters. Based on their solubility, drugs are divided into four kinds under the BCS categorization system. BCS Class II and Class IV drugs have problems with solubility. Increasing both the bioavailability and the solubility of poorly soluble medications can be accomplished in several ways. Some techniques—like solid dispersion, solid complexation, liquisolid, hydrotropy, sonocrystallization, and self-emulsifying techniques—are commonly used for solubility augmentation. Until an orally active medication dissolves in the lining of the stomach and/or intestinal fluids, it cannot pass through the GI tract membrane and enter the bloodstream. Therefore, a medication that is insoluble in water will typically exhibit limited absorption by dissolution, and a medication that is weakly permeabilized via membranes would typically exhibit limited absorption through permeation. Consequently, improving the oral bioavailability of active substances is the focus of two areas of pharmaceutical research: (i) accelerating the process of dissolution and solubility of drugs that are poorly soluble in water, and (ii) accelerating the permeability of poorly permeable drugs.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"23 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139861955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of a 2-aminothiazole framework using classical QSAR model targeting chloroquine-sensitive Plasmodium falciparum 利用经典 QSAR 模型鉴定针对氯喹敏感恶性疟原虫的 2-氨基噻唑框架

International Journal of Research in Pharmaceutical Sciences Pub Date : 2024-02-06 DOI: 10.26452/ijrps.v15i1.4659

Ravindran Karuppaiyan, Anitha Gunavel, Kasthuri Bai Solai, Prabha Thangavelu

{"title":"Identification of a 2-aminothiazole framework using classical QSAR model targeting chloroquine-sensitive Plasmodium falciparum","authors":"Ravindran Karuppaiyan, Anitha Gunavel, Kasthuri Bai Solai, Prabha Thangavelu","doi":"10.26452/ijrps.v15i1.4659","DOIUrl":"https://doi.org/10.26452/ijrps.v15i1.4659","url":null,"abstract":"Chloroquine-sensitive Plasmodium falciparum is the most deadly form of human malaria. It is associated with a number of mutations in P. falciparum. Chloroquine-resistant transporter is a protein that serves as a transporter in the parasite's digesting vacuole membrane. In order to combat chloroquine-sensitive P. falciparum strains (NF54), this study employs QSAR modelling to examine possible structural alterations of 2-amino-thiazole derivatives. The traditional QSAR model was built using the PaDEL descriptor via QSARINS software. The model was found to have an internal cross-validation value of Q2loo = 0.7890 and an external validation parameter of RMSE ext = 0.6938. The predicted pIC50 values from the QSAR techniques for the case study chemicals were compared and found to be well fitted to the model and well predicted for the external set of compounds. The outcome demonstrates the value of using the suggested method in the creation of new medication candidates could fill the critical gap in scientific knowledge and open up novel possibilities for pharmaceutical development.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"16 S15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139801528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Systematic Review of Solubility Enhancement Techniques Used for BCS Class II & IV 用于 BCS II 级和 IV 级的溶解度增强技术系统回顾

International Journal of Research in Pharmaceutical Sciences Pub Date : 2024-02-06 DOI: 10.26452/ijrps.v15i1.4658

Pavankumar Dhoble, Bharat Tekade, Vishal Bodke, Mohan Kale

{"title":"A Systematic Review of Solubility Enhancement Techniques Used for BCS Class II & IV","authors":"Pavankumar Dhoble, Bharat Tekade, Vishal Bodke, Mohan Kale","doi":"10.26452/ijrps.v15i1.4658","DOIUrl":"https://doi.org/10.26452/ijrps.v15i1.4658","url":null,"abstract":"Because of their low solubility, pharmaceutical researchers encounter tremendous difficulties in creating sustainable and more soluble drugs (BCS class II). About 40% of oral dosage forms have formulation and development problems due to water insolubility. The rate of dissolving, absorption, distribution, and excretion of an active medicinal substance is determined by its solubility parameters. Based on their solubility, drugs are divided into four kinds under the BCS categorization system. BCS Class II and Class IV drugs have problems with solubility. Increasing both the bioavailability and the solubility of poorly soluble medications can be accomplished in several ways. Some techniques—like solid dispersion, solid complexation, liquisolid, hydrotropy, sonocrystallization, and self-emulsifying techniques—are commonly used for solubility augmentation. Until an orally active medication dissolves in the lining of the stomach and/or intestinal fluids, it cannot pass through the GI tract membrane and enter the bloodstream. Therefore, a medication that is insoluble in water will typically exhibit limited absorption by dissolution, and a medication that is weakly permeabilized via membranes would typically exhibit limited absorption through permeation. Consequently, improving the oral bioavailability of active substances is the focus of two areas of pharmaceutical research: (i) accelerating the process of dissolution and solubility of drugs that are poorly soluble in water, and (ii) accelerating the permeability of poorly permeable drugs.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"118 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139802037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of a 2-aminothiazole framework using classical QSAR model targeting chloroquine-sensitive Plasmodium falciparum 利用经典 QSAR 模型鉴定针对氯喹敏感恶性疟原虫的 2-氨基噻唑框架

International Journal of Research in Pharmaceutical Sciences Pub Date : 2024-02-06 DOI: 10.26452/ijrps.v15i1.4659

Ravindran Karuppaiyan, Anitha Gunavel, Kasthuri Bai Solai, Prabha Thangavelu

{"title":"Identification of a 2-aminothiazole framework using classical QSAR model targeting chloroquine-sensitive Plasmodium falciparum","authors":"Ravindran Karuppaiyan, Anitha Gunavel, Kasthuri Bai Solai, Prabha Thangavelu","doi":"10.26452/ijrps.v15i1.4659","DOIUrl":"https://doi.org/10.26452/ijrps.v15i1.4659","url":null,"abstract":"Chloroquine-sensitive Plasmodium falciparum is the most deadly form of human malaria. It is associated with a number of mutations in P. falciparum. Chloroquine-resistant transporter is a protein that serves as a transporter in the parasite's digesting vacuole membrane. In order to combat chloroquine-sensitive P. falciparum strains (NF54), this study employs QSAR modelling to examine possible structural alterations of 2-amino-thiazole derivatives. The traditional QSAR model was built using the PaDEL descriptor via QSARINS software. The model was found to have an internal cross-validation value of Q2loo = 0.7890 and an external validation parameter of RMSE ext = 0.6938. The predicted pIC50 values from the QSAR techniques for the case study chemicals were compared and found to be well fitted to the model and well predicted for the external set of compounds. The outcome demonstrates the value of using the suggested method in the creation of new medication candidates could fill the critical gap in scientific knowledge and open up novel possibilities for pharmaceutical development.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"184 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139861498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Appropriateness of Surgical Antimicrobial Prophylaxis in a tertiary care hospital: A prospective observational study 一家三甲医院手术抗菌预防的适当性：前瞻性观察研究

International Journal of Research in Pharmaceutical Sciences Pub Date : 2023-11-27 DOI: 10.26452/ijrps.v14i4.4549

Shailaja K, Fragrance Jemimah D, Aritta Hillari L S, Priyanka N

{"title":"Appropriateness of Surgical Antimicrobial Prophylaxis in a tertiary care hospital: A prospective observational study","authors":"Shailaja K, Fragrance Jemimah D, Aritta Hillari L S, Priyanka N","doi":"10.26452/ijrps.v14i4.4549","DOIUrl":"https://doi.org/10.26452/ijrps.v14i4.4549","url":null,"abstract":"Surgical site infections (SSIs) are a significant concern in global healthcare, particularly in middle and low-income countries, leading to increased hospitalizations, morbidity, mortality, and financial strain. Ranked third in the CDC's National Nosocomial Infections Surveillance System, SSIs have prompted a focus on preventive measures, notably surgical antimicrobial prophylaxis (SAP). However, SAP is often used inappropriately, contributing to the rise of Antimicrobial Resistance (AMR). Addressing this, a six-month prospective observational study was conducted in a tertiary care hospital to assess the adherence to SAP guidelines among 386 patients undergoing surgeries in various specialties. The study aimed to evaluate the appropriateness of SAP practices and identify factors leading to non-compliance. Results showed that only 58.3% of patients fully adhered to the guidelines. While 100% compliance was observed in SAP indication, lower adherence was noted in the timing of administration (97.7%), choice of SAP (85%), and duration of prophylaxis (70.2%). These findings underscore a significant gap between recommended SAP practices and actual implementation. This gap highlights the need for stronger Institutional Antimicrobial Stewardship (AMS) programs and the critical role of clinical pharmacists in regularly evaluating SAP and prescribing practices. To combat the rise of antibiotic resistance while ensuring patient safety, enhancing SAP practices in line with national and international recommendations is essential. The study advocates for more active interventions at the time of order to optimize antibiotic use, thereby addressing the challenge of compliance in SAP guidelines.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139229467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacognosy, Phytochemical and Pharmacological Potential of Sacostemma acidum Voigt Sacostemma acidum Voigt 的药理、植物化学和药理潜力

International Journal of Research in Pharmaceutical Sciences Pub Date : 2023-11-27 DOI: 10.26452/ijrps.v14i4.4548

Pravanjan Kumar Tripathy, M. Mishra

{"title":"Pharmacognosy, Phytochemical and Pharmacological Potential of Sacostemma acidum Voigt","authors":"Pravanjan Kumar Tripathy, M. Mishra","doi":"10.26452/ijrps.v14i4.4548","DOIUrl":"https://doi.org/10.26452/ijrps.v14i4.4548","url":null,"abstract":"Sarcostemma acidum Voigt, commonly known as Somlata, belongs to the Apocynaceae family and is a leafless plant with significant traditional medicinal use. Found mainly in Bihar, West Bengal, Odisha, and South India, it thrives in dry rocky areas. The shrub, characterized by numerous branches and an absence of leaves, features green, cylindrical stems ranging from 2 to 4 meters in length and 0.5 cm to 1 cm in diameter. The plant's leaves, though present in opposite positions, are reduced to scales, rendering it leafless. The flowers are actinomorphic, displaying a light yellow or white hue. Microscopic analysis of the stem of Sarcostemma acidum reveals three primary components: the outer epidermis layer, cortex, and vascular bundles. The outermost epidermis consists of a single layer of cells, and the cortex comprises collenchyma and parenchymal cells. The aqueous extract of S. acidum contains a diverse array of compounds, including carbohydrates, glycosides, alkaloids, tannins, flavonoids, proteins, free amino acids, steroids, triterpenoids, fixed oils, fats, mucilage, gums, and waxes. Different parts of S. acidum are utilized for various purposes, such as a natural restorative for health, ear drops in otitis, and application on wounds and cuts. The stem extract exhibits antipsychotic effects and inhibits spermatogenesis. Recent studies also highlight its analgesic, antipyretic, and antidiabetic properties. This plant holds promise for further research in isolating active constituents with therapeutic effects.","PeriodicalId":14285,"journal":{"name":"International Journal of Research in Pharmaceutical Sciences","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139232286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0