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International Journal of Radiation Biology最新文献

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Value of 18F-FDG PET/CT-based radiomics features for differentiating primary lung cancer and solitary lung metastasis in patients with colorectal adenocarcinoma. 基于 18F-FDG PET/CT 的放射组学特征在区分结直肠腺癌患者的原发性肺癌和单发肺转移瘤方面的价值。
IF 2.6 4区 医学
International Journal of Radiation Biology Pub Date : 2024-09-17 DOI: 10.1080/09553002.2024.2404465
Na Wang,Meng Dai,Fenglian Jing,Yunuan Liu,Yan Zhao,Zhaoqi Zhang,Jianfang Wang,Jingmian Zhang,Yingchen Wang,Xinming Zhao
{"title":"Value of 18F-FDG PET/CT-based radiomics features for differentiating primary lung cancer and solitary lung metastasis in patients with colorectal adenocarcinoma.","authors":"Na Wang,Meng Dai,Fenglian Jing,Yunuan Liu,Yan Zhao,Zhaoqi Zhang,Jianfang Wang,Jingmian Zhang,Yingchen Wang,Xinming Zhao","doi":"10.1080/09553002.2024.2404465","DOIUrl":"https://doi.org/10.1080/09553002.2024.2404465","url":null,"abstract":"OBJECTIVETo investigate the value and applicability of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) radiomics in differentiating primary lung cancer (PLC) from solitary lung metastasis (SLM) in patients with colorectal cancer (CRC).MATERIALS AND METHODSThis retrospective study included 103 patients with CRC and solitary pulmonary nodules (SPNs). The least absolute shrinkage and selection operator (LASSO) was used to screen for optimal radiomics features and establish a PET/CT radiomics model. PET/CT Visual and complex models (combining radiomics with PET/CT visual features) were developed. The area under the receiver operating characteristic (ROC) curve (AUC) was used to determine the predictive value and diagnostic efficiency of the models.RESULTSThe AUC of the PET/CT radiomics model for differentiating PLC from SLM was 0.872 (95% CI: 0.806-0.939), which was not different from that of the visual (0.829 [95% CI: 0.749-0.908; p = .352]). However, the AUC of the complex model (0.936 [95% CI:0.892-0.981]) was significantly higher than that of the PET/CT radiomics (p = .005) and visual model (p = .001). The sensitivity (SEN), specificity (SPE), accuracy (ACC), positive predictive value (PPV), and negative predictive value (NPV) of PET/CT radiomics for differentiating PLC from SLM were 0.720, 0.887, 0.806, 0.857, and 0.770, respectively.CONCLUSIONPET/CT radiomics can effectively distinguish PLC and SLM in patients with CRC and SPNs and guide the implementation of personalized treatment.","PeriodicalId":14261,"journal":{"name":"International Journal of Radiation Biology","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142266241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Differential biological effect of low doses of ionizing radiation depending on the radiosensitivity in a cell line model 低剂量电离辐射的生物效应因细胞系模型的辐射敏感性而异
IF 2.6 4区 医学
International Journal of Radiation Biology Pub Date : 2024-09-17 DOI: 10.1080/09553002.2024.2400514
Elia Palma-Rojo, Joan-Francesc Barquinero, Jaime Pérez-Alija, Juan R. González, Gemma Armengol
{"title":"Differential biological effect of low doses of ionizing radiation depending on the radiosensitivity in a cell line model","authors":"Elia Palma-Rojo, Joan-Francesc Barquinero, Jaime Pérez-Alija, Juan R. González, Gemma Armengol","doi":"10.1080/09553002.2024.2400514","DOIUrl":"https://doi.org/10.1080/09553002.2024.2400514","url":null,"abstract":"Exposure to low doses (LD) of ionizing radiation (IR), such as the ones employed in computed tomography (CT) examination, can be associated with cancer risk. However, cancer development could depen...","PeriodicalId":14261,"journal":{"name":"International Journal of Radiation Biology","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142266242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term biological effects after acute 131I-administration of two rat models (with and without thyroid). 两种大鼠模型（有甲状腺和无甲状腺）急性服用 131I 后的长期生物效应。
IF 2.6 4区 医学
International Journal of Radiation Biology Pub Date : 2024-09-11 DOI: 10.1080/09553002.2024.2400484
Meriem Mezaguer-Lekouaghet,Maâmar Souidi,Samia Hadjrabia,Saâdia Mameri,Mounir Aït-Ziane,Abdelwahab Badreddine,Ahcène Baz,Zohra Lounis-Mokrani
{"title":"Long-term biological effects after acute 131I-administration of two rat models (with and without thyroid).","authors":"Meriem Mezaguer-Lekouaghet,Maâmar Souidi,Samia Hadjrabia,Saâdia Mameri,Mounir Aït-Ziane,Abdelwahab Badreddine,Ahcène Baz,Zohra Lounis-Mokrani","doi":"10.1080/09553002.2024.2400484","DOIUrl":"https://doi.org/10.1080/09553002.2024.2400484","url":null,"abstract":"PURPOSERadioiodine-131 (RAI or iodine-131) is one of the most frequently used radionuclides for diagnosis and therapy of thyroid diseases (90% of all therapies in nuclear medicine). In order to optimize the patient protection, it is important to evaluate the long-term biological effects of RAI therapy on non-target organs.MATERIALS AND METHODSAn experimental animal model has been adopted, it consists on miming RAI therapy. An activity of RAI has been administrated in two models of Wistar rats: the first model with an intact thyroid gland (Thy + model), and the second one was thyroidectomized (Thy- model). For each model, 6 rats were orally contaminated with a solution 18.5 ± 1MBq of [131I]NaI and 6 others rats were used as controls. The 24 rats have been placed in individual cages for a period of 08 months then they were euthanized. The blood was collected by cardiac puncture and all organs were immediately removed. A fraction of thyroid, liver, kidneys and testicles was put in vials containing formaldehyde (10%) for histological investigation.RESULTSHistological observations show some liver disorders more accentuated in the case of the Thy- model, the appearance of kidney tissue effects (hemosiderin deposits, fibrosis and glomerular necrosis) for both models and an absence of any anomaly for the testicles slides. The disturbance of blood parameters specific to each organ has been revealed.CONCLUSIONSLong-term biological effect of 131I-administration shows the appearance of various histological disorders confirmed by disturbances in hepatic and renal functions.","PeriodicalId":14261,"journal":{"name":"International Journal of Radiation Biology","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142200541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The elicitation effects of diode and He-Ne laser irradiations on the alleviation of nutrient-deficiency induced damage in anthocyanin-producing red-fleshed apple cell suspension. 二极管激光和氦氖激光辐照对减轻花青素生产红肉苹果细胞悬浮液中营养缺乏引起的损伤的激发效应。
IF 2.6 4区 医学
International Journal of Radiation Biology Pub Date : 2024-09-11 DOI: 10.1080/09553002.2024.2398083
Hashem Kazemzadeh-Beneh,Ebrahim Safari,Fariborz Zaare-Nahandi,Nasser Mahna
{"title":"The elicitation effects of diode and He-Ne laser irradiations on the alleviation of nutrient-deficiency induced damage in anthocyanin-producing red-fleshed apple cell suspension.","authors":"Hashem Kazemzadeh-Beneh,Ebrahim Safari,Fariborz Zaare-Nahandi,Nasser Mahna","doi":"10.1080/09553002.2024.2398083","DOIUrl":"https://doi.org/10.1080/09553002.2024.2398083","url":null,"abstract":"PURPOSEWe explored the elicitation role of the laser irradiations on the alleviation of nutrient-deficiency induced damage in anthocyanin-producing red-fleshed apple cell suspension in continuous production of anthocyanin.METHODSAnthocyanin-producing red-fleshed apple cells were irradiated by 4 intensity levels of red He-Ne (RHNL) and blue diode (BDL) lasers for 20 min.RESULTSNutrient deficiency indicated negative effect on total soluble proteins (TSP), superoxidase dismutase (SOD) activity, and total phenolics content (TPC) while it displayed a positive effect on malondialdehyde (MDA), total flavonoids content (TFC), O2-, H2O2-, and lipoxygenase (LOX) and polyphenol oxidase (PPO) activities in light controls, illustrating oxidative stress. The laser irradiations on suspension cells indicated variable effects on measured parameters and were time of growth-, levels of intensity-, and laser type-dependent. Likewise, the elicitation effects of lasers relied on a critical threshold among ROS generation and antioxidative system which determines the fate of cells against oxidative stress. The same trend was displayed by RHNL at 6.46 mWcm-2 intensity and BDL at 13.73 mWcm-2. These intensities resulted in a significant increase in SOD, APX, POD, and CAT activities and TSP, TPC, TFC, proline, and glycine betaine accumulation, while induced decrease in LOX, and PPO activities and MDA, and ROS generation, alleviating cellular injury from prolonged nutrient deficiency by diminishing lipid peroxidation and oxidative damages of cell membrane.CONCLUSIONResults suggested that lasers application on mitigating nutrient deficiency stress relied on establishing a suitable balance between ROS generation and antioxidative system, which enables the nutrient-starved anthocyanin-producing cells to continuously produce anthocyanin.","PeriodicalId":14261,"journal":{"name":"International Journal of Radiation Biology","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142200545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gamma-rays induced genome wide stable mutations in cowpea deciphered through whole genome sequencing 通过全基因组测序破译伽马射线诱导的豇豆全基因组稳定突变
IF 2.6 4区 医学
International Journal of Radiation Biology Pub Date : 2024-04-29 DOI: 10.1080/09553002.2024.2345087
Dhanasekar Punniyamoorthy, Jegadeesan Souframanien
{"title":"Gamma-rays induced genome wide stable mutations in cowpea deciphered through whole genome sequencing","authors":"Dhanasekar Punniyamoorthy, Jegadeesan Souframanien","doi":"10.1080/09553002.2024.2345087","DOIUrl":"https://doi.org/10.1080/09553002.2024.2345087","url":null,"abstract":"Gamma rays are the most widely exploited physical mutagen in plant mutation breeding. They are known to be involved in the development of more than 60% of global cowpea (Vigna unguiculata (L.) Walp...","PeriodicalId":14261,"journal":{"name":"International Journal of Radiation Biology","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140809775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of changing the radiation dose range on the in vitro cytogenetic dose response to gamma-rays 改变辐射剂量范围对伽马射线体外细胞遗传剂量反应的影响
IF 2.6 4区 医学
International Journal of Radiation Biology Pub Date : 2024-04-22 DOI: 10.1080/09553002.2024.2338511
Volodymyr A. Vinnikov
{"title":"Effect of changing the radiation dose range on the in vitro cytogenetic dose response to gamma-rays","authors":"Volodymyr A. Vinnikov","doi":"10.1080/09553002.2024.2338511","DOIUrl":"https://doi.org/10.1080/09553002.2024.2338511","url":null,"abstract":"To examine the distortion of the linear quadratic (LQ) model of in vitro cytogenetic dose response over an extended range of γ-ray doses by analyzing the available literature data, and to establish...","PeriodicalId":14261,"journal":{"name":"International Journal of Radiation Biology","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140636719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reasons why the idea that radiation exposures induce cancer needs to be revisited 需要重新审视辐照诱发癌症这一观点的原因
IF 2.6 4区 医学
International Journal of Radiation Biology Pub Date : 2024-04-22 DOI: 10.1080/09553002.2024.2338516
Nori Nakamura
{"title":"Reasons why the idea that radiation exposures induce cancer needs to be revisited","authors":"Nori Nakamura","doi":"10.1080/09553002.2024.2338516","DOIUrl":"https://doi.org/10.1080/09553002.2024.2338516","url":null,"abstract":"It has long been thought that the carcinogenic effect of radiation resulted from the induction of oncogenic mutations which then led to an increase in the proportion of cancer-bearing individuals. ...","PeriodicalId":14261,"journal":{"name":"International Journal of Radiation Biology","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140636724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative study of the anti-inflammatory activity of etoricoxib and Matcha green tea against acute kidney injury induced by gamma radiation in rats 依托考昔和抹茶绿茶对伽马射线诱导的大鼠急性肾损伤的抗炎活性比较研究
IF 2.6 4区 医学
International Journal of Radiation Biology Pub Date : 2024-04-22 DOI: 10.1080/09553002.2024.2338515
Sahar Khateeb, Eman F.S. Taha
{"title":"Comparative study of the anti-inflammatory activity of etoricoxib and Matcha green tea against acute kidney injury induced by gamma radiation in rats","authors":"Sahar Khateeb, Eman F.S. Taha","doi":"10.1080/09553002.2024.2338515","DOIUrl":"https://doi.org/10.1080/09553002.2024.2338515","url":null,"abstract":"The primary objective of this study was to conduct a comparative analysis of the anti-inflammatory activity between Etoricoxib (ETO) and Matcha green tea (MG) in the context of acute kidney injury ...","PeriodicalId":14261,"journal":{"name":"International Journal of Radiation Biology","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140636854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meeting report: the 66th annual meeting of the Japanese Radiation Research Society in Tokyo, Japan, 6–8 November 2023 会议报告：2023 年 11 月 6 日至 8 日在日本东京举行的日本辐射研究学会第 66 届年会
IF 2.6 4区 医学
International Journal of Radiation Biology Pub Date : 2024-04-17 DOI: 10.1080/09553002.2024.2338514
Haruka Izawa, Yuzuki Nakamura, Shinya Yokomizo, Masaru Takabatake
{"title":"Meeting report: the 66th annual meeting of the Japanese Radiation Research Society in Tokyo, Japan, 6–8 November 2023","authors":"Haruka Izawa, Yuzuki Nakamura, Shinya Yokomizo, Masaru Takabatake","doi":"10.1080/09553002.2024.2338514","DOIUrl":"https://doi.org/10.1080/09553002.2024.2338514","url":null,"abstract":"The 66th Annual Meeting of the Japanese Radiation Research Society took place in Tokyo, Japan, from 6 to 8 November 2023. The meeting covered a wide range of radiation research topics, including ba...","PeriodicalId":14261,"journal":{"name":"International Journal of Radiation Biology","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140608736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondrial reactive oxygen species impact human fibroblast responses to protracted γ-ray exposures 线粒体活性氧影响人类成纤维细胞对长期γ射线照射的反应
IF 2.6 4区 医学
International Journal of Radiation Biology Pub Date : 2024-04-17 DOI: 10.1080/09553002.2024.2338518
Luke A. Whitcomb, Xu Cao, Dilip Thomas, Claudia Wiese, Alissa S. Pessin, Robert Zhang, Joseph C. Wu, Michael M. Weil, Adam J. Chicco
{"title":"Mitochondrial reactive oxygen species impact human fibroblast responses to protracted γ-ray exposures","authors":"Luke A. Whitcomb, Xu Cao, Dilip Thomas, Claudia Wiese, Alissa S. Pessin, Robert Zhang, Joseph C. Wu, Michael M. Weil, Adam J. Chicco","doi":"10.1080/09553002.2024.2338518","DOIUrl":"https://doi.org/10.1080/09553002.2024.2338518","url":null,"abstract":"Purpose: Continuous exposure to ionizing radiation at a low dose rate poses significant health risks to humans on deep space missions, prompting the need for mechanistic studies to identify counter...","PeriodicalId":14261,"journal":{"name":"International Journal of Radiation Biology","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140608737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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