Mitochondrial reactive oxygen species impact human fibroblast responses to protracted γ-ray exposures

IF 2.1 4区医学 Q2 BIOLOGY

International Journal of Radiation Biology Pub Date : 2024-04-17 DOI:10.1080/09553002.2024.2338518

Luke A. Whitcomb, Xu Cao, Dilip Thomas, Claudia Wiese, Alissa S. Pessin, Robert Zhang, Joseph C. Wu, Michael M. Weil, Adam J. Chicco

引用次数: 0

Abstract

Purpose: Continuous exposure to ionizing radiation at a low dose rate poses significant health risks to humans on deep space missions, prompting the need for mechanistic studies to identify counter...

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线粒体活性氧影响人类成纤维细胞对长期γ射线照射的反应

目的：持续暴露于低剂量率的电离辐射对执行深空任务的人类健康构成重大风险，因此需要进行机理研究，以确定应对措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Radiation Biology 医学-核科学技术

CiteScore

5.00

自引率

11.50%

发文量

142

审稿时长

3 months

期刊介绍： The International Journal of Radiation Biology publishes original papers, reviews, current topic articles, technical notes/reports, and meeting reports on the effects of ionizing, UV and visible radiation, accelerated particles, electromagnetic fields, ultrasound, heat and related modalities. The focus is on the biological effects of such radiations: from radiation chemistry to the spectrum of responses of living organisms and underlying mechanisms, including genetic abnormalities, repair phenomena, cell death, dose modifying agents and tissue responses. Application of basic studies to medical uses of radiation extends the coverage to practical problems such as physical and chemical adjuvants which improve the effectiveness of radiation in cancer therapy. Assessment of the hazards of low doses of radiation is also considered.