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International Journal of Pharmaceutical and Biological Science Archive最新文献

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FORMULATION AND EVALUATION OF CONTROLLED RELEASE OSMOTIC TABLET OF CARVEDILOL PHOSPHATE 磷酸卡维地洛控释渗透片的研制与评价
International Journal of Pharmaceutical and Biological Science Archive Pub Date : 2019-04-24 DOI: 10.32553/ijpba.v7i2.115
Sunny Sharma, Anil G. Raval
{"title":"FORMULATION AND EVALUATION OF CONTROLLED RELEASE OSMOTIC TABLET OF CARVEDILOL PHOSPHATE","authors":"Sunny Sharma, Anil G. Raval","doi":"10.32553/ijpba.v7i2.115","DOIUrl":"https://doi.org/10.32553/ijpba.v7i2.115","url":null,"abstract":"Carvedilol Phosphate Osmotic Tablets were prepared using a Direct Compression approach. A mixture of osmogens i.e. NaCl and Mannitol was used to achieve a desired osmotic pressure in the tablets which were then coated with Cellulose Acetate polymer with PEG as a plasticizer and Povidone K30 as a pore former. Early screening batches showed drastic effect of osmogens and pore former, as well as % weight gain on drug release of the tablets. The prepared tablets were evaluated for Weight variation, Thickness, Hardness, Dissolution, and the final optimized formulation was exposed to Accelerated Stability Study. A full factorial statistical optimization was carried out on the best optimized formulation to establish the design space for selected factors i.e., NaCl and Povidone K30 against Response Dissolution. A significant effect of both factors was found on Dissolution rate, which justifies the use and rationale of the excipients \u0000Key Words: Carvedilol Phosphate, Osmotic Tablets, Direct Compression, NaCl, Mannitol, Cellulose Acetate.","PeriodicalId":14229,"journal":{"name":"International Journal of Pharmaceutical and Biological Science Archive","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82083551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
“FORMULATION DEVELOPMENT AND EVALUATION OF GASTRORETENTIVE FLOATING FILMS OF LAFUTIDINE” 拉弗丁胃保留漂浮膜的配方开发与评价
International Journal of Pharmaceutical and Biological Science Archive Pub Date : 2019-04-23 DOI: 10.32553/ijpba.v7i2.114
Hir. R. Mehta, V. Patel
{"title":"“FORMULATION DEVELOPMENT AND EVALUATION OF GASTRORETENTIVE FLOATING FILMS OF LAFUTIDINE”","authors":"Hir. R. Mehta, V. Patel","doi":"10.32553/ijpba.v7i2.114","DOIUrl":"https://doi.org/10.32553/ijpba.v7i2.114","url":null,"abstract":"The present invention was aimed to formulate and evaluate Lafutidine gastro retentive films. The films were prepared by solvent casting technique using different film forming polymers like HPMC and Ethyl cellulose. PEG 400 used as a plastsizer. The prepared films were evaluated for number of parameters like Physical appearance, Weight variation, Thickness, Folding endurance, Tensile strength, unfolding behavior, floating properties, drug content and In vitro drug release studies. From the trial batches the best release for gastroretentive film was shown by formulation T5 (Ethyl cellulose and PEG 400). Formulation T5 exhibited good appearance, better mechanical strength with acceptable flexibility. Also, formulation T5 was given more than 90 % drug released after 12 hr and 97.56 % Drug content.  For optimization of formulation, 32 factorial design was applied by taking Ethyl cellulose and PEG 400 as an independent variables. Drug release at 8 hour and folding endurance selected as dependent variables. Based on drug release study, L8 batch found most satisfactory in all formulation and the effect of Ethyl cellulose and PEG 400 found significant. L8 batch found stable during stability study. \u0000Key words: Lafutidine, Floating Films, Ethyl Cellulose.","PeriodicalId":14229,"journal":{"name":"International Journal of Pharmaceutical and Biological Science Archive","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79116262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EFFECT OF AZARDIRACHTA INDICA LEAF EXTRACT ON GILL OF FRESHWATER FISH, LABEO ROHITA 印楝叶提取物对淡水鱼鳃的影响
International Journal of Pharmaceutical and Biological Science Archive Pub Date : 2019-04-03 DOI: 10.32553/ijpba.v7i2.111
S. Geetha, J. Roopavathy, S. Sharon
{"title":"EFFECT OF AZARDIRACHTA INDICA LEAF EXTRACT ON GILL OF FRESHWATER FISH, LABEO ROHITA","authors":"S. Geetha, J. Roopavathy, S. Sharon","doi":"10.32553/ijpba.v7i2.111","DOIUrl":"https://doi.org/10.32553/ijpba.v7i2.111","url":null,"abstract":"An investigation on the toxicity of  biopesticidal plant  Azardiracta indica aqueous leaf extracts to Labeo rohita. The LC50 value of Azardiracta indica aqueous leaf extracts was 1.1ml/lit respectively. The sub lethal concentration for Azardiracta indica was 0.11ml/lit and 0.33 ml/lit respectively. The fishes were exposed to the sub lethal concentration for a period of 15 days.  At the end of 15th day the fishes were dissected and the gill were removed from exposed and control group fishes. The tissues were processed and sectioned at 4µm and then were stained with Haematoxylin- Eosin. The observation of the slides was done under light microscope at 40x magnification and photographed. The exposed group showed histopathological changes in the tissues, such as: shrunken and narrow secondary gill lamellae, mild to moderate infiltration of inflammatory cells in the primary and secondary gill lamellae.  This result indicated that the aqueous extract of Azardiracta indica has considerable impact on the respiratory organ of fresh water fish, Labeo rohita. \u0000Key words: Labeo rohita, Azardiracta indica, secondary lamellae","PeriodicalId":14229,"journal":{"name":"International Journal of Pharmaceutical and Biological Science Archive","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82185854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
HOW TO WRITE A RESEARCH ABSTRACT 如何写研究摘要
International Journal of Pharmaceutical and Biological Science Archive Pub Date : 2019-04-03 DOI: 10.32553/IJPBA.V7I2.109
Indrajeet P. Shah
{"title":"HOW TO WRITE A RESEARCH ABSTRACT","authors":"Indrajeet P. Shah","doi":"10.32553/IJPBA.V7I2.109","DOIUrl":"https://doi.org/10.32553/IJPBA.V7I2.109","url":null,"abstract":"An abstract is like a movie trailer. People will only consider reading the rest of the manuscript if they find your abstract interesting. It is an outline/brief summary of your paper and your whole project. \u0000Keywords: Abstract, research, descriptive and informative research.","PeriodicalId":14229,"journal":{"name":"International Journal of Pharmaceutical and Biological Science Archive","volume":"45 7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82738587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DIVERSITY OF BIRDS IN KUMARASAMY LAKE AND SINGANALLUR LAKE kumarasamy湖和singanallur湖鸟类的多样性
International Journal of Pharmaceutical and Biological Science Archive Pub Date : 2019-04-03 DOI: 10.32553/ijpba.v7i2.110
S. Sharon, J. Roopavathy, S. Geetha
{"title":"DIVERSITY OF BIRDS IN KUMARASAMY LAKE AND SINGANALLUR LAKE","authors":"S. Sharon, J. Roopavathy, S. Geetha","doi":"10.32553/ijpba.v7i2.110","DOIUrl":"https://doi.org/10.32553/ijpba.v7i2.110","url":null,"abstract":"A bird survey is carried out  in lakes of Coimbatore (kumarasamy and singanallur) to examine the diversity and richness distribution of bird species in wetland region. This survey was taken from july 2018 to December 2018 to suitably access the bird diversity. A total number of 50 species from 13 orders and 34 families were recorded. The month of October and November maximum numbers of birds were identified. Pelicaniformes contributed maximum number of species. Finally, least number of birds recorded in Gruiformes, Strigiformes, Psittaciformes, Gariformes, Columbiformes and Podicipitiformes. Maximum bird species were recorded in Singanallur Lake and minimum in Kumarasamy Lake. The study revealed that Kumarasamy and Singanallur Lake acts as a refuge site for many water birds. Hence it is recommended that protection of the wetland from the human disturbance is of urgent need.    \u0000Key words: Kumarasamy, Threatened, Gariformes","PeriodicalId":14229,"journal":{"name":"International Journal of Pharmaceutical and Biological Science Archive","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76774860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CYBERKNIFE ROBOTIC RADIOSURGERY SYSTEM 射波刀机器人放射外科系统
International Journal of Pharmaceutical and Biological Science Archive Pub Date : 2019-03-09 DOI: 10.32553/IJPBA.V7I1.108
Saibya Gupta, Priya Gupta
{"title":"CYBERKNIFE ROBOTIC RADIOSURGERY SYSTEM","authors":"Saibya Gupta, Priya Gupta","doi":"10.32553/IJPBA.V7I1.108","DOIUrl":"https://doi.org/10.32553/IJPBA.V7I1.108","url":null,"abstract":"The latest addition to the CyberKnife product family, which was released in September 2009. This review updates the previous technical reviews of the original system version published in the late 1990s. There is a clear dose response for localized prostate cancer radiotherapy and there probablyis a radiobiological rationale for hypo-fractionation. Combining the two should maximize tumor control and increase the therapeutic ratio. Technical developments over the last decade have impacted virtually every aspect of the CyberKnife System. These developments have increased the geometric accuracy of the system and have enhanced the dosimetric accuracy and quality of treatment, with advanced inverse treatment planning algorithms, rapid Monte Carlo dose calculation, and post-processing tools that allow trade-offs between treatment efficiency and dosimetric quality to be explored. The CyberKnife can produce superior DVHs for sparing of rectum and bladder and excellent DVHs for target coverage compared with IMRT, and possesses dose heterogeneities to the same degree as IMRT plans. \u0000Keywords: CyberKnife System; Radiosurgery; Stereotactic Body Radiation Therapy; Hypofractionation; IMRT Hetrogeneities","PeriodicalId":14229,"journal":{"name":"International Journal of Pharmaceutical and Biological Science Archive","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81599164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A REVIEW ON PHARMACOLOGICAL ACTIVITY OF BENINCASA HISPIDA 黑豆的药理活性研究进展
International Journal of Pharmaceutical and Biological Science Archive Pub Date : 2019-01-01 DOI: 10.32553/ijpba.v7i2.124
Neha Ayubkhan, D. George, Dr.Lincy Joseph, Dr K Sujith
{"title":"A REVIEW ON PHARMACOLOGICAL ACTIVITY OF BENINCASA HISPIDA","authors":"Neha Ayubkhan, D. George, Dr.Lincy Joseph, Dr K Sujith","doi":"10.32553/ijpba.v7i2.124","DOIUrl":"https://doi.org/10.32553/ijpba.v7i2.124","url":null,"abstract":"Benincasa hispida is a well-known plant and is cultivated throughout the plains of india and on the hills upto 1200 meter altitude. It is a popular vegetable crop widely used for nutritional and medicinal properties especially in asian countries. Benincasa hispida fruit has been valued as a nutritious vegetable as it provide a good source for natural sugars,organic acid, amino acid,vitamins and mineral elements. Phytochemical constituents of this plant are mannitol, triterpenoids, cucurbitin, β-sitosterin, flavanoids, glycosides, carotenes, vitamins and uronic acid. The pharmacological studies revealed that the plant exerted many pharmacological activities such as antiulcer, antihyperlipidemic, antihelmintic, antioxidant, neuropharmacological activity, diuretic activity. Keywords:  Benincasa hispida, antiulcer, diuretic, antihyperlipidemic, antihelminthic.","PeriodicalId":14229,"journal":{"name":"International Journal of Pharmaceutical and Biological Science Archive","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85098369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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