International Journal of Pharmaceutical and Biological Science Archive最新文献

IONTOPHORESIS: A FUNCTIONAL APPROACH FOR ENHANCEMENT OF TRANSDERMAL DRUG DELIVERY 离子透入:一种增强经皮给药的功能方法

International Journal of Pharmaceutical and Biological Science Archive Pub Date : 2021-06-04 DOI: 10.32553/IJPBA.V9I3.190

Sanjoy De, Souvik Mallik, Sabuj Kumar Bhattacharya, Shibam Acharya, Partha Sarathi Mondal, Soumyadipta Rakshit, B. C. Nandy

{"title":"IONTOPHORESIS: A FUNCTIONAL APPROACH FOR ENHANCEMENT OF TRANSDERMAL DRUG DELIVERY","authors":"Sanjoy De, Souvik Mallik, Sabuj Kumar Bhattacharya, Shibam Acharya, Partha Sarathi Mondal, Soumyadipta Rakshit, B. C. Nandy","doi":"10.32553/IJPBA.V9I3.190","DOIUrl":"https://doi.org/10.32553/IJPBA.V9I3.190","url":null,"abstract":"Iontophoresis is one of the most widely studied active techniques for enhancing transdermal delivery of drugs. However, its ability to enhance the delivery of highly lipophilic compounds is poor due to lack of any charge and poor water solubility of molecules. The skin has been used as a port for systemic delivery of therapeutic agents since several decades. The composition of stratum corneum renders it a daunting barrier to the topical and transdermal administration of therapeutic agents. The number of drug molecules for transdermal delivery is limited owing to the physicochemical restrictions. \u0000The delivery of drugs into systemic circulation via skin has generated much attention during the last decade. Transdermal therapeutic systems propound controlled release of active ingredients through the skin and into the systemic circulation in a predictive manner. Drugs administered through these systems escape first-pass metabolism and maintain a steady state scenario similar to a continuous intravenous infusion for up to several days. \u0000Keywords: Iontophoresis, non-invasive, stratum corneum, acid-alkaline reaction, chemical permeation enhancer, reverse iontophoresis.","PeriodicalId":14229,"journal":{"name":"International Journal of Pharmaceutical and Biological Science Archive","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84980104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation And In-Vitro Evaluation Of Cocrystals Of Pantoprazole Sodium For Immediate Release 泮托拉唑钠速释共晶的制备及体外评价

International Journal of Pharmaceutical and Biological Science Archive Pub Date : 2021-02-13 DOI: 10.32553/IJPBA.V9I1.176

S. Jain, M. Bansal, Ashutosh Sharma

{"title":"Formulation And In-Vitro Evaluation Of Cocrystals Of Pantoprazole Sodium For Immediate Release","authors":"S. Jain, M. Bansal, Ashutosh Sharma","doi":"10.32553/IJPBA.V9I1.176","DOIUrl":"https://doi.org/10.32553/IJPBA.V9I1.176","url":null,"abstract":"Pantoprazole is extensively metabolized in the liver and has a total serum clearance of 0.1 l/h/kg, a serum elimination half-life of about 1.1 h, and an apparent volume of distribution of 0.15 L/kg. 98% of pantoprazole is bound to serum proteins. Elimination half-life, clearance, and volume of distribution are independent of the dose. Almost 80% of an oral or intravenous dose is excreted as metabolites in urine; the remainder is found in feces and originates from biliary secretion. The clearance of pantoprazole is only slightly affected by age, with its half-life being approximately 1.25 h in the elderly. Pantoprazole is an acid labile drug that requires protection from degradation in acidic media. Hence, co-crystallization of pantoprazole sodium with appropriate co-formers will inhibit its degradation in acidic medium ensuring fast release in the stomach. The acid-labile drugs for oral administration may also be protected from gastric acidity by inhibiting its degradation upon entering into acidic environment. So, the current approach includes co-crystallization of the provided drug with appropriate co-former which prevents degradation of drug by quick absorption and protects the drug from low pH. Apart from that, the formulations also modulate or control the drug release for an immediate action. \u0000Keywords: Pantoprazole sodium, Co-crystal, solvent drop method, Co-former.","PeriodicalId":14229,"journal":{"name":"International Journal of Pharmaceutical and Biological Science Archive","volume":"92 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90429492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biochemical and Toxicological Investigations of 5-Fluorouracil, Nimesulide, and Ascorbic Acid in Hepatocellular Carcinoma 5-氟尿嘧啶、尼美舒利和抗坏血酸在肝细胞癌中的生化和毒理学研究

International Journal of Pharmaceutical and Biological Science Archive Pub Date : 2020-06-15 DOI: 10.22377/ijpbamds

Sanjay Bais

{"title":"Biochemical and Toxicological Investigations of 5-Fluorouracil, Nimesulide, and Ascorbic Acid in Hepatocellular Carcinoma","authors":"Sanjay Bais","doi":"10.22377/ijpbamds","DOIUrl":"https://doi.org/10.22377/ijpbamds","url":null,"abstract":"Introduction: Blood pressure (BP) control continues to be important in reducing cardiovascular risk, along with the modification of other cardiovascular risk factors, especially cholesterol level. Lifestyle modification to reduce BP may control Stage 1 hypertension. Drug treatment should be based on evidence of improved outcomes and individualized account for the patient age, race, and quality of life. BP varies from minute to minute and is influenced by measurement technique, time of day, emotion, pain, discomfort, hydration, temperature, exercise, posture, and drugs. Purpose of Review: In this review, we examine how synthetic novel drugs involved in the management of hypertension not only in the wider population but also within special population groups such as the elderly, pregnant women, and those with a trial fibrillation. Conclusion: The extensive synthetic work carried out shows that some molecules are very effectively managing the hypertension in all ages of patients. Summary: We have made an attempt in reviewing the literature on 1,2 pyrazoline derivatives for their medicinal uses with the help of chemical abstract, journals, and internet surfing.","PeriodicalId":14229,"journal":{"name":"International Journal of Pharmaceutical and Biological Science Archive","volume":"191 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78529727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A COMPARATIVE STUDY OF YOGIC AND AYURVEDIC INTERVENTION IN THE MANAGEMENT OF TAMAKA SHWASA. 瑜伽和阿育吠陀在tamaka shwasa管理中的干预比较研究。

International Journal of Pharmaceutical and Biological Science Archive Pub Date : 2019-11-10 DOI: 10.32553/ijpba.v7i5.138

Dr Arpan A. Bhatt, Dr Shweta Pandey, Dr Brajesh Singh, Dr Gauravi Vyas, Dr. Gyanendra Datta Shukla, Dr Upasna

{"title":"A COMPARATIVE STUDY OF YOGIC AND AYURVEDIC INTERVENTION IN THE MANAGEMENT OF TAMAKA SHWASA.","authors":"Dr Arpan A. Bhatt, Dr Shweta Pandey, Dr Brajesh Singh, Dr Gauravi Vyas, Dr. Gyanendra Datta Shukla, Dr Upasna","doi":"10.32553/ijpba.v7i5.138","DOIUrl":"https://doi.org/10.32553/ijpba.v7i5.138","url":null,"abstract":"Asthma is one of the commonest respiratory disease (as Jamnagar situated on sea coast has more moisture present in the air and polluting environment is increasing due to rapid industrial development i.e. industries using various chemicals/ pollutants, increases the incidences of Respiratory tract diseases) as well as a significant disease burden worldwide costing billions of dollars. The WHO estimates that there are between 15 and 20 million people with Asthma in India. The increase is likely to be particularly dramatic in India, which is projected to become the world’s most populous nation by 2050. An absolute 2% increase in the prevalence of Asthma in India would result in an additional 20 million people with the disease. Anti-asthmatic drugs that are available in the market are expensive and have adverse effects. Thus, it is wise to look for an adjunct therapy to alleviate these problems. Therefore, the main aim of this study is to see the effect of Yoga on patterns of clinical features, peak expiratory flow rates and use of drugs in Asthmatic patients. \u0000Yoga intervention group (Group A) showed 70.58% reduction in the use of emergency medicine while it was 68.09% in Ayurvedic conventional group (Group B). There was a 24.93% increment in the PEFR in the Group A while only 16.49% in the Group B. There was statistically significant reduction in frequency and duration of Asthma attacks in both the Groups. Yoga exercise among Asthmatic patients resulted in a decreased number of attacks and use of drugs. It also shows significant improvement in the peak expiratory flow rate in Yoga intervention Group. Further large scale study is recommended. \u0000Keywords: Asthma, Yoga, Expiratory flow rate.","PeriodicalId":14229,"journal":{"name":"International Journal of Pharmaceutical and Biological Science Archive","volume":"55 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82830124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

PHARMACOKINETICS OF INH AND PZA IN MDR-TB: A REVIEW inh和pza在耐多药结核病中的药代动力学研究进展

International Journal of Pharmaceutical and Biological Science Archive Pub Date : 2019-09-27 DOI: 10.32553/ijpba.v7i5.137

S. Ramya, S. Shanmugam

引用次数: 0

A REVIEW ON ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF CALCIUM CHANNEL BLOCKERS AND ANGIOTENSIN- CONVERTING ENZYME INHIBITORS IN BULK AND PHARMACETICAL FORMULATION 钙通道阻滞剂和血管紧张素转换酶抑制剂在原料药和制剂中分析方法的发展和验证综述

International Journal of Pharmaceutical and Biological Science Archive Pub Date : 2019-07-27 DOI: 10.32553/IJPBA.V7I4.131

C GawadeSonba., G. K. Dyade, D. Jadhav

{"title":"A REVIEW ON ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF CALCIUM CHANNEL BLOCKERS AND ANGIOTENSIN- CONVERTING ENZYME INHIBITORS IN BULK AND PHARMACETICAL FORMULATION","authors":"C GawadeSonba., G. K. Dyade, D. Jadhav","doi":"10.32553/IJPBA.V7I4.131","DOIUrl":"https://doi.org/10.32553/IJPBA.V7I4.131","url":null,"abstract":"A simple, economical and rapid by UV detector and PDA Detector was used for Estimation of Trandolapril and Verapamil in combination and other drugs in various Pharmaceutical formulation. Calcium channel blockers(CCBs) and angiotensin- converting enzyme (ACE) inhibitors has been developed and fully validated by High performance liquid Chromatographic Methods. Calcium channel blockers (CCBs) or Calcium antagonists are among the most widely used drugs in cardiovascular medicine and hypertension also in angina. CCBs promote vasodilator activity by reducing calcium influx into vascular smooth muscle cells by interfering with calcium channels in the cell membrane. Trandolapril is a potent nonsulfhydryl and dicarboxyl containing Angiotensin converting inhibitor (ACE). Trandolapril used to treatment of hypertension appears to result the inhibition of tissue ACE activity and to improve survival myocardial infarction thereby reduce angiotensin II formation. \u0000It includes drugs like Trandolapril, Norverapamil, Nifedipine, Verapamil. This Review enlists different method Developed, Validated and determination of Calcium channel blockers and angiotensin- converting enzyme inhibitors Like, RP-HPLC, LC-MS/MS and HPLC UV- Spectophotometric method. This method was also validated for various validation terms indicates that precise, accurate, linearly, and limit of Detection and limit of Quantitation as per ICH guidelines. \u0000Keywords: HPLC Chromatography, Calcium Channel blocker, angiotensin- converting enzyme (ACE) inhibitors, Hypertension, Validation etc.","PeriodicalId":14229,"journal":{"name":"International Journal of Pharmaceutical and Biological Science Archive","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91094899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

METHOD DEVELOPMENT AND VALIDATION OF MESALAMINE IN PHARMACEUTICAL DOSAGE FORM: A REVIEW 药物剂型中美沙拉胺的方法开发与验证综述

International Journal of Pharmaceutical and Biological Science Archive Pub Date : 2019-06-25 DOI: 10.32553/IJPBA.V7I3.130

S. Desai, R. Kale

{"title":"METHOD DEVELOPMENT AND VALIDATION OF MESALAMINE IN PHARMACEUTICAL DOSAGE FORM: A REVIEW","authors":"S. Desai, R. Kale","doi":"10.32553/IJPBA.V7I3.130","DOIUrl":"https://doi.org/10.32553/IJPBA.V7I3.130","url":null,"abstract":"Anti-inflammatory agents are the important class of drugs used in various commercial pharmaceutical formulations for the treatment of fever, inflammation and minor pain. One of the important anti-inflammatory drug is Mesalamine which belongs to the class of Amino-salicylic acid derivatives. Mesalamine is a bowel specific anti-inflammatory drug used in the treatment of inflammatory bowel diseases such as ulcerative colitis and Crohn’s disease.it is available in different pharmaceutical dosage forms such as delayed release, extend release and enteric coated tablets and capsulesetc., The several of Mesalamine brand’s available in market are Apriso, Asacol MR-400mg, Lialda, Pentasa-500mg, Asalosa- 800 etc. Hence routine quality control of Mesalamine in these pharmaceutical dosage forms requires effective analytical procedures. In this present review an extensive survey of research work published in various research journals has reviewed and found that various instrumental analytical methods were developed, validated and used for the estimation of Mesalamine in bulk drug and formulation. The developed analytical methods include Spectrometric such as Ultraviolet (UV) and Visible; Spectroflourimetric and Chromatographic methods such as High Performance Liquid Chromatographic (HPLC), Reverse Phase High Performance Liquid Chromatographic (RP-HPLC), Ultra Performance Liquid Chromatographic (UPLC) \u0000Keywords: HPLC, Mesalamine, Anti-inflammatory, Method Development","PeriodicalId":14229,"journal":{"name":"International Journal of Pharmaceutical and Biological Science Archive","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81649079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

A REVIEW ON ANALYTICAL METHODS FOR ESTIMATION OF TENOFOVIR DISOPROXIL FUMARATE AND EMTRICITABINE IN BULK AND PHARMACEUTICAL DOSAGE FORMS 富马酸替诺福韦二氧吡酯和恩曲他滨原料药和药物剂型的分析方法综述

International Journal of Pharmaceutical and Biological Science Archive Pub Date : 2019-06-16 DOI: 10.32553/IJPBA.V7I3.129

M LakadeM., R. Kale

引用次数: 2

A REVIEW ON FLOATING MICROSPHERES 漂浮微球研究进展

International Journal of Pharmaceutical and Biological Science Archive Pub Date : 2019-06-14 DOI: 10.32553/IJPBA.V7I3.128

T. Shinde, A. N. Barhate

引用次数: 1

ANALYTICAL METHOD DEVELOPMENT AND VALIDATION: A REVIEW 分析方法的开发和验证:综述

International Journal of Pharmaceutical and Biological Science Archive Pub Date : 2019-05-21 DOI: 10.32553/ijpba.v7i3.126

M. Patil, Rvindra. R. Patil, S. Chalikwar, S. Surana, S. Firke

引用次数: 6