PHARMACOKINETICS OF INH AND PZA IN MDR-TB: A REVIEW

Abstract

Tuberculosis remains a leading cause of morbidity and mortality in developing countries, including india. Isoniazid and pyrazinamide are powerful drugs administered as the First line and second line Anti-TB drugs in Tuberculosis affected patient. It plays a key role in shortening the TB therapy. Isoniazid (INH), and pyrazinamide (PZA) are the main drugs for the treatment of tuberculosis (TB). Mycobacterium tuberculosis is responsible for causing tuberculosis can acquire multiple drug resistance (MDR) by not responding to the most powerful anti-TB agents. The complications of drug resistance in TB elevates the some of the risk factors like inadequate treatment compliance, noncompliance of the patients to the treatment. Pharmacokinetics provides a basic time course of drugs and their effects in the body. These pharmacokinetic processes referred to as ADME. Key words Isoniazid, Pyrazinamide, MDR, ADME, TB