A REVIEW ON ANALYTICAL METHODS FOR ESTIMATION OF TENOFOVIR DISOPROXIL FUMARATE AND EMTRICITABINE IN BULK AND PHARMACEUTICAL DOSAGE FORMS

Tenofovir Disoproxil Fumarate and Emtricitabine are very effectively used in the prevention of HIV-1 infections. They are generally administered as tablets. These are Nucleotide Reverse Transcriptase Inhibitors (NtRTIs), an acyclic nucleoside phosphonate (nucleotide) analog of adenosine 5′-monophosphate. Emtricitabine and Tenofovir disoproxil fumarate reveals equally prevention of the enzyme that is HIV-1 reverse transcriptase. For determination of Tenofovir disoproxil fumarate and Emtricitabine in bulk and pharmaceutical dosage form, several analytical methods including UV, HPLC, UPLC and HPTLC techniques are reported in literature. For qualitative and quantitative estimation of Tenofovir disoproxil fumarate and Emtricitabine these analytical methods can be used and also for the related degradants in bulk formulations and biological fluid. The present paper illustrates the review on analytical methods which involves the estimation of the antiviral drugs. Keywords: Emtricitabine, Tenofovir disoproxil fumarate, UV Spectroscopy, RP-HPLC, UPLC,   HPTLC.