International Journal of Pharmacy and Pharmaceutical Sciences最新文献

{"title":"A CASE STUDY ON SCRUB TYPHUS","authors":"SENTHILPANDI K., JULEGA K. S.","doi":"10.22159/ijpps.2023v15i10.49102","DOIUrl":"https://doi.org/10.22159/ijpps.2023v15i10.49102","url":null,"abstract":"Scrub typhus is a mite-borne typhus caused by Orientia tsutsugamushi and it is characterized by acute febrile illness, rash, eschar and an incubation period ranging from 6 to 21 d. It affects various organs such as lungs, heart, spleen, liver, and kidney. We report a case on 5 y old male child was admitted with complaints of fever and vomiting. Based on a general examination, the patient had eschar on the scrotum. Diagnosis was made based on clinical features, and the serology IgM for scrub typhus was positive. He was treated with doxycycline. To prevent complications, the patient needs effective management, early administration of antibiotics and preventive measures to control vector bite.","PeriodicalId":14188,"journal":{"name":"International Journal of Pharmacy and Pharmaceutical Sciences","volume":"153 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135459227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANTIMICROBIAL AND PHYTOCHEMICAL INVESTIGATION OF CALOTOROPIS PROCERA FLOWERS EXTRACTS","authors":"SARA HUSSEIN ALTAYEB, ASAAD KHALID","doi":"10.22159/ijpps.2023v15i10.48379","DOIUrl":"https://doi.org/10.22159/ijpps.2023v15i10.48379","url":null,"abstract":"Objective: The present study was planned to screen extracts of different polarities of the flowers of Calotropis procera for the detection of different secondary metabolites, estimate the antibacterial activity of the prepared extracts, and study the active extracts by different chromatographic and spectroscopic methods. Methods: The diethyl ether, methanol, and water extracts were phytochemically screened. Petroleum ether, chloroform, and methanol extracts were also tested against two Gram-positive bacteria, namely Bacillus subtilis and Staphylococcus aureus, and two Gram-negative bacteria, namely E. coli and Pseudomonas aeruginosa with diffusion method. The methanolic extract was further investigated by column chromatography (CC) and preparative thin-layer chromatography (PTLC). Three pure compounds have been isolated and investigated by IR-spectroscopy. Results: Phytochemical screen showed the presence of various secondary metabolites such as flavonoids, alkaloids, steroids, cardiac glycosides, reducing sugars, and saponins. The antibacterial assay revealed that the methanolic extract was the most active against the tested bacteria, especially against Pseudomonas aeruginosa with the high zone of inhibition (23 mm) at 100 mg/ml, and E. coli (22 mm) at 100 mg/ml, followed by chloroform extract, while the petroleum ether extract was insignificantly active. Column Chromatography analysis of the methanolic extract separated fifteen fractions. The PTLC of fraction No.14 enabled the isolation of three pure compounds (A, B, and C). The IR-spectroscopy analysis of the three isolated compounds exhibited that they could referred to the alkaloids or cardiac glycosides. Conclusion: The methanolic extract showed significant activity against tested bacteria, especially E. coli and Pseudomonas aeruginosa. The result also indicates the presence of secondary metabolites in C. procera extracts. Subsequently the therapeutic efficacy compounds isolated and purified from C. procera could be used as an important source against bacterial ailments in humans and plants.","PeriodicalId":14188,"journal":{"name":"International Journal of Pharmacy and Pharmaceutical Sciences","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135457752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CARDIAC AUTONOMIC DYSFUNCTION IN PATIENTS WITH EPILEPSY","authors":"RASHMI H., PRAVEEN PANCHAKSHARIMATH, ROHITH V.","doi":"10.22159/ijpps.2023v15i10.49095","DOIUrl":"https://doi.org/10.22159/ijpps.2023v15i10.49095","url":null,"abstract":"Objective: The objective of this research was to appraise autonomic impairment through the examination of both time-domain and frequency-domain parameters of heart rate variability in individuals with epilepsy. Methods: Thirty epilepsy patients and thirty healthy subjects were enrolled in our study for evaluation of autonomic functions, which was assessed by comparing heart rate variability between epilepsy patients and healthy subjects. Results: There was no notable disparity observed in mean heart rate between the two groups. However, the frequency-domain metrics-LF Power, HF Power, and LF/HF ratio exhibited statistically noteworthy differences when comparing the patients to the control group (p-value<0.05). Conversely, parameters such as SDNN, RMSST, and pNN50 did not demonstrate statistically considerable differences in comparison to the controls (p-value>0.05). The parameters did not exhibit statistically significant distinctions between individuals with epilepsy for under 10 y and those diagnosed with epilepsy for over 10 y. Conclusion: Our investigation revealed a notable contrast in HRV metrics between the patient group and the group of individuals in good health. The potential utilization of HRV as an indicator of susceptibility to SUDEP could enhance the quality of guidance provided to both patients and their families. Additional exploration is warranted, involving more extensive participant cohorts, and examining the impact of antiepileptic medications on HRV, within future studies.","PeriodicalId":14188,"journal":{"name":"International Journal of Pharmacy and Pharmaceutical Sciences","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135459012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SYNTHESIS OF UREA AND MAGNETITE-BASED CHITIN AS ADSORBENTS FOR THE REMOVAL OF AMLODIPINE BESYLATE","authors":"Cesar Londono, Kelly Barrera, John Rojas","doi":"10.22159/ijpps.2023v15i9.48685","DOIUrl":"https://doi.org/10.22159/ijpps.2023v15i9.48685","url":null,"abstract":"Objective: Development of urea and magnetite-based chitin adsorbents for the removal of amlodipine besylate.\u0000Methods: Amlodipine is a calcium channel blocker widely used to treat hypertension and angina. However, it is important to treat the residues before disposal so they do not pollute the effluent water sources. The amlodipine sorption property of chitin-based subtract (CBS) was improved by treatment with magnetite and urea, followed by pyrolysis at 500 °C. The FT-IR characterization, elemental composition, pore properties, and sorption isotherms were also assessed.\u0000Results: The sorption capacity of amlodipine increased from 4.6 to 9.3 mg/g for the urea and magnetite-treated products, respectively. Further, modified chitin products showed a pore volume (micro and mesopore composition), pore percentage, and roughness of 0.01 cm3g-1, 0.02 cm3g-1, 32% and 68%, and 1.2, respectively. The CBS and derivatives did not present Langmurian behavior, indicating a characteristic heterogeneous surface and the presence of energetically distinct sorption sites. The sorption equilibrium was achieved within 5 min, resulting in a net physical sorption.\u0000Conclusion: The insertion of nitrogen and iron moieties on the surface of chitin improved the adsorption capacity of amlodipine.","PeriodicalId":14188,"journal":{"name":"International Journal of Pharmacy and Pharmaceutical Sciences","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81336159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INVESTIGATING THE EVOLUTION OF OPTIMAL PRODUCT AVAILABILITY FOR PUBLIC HEALTH PROGRAMS IN KATSINA STATE, NIGERIA","authors":"K. Gulma","doi":"10.22159/ijpps.2023v15i9.48621","DOIUrl":"https://doi.org/10.22159/ijpps.2023v15i9.48621","url":null,"abstract":"Objective: This study aimed to explore the evolution of the availability of public health commodities across all the supported health facilities in Katsina State, northwestern Nigeria.\u0000Methods: To achieve this, Quarterly Stock Status Reports (QSSR) were produced from the analysis of the Logistics Management Information System (LMIS) reports of facilities, local government stores, and central stores of all the public health programs in the state from April 2017 to March 2018 (one year). Analyses entailed computing the Month of Stock (MoS) for all commodities by dividing their Stock on Hand (SoH) by the Average Monthly Consumption (AMC). The product availability for the following public health programs was assessed for four consecutive quarters (Apr.-Jun. 2017, Jul.-Sep. 2017, Oct.-Dec. 2017, and Jan.-Mar. 2018)-HIV/AIDS, tuberculosis, malaria, reproductive health/family planning (FP), routine immunization, nutrition, Neglected Tropical Diseases (NTD), Maternal, Newborn, and Child Health (MNCH), and the state’s Free Medicare Scheme (FMS).\u0000Results: The one-year trend provided a precise representation of the commodity security of each public health supply chain across various programs within the state. While only one program (routine immunization) recorded 100% all-time product availability, TB appeared to be the most stable (95% of products in optimal quantities) of all the assessed public health programs employing MoS as a performance measure. It is important to note that nutrition, neglected tropical diseases, and the Free Medicare scheme did not operate with MoS as a measure of stock status but recorded product availability of 78.5%, 80%, and 84.6%, respectively.\u0000Conclusion: There is a necessity for periodic stock assessment across all public health programs for other states to establish accurate stock positions and identify programs that require enhanced logistical and supply chain technical support.","PeriodicalId":14188,"journal":{"name":"International Journal of Pharmacy and Pharmaceutical Sciences","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88921735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AIF-1 GENE AS STRONG PROGNOSTIC BIOMARKER FOR ORAL CANCER","authors":"Divya Tandon","doi":"10.22159/ijpps.2023v15i9.48115","DOIUrl":"https://doi.org/10.22159/ijpps.2023v15i9.48115","url":null,"abstract":"Objective: Oral Squamous Cell Carcinoma (OSCC), which is the sixth most prevalent type of cancer across the globe caused by cigarette smoking, smokeless tobacco use, excessive and extreme alcohol use, oral trauma, HPV (Human Papilloma Virus) infection as well as genetic mutations. AIF-1(Allograft Inflammatory Factor) has been identified as an inflammatory response modulator, and its increased expression has been linked to carcinogenesis.\u0000Methods: In this study, 200 OSCC patients and 200 matched controls were compared to investigate if there was any association between the AIF-1(Allograft Inflammatory Factor) gene and the risk of cancer of oral cavity in the North Indian population. AIF-1(Allograft Inflammatory Factor) gene polymorphism rs2857595 were detected using TaqMan probe assay.\u0000Results: The findings of our study revealed that AA genotype of AIF-1(Allograft Inflammatory Factor) Gene increases the susceptibility of Oral Squamous Cell Carcinoma. The association of AA genotype with Oral Squamous Cell Carcinoma is more in co-dominant model and the combination of both the mutant genotypes (AA+AG) is more significantly associated with Oral Squamous Cell Carcinoma in recessive model. GG genotype of AIF-1 (Allograft Inflammatory Factor) gene comes out with a protective effect against the risk of (OSCC Squamous Cell Carcinoma). To further understand the role of AIF-1(Allograft Inflammatory Factor) polymorphism, we compared the association of genotypes with various clinicopathological characteristics of Oral Squamous Cell Carcinoma patients. And we found that the patients with AA genotype have a significantly higher risk of developing high-grade tumors and more nodal involvement.\u0000Conclusion: Thus, rs2857595 locus AA genotype of AIF-1(Allograft Inflammatory Factor) can be considered as important point in the development of accurate preventive approach and a prognostic indicator for oral cancer.","PeriodicalId":14188,"journal":{"name":"International Journal of Pharmacy and Pharmaceutical Sciences","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82120037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANTIOXIDANT AND ANTI-SICKLING ACTIVITY OF EXTRACTS FROM THE STEM AND ROOTS BARKS OF STRYCHNOS INNOCUA (DEL.)","authors":"Mawate Florance Brukum, K. Kpegba, Kodjo Selom Evenamede, A. Agbonon, Oudjaniyobi Simalou","doi":"10.22159/ijpps.2023v15i9.48625","DOIUrl":"https://doi.org/10.22159/ijpps.2023v15i9.48625","url":null,"abstract":"Objective: In Togo Strychnos innocua represents a plant traditionally used to cure sickle cell disease. This study aims to carry out a phytochemical study and evaluate the antioxidant and anti-sickling activity of Strychnos innocua root and stem barks to support its use.\u0000Methods: Hydroethanolic and ethanolic extracts of each plant organ were obtained by maceration. Polyphenol content was determined using the Folin-Ciocalteu’s reagent and the flavonoid content using Aluminium trichloride (AlCl3) method. The anti-sickling activity of hydroethanolic extracts of root and stem barks was tested on SS blood samples from sickle cell patients using the Emmel test. Antioxidant activity was assessed by DPPH and FRAP methods on both the hydroethanolic and ethanolic extracts.\u0000Results: Results indicate that the highest levels of polyphenols were measured in the hydroethanolic extract of the root barks (59.32±1.77 mg GAE/g) and the ethanol extract of the stem barks (98.27±2.44 mg GAE/g). The hydroethanolic extract of the root barks and the ethanolic extract of the stem barks showed high levels of flavonoids. Extracts from both organs significantly reduced falciformation (p<0.001) at a rate of 22% (root) and 35% (stem) compared with the control (94%). In addition, root and stem extracts showed slight antioxidant activity.\u0000Conclusion: Results justify the traditional use of Strychnos innocua roots in treating sickle cell anaemia.","PeriodicalId":14188,"journal":{"name":"International Journal of Pharmacy and Pharmaceutical Sciences","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89900105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DEVELOPMENT AND VALIDATION OF NOVEL UV-VISIBLE SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF TEPOTINIB IN BULK AND IN PHARMACEUTICAL FORMULATION","authors":"Monika Shirwar, Shubhangi Birajdar, S. Garad, S. Kumbhar","doi":"10.22159/ijpps.2023v15i9.48431","DOIUrl":"https://doi.org/10.22159/ijpps.2023v15i9.48431","url":null,"abstract":"Objective: The objective of the study is to develop a new, simple, rapid, accurate, and economical UV-spectrophotometric method and validate the same for the estimation of Tepotinib in bulk and in pharmaceutical formulation as per ICH guidelines.\u0000Methods: The present work was carried out using the UV-Visible double-beam spectrophotometer model Systronics 2201. Tepotinib was found soluble in water, methanol, methanol so, analytical-grade methanol was used as a solvent for conducting the work. The λmax of the tepotinib was determined by dissolving pure drug in methanol scanned in the range of 200-800 nm. The present method was validated for the linearity, accuracy, precision, Limit of Detection and Limit of Quantification.\u0000Results: The maximum absorbance of tepotinib obtained at a wavelength of 272 nm. The method was found linear in the range of 3-15 µg/ml with the regression coefficient of 0.996 and the equation y = 0.0699x+0.0335. The accuracy was found to be in the range of 96.8-98.5%, the intra-day and inter-day precision % RSD value was 0.262 and 0.69, respectively and the LOD and LOQ were 0.0925 µg/ml and 0.28 µg/ml respectively.\u0000Conclusion: The method demonstrated good reproducibility and recovery so, proposed method can be successfully applied for the routine analysis of tepotinib in bulk and pharmaceutical dosage form.","PeriodicalId":14188,"journal":{"name":"International Journal of Pharmacy and Pharmaceutical Sciences","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73937343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CLINICAL PROFILE AND TREATMENT RESPONSE TO SOFOSBUVIR-VELPATASVIR REGIMEN AND ITS IMPACT ON THE QUALITY OF LIFE IN CHRONIC HEPATITIS C PATIENTS","authors":"Ajit Pratap Singh, Pankaj Asati, Kanishk Yadav","doi":"10.22159/ijpps.2023v15i9.48349","DOIUrl":"https://doi.org/10.22159/ijpps.2023v15i9.48349","url":null,"abstract":"Objective: Chronic Hepatitis C infection is one of the major global contributors to liver-related morbidity and mortality. Successful antiviral therapy with the direct-acting antiviral combination sofosbuvir-velpatasvir has shown to improve survival, liver-related outcomes, all-cause mortality, and even reverse fibrosis. We evaluated the treatment response of this regimen in terms of its impact on the Quality of life of patients during and after the therapy.\u0000Methods: This is an Observational, prospective, descriptive study of serologic HCV RNA-positive cases. Data on change in clinical, biochemical profile, and quality of life using 2 standardized questionnaires SF-36 and CLDQ was analyzed at baseline, 12 w from baseline, and 24 w after therapy cessation.\u0000Results: 62 out of the 87 patients registered during the study completed the desired study duration. 95% achieved sustained virological response (SVR) at 12 w and 100% at 24 w from baseline. Improved clinical profile with symptom resolution and change in the biochemical parameters and quality-of-life scores was statistically significant (P value-<0.001 and 0.005) at 12 w from baseline and 24 w after therapy cessation, respectively.\u0000Conclusion: Patients achieving SVR with sofosbuvir-velpatasvir have been shown to improve clinical profile with normalization in biochemical markers of liver disease, which is reflected in all the quality-of-life domains of SF-36 and CLDQ-HCV. However, long-term follow-up with larger sample size is required for improved study validity and to improve long-term liver-related outcomes.","PeriodicalId":14188,"journal":{"name":"International Journal of Pharmacy and Pharmaceutical Sciences","volume":"2013 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86201886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HPTLC METHOD FOR SIMULTANEOUS ESTIMATION OF LAMIVUDINE, TENOFOVIR DISOPROXIL FUMARATE, AND DORAVIRINE","authors":"M. Damle, Ritesh Khairnar","doi":"10.22159/ijpps.2023v15i9.48681","DOIUrl":"https://doi.org/10.22159/ijpps.2023v15i9.48681","url":null,"abstract":"Objective: The objective of this study was to develop and validate an HPTLC method for the simultaneous estimation of Lamivudine, Tenofovir disoproxil fumarate, and doravirine. The method is aimed to provide reliable and efficient quantification of these drugs.\u0000Methods: The chromatographic separation of drugs was performed on aluminum plates coated with silica gel 60 F254. Samples were spotted on the plate as a 6 mm wide band using a linomat applicator and a 100 µl syringe. The mobile phase used was a mixture of ethyl acetate, methanol, and chloroform (07:02:01 % v/v/v). Densitometric scanning at 226 nm was conducted using a Deuterium lamp as the radiation source, and the data were analyzed using win CATS software. The method was validated following the ICH Guideline ICH Q2 (R1).\u0000Results: The optimized method lead to the resolution of drugs with the Rf values of doravirine (0.75±0.02), Tenofovir disoproxil fumarate (0.57±0.02), and lamivudine (0.37±0.02). Doravirine exhibited a linear range of 500-1500 ng/band with a favorable linear equation and regression coefficient of 0.999. Tenofovir disoproxil fumarate and lamivudine showed a linear range of 1500-4500 ng/band, and both compounds displayed a linear relationship with a regression coefficient of 0.997. The method's accuracy was assessed through recovery studies, and the LOD and LOQ were determined for each drug.\u0000Conclusion: The optimized HPTLC method was validated in this study, following the ICH Q2 (R1) guidelines, it demonstrates its efficacy for the quantitative analysis of Doravirine, Tenofovir disoproxil fumarate, and lamivudine. The method offers reliable quantification of these compounds in a combined dosage form and can be used for routine analysis in pharmaceuticals.","PeriodicalId":14188,"journal":{"name":"International Journal of Pharmacy and Pharmaceutical Sciences","volume":"73 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76802990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}