International Journal of Pharmacy and Pharmaceutical Sciences最新文献

{"title":"EVALUATION OF THE EFFECT OF THE AQUEOUS EXTRACT OF THE RECIPE MADE FROM THE LEAVES OF OCIMUM GRATISSIMUM. LINN (LAMIACEAE) AND TERMINALIA SUPERBA STEAM BARK. ENGL (COMBREATACEAE) ON LOPERAMIDE-INDUCED CONSTIPATION","authors":"ELION ITOU ROMARIC DE GARDE, BOUKONGO ROGER PAVEL, MAMBEKE HONO MAMBEKE, ETOU OSSIBI ARNAUD WILFRID, MORABANDZA CYR JONAS, ABENA ANGE ANTOINE","doi":"10.22159/ijpps.2023v15i11.49203","DOIUrl":"https://doi.org/10.22159/ijpps.2023v15i11.49203","url":null,"abstract":"Objective: This study aimed to contributing to the promotion of the recipe made from the leaves of O. grastissium and the bark of T. superba used as a laxative. Methods: Constipation was induced in rats by oral administration of loperamide (3 mg/kg body weight) for three days. The constipated rats were treated with the aqueous extract of the recipe (125, 250 and 500 mg/kg) for 7 d. In addition, the effect of the aqueous extract of the recipe was also evaluated on the secretion of prostaglandin E2, nitric oxide (NO), on the accumulation of intestinal fluid, the secretion of electrolytes as well as on some biochemical parameters. Results: The results obtained show that the aqueous extract at the doses used significantly reduced the delay (p<0.001), significantly increased (p<0.01 and p<0.001) the frequency and quantity of stools excreted in rats made constipated by the loperamide. Similarly, the aqueous extract of the recipe stimulated a significant increase (p<0.001) in the secretion of prostaglandin E2, nitric oxide, water, ions such as K+, Na+, Ca2+and Cl-leading to intraluminal water retention and accumulation of intestinal fluid. Moreover, unlike castor oil, the aqueous extract of the recipe at the doses used does not cause any significant increase in biochemical parameters compared to control animals. Conclusion: The results obtained show that the aqueous extract of the recipe has a laxative activity, which would be due to the chemical compounds highlighted. These results could justify the traditional use of this recipe.","PeriodicalId":14188,"journal":{"name":"International Journal of Pharmacy and Pharmaceutical Sciences","volume":"17 12","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135271846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DEVELOPMENT, CHARACTERIZATION, AND EVALUATION OF THE ANTIMICROBIAL PROPERTIES OF BIODEGRADABLE POROUS SCAFFOLDS LOADED WITH NATURAL VANILLIN","authors":"R. M. AKILA, M. JANANI","doi":"10.22159/ijpps.2023v15i11.48987","DOIUrl":"https://doi.org/10.22159/ijpps.2023v15i11.48987","url":null,"abstract":"Objective: The study's objective is to create biodegradable porous scaffolds that are filled with natural vanillin and assess their in vitro antibacterial activity. Methods: Scaffolds were fabricated by blending different ratios of chitosan and gelatin along with vanillin using the freeze-drying method. Then the following characterization and evaluation of scaffolds, such as FTIR, SEM, porosity, swelling behaviour, degradation studies, in vitro drug release, and antibacterial studies, were carried out. Results: All of the scaffolds that were created had heterogeneous, well-connected pores and were pale yellow in color. This was validated by SEM, where the porosity is greater than 80% and the mean pore size ranges from 105.25±6.35 µm to 188.58±7.51 µm. With an increase in gelatin concentration, all of the scaffolds showed the maximum water absorption and retention capabilities of 760.15%±4.38% and 664.73%±5.82%. In the 7-day degradation investigation, all samples lost close to 60% of their mass. In the formulation CG11, the vanillin was released gradually over about 96 h. According to the present study, the developed scaffolds CG13-A and CG13-B, as well as CG11-A and CG11-B, displayed a higher zone of inhibition. Conclusion: Due to its potent antibacterial capabilities, it may be inferred from the current research that vanillin clothed in chitosan-gelatin scaffolds would be a superior option for treating various wound infections, including diabetic wounds.","PeriodicalId":14188,"journal":{"name":"International Journal of Pharmacy and Pharmaceutical Sciences","volume":"29 3-4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135272458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANTI-INFLAMMATORY ACTIVITY OF SIDDHA POLYHERBAL FORMULATION SEVVIYADHI CHOORANAM ON CARRAGEENAN INDUCED PAW EDEMA IN WISTAR ALBINO RATS","authors":"SHAMSHALNIHA S., ANBU N.","doi":"10.22159/ijpps.2023v15i11.49131","DOIUrl":"https://doi.org/10.22159/ijpps.2023v15i11.49131","url":null,"abstract":"Objective: The aim of the study was to explore the anti-inflammatory activity of Siddha polyherbal formulation Sevviyadhi chooranam in Carrageenan induced paw edema in wistar albino rats, and compared with the standard drug Indomethacin. Methods: The Siddha polyherbal formulation Sevviyadhi chooranam indicated for sinusitis was prepared based on GMP (Good Clinical Practice) guidelines. Study procedure was approved by Institutional Animal Ethics Committee (IAEC). The experimental animals were measured for paw edema volume at 1, 2, 3, 4, 5 h using Plethysmometer (Model 7150 UGO Basile, Italy). Edema was expressed as mean increase in paw volume relative to control animals. And then, findings were compared with Indomethacin (Standard drug). Results: The findings revealed that test drug Sevviyadhi chooranam at higher dosage 200 mg/kg (Group V) had equal effect on anti-inflammatory activity with percentage protection of 93.2% when compared with the standard drug Indomethacin at about 40 mg/kg (Group III) with percentage protection 93.2%. However, the test drug Sevviyadhi chooranam at a higher dosage 200 mg/kg (Group V) with a percentage protection 93.2% was highly effective when compared with lower dosage about 100 mg/kg (Group IV) with a percentage protection 27.12%. Hence, the study resulted that the Siddha polyherbal formulation Sevviyadhi chooranam has an optimistic anti-inflammatory activity with more therapeutic value. Conclusion: The study concluded that the Siddha polyherbal formulation Sevviyadhi chooranam has a promising anti-inflammatory activity, probably due to the presence of biologically active phytocompounds. However, it is important to admit that there are some scientific evidences of the potential actions of these phytocompounds in anti-inflammatory activity.","PeriodicalId":14188,"journal":{"name":"International Journal of Pharmacy and Pharmaceutical Sciences","volume":"31 5-6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135272449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CURRENT PERSPECTIVES ON APPLICATIONS OF NANOPARTICLES FOR CANCER MANAGEMENT","authors":"ROHIT R. BHOSALE, BHAGYESH U. JANUGADE, DHANASHRI D. CHAVAN, VANDANA M. THORAT","doi":"10.22159/ijpps.2023v15i11.49319","DOIUrl":"https://doi.org/10.22159/ijpps.2023v15i11.49319","url":null,"abstract":"In the realm of cancer diagnostics, imaging and therapeutics, nanocarrier-based drug delivery systems have gained extensive importance owing to their promising attributes and potential to enhance therapeutic effectiveness. The primary area of research revolves around formulating innovative intelligent nanocarriers such as nanoparticles (NPs) which are capable of selectively responding to cancer-specific conditions and efficiently delivering medications to target cells. These nanocarriers, whether operating in a passive or active manner, can transport loaded therapeutic cargos to the tumor site while minimizing drug elimination from the drug delivery systems. This review primarily focuses on presenting recent advancements in the development and utilization of nanoparticles in the treatment of various cancer types, such as pancreatic cancer, prostate cancer, colorectal cancer, cervical cancer, and breast cancer.","PeriodicalId":14188,"journal":{"name":"International Journal of Pharmacy and Pharmaceutical Sciences","volume":"18 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135271843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COMPARATIVE STUDY OF VITAMIN B12 DEFICIENCY ASSOCIATED WITH METFORMIN AND METFORMIN IN COMBINATION WITH DPP-4 INHIBITORS IN A TERTIARY CARE HOSPITAL","authors":"NABIHA SUBHANI MISBAH, SYEDA AYESHA SIDDIQUA, JUWARIA MASOOD, NASER ASHRAF TADVI, AROOBA FATIMA","doi":"10.22159/ijpps.2023v15i10.47818","DOIUrl":"https://doi.org/10.22159/ijpps.2023v15i10.47818","url":null,"abstract":"Objective: To estimate the prevalence of vitamin B12 deficiency in type 2 diabetes mellitus patients receiving metformin and metformin in combination with DPP-4 inhibitors. To evaluate the vitamin B12 levels induced by long-term metformin usage. Methods: It is a retrospective, comparative study of 6 mo, conducted at Shadan Institute of Medical Sciences, Hyderabad. 300 diabetic patients of age group between 30-85 y of either gender were divided into Group-A, receiving metformin and Group-B, receiving metformin+DPP-4 inhibitors. Ethics committee approval was o btained. The baseline and after 6 mo values of Vitamin B12 were noted and analyzed by using SPSS software. Results: The majority of the patients were from the age group of 56-65 y (n=42, 28%) in Group-A and 46-55 y (n=61, 40.7%) in Group B. Male predominance was observed in both groups (n=81, 54% and n=76, 50.7%). Duration of Diabetes mellitus was ≤5 y in both groups (n=87, 58% and n=112, 74.7%). Vitamin B12 mean values for Group-A (Baseline-478.61, After 6 mo-195.94) and Group-B (Baseline-527.82, After 6 mo-299.05) were obtained. Mean reduction with a statistical significance in both study groups was observed (Group-A-282.66 and Group-B-228.77). Most of the patients showed numbness (14%) in Group-A and general weakness (7.3%) in Group B, respectively. Conclusion: Type 2 diabetic patients who were on metformin therapy only have a prevalence of vitamin B12 deficiency compared to Metformin in combination with DPP-4 inhibitors receiving patients.","PeriodicalId":14188,"journal":{"name":"International Journal of Pharmacy and Pharmaceutical Sciences","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135458741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DEVELOPMENT, FORMULATION, AND EVALUATION OF ALOE VERA TOOTH GEL: AN ANTIMICROBIAL STUDY","authors":"ANANDAMOY RUDRA, ABU SHOEB","doi":"10.22159/ijpps.2023v15i10.48765","DOIUrl":"https://doi.org/10.22159/ijpps.2023v15i10.48765","url":null,"abstract":"Objective: The purpose of the current study was to develop and formulate tooth gel using Aloe vera leaf extract and evaluate. The experiment was designed to provide scientific proof of the antimicrobial activity of Aloe vera (Aloe barbadensis Mill) in tooth gel formulation against bacteria Staphylococcus aureus which causes infections associated with dental caries. Methods: Transparent Aloe vera gel extract was consistently blended for five minutes at 1000 Rotations Per Minute (RPM). Carbopol 940 and Carboxy Methyl Cellulose (CMC) were used as excipients in the formulation of Aloe vera tooth gel. Results: The formulated Aloe vera tooth gel was evaluated by physical examination such as color (yellowish green), good homogeneity and smoothness. pH and viscosity of developed tooth gel preparation were found to be 7.9 and 4.9 Pa. S respectively. The developed Aloe vera tooth gel showed considerable effectiveness with a Zone of Inhibition (ZOI) of 0.022 m, according to an antimicrobial study against Staphylococcus aureus. A comparison between formulated gel and marketed products (Colgate Natural Extract Aloe vera, Himalaya Herbal Active Fresh, Dabur Red) was also carried out. Conclusion: The formulated herbal tooth gel exhibited antimicrobial activity against gram-positive bacteria Staphylococcus aureus. The developed formulation (F4) with the ZOI of 0.022 m could be comparable with the marketed product.","PeriodicalId":14188,"journal":{"name":"International Journal of Pharmacy and Pharmaceutical Sciences","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135458855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DEVELOPMENT AND EVALUATION OF HYDROGEL OF AN ANTI-FUNGAL DRUG","authors":"SAYANTAN BHATTACHARYA, BIPLAB PAUL, GOPA ROY BISWAS","doi":"10.22159/ijpps.2023v15i10.48728","DOIUrl":"https://doi.org/10.22159/ijpps.2023v15i10.48728","url":null,"abstract":"Objective: Topical gel preparations are used for application on skin or to certain mucosal surfaces for local action or for their emollient or protective action. Topical delivery of drugs can be achieved by incorporating drugs into the hydrogel matrix for effective delivery of drugs, thus avoiding first-pass metabolism and for increased local action in pain management and skin diseases. Methods: Hydrogel is a network of polymer chains that are hydrophilic, sometimes found as a colloidal gel in which water is the dispersion medium. Miconazole nitrate (MN) is a broad-spectrum antifungal agent of the imidazole group. It has been selected as a model drug for the preparation of hydrogel. For the preparation of hydrogel, Carbopol of different grades like 934p, 971p, and 974p have been selected. Drug–polymer interaction has been carried out by FT-IR spectroscopy. Standard curve of miconazole nitrate was prepared in phosphate buffer pH 5.5 and 7.4. Physico-chemical characteristics of the hydrogel, like pH, viscosity and % swelling index, were studied. % cumulative drug permeation study through dialysis membrane was done in phosphate buffer pH 7.4. Results: The results were found to be satisfactory. Carbopols have been used in different ratios to get a number of formulations. Out of these, nine formulations have been chosen by their satisfactory physicochemical characteristics and used for the study. The average pH, viscosity, % swelling index and drug content were found to be 7.36, 1.09 x 100 cps, 23.1 and 98.36 %, respectively. Drug permeation kinetics through the dialysis membrane has been done in a Franz diffusion cell at phosphate buffer pH-7.4. The permeation of Miconazole Nitrate through the dialysis membrane was maximum in F1 and minimum in F9. The drug permeation through the dialysis membrane followed zero-order kinetics. Conclusion: A sharp correlation between the % swelling index and the Cumulative % of drug permeated through the dialysis membrane has been found. With the increase in the % swelling index over a period of 6 h the permeation decreased; thus, the swelling of the formulations is responsible to inhibit the permeation of Miconazole Nitrate through the skin.","PeriodicalId":14188,"journal":{"name":"International Journal of Pharmacy and Pharmaceutical Sciences","volume":"63 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135458861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A COMPARATIVE STUDY OF OLOPATADINE 0.01% COMBINED FLUOROMETHOLONE 0.1% TREATMENT VERSUS OLOPATADINE 0.01% COMBINED KETOROLAC 0.4% TREATMENT IN ALLERGIC CONJUNCTIVITIS IN SAROJINI DEVI EYE HOSPITAL","authors":"N. KARUNA SREE, KHATIJATUL KUBRA NAMEERA, THOMAS SANGA, FAHEEM BEGUM, V. NAVYA, NABEELA FATIMA","doi":"10.22159/ijpps.2023v15i10.47483","DOIUrl":"https://doi.org/10.22159/ijpps.2023v15i10.47483","url":null,"abstract":"Objective: Comparative study of the efficacy of olopatadine 0.01% combined fluorometholone 0.1% treatment versus olopatadine 0.01% combined ketorolac 0.4% in the treatment of Allergic Conjuctivitis. Methods: This was a randomized control trial done on 80 subjects with 40 subjects in each group. The clinical signs (chemosis, mucus secretion, eyelid edema) and symptoms (itching, redness, watery eyes, burning) of the patients were evaluated by summing up the scores using a 3-point scale at baseline,1st and 7th day of initiation of treatment. Results were analyzed by Student’s Independent t-test to assess the significant difference of means between the groups. p-value less than 0.05 was considered significant. Results: The mean age of the study subjects was 29.8±13.5 in Group A and 32.6±8.8 in Group B. Majority were females in both group A and group B with 52.5% and 62.5% respectively. The reduction was high for chemosis (87.7%) followed by mucous secretion (87.5%) in group A. Highest reduction was seen with itching (59.9%) followed by burning (52.5%) in group B. Significant difference between the groups was noticed with itching (p=0.04), mucous secretion(p=<0.001), chemosis (p=0.01) and eyelid oedema (p=0.009). No significant difference was observed between the two groups (p=0.15) regarding adverse events. Conclusion: Olopatadine 0.01% combined fluorometholone 0.1% had better efficacy than olopatadine 0.01% combined ketorolac 0.4%.","PeriodicalId":14188,"journal":{"name":"International Journal of Pharmacy and Pharmaceutical Sciences","volume":"55 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135459354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DEVELOPMENT AND VALIDATION OF STABILITY INDICATING HPTLC METHOD FOR PIMAVANSERIN TARTRATE","authors":"MRINALINI C. DAMLE, ROSHANI R. PARDESHI, SHUBHANGI R. BIDKAR","doi":"10.22159/ijpps.2023v15i10.48820","DOIUrl":"https://doi.org/10.22159/ijpps.2023v15i10.48820","url":null,"abstract":"Objective: The aim of current research work was to investigate degradation behavior of Pimavanserin tartrate upon exposure to stress conditions recommended by ICH Q1A (R2) and Q1B guidelines. Methods: Chromatographic separation was achieved on Merck’s TLC aluminum plates pre-coated with silica gel G 60 F254 as stationary phase and Methanol: Chloroform (2:8 v/v) as mobile phase. Densitometry scanning was carried out at 224 nm. Results: The retardation factor (Rf) was observed to be 0.56±0.02. Pimavanserin tartrate showed degradation in all stress conditions, but no degradation product was found in any stress condition. Peak purity was found to be 0.999 indicating no interference by degradation products to drug peak. The developed HPTLC method was successfully validated as per ICH Q2 (R1) guideline. Method was found to be linear within the range of 400-2000 ng/band with correlation coefficient R2= 0.9982. % RSD for intra-day and inter-day precision were found to be 1.35 and 1.78 % and % recovery was found to be in range 98-102 %. LOD and LOQ were found to be 17.58 ng/band and 53.27 ng/band respectively. Conclusion: A simple, economic stability indicating high performance thin layer chromatography method has been developed and validated for Pimavanserin tartrate. It is used for the treatment of delusions and hallucinations in Parkinson’s disease.","PeriodicalId":14188,"journal":{"name":"International Journal of Pharmacy and Pharmaceutical Sciences","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135459224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EVALUATION OF ANTI ULCER ACTIVITY OF HYDROALCOHOLIC EXTRACTS OF GYMNEMA SYLVESTRE ON ALBINO WISTAR RATS","authors":"DHIVYADHARSHINI NAGARAJAN, MANIMEKALAI PICHAIVEL, SABARINATH CHANDRASEKAR, SELVA PRASANTHI PARAMESHWARAN, SARANYA KANNAN","doi":"10.22159/ijpps.2023v15i10.48922","DOIUrl":"https://doi.org/10.22159/ijpps.2023v15i10.48922","url":null,"abstract":"Objective: The present research is designed to evaluate the anti-ulcer activity of HAGS (Hydroalcoholic extract of Gymnema sylvestre) in NSAIDs and pylorus ligation-induced rat models. Methods: The antiulcer activity of the hydroalcoholic extracts of Gymnema sylvestre (100 and 200 mg/kg, p. o.) was evaluated in ethanol, indomethacin, pylorus ligation and acetic acid-induced ulcer models in rats. Parameters such as mean ulcer indices and percentage ulcer inhibition were assessed in ethanol, indomethacin and acetic acid-induced ulcer models, while the gastric volume, pH, and titratable acidity were evaluated in the pylorus ligation ulcer model. Results: Hydroalcoholic extract of Gymnema sylvestre (100 mg/kg) and (200 mg/kg) could significantly (P<0.001) reduce the ulcer index, ulcerated area and total acidity compared to standard drug and thereby significantly (P<0.001) increase percentage inhibition of ulcers and protected area which was evident by the significant rise in pH of gastric content. A significant increase was observed in pH, NP-SH, GSH, enzymic antioxidants and protein with a significant decrease in volume of gastric juice, free and total acidity, acid output and LPO levels activities in 100 mg/kg and 200 mg/kg of HAGS treated rats compared to disease control rats. The effect of extracts was dose-dependent and results were comparable to that of the standard drug Cimetidine. Conclusion: It is concluded that the Hydroalcoholic extract of Gymnema sylvestre shows a significant effect on NSAIDs and Pylorus ligation-induced rat models. It shows a significant reduction in the lesion index.","PeriodicalId":14188,"journal":{"name":"International Journal of Pharmacy and Pharmaceutical Sciences","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135457756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}