A COMPARATIVE STUDY OF OLOPATADINE 0.01% COMBINED FLUOROMETHOLONE 0.1% TREATMENT VERSUS OLOPATADINE 0.01% COMBINED KETOROLAC 0.4% TREATMENT IN ALLERGIC CONJUNCTIVITIS IN SAROJINI DEVI EYE HOSPITAL

Abstract

Objective: Comparative study of the efficacy of olopatadine 0.01% combined fluorometholone 0.1% treatment versus olopatadine 0.01% combined ketorolac 0.4% in the treatment of Allergic Conjuctivitis. Methods: This was a randomized control trial done on 80 subjects with 40 subjects in each group. The clinical signs (chemosis, mucus secretion, eyelid edema) and symptoms (itching, redness, watery eyes, burning) of the patients were evaluated by summing up the scores using a 3-point scale at baseline,1st and 7th day of initiation of treatment. Results were analyzed by Student’s Independent t-test to assess the significant difference of means between the groups. p-value less than 0.05 was considered significant. Results: The mean age of the study subjects was 29.8±13.5 in Group A and 32.6±8.8 in Group B. Majority were females in both group A and group B with 52.5% and 62.5% respectively. The reduction was high for chemosis (87.7%) followed by mucous secretion (87.5%) in group A. Highest reduction was seen with itching (59.9%) followed by burning (52.5%) in group B. Significant difference between the groups was noticed with itching (p=0.04), mucous secretion(p=<0.001), chemosis (p=0.01) and eyelid oedema (p=0.009). No significant difference was observed between the two groups (p=0.15) regarding adverse events. Conclusion: Olopatadine 0.01% combined fluorometholone 0.1% had better efficacy than olopatadine 0.01% combined ketorolac 0.4%.