International Journal Of Medical Science And Clinical Invention最新文献

{"title":"Effect of Aqueous Extract of Alstonia Boonei on Liver Enzymes and Its Anti-Inflammatory Activity on Formalin- Induced Arthritic Wistar Rats","authors":"Eseoghene Valentine Egho, Mr Fidelis Oyakhire, E. Ogie, Harrison Nnamdi Obi, Promise Bassey Ochannah, Irabonosa Asiriuwa, Chinedu Emmanuel Okafor","doi":"10.18535/ijmsci/v9i09.06","DOIUrl":"https://doi.org/10.18535/ijmsci/v9i09.06","url":null,"abstract":"The anti-inflammatory effect of the aqueous extract of Alstonia boonei on the level of liver biomarker in the plasma of normal and arthritic rats was evaluated using the formalin-induced arthritis inflammation tests. Thirty (30) adult female Wister rats were divided into six groups of five rats each. Group 1  as control, group 2(formalin induced group) while groups 3, 4 and 5 were respectively gavage with 150mg/kg, 300mg/kg  and 600mg/kg body weight of the extract daily while group 6 was given reference drug( 5mg/kg body weight of indomethacin for 5 days). After formalin treatment, the paw thickness in formalin-induced group was increased compared with control group. The levels of TNF-alpha, CRP, liver enzymes were increased with severe chronic inflammation sign at histopathologically observation. The animals were sacrificed 24hours after the end of treatments, the skin sample of the right paw was taken for TNF alpha  evaluation and blood samples  were obtained for assay of the levels of ALT, AST, ALP and C-reactive protein(CRP). Liver enzymes were determined using colorimetric methods while TNFalpha and CRP was determined using ELISA technique. Oral administration of the extract produced significant anti-edematogenic, anti-inflammatory activity and dramatic reduction in liver enzymes, TNF alpha and CRP with a dose of 150mg/kg and 300 mg/kg throughout the period of the experiment. This effect of A.boonei at 300mg/kg was  similar to  indomethacin group which showed a highly significant (p<0.05) inhibition compared to control group.The result of this study suggests that aqueous extract of A. boonei possesses chronic anti-inflammatory activity which may be mediated by either inhibition or by blocking the release of prostaglandins, histamine and pro-inflammatory cytokine (TNF alpha),which suggest that  Alstonia boonei is an alternatve approach for treatment of chronic inflammatory disease, thus supporting its usage for anti- inflammatory treatment and  potential effect to resuscitate the hepatocytes.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":"160 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73798616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Use of Scent Within the Changing Landscape of Theatre and Its Application to Long-Term Rehabilitation","authors":"Nicholas Saldivar, Thomas Varkey, B. J. Rafidi, Jack B. Ding, Taydan Tran, Kartik Akkihal","doi":"10.18535/ijmsci/v9i09.05","DOIUrl":"https://doi.org/10.18535/ijmsci/v9i09.05","url":null,"abstract":"The intentional and unintentional use of scents have long been implemented in the arts. As an element of design, the use of fragrances may increase audience immersion by engaging the sense of smell through the olfactory receptors, in addition to becoming a tool for the performers. Since the COVID-19 pandemic began, most performing companies have been forced to shift the showcasing of work primarily online. Many of the subtle effects produced by both the cast and the design team that one may appreciate in-person are inevitably lost in virtual theatre, falling secondary to the screen. One potential solution for ensuring that digital productions can continue traditions of theatre while considering the safety of guests would be through the utilization of strategically crafted scents that support the performance’s story and the overall direction of the production. In virtual performances, the use of scent can be useful to ground both the audience and performers within the same world by linking the play to old memories or creating new ones. The paper finally looks at ways that this linkage can be utilized in longterm care facilities for the betterment of patients.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81839785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Memory and Cognitive Impairment in Myasthenia Gravis","authors":"L. Susanti","doi":"10.18535/ijmsci/v9i09.04","DOIUrl":"https://doi.org/10.18535/ijmsci/v9i09.04","url":null,"abstract":"Myasthenia gravis (MG) is an autoimmune disease in the neuromuscular junction. This is a relatively uncommon disorder characterized by fluctuating muscle weakness, worst with exertion and improves with rest. This disease is treatable but can result in significant morbidity and mortality. The etiology of  MG is commonly acquired autoimmune but, in some case, result from genetic abnormalities in the neuromuscular junction.1 The incidence of  MG  is about 4.1-30 points million per year, and the prevalence rate ranges from 150-200 cases per million.2  It is believed that MG incidence has increased worldwide over the past seven decades. The majority of MG was estimated at 1 in 200,000 from 1915 to 1934, grew to 1 per 20,000 after the introduction of anticholinesterase drugs in 1934, and rose to 1 per 17,000 population after the discovery of AChR antibodies in 1969.3 Sex and age appear to influence the occurrence of myasthenia gravis. Below 40 years of age, the female: male ratio is about 3: 1; however, between 40 and 50 years, as well as during puberty, it is roughly equal. Over 50 years, it occurs more commonly in males.3 \u0000            Cognitive impairment in patients with myasthenia gravis is still a matter of debate. There is some evidence that central nervous system involvement in myasthenia gravis contributes to cognitive impairment—nearly 60% of individuals with MG report memory difficulties.4 Mao et al. reported in their metanalysis study that patients with suspected MG performed worse than healthy controls regarding verbal learning and memory.5 Research by Klaus et al., 2022 on myasthenia gravis showed structural and functional changes in the patient's brain. Structural changes were seen in the form of a significant decrease in the volume of gray matter in the cingulate gyrus, inferior parietal lobe, and fusiform gyrus. Functional changes are characterized by decreased performance in cognitive function, working memory, and somatosensory-related spatial orientation.6","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84447695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrapancreatic Peristaltic Duodenal Duplication Cyst; Presenting with Acute Pancreatitis and Intraabdominal Bleeding","authors":"Sevinç Kalın, Zeliha Akış Yıldız, C. Hasbal Akkuş, Seher Erdoğan, G. Atay, I. Tosun, Z. İlçe, B. Sözeri","doi":"10.18535/ijmsci/v9i09.03","DOIUrl":"https://doi.org/10.18535/ijmsci/v9i09.03","url":null,"abstract":"Congenital anomalies and variations should be kept in mind when evaluating diseases in the pediatric patient group. A 12 years old girl presented with findings of acut abdomen. Clinical and laboratory data were consistent with acute pancreatitis. Imaging findings showed a peristaltic cystic tissue with a thick wall and central lumen in the head of the pancreas. In the operation, it was shown that this cystic lesion was associated with the accessory pancreatic duct and had no duodenal connection. In the pathology report, the presence of duodenal intestinal tissue compatible with a duplication cyst located in the head of the pancreas was proven. By sharing this rare case, keeping in mind the underlying congenital anomalies in any pathology in children and emphasizing the importance of ultrasonographic dynamic real-time examination in abdominal imaging.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79161438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factor V Gene Polymorphism (G1691A) Among Sudanese Patients with Intracerebral Hemorrhage, Khartoum State, 2022","authors":"Abubker Alsiddig Abd Algader, T. Alabid, Esraa Kamal Almahy Abdallah, Manasik Siddig hasssan, W. Ibrahim, Sawsan A. Hamed, Alsadig Gassoum, Maye M. Merghani, Nihad alsadig Babiker","doi":"10.18535/ijmsci/v9i09.02","DOIUrl":"https://doi.org/10.18535/ijmsci/v9i09.02","url":null,"abstract":"Background \u0000Intracranial hemorrhage refers to any bleeding within the intracranial vault, including the brain parenchyma and surrounding meningeal spaces. In Sudan, there is no published data regarding factor V Leiden mutation. Therefore this study was designed to detect the possible present of factor V polymorphism (G1691A) among Sudanese patients with intercereberal hemorrhage.\u0000Material and method\u0000This study was a cross sectional hospital-based study, conducted at the research laboratory of the national center of neurological sciences (NCNS), Khartoum, Sudan during the period June 2022 to August 2022.It included all patients attended with Intracerebral hemorrhage, DNA extraction was done from blood of all patients and controls.PCR for factor V gene was done and thus Sanger sequencing.\u0000Results\u0000The PCR results showed; 100% were positive for factor V gene. Sequencing results revealed single based exchange in factor V geneG to A (G1691A).\u0000Conclusion\u0000Factor V gene polymorphism (G1691A) was detected and might be in association with intercereberal hemorrhage among Sudanese patients","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86226186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demographic and Clinical Characteristics of Endometrial Cancer in Northwestern Iran, Urmia: A Ten-Year Cross-Sectional Study","authors":"H. Ayatollahi, Elham Rajabi, R. Razavi, Samira Jahangard","doi":"10.18535/ijmsci/v9i09.01","DOIUrl":"https://doi.org/10.18535/ijmsci/v9i09.01","url":null,"abstract":"Background: endometrial cancer is the most frequent genital cancer in women  in the developing nation. The purpose of this study was to investigate on  the demographic and clinical aspects of endometrial cancer, or to explain its epidemiology in patients admitted to Urmia's Kosar Hospital. \u0000Methods: From 2006 to 2016, the medical records of 179 hospitalized women with an initial diagnosis of endometrial cancer were analyzed in this cross-sectional research. The patients’ clinical and demographic information, including age, menstrual age, first visit reason, number of deliveries, menstrual pattern, history of previous disease in patients and their relatives, disease stage, clinical parameters (including WBC, Hb, and MCV), pathology type, and the presence or absence of metastasis was extracted from their medical records and analyzed. \u0000Results: The patients in our research had a mean age of more than 50 years. Nearly 80% of the patients were menopausal, and approximately 90% of the patients presented with bleeding complaints. Patients with endometrioid type adenocarcinoma had the highest frequency of pathology. \u0000Conclusion: Our findings show a high proportion of bleeding complaints among the patients evaluated, which might reflect the importance of this finding and help to guide the disease’s diagnosis and therapy. However, further research is needed to establish the epidemiology of this condition in the country.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84641230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Déterminants of the Use of Modern Contraceptive Methods by Women in the Commune of Ruashi","authors":"Mungende Ndaienen Marie Thérèse, Luboya Numbi Oscar, Mwembo Tambwe A Nkoy","doi":"10.18535/ijmsci/v9i08.04","DOIUrl":"https://doi.org/10.18535/ijmsci/v9i08.04","url":null,"abstract":"La planification familiale permet aux personnes et aux couples d’anticiper et d’atteindre le nombre d’enfants désiré, ainsi que l’espacement et le moment de leur naissance. Il est réalisé par l’utilisation de méthodes contraceptives et le traitement de l’infertilité involontaire. La capacité d’une femme à espacer et à limiter ses grossesses a un impact direct sur sa santé et son bien-être ainsi que sur l’issue de chaque grossesse.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86301317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential of Strawberry (Fragaria x annanasea) Extract as Whitening Agent for Discolored Teeth","authors":"E. Rachmawati, M. Febriani","doi":"10.18535/ijmsci/v9i08.02","DOIUrl":"https://doi.org/10.18535/ijmsci/v9i08.02","url":null,"abstract":"The Bleaching technique has long been applied in dentistry. Strawberry (Fragaria x annanasea) is a non-dental material that can be used for natural bleaching. The strawberries contain ellagic acid and malic acid which can whiten teeth. Other ingredients found in strawberries also have a low pH so they can whiten teeth better when compared to other fruits. Strawberries also give bad side effects, namely increased tooth sensitivity. This research aims to explain the potential of strawberry (Fragaria x annanasea) extract as a whitening agent against discolored teeth. Based on reference sources obtained from journals, textbooks, and websites accessed through the databases of Google Scholar, Science Direct, EBSCO, and PubMed (National Library of Medicine, Bethesda, MD, USA) and searched for the keywords “Bleaching, Strawberries (Fragaria x annanasea), and Discoloration.” The types of journals taken are scientific and descriptive journals published from 2010 – 2020 and dental material textbooks from 2010 – 2020. The research concludes that the use of strawberry (Fragaria x annanasea) fruit extract can provide a whitening effect on teeth that have changed color and is the best solution compared to synthetic tooth whiteners. In addition, strawberries also provide side effects, namely increased tooth sensitivity.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":"15 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90342414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Conventional Therapy on Quality Of Life in CMT Disease. Review and Meta-Analysis","authors":"Dr. Andrea Dincher, Lena Michelle Dincher","doi":"10.18535/ijmsci/v9i07.04","DOIUrl":"https://doi.org/10.18535/ijmsci/v9i07.04","url":null,"abstract":"Objectives: Up to now, only symptoms of Charcot-Marie-Tooth disease can be treated. This work investigates which therapy is the most effective in Quality of Life in Charcot-Marie-Tooth.\u0000Methods: A literature research was conducted (search terms “Whole Body Vibration” or “WBV” or “Exercise” or “Rehabilitation” and “Charcot Marie Tooth” or “CMT” or “Hereditary Neuropathy” or “HMSN”) in five online databases. Inclusion: Publications from January 1990 to April 2022. Exclusion: No conventional treatment or Charcot-Marie-Tooth. Methodological quality: assessed by PEDro score. Effect sizes: calculated by Standardized Mean Differences and 95 % Confidence Intervals.\u0000Results: Of the 5,941 publications found, 17 focused conventional treatment for Charcot-Marie-Tooth disease of whom four had a good quality and investigated Quality of Life. No study investigates Whole Body Vibration. There is no effect (SMD = .29) in health related Quality of Life, a low effect (SMD = -.42) in Activities of Daily Living favoring experimental groups and no effect (SMD = .13) in Disability favoring control groups.\u0000Conclusions: These interventions cannot improve Quality of Life in Charcot-Marie-Tooth. Since no studies investigated \"Whole Body Vibration\" in Charcot-Marie-Tooth, this should be done as well as a motor ability training program. Such studies are in planning.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85791496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Right Sided Infective Endocarditis and Mycotic Pulmonary Artery Aneurysm- A Brief Review of Important Literature","authors":"Arshan Khan, H. Asif, Abdul Wasay, Sanaullah Khan, C. Agyingi, Muhammad Haseeb","doi":"10.18535/ijmsci/v9i07.03","DOIUrl":"https://doi.org/10.18535/ijmsci/v9i07.03","url":null,"abstract":"Right-sided infective endocarditis (IE) involves the infection of the endocardial surface of either the tricuspid or pulmonary valve. The tricuspid valve is involved in almost 90% of cases. Isolated right-sided infective endocarditis can present with multiple complications; the most common of which include valvular insufficiency, abscess formation, and septic pulmonary embolism. Other complications include pulmonary infarcts, pleural effusion, empyema, and pneumothorax. Mycotic pulmonary artery aneurysm is a rare complication of right-sided infective endocarditis. Staphylococcus and Streptococcus species are the most common culprits for mycotic pulmonary artery aneurysms. IV drug use and bacterial endocarditis are the two major known risk factors for mycotic aneurysm. Computerized tomography angiography is the mainstay of imaging modalities to diagnose mycotic pulmonary artery aneurysms. MRI angiography can also be used to diagnose mycotic pulmonary aneurysms, but this imaging modality is not available widely.  The mycotic pulmonary aneurysm is treated both surgically and conservatively depending on the symptoms and clinical status of the patient. The surgical approach includes emergent arterial embolization, lobectomy, resection, banding, and aneurysmectomy.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83486775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}