International Journal Of Medical Science And Clinical Invention最新文献

{"title":"Emerging roles for the RXFP1 in myeloid series leukemia","authors":"Ayriana Safari Baesmat, Berna Bayrakdar","doi":"10.18535/ijmsci/v11i6.05","DOIUrl":"https://doi.org/10.18535/ijmsci/v11i6.05","url":null,"abstract":"Purpose: The study investigates the role of Relaxin Family Peptide Receptor 1 (RXFP1) in myeloid leukemia cell function. It found that RXFP1 has been associated with cAMP, PI3K/Akt, NO/cGMP, MAPK and ERK1/2 signaling. High RXFP1 expression was associated with shorter cancer-specific survival RXFP1 mutated leukemia patients. The study suggests that RXFP1 may promote invasion and progression in both types of AML and CML. \u0000Methods: The gene expression data were retrieved from Gene Expression Omnibus (GEO). Fold change, p.value t-test and David Functional analysis, hierarchical clustering was performed. \u0000Conclusion: PCDH9, AREG, CTSG, RXFP1, CCDC152, ANXA, CD24 and VPREB1 gene expression alterations were identified depending on leukemia in human moocyte cells. Seven of these genes were identified as downregulated in leukemia groups in human monocyte cells and one of these genes were identified as upregulated in leukemia cells.Therefore, it is hypothesized that downregulation or upregulation of these genes may affect AML/CML pathogenesis by reducing cell proliferation. And it is predicted that RXFP1 mutation may be an important factor for myeloid leukemia.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141343195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between Troponin and Red Cell Distribution Width Levels and Mortality in Post-Covid Patients","authors":"M. Doganci, Güler Eraslan Doğanay","doi":"10.18535/ijmsci/v11i6.03","DOIUrl":"https://doi.org/10.18535/ijmsci/v11i6.03","url":null,"abstract":"Introduction: There are very few studies on the TR value, which expresses the simultaneous increase in Troponin and Red Cell Distribution Width (RDW), which are markers of myocardial damage commonly seen in Covid-19 disease. This study aims to show the relationship of troponin, RDW and TR values with mortality and prognostic factors post-Covid-19. \u0000Methods: 204 patients diagnosed with Covid-19 who were admitted to the adult tertiary Covid ICU between April,2021 and March,2022 were included in the study. Demographic data, comorbidities, treatments, length of stay in intensive care and hospital, and laboratory parameters were evaluated. According to our hospital's reference ranges, RDW value over 16% and troponin value over 15ng/L were defined as high value. Patients with both troponin value over 15ng/L and RDW value over 16% were considered to have high TR. \u0000Results: In the study, when the values checked at the time of discharge/before discharge were examined, it was seen that the intubation rate was higher and the duration of mechanical ventilation was longer in patients with high troponin and TR levels. In patients with high RDW and TR values, platelet, hemoglobin and hematocrit values were lower before discharge/discharge compared to those with low RDW and TR values. \u0000Conclusion: In our study, it was found that the intubation rate was higher and mechanical ventilation durations were longer in patients with elevated troponin and TR. We are of the opinion that early intubation practices applied in our clinic for patients with high TR and desaturation are reduced mortality.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141359211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-Guided Off-Plan Lumbar Seated Erector Spinae Plane Blocks : Are There Advantages?","authors":"I. J, Syed Kz, Galanis N, Michael J, Gyer G, Akhtar A","doi":"10.18535/ijmsci/v11i6.01","DOIUrl":"https://doi.org/10.18535/ijmsci/v11i6.01","url":null,"abstract":"The erector spinae plane block (ESPB) has been widely used as a treatment strategy for a variety of acute and chronic painful conditions. ESPBs are typically performed under ultrasound guidance [USG] in an in-plane long axis approach, targeting the tip of the lumbar transverse process while the patient lies prone. Off-Plane Seated Injection Technique-ESPB [OPSIT-E] represents a useful alternative in situations where a standard prone spine injection would be technically challenged by circumstances which may include morbid obesity, orthopnoea, recent upper limbs surgeries, chest pain from recent pacemaker implant, and in a subjects were in-plane approaches may be complicated by skin lesions. A seated forward flexed off-plane injection position, may also flatten the lumbar lordosis, shift adipose tissue more anteriorly, lessening skin to target distance and facilitating bony landmark identification, in high BMI and hyperlordotic subjects. The relatively larger curved transverse arc radius of the curvilinear probe [GE G1-5] in comparison to its transverse arc, also appears to offer improved central field of skin-transducer contact, earlier needle visualization, improved acute angle trajectory visualization of deep structures, which may be due to less crepuscular beam dispersion in comparison to transverse probe orientation. Even with a linear probe, the orthogonal technique facilitates a more perpendicular vector, lessening needle transit to target distance, which may in turn decrease procedure time, and improve patient comfort. The OPSITE, may also be easier to teach, learn, and master, as other studies have generally reported a higher rate of off-lane injection success among novice vascular interventionists.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141266315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective Study of Various Factors In Pediatric To Severe Dengue Infection","authors":"Mohammad Sazzad Hossain Chowdhury, Md. Obaidul Islam, Md. Asaduzzaman","doi":"10.18535/ijmsci/v11i4.01","DOIUrl":"https://doi.org/10.18535/ijmsci/v11i4.01","url":null,"abstract":"Introduction: Dengue epidemics are known to have occurred over the last three centuries in tropical, subtropical and temperate areas of the world. Annually a 100 million cases of Dengue fever and half a million cases of dengue hemorrhagic fever (DHF) occur in the world with a case fatality in Asian countries of 0.5%–3.5%.  Objective: To assess the various factors in pediatric to severe dengue infection. Methods: A hospital-based Retrospective study was conducted at Department Of Paediatric, Mugda Medical College Hospital, Dhaka, Bangladesh from October to December 2023. Number of patients included in the study was 50. In children with high degree clinical suspicion of Dengue infection NS 1 antigen (who came within first 48 hours of fever) and/or Dengue antibody IgM, IgG (who came after five days of fever) were performed. Positive Dengue cases were taken written informed consent & interviewed on the risk factors of Dengue infection. Data related to patients demography, risk factors, clinical presentation, pattern of Dengue infection and outcome were documented on the pre-structured questionnaire. Results: The study was enrolled 100 patients of suspected dengue fever of whom 50 (50.0%) were serologically confirmed to have dengue infection. 30 (60%) patients were males and 20 (40%) were females. 38 (76%) patients had classic dengue fever while 12 (24%) fulfilled the criteria of dengue hemorrhagic fever. Of those patients with dengue hemorrhagic fever, 6 patients had developed dengue shock syndrome. Among the study 44 (88%) from urban and 6 (12%) rural area patients. All cases and is the most common symptom followed by headache, myalgia, vomiting etc. Hemorrhagic manifestations were seen that included petechiae, ecchymosis, gum bleeding, hematuria, malena, hematemesis and epistaxis. Most common complicationswere hepatic dysfunction, renal failure, multi organ failure, encephalopathy and ARDS. Among 50 suspected dengue cases 38 (76.0%) cases were serologically dengue positive. Among the 38 serologically dengue positive patients 17 (44.7%) were NS1 antigen positive, 13 (34.2%) IgM antibodies and 8(21.0%) both IgM and IgG antibodies positive. The distribution of the serologically dengue positive patients out of 50 clinically suspected cases. Conclusion: Dengue is one amongst the key causes of dedifferentiated fever. It presents as an extremely broad wellness and is hardly recognized as a clinical entity by primary health care physicians. This study highlights the practician the importance of break bone fever to clinicians within the areas of medical specialty, manifestations, complications and outcome of the wellness","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140744230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Master Of Medicine (Mmed) Component Of Specialization, Have We Addressed The Challenges?","authors":"Philani Ntombela, Morule Kgagudi, Collen Nkosi","doi":"10.18535/ijmsci/v10i9.03","DOIUrl":"https://doi.org/10.18535/ijmsci/v10i9.03","url":null,"abstract":"Background: Since its inception by the health professions council of South Africa (HPCSA) as a mandatory requirement in 2011, conducting research has presented multiple challenges for clinical specialist trainees. Objective: We aim to evaluate the literature looking at challenges encountered by both the specialist trainees and research supervisors. Data source: PubMed, SciELo SA, Google scholar and ERIC were searched. References of included articles were also evaluated for relevant articles. Data extraction: Data extraction was performed by all 3 authors. The databases were searched from inception to the present day, for only English language articles and those that reported on challenges. Conclusion: Many challenges still exist for both student and supervisor. Co-supervision should be normalised and a significant part of the solution is reinforcing already existing protocols. Recommendations: There is no one size fit all for all the academic institutions but standardized protocols for each centre are encouraged. Co-supervision is strongly encouraged.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135959701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amino Acid Profile Identified In Plasma Has Predictive and Diagnostic Value in Heart Failure Patients","authors":"Veysel Tosun, M.D, Yasemin Behram Kandemir M.D, İsmail Koyuncu, M.D, Özgür Yüksekdağ, M.D, Ünal Güntekin, M.D","doi":"10.18535/ijmsci/v10i9.02","DOIUrl":"https://doi.org/10.18535/ijmsci/v10i9.02","url":null,"abstract":"Background: Metabolic disruptions have effects on the pathogenesis and progression of heart failure (HF). Because of these disruptions are remarkable in HF patients, identity of new biomarkers is necessary to facilitate the determination of HF. In the present study we planned to evaluate the relationship between plasma amino acids and HF. Materials and methods: 40 patients with cardiomyopathy (CMP) and 40 healthy controls were included in this cross-sectional prospective study. A profile consisting of 26 amino acids was measured by liquid chromatography and mass spectrometry method (LC-MS) from blood samples taken from fasting plasma. Results: 5 amino acids (asparagine, beta-alanine, phenylalanine, tyrosine, and isoleucine) levels were higher in CMP patients. Glutamine, isoleucine, and glycine could effectively distinguish CMP and healthy controls. Isoleucine and beta-alanine may be potential biomarkers for CMP. Isoleucine/alloisoleucine, histidine/isoleucine, aspartic acid/isoleucine, and glycine/phenylalanine could predict CMP patients. Three differential pathways (phenylalanine metabolism, tyrosine metabolism, and phenylalanine, tyrosine, tryptophan biosynthesis) were found to be the underlying molecular metabolisms of HF. Conclusion: The present study demonstrating that fasting plasma amino acids were closely associated with HF. Monitoring these amino acids with LC-MS could help the diagnosis and predicting HF, and provide new diagnostic goals and curative practices.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136061938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uncommon Malpositioned Inserted Biliary Stent Causing Common Bile Duct to Portal Vein Fistula: Case Report","authors":"Viky Hibatu Wafi, Bambang Suprapto, Ahmad Tobroni Nasution","doi":"10.18535/ijmsci/v10i9.01","DOIUrl":"https://doi.org/10.18535/ijmsci/v10i9.01","url":null,"abstract":"Endoscopic biliary stent is a common practice in recent years. One of the complications might occur is stent malposition. A 31 years old male with obstructive jaundice secondary to gallstone, presented with persistent upper right quadrant abdominal pain immediately after biliary stenting. During evaluation, biliary stent was found in the portal vein, he immediately underwent repair laparoscopic converted to laparotomy due to obscured stent. Intraoperative findings include fistula in the common bile duct (CBD) to portal vein. Malposition of biliary stent is common occurrence. However, only 5% malposition to proximal and <1% cause perforation or fistula. Anatomical variation of extrahepatic biliary system is common and might be a contributing factor. Thus, adequate knowledge of the anatomical variation helps in stent placement and preventing associated complication. We report a rare case of CBD stent malposition to proximal portal vein with fistula.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135108659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective analysis of vulvar benign masses: 5-year single center experience","authors":"Nazli KORKMAZ, Necdet ÖNCÜ","doi":"10.18535/ijmsci/v10i8.05","DOIUrl":"https://doi.org/10.18535/ijmsci/v10i8.05","url":null,"abstract":"Aim Although benign lesions in the vulva occur rarely, they are one of the reasons for women to apply to the hospital. Although the most common benign masses in the vulva are bartholin cysts; First of all, it is necessary to rule out malignancy. Our aim is to analyze the demographic and presentation characteristics, clinical and laboratory findings, and surgical operation results of women who applied to a tertiary center with a vulvar mass. Materials and methods All women who had vulvar mass in a tertiary perinatology center between January 2016 and January 2021 were retrospectively included in this study. The demographic data of the patients (age, gravida, parity, abortus numbers), complaints and comorbidities were analyzed. Clinical findings, hospitalization times, treatments and surgery results were recorded. Results Overall, 198 patients who had vulvar masses were included in this study. The median age was 35.0 years. While 15.2% of the patients were nulliparous; 51.1% (n=135) had at least one abortion history. The most common complaints were genital swelling/mass in 77.8% and pain in 36.9%. The most common diagnoses were “bartholin cyst/abscess” in 89.9% and vulvar mass in 6.6%. Cyst excision, abscess drainage and mass excision were performed in 59.6%, 30.3% and 6.6%, respectively. No morbidity or mortality was observed in any of the patients. Conclusion Bartholin's cysts/abscesses are the most common cause of benign masses of the vulva. However, in all women presenting with a vulvar mass, malignancies should be excluded and a biopsy should be obtained if necessary.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136241213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glomus Tumor of Rare Localization in the Thigh; Case Report and Literature Review","authors":"Suheyla Karaduman, Sarvinoz Albalushi, Alesia Talpeka, Nishtha Nigam, Renu Bhargavi Boyapati, Dilisha Chandanala, Ratesh Khillan, MD, Bahadir Simsek, MD, Aditya Vikram Maheshwari MD, Daniel Levitan, MD","doi":"10.18535/ijmsci/v10i8.04","DOIUrl":"https://doi.org/10.18535/ijmsci/v10i8.04","url":null,"abstract":"Glomus tumors are rare tumors primarily found on the nail bed of the fingers and rarely occur in other parts of the body. We present a case of a 71-year-old male who came in with a 5-year history of glomus tumor (GT) of the right lateral thigh associated with progressively increasing intermittent sharp pain. He denied any numbness or paresthesias of the extremity. Physical examination revealed a tender mass on the lateral side of the right upper leg associated with edema and erythema. Surgical excision and immunohistochemistry were performed. A histopathological diagnosis of glomus tumor was made. The postoperative recovery was successful and the patient reported resolution of the pain.\u0000We performed a literature review of reported cases of GTs of the thigh. The review showed that all patients had a long period of symptomatic disease before an accurate diagnosis could be made and were easily treated with surgical excision. No evidence of recurrence was noted after surgical removal. GTs of the thigh rarely recur due to their solid and encapsulated structure. This also makes them easy to recognize and surgically remove.\u0000This study highlights the unusual location of the GT, its impact on our patient, and reviews relevant academic literature. Tumors in these areas are frequently misdiagnosed due to vague symptoms. GTs should be included in the differential diagnosis of patients who experience pain with nonspecific symptoms that are not limited to specific body locations","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76062775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The correlation between crime and religiosity in forensic psychiatry service patients","authors":"B. S. Emir, S. Yıldız, Eren Aslanoğlu, Ufuk Doğan","doi":"10.18535/ijmsci/v10i8.03","DOIUrl":"https://doi.org/10.18535/ijmsci/v10i8.03","url":null,"abstract":"Aim: Religion has been perceived as a means of social control throughout human history, emphasizing the association between religiosity and crime. The present study aimed to investigate the correlation between religious commitment and crime in forensic psychiatry service patients.\u0000Method: The study was conducted on 100 patients hospitalized in the forensic psychiatry service after committing a crime. Sociodemographic and clinical data form, Religiosity Scale (RS), Intrinsic Religious Motivation Scale (IRMS) were administered to the participants.\u0000Results: The mean Intrinsic Religious Motivation Scale, Religiosity Scale and sub-dimension scores of the patients were high. A significant difference was determined between the RS total and sub-dimension scores of the patients who committed murder, and the total score was lower when compared to the patients who were incarcerated for other crimes (p<0.05). The \"Religious Knowledge\" sub-dimension score of the patients incarcerated for theft was significantly higher (p<0.05). It was observed that there was a moderate and positive correlation between the mean IRMS and RS scores (r: .468, p<0.05).\u0000Conclusion: The study findings demonstrated that the religiosity levels of the forensic psychiatry service patients were high based on the scale scores, and religiosity differed based on the type of crime committed. Further studies are required to investigate the correlation between crime and religion.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74720513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}