International Journal Of Medical Science And Clinical Invention最新文献

{"title":"Music Therapy as a Low-Cost Treatment for Alzheimer’s Disease","authors":"Sukrith Reddy Muddasani","doi":"10.18535/ijmsci/v10i8.02","DOIUrl":"https://doi.org/10.18535/ijmsci/v10i8.02","url":null,"abstract":"Introduction\u0000Alzheimer's disease affects over 55 million people globally, projected to double by 2030 and triple by 2050. It ranks among the top 10 causes of death, necessitating urgent treatment and cures. Music therapy positively impacts brain development and plasticity, particularly in the medial temporal lobe. It shows promise as a therapeutic approach for enhancing neuroplasticity in the hippocampus, benefiting individuals with Alzheimer's disease.\u0000Materials and Methods\u0000This review explores music therapy as a cost-effective and side-effect-free avenue for patients to alleviate neurodegenerative symptoms based on the analysis of 21 other articles published by renowned authors.\u0000Discussion\u0000Alzheimer's disease causes hippocampal abnormalities and cognitive decline. Music, with musical mnemonics and enhanced working memory, shows promise for memory improvement. Music therapy induces neuroplasticity, potentially treating hippocampal neuron loss. Vocal training improves psychomotor speed and reduces dementia symptoms. Further exploration of music therapy may offer novel strategies for alleviating Alzheimer's symptoms and benefiting neurological disorders. Mechanisms underlying therapeutic benefits require further investigation. Music therapy holds inherent potential for Alzheimer's and related neurodegenerative diseases.\u0000Conclusion\u0000Empirical evidence shows musical training enhances hippocampal plasticity and gray matter volume, suggesting music therapy may treat hippocampal neuron loss in Alzheimer's disease, improving working memory. It holds promise for Alzheimer's and related neurodegenerative disorders by enhancing hippocampal function, but further research on underlying mechanisms is needed.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86256853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity and Venous Disorders-An Overview","authors":"Dr Sirshendu Pal, Dr Rupsha Dutta Pal","doi":"10.18535/ijmsci/v10i8.01","DOIUrl":"https://doi.org/10.18535/ijmsci/v10i8.01","url":null,"abstract":"The prevalence of obesity, particularly central obesity, is increasing globally. It has been identified as a risk factor for not only cardiovascular diseases but also venous disorders. This brief review attempts to revisit the pathophysiology, classification and management of venous disorders in the context of central adiposity","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85949409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Etiology and Risk Factors of Ischemic Stroke in Young Adults: A Mongolian Two-Center Study","authors":"Delgermaa Tsagaankhuu, B. Gongor, T. Guntev","doi":"10.18535/ijmsci/v10i7.08","DOIUrl":"https://doi.org/10.18535/ijmsci/v10i7.08","url":null,"abstract":"Introduction: Young adults experiencing ischemic stroke often present with distinct risk factors and underlying causes that are less prevalent or different compared to older individuals. However, the existing classifications may not fully capture the unique risk and etiological factors specific to young adults. In this study, we utilized a modified risk factor categorization derived from the International Pediatric Stroke Study (IPSS) to analyze the risk factor profiles of Mongolian young patients diagnosed with ischemic stroke.\u0000Methods: This study is a retrospective analysis conducted at two medical centers. We included patients between the ages of 18 and 49 years who were admitted to the First and Third Central Hospitals of Ulaanbaatar for their first-ever ischemic stroke during the period from 2018 to 2021. The study aimed to consecutively collect and analyze the risk factors of these patients, which were subsequently categorized into 10 groups based on the modified IPSS criteria. We also examined the potential differences in risk factor distribution based on both sex and age, thereby exploring any notable variations among these patient subgroups.\u0000Results: The study included a total of 306 patients, with a median age of 42 years, and 60.5% of the participants were men. Among all patients, at least one IPSS risk factor category was identified in 91.5% of the cases. The most common IPSS subtype observed was atherosclerosis-related risk factors, accounting for 81% of the cases followed by cardiac disorders (16%), chronic systemic conditions (13.1%), arteriopathy (11.4%), and chronic head and neck disorders (6.2%). The prevalence of chronic systemic conditions was higher in patients aged below 35 years (16.7% vs. 11.4%) and in women (21.5% vs. 7.6%, p < 0.05). Atherosclerosis-related risk factors were more dominant in patients aged 35 years and older (87.1% vs. 67.7%, p < 0.0001) and in men (93.0% vs. 62.8%, p < 0.0001).\u0000Conclusions: The IPSS classification has the potential to serve as an effective tool in identifying the risk factors associated with ischemic stroke in young adults","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74932404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Biodegradable Mesh-Covered Drug Eluting Coronary Embolic Protection Stent: A Promising Solution for Embolization Treatment for Coronary Arteries","authors":"Minocha Dr. Pramod Kumar, Kothwala Deveshkumar Mahendralal, Lodha Dikshita Yogendrasinh, D. Samir, Ayush Kumar","doi":"10.18535/ijmsci/v10i7.06","DOIUrl":"https://doi.org/10.18535/ijmsci/v10i7.06","url":null,"abstract":"\u0000\u0000\u0000 \u0000\u0000\u0000 \u0000 \u0000\u0000\u0000\u0000The newly developed \"Mesh Covered Drug Eluting Coronary Embolic Protection Stent\" is specifically designed to address the problem of distal embolization during percutaneous coronary intervention (PCI), a common procedure for treating myocardial infarction. This study aimed to evaluate the strength of the mesh component in patients with coronary artery disease. The stent system consists of a cobalt-chromium metal stent covered with a knitted mesh made of biodegradable PLGA polymer, which effectively prevents embolic events. The findings of the study demonstrated that the stent system exhibited high radial strength, withstanding significant levels of deformation before failure. This indicates that the mesh covered drug eluting coronary embolic protection stent has the potential to effectively mitigate distal embolization during PCI. The use of a biodegradable mesh in conjunction with the stent offers advantages over traditional stents by reducing the risk of restenosis, thrombosis, and inflammation, thereby improving long-term outcomes. Through bench-scale experiments, we have verified that the \"Mesh Covered Drug Eluting Coronary Embolic Protection Stent\" exhibits robust strength, validating its potential as an effective solution for addressing distal embolization during percutaneous coronary intervention.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89502873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiological Analysis of Pseudomonas Aeruginosa and Staphylococcus Aureus Strains Isolated From Chronic Wounds","authors":"Ö. Akgül, Gülhan Bora","doi":"10.18535/ijmsci/v10i7.05","DOIUrl":"https://doi.org/10.18535/ijmsci/v10i7.05","url":null,"abstract":"Background: Wounds are classified as acute and chronic according to their clinical course. Although chronic wounds are rare, they can lead to death due to delays in healing. In both types of wounds, colonization with gram positive and gram negative bacteria can be observed. The diagnosis of microorganisms and antibiotic susceptibility profiles are known to be very important in treatment.\u0000Material and Method: Swabs were taken from patients diagnosed with chronic wounds in our hospital. The samples were subjected to isolation and identification methods for microbiological analysis. Phenotypic antibiotic susceptibility analysis of each isolate was performed. Target gene analysis was performed for Staphylococcus aureus and Pseudomonas aeruginosa strains.\u0000Discussion: Acute and chronic wound wounds can cause significant health problems and even death. Especially chronic wounds may cause sepsis due to their delayed healing. Wounds can be colonized with hospital and community-acquired bacteria. Wounds can also be colonized with both gram-positive and gram-negative bacteria. In our study, colonization with S. aureus and P. aeruginosa was more common. Males were more susceptible than females.\u0000Conclusion: The most frequently isolated strains from patients with chronic wounds were S. aureus and P. aeruginosa. These strains were found to have multiple drug resistance. It was observed that strains with resistance genes posed a serious risk. A good understanding of the profiles of hospital and community-acquired wounds is very important in terms of establishing the correct treatment processes.  ","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82636075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between the Symptoms of Major Depression during Pregnancy, Fetal Indicators and Delivery Complications","authors":"Shpresa Agani, Nysret Agani","doi":"10.18535/ijmsci/v10i7.04","DOIUrl":"https://doi.org/10.18535/ijmsci/v10i7.04","url":null,"abstract":"Introduction: Studies have shown a high prevalence rate of the symptoms of major depression in the general population of women on Kosovo (43.18%), therefore research on the impact of depression during pregnancy on the intrauterine fetal development and complications during and after delivery in the population of women on Kosovo at reproductive age has scientific and professional rationale.\u0000Objective: The purpose of the study is to research correlation of major depression symptoms during pregnancy with the indicators of intrauterine fetal development and complications during delivery.\u0000Method: The research is prospective randomized and after fulfilling the selective criteria included three hundred pregnant women in the second trimester and at the beginning of the third trimester of pregnancy in the general population of women on Kosovo. Scale of the major depression symptoms was determined with the Hopkins Symptom Check List (HSCL-25). Statistical package for results analysis included software SPSS 12, ANOVA analyses, frequencies, Chi square test, and linear regression analysis.\u0000Results: Significant correlation was proven between the symptoms of major depression during early and mid-pregnancy with: uterine contractions at the beginning of labor, perineal lacerations during delivery, tachycardia in the newborn baby, duration of newborn’s stay in the neonatal intensive care unit, the woman's duration of hospital stay in the department before and after delivery, and the delayed start of breastfeeding. Findings proved that there is no significant correlation between the emotional state of pregnant women and the slowing down of the intrauterine fetal development.\u0000Discussion: Based on the study results and the data from the literature, these clinical correlations are a result of interaction between the major depression during pregnancy with neuroendocrine trajectories of pregnancy, fetus and placental functions.\u0000Conclusion: Major depression during early and mid-term pregnancy may have impact on specific clinical parameters of the childbirth and newborn baby. The obtained results suggest the need for systematic mental health support of the woman during pregnancy.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88229057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Unspecified Anxiety during Pregnancy on the Fetus Development and Childbirth Complications","authors":"Shpresa Agani, Nysret Agani","doi":"10.18535/ijmsci/v10i7.03","DOIUrl":"https://doi.org/10.18535/ijmsci/v10i7.03","url":null,"abstract":"Introduction: The high levels of chronic psychosocial stress and traumatic experiences faced by the general population of Kosovo in recent decades resulted in a high prevalence of unspecified anxiety (45.17%) among women at the reproductive age. On this psychological ground there are objective hypotheses that fetal growth and childbirth process may be affected. \u0000Objective: The purpose of the study is to research the correlation of unspecified anxiety during pregnancy with the intrauterine development of the fetus and complications during childbirth.\u0000Method: The research is prospective randomized and after fulfilling the selective criteria included three hundred (300) pregnant women in the second trimester and at the beginning of the third trimester of pregnancy in the general population of women on Kosovo. Scale of unspecified anxiety was determined with the Hopkins Symptom Check List (HSCL-25). Statistical package for results analysis included software SPSS 12, ANOVA analyses, frequencies, Chi square test, and linear regression analysis.\u0000Results: Findings proved that there is no significant correlation between the emotional state of pregnant women and the slowing down of the intrauterine fetal development. However, the study proved the significant correlation between the degree of unspecified anxiety during early and mid-term pregnancy with the degree of cervix effacement at the beginning of the birth act, and with tachycardia in the newborn baby.\u0000Discussion: Based on the study results and the data from the literature, these clinical correlations occur based on the interference of unspecified anxiety during pregnancy with neuroendocrine trajectories of pregnancy, fetus and placental functions.\u0000Conclusion: Unspecified anxiety during early and mid-term pregnancy may initiate cervix effacement and may cause fetal tachycardia at birth. The obtained results suggest the need for greater care for the emotional state of the woman during pregnancy.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81221324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjustments to Stimulation Frequency and Duration of STEP VEPs in Paediatric CVI","authors":"A. Mackay","doi":"10.18535/ijmsci/v10i7.02","DOIUrl":"https://doi.org/10.18535/ijmsci/v10i7.02","url":null,"abstract":"Recent research has demonstrated that the agreement between VEP and subjective VA is influenced by both technical and clinical factors [1-3].  In normal visual development, spatial resolution threshold is limited by the density of retinal bipolar cells [4] which initiate three distinct functional pathways; magnocellular, parvocellular, and koniocellular [5].  Ophthalmological conditions during development with pathology before the LGN and resulting in moderate or severe visual impairment [6] may preferentially preserve the magnocellular pathway making steady state VEPs the ideal assessment. ","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90929712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence of Thyroid Carcinoma in Large (≥4cm) Benign Thyroid Nodules: A Retrospective Single Center Study","authors":"Ismail Seerat, Talha Kareem, Ali Haider Raza, Muhammad Irshad Hussain, Natasha Saleem, Syed Muhammad Ali, Aryan Ahmed","doi":"10.18535/ijmsci/v10i7.01","DOIUrl":"https://doi.org/10.18535/ijmsci/v10i7.01","url":null,"abstract":"Objective: The purpose of our study is to see the incidence of thyroid carcinoma in large (≥4cm) Fine Needle Aspiration Cytology (FNAC) proven benign thyroid nodules.\u0000Study Design: Retrospective cross-sectional study\u0000Place & duration of Study: Department of General Surgery, Recep Tayyip Erdogan Hospital, Muzaffargarh from August 2014 to May 2021\u0000Methodology: 238 patients with large benign thyroid nodules who underwent thyroid surgery were included in the study. The type of thyroid nodules (solitary or dominant), size of thyroid nodule (mm) and histopathology of the thyroid nodules after surgery were collected. The data was analyzed by IBM Statistical Package for Social Sciences (IBM SPSS Statistics for Windows version 20.0. Armonk, New York). Tables were constructed using Microsoft Excel 2018. \u0000Results:  A total of 238 patients with large benign thyroid nodules were included in the study. 156 patients (65.9%) had thyroid nodule size in the range of 40mm to 50mm rest of the patients had nodule size above 50mm. The incidence of thyroid carcinoma was 14.3% (34/238). There was no significant effect of age, gender & type of thyroid nodule on risk of thyroid carcinoma.\u0000Conclusion: The risk of thyroid carcinoma in large (≥4cm) benign thyroid nodules is significant and there is a need to change our approach in their management to diagnose and manage them timely. Therefore, large (≥4cm) thyroid nodules may be considered for surgery even if preoperative FNAC is benign.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84593501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"1470 Nm Diode Laser Effectiveness in Facial Fat Reduction with the Endolifting Technique: Pilot Study","authors":"Layla Dias, Denise Almeida, Fábio dos Santos Borges, Clarissa Bravin, Sonia Cruz, Priscila Caruso, D. Almeida, Carin Bogado","doi":"10.18535/ijmsci/v10i6.02","DOIUrl":"https://doi.org/10.18535/ijmsci/v10i6.02","url":null,"abstract":"Introduction: Endolifting technique, also known as Endolaser or Endolift, consists of using a laser beam with a wavelength of 1470 nm emitted through an optical fiber inserted into the subdermal tissue in order to reduce subcutaneous fat and tone the skin through the intense production of collagen.\u0000Objective: This study aimed to collect preliminary results about the effectiveness of the 1470 nm diode laser in reducing facial fat with the endolifting technique.\u0000Material and methods: 10 patients were assisted with just one endolifting session, where the mandibular and submental regions were treated. It was by using 400 micron optical fiber, power ranging from 4 to 8 W, in continuous mode. After the procedure, patients were instructed to remain with a bandage on the treated area for 4 days and. Then, after this period they received 4 sessions of manual lymphatic drainage, which was performed once a week.\u0000Results: After treatment and reassessment at the end of 60 days, it was noticed a clear decrease in fat in the cheeks, as well as in the submental region. Also, the skin where the jowl fat was removed underwent intense retraction, as it was seen a decrease in flaccidity and wrinkles.\u0000Conclusion: It was concluded that the endolifting technique is extremely effective in promoting the reduction of unsightly subcutaneous fat on the face and neck, as well as indirectly intervening in the skin to promote rejuvenation to varying degrees. Likewise, this technique can be attested as a safe method due to the absence of complications or intercurrences throughout the care and follow-up of patients after treatment.","PeriodicalId":14151,"journal":{"name":"International Journal Of Medical Science And Clinical Invention","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89336321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}