International Journal of Hypertension最新文献

{"title":"Hypertensive Response to Exercise in Athletes: Unremarkable Finding or Relevant Marker for Future Cardiovascular Complications?","authors":"Laura Würzburger,&nbsp;Patrick Wiech,&nbsp;Valentina A Rossi,&nbsp;Daniel Neunhäuserer,&nbsp;Stefano Caselli,&nbsp;Christian M Schmied,&nbsp;David Niederseer","doi":"10.1155/2022/8476751","DOIUrl":"https://doi.org/10.1155/2022/8476751","url":null,"abstract":"<p><strong>Background: </strong>In the general population, hypertensive response to exercise (HRE) predicts new-onset resting hypertension or other cardiovascular diseases.</p><p><strong>Methods: </strong>PubMed was searched for English articles published between January 1st 2000 and April 30th 2020. Additional studies were identified via reference lists of included studies. 92 papers were selected for full text analysis, finally 30 studies were included.</p><p><strong>Results: </strong>The results from 5 follow-up studies suggested an association between HRE and the risk of developing hypertension, while 10 studies reported a link with adverse cardiovascular events in the general population. Another study showed an association between HRE and future hypertension in athletes after a follow-up of 7 years. HRE in athletes was associated with left ventricular hypertrophy in three studies. Two other studies showed a link between HRE and focal myocardial fibrosis in triathletes and myocardial injury, respectively. One study found lower Apoliprotein-1 serum levels in athletes with HRE leading to a higher risk for cardiovascular disease. Only in one study no association with cardiovascular dysfunction in athletes with HRE was found.</p><p><strong>Conclusions: </strong>Based on current evidence, HRE is not a normal finding in athletes. If detected, it should be interpreted as a risk factor for future cardiovascular complications. Future research should address the adequate follow-up and management of athletes with HRE.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":" ","pages":"8476751"},"PeriodicalIF":1.9,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9678482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40481939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality in Elderly Patients Taking Furosemide: Prospective Cohorts Study.","authors":"Alejandro Rodríguez-Molinero,&nbsp;Antonio Miñarro,&nbsp;Leire Narvaiza,&nbsp;César Gálvez-Barrón,&nbsp;Natalia Gonzalo León,&nbsp;Esther Valldosera,&nbsp;Eva De Mingo,&nbsp;Oscar Macho,&nbsp;David Aivar,&nbsp;Efren Pinzón,&nbsp;Adilis Alba,&nbsp;Jorge Passarelli,&nbsp;Nadia Stasi,&nbsp;Isabel Collado,&nbsp;José R Banegas","doi":"10.1155/2022/4708259","DOIUrl":"https://doi.org/10.1155/2022/4708259","url":null,"abstract":"<p><strong>Objectives: </strong>Low blood pressure (BP) has been proposed as a risk factor of death in elderly patients. However, this association could be partially accounted for by the deleterious effects of BP-lowering drugs. We analyzed whether these drugs are associated to an increased risk of death in elderly patients taking multiple potential confounders into account.</p><p><strong>Design: </strong>This is a prospective cohort study. <i>Setting and Participants.</i> Probabilistic sample of 772 community-dwelling patients aged >65 years living in Spain, who were appointed for an initial clinical visit and followed up through telephone calls 4, 6, 9, 12, and 60 months afterwards.</p><p><strong>Methods: </strong>At baseline visit, BP was measured using standardized methods, and BP medications and risk factors of death in elderly patients (BMI, oxygen saturation, toxic habits, comorbidity, muscular strength, and functional and cognitive capacity) were collected. During the follow-up, the vital status of patients and the date of death were ascertained.</p><p><strong>Results: </strong>During a median 5-year follow-up, 226 all-cause deaths occurred among the 686 participants included in the analysis. In a Cox regression model that included all the BP drug classes, diuretics and nitrites were significantly associated with mortality (<i>p</i> < 0.005). Within diuretics, furosemide was found to be responsible for the association of the group. In multivariable Cox regression models adjusted for BP and the rest of the mortality risk factors, furosemide remained as the only BP drug that was independently associated with mortality (hazard ratio 2.34; <i>p</i> < 0.01).</p><p><strong>Conclusions: </strong>Furosemide was prospectively associated with increased mortality in older people. If confirmed, this drug should be taken into account by prescribers and considered a confounder in BP studies.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":" ","pages":"4708259"},"PeriodicalIF":1.9,"publicationDate":"2022-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9637038/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40453141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of H-Type Hypertension with miR-21, miR-29, and miR-199 in Kazahks of Xinjiang, China.","authors":"Xin He,&nbsp;RuLin Ma,&nbsp;Yu Li,&nbsp;Haixia Wang,&nbsp;YiZhong Yan,&nbsp;YiDan Mao,&nbsp;ShengYu Liao,&nbsp;XueYing Sun,&nbsp;ShuXia Guo,&nbsp;Heng Guo","doi":"10.1155/2022/4632087","DOIUrl":"https://doi.org/10.1155/2022/4632087","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to analyze the expressions of miR-21, miR-29, and miR-199 in the serum of the patients with H-type hypertension among Kazakhs. Then, we analyzed the effect of MTHFR 677C > T polymorphism on the association between the above miRNA and H-type hypertension.</p><p><strong>Method: </strong>In this study, the expression of miR-21, miR-29, and miR-199 was quantitatively measured in 120 serum samples and then stratified according to the C677T polymorphism to analyze the relationship between target miRNAs and HHcy.</p><p><strong>Results: </strong>The expression of miR-21/-29 in the hypertension group was higher than the normal group (<i>P</i> < 0.001). And the expression of miR-199 was higher in the hcy group than in the normal group (<i>P</i> < 0.001). In the CC and CT genotypes of MTHFR 677C > T, the expression of miR-21 was lower in the HHcy patients than in the normal individuals (<i>P</i> = 0.005 and <i>P</i> = 0.001) and miR-199 was significantly higher in the HHcy patients than in the normal ones (<i>P</i> = 0.002 and <i>P</i> = 0.048). No such difference was found in the TT genotype. Logistic regression analysis showed that after adjusting for sex, age, BMI, systolic blood pressure, diastolic blood pressure, and MTHFRC677 T gene polymorphism, miR-21 was negatively correlated with hcy (OR = 0.222, 95% CI (0.101-0.485), <i>P</i> < 0.001) and miR-199 was positively correlated with hcy (OR = 1.823,95%CI (1.272∼2.614), <i>P</i> = 0.001).</p><p><strong>Conclusion: </strong>miR-21, miR-29, and miR-199 are associated with H-type hypertension in the Kazakhs, especially hyperhomocysteinemia. And these three miRNAs may serve as biomarkers to provide clues to the potential pathogenesis of H-type hypertension.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":" ","pages":"4632087"},"PeriodicalIF":1.9,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33489337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Syndecan-4 is More Sensitive in Detecting Hypertensive Left Ventricular Diastolic Dysfunction in 2K2C Rats.","authors":"Wenyue Dai, Yanqiu Liu, Fengjuan Yao, Wei Li, Jia Liu, Cuiling Li, Donghong Liu","doi":"10.1155/2022/1447425","DOIUrl":"10.1155/2022/1447425","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to investigate the changes of syndecan-4 (SDC-4) during the hypertensive period in two kidney-two clip (2K2C) hypertension rats and compare them to brain natriuretic peptide (BNP) and the echocardiographic parameters for diastolic function evaluation in the rat model of 2K2C hypertension.</p><p><strong>Methods: </strong>A total of 36 Sprague-Dawley (SD) rats were used in this study. Hypertension was induced in 21 by 2K2C surgery, and 15 were sham-operated. Both the 2K2C hypertension group (<i>n</i> = 21) and the sham-operated group (<i>n</i> = 15) were equally divided into 3 subgroups according to the schedules (week 4, week 8, and week 12). Serum SDC-4 and BNP were detected by ELISA, and echocardiography indexes were acquired.</p><p><strong>Results: </strong>The level of SDC-4 and cardiac fibrosis increased gradually as the experiment was processed, and BNP, Tei index, and E/E' followed to be raised as high blood pressure was maintained after four weeks in the 2K2C hypertension rats. In the earlier 4 weeks, only SDC-4 and cardiac fibrosis were significantly increased in 2K2C hypertensive rats in comparison with normotensive rats. And it was shown that SDC-4 was positively correlated with BNP level during the entire study (<i>r</i> = 0.762, <i>p</i> < 0.01).</p><p><strong>Conclusion: </strong>SDC-4 increases gradually during the process of diastolic dysfunction in 2K2C hypertensive rats. SDC-4 is the earliest biomarker reflecting diastolic dysfunction in this model, superior to E/E' and the Tei index. Our results indicate that serum SDC-4 could act as an early biomarker to show diastolic dysfunction.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":" ","pages":"1447425"},"PeriodicalIF":1.9,"publicationDate":"2022-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9553681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33516101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>APOE</i> Genetic Polymorphism rs7412 T/T Genotype May Be a Risk Factor for Essential Hypertension among Hakka People in Southern China.","authors":"Hui Rao,&nbsp;Heming Wu,&nbsp;Zhikang Yu,&nbsp;Qingyan Huang","doi":"10.1155/2022/8145896","DOIUrl":"https://doi.org/10.1155/2022/8145896","url":null,"abstract":"<p><strong>Objective: </strong>One of the causes of hypertension is a genetic factor. The purpose of this study was to look at the relationship between apolipoprotein E (APOE) and methylenetetrahydrofolate reductase (MTHFR) polymorphisms and essential hypertension in the Hakka population.</p><p><strong>Methods: </strong>The study included 2,850 patients with hypertension and 2,034 controls. <i>APOE</i> rs429358, rs7412, and <i>MTHFR</i> rs1801133 were genotyped by polymerase chain reaction (PCR)-microarray. The differences in these polymorphisms between the two groups were analyzed.</p><p><strong>Results: </strong>The genotype and allele frequency of <i>APOE</i> and <i>MTHFR</i> polymorphisms did not differ significantly between hypertensive patients and controls. Patients with hypertension who were <i>APOE</i> rs429358C/C homozygous had higher TG, TC, LDL-C, and Apo-B levels, whereas patients with the T/T genotype had higher HDL-C levels. Patients with hypertension who were <i>APOE</i> rs7412T/T homozygous had higher TG and TC levels and lower LDL-C and Apo-B levels. Homocysteine (Hcy) levels in patients with <i>MTHFR</i> CC, CT, and TT genotypes were increased, while patients with the TT genotype and T allele had higher Hcy levels than those of patients with other genotypes and the C allele. The <i>APOE</i> rs7412T/T genotype in the co-dominant model (<i>APOE</i> rs7412T/T vs. C/C) (gender-, age-, smoking-, and drinking-adjusted OR 2.682, 95% CI, 1.072-6.710, <i>P</i>=0.035) was a significant risk factor for hypertension. The <i>APOE</i> rs429358 and <i>MTHFR</i> rs1801133 genotypes in co-dominant, dominant, and recessive models were not significant risk factors for hypertension.</p><p><strong>Conclusions: </strong>It supports that <i>APOE</i> polymorphisms are related to hypertension in the Hakka population. Specifically, the <i>APOE</i> rs7412T/T genotype may be a risk factor for hypertension.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":" ","pages":"8145896"},"PeriodicalIF":1.9,"publicationDate":"2022-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9492438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33482989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Psychological Distress, Self-Care, and Medication Adherence in Association with Hypertension Control.","authors":"Maryam Eghbali,&nbsp;Maedeh Akbari,&nbsp;Kimiya Seify,&nbsp;Mohammad Fakhrolmobasheri,&nbsp;Maryam Heidarpour,&nbsp;Hamidreza Roohafza,&nbsp;Maryam Afzali,&nbsp;Fateme-Sadat Mostafavi-Esfahani,&nbsp;Parisa Karimian,&nbsp;Anis Sepehr,&nbsp;Davood Shafie,&nbsp;Alireza Khosravi","doi":"10.1155/2022/7802792","DOIUrl":"https://doi.org/10.1155/2022/7802792","url":null,"abstract":"<p><strong>Background: </strong>Most of the patients with hypertension (HTN) who undergo medical therapy unaccompanied by psychological and behavioral interventions may not achieve their goal in HTN treatment. Self-care is a key factor in controlling HTN. Given that depression, stress, and anxiety are the most psychological disorders in chronic illnesses. Their impact on self-care, quality of life, and HTN control must be studied more.</p><p><strong>Methods: </strong>We analyzed the difference in medication adherence in 252 patients with low vs. high psychological distress. Also, patients with controlled and uncontrolled HTN were compared according to their psychological distress scores. We further assessed the relation of psychological distress, self-care, and medication adherence with patients' demographic characteristics.</p><p><strong>Results: </strong>61.3% of our participants were female with a mean age of 60.6 ± 11.35 and male participants had a mean age of 60.5 ± 11.55. The psychological distress score was significantly higher in women with uncontrolled HTN (<i>p</i> value = 0.044). Also, individuals with controlled HTN tend to have a higher medication adherence score (<i>p</i> value = 0.01) and higher self-care score (<i>p</i> value = 0.033). Hypertensive females had a higher psychological distress score (3.35 ± 2.05) and a lower self-care score (64.05 ± 8.16). There was a positive relationship between age and drug adherence. The self-care score was higher (65.95 ± 7.88) in patients having lower psychological distress levels.</p><p><strong>Conclusion: </strong>A lower psychological distress score can result in better self-care, enhancing the probability of better HTN control; thus, psychological interventions may be necessary for the treatment of HTN. However, more studies are needed to assess the effectiveness of this intervention.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":" ","pages":"7802792"},"PeriodicalIF":1.9,"publicationDate":"2022-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436608/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40349050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of Nonadherence to Medications among Hypertensive Patients in Ghana: An Application of the Health Belief Model.","authors":"Fidelis Atibila,&nbsp;Emmanuel Timmy Donkoh,&nbsp;Rob Ruiter,&nbsp;Gerjo Kok,&nbsp;Gill Ten Hoor","doi":"10.1155/2022/1418149","DOIUrl":"https://doi.org/10.1155/2022/1418149","url":null,"abstract":"<p><strong>Introduction: </strong>Hypertension (HPT) is recognized as a significant public health problem worldwide from a health and economic perspective. This study determined predictors of nonadherence to HPT medications in Ghana using the health belief model.</p><p><strong>Methods: </strong>A cross-sectional descriptive survey employing a quantitative approach was conducted among HPT patients who routinely attend clinics at selected hospitals in the Brong Ahafo region of Ghana. Respondents (<i>n</i> = 399) were recruited using a multistage sampling technique.</p><p><strong>Results: </strong>The prevalence of nonadherence was 63.7% (<i>n</i> = 254). Nonadherence to hypertension medication was associated with lower education status (<i>p</i>=0.009). In logistic regression analysis, patients with high \"perceived susceptibility\" and \"perceived severity\" were more likely to forfeit their HPT medication schedules, while patients with high \"perceived barriers\" and \"cues to action\" were less likely to skip their medication.</p><p><strong>Conclusion: </strong>The present study suggests a plausible path to improving medication adherence in this population. Given the high prevalence of nonadherence, policymakers need to urgently design tailor-made health promotion interventions to ensure optimal health outcomes.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":" ","pages":"1418149"},"PeriodicalIF":1.9,"publicationDate":"2022-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9433278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40347886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Present Evidence of Determinants to Predict the Efficacy of Renal Denervation.","authors":"Hao Zhou,&nbsp;Yanping Xu,&nbsp;Weijie Chen,&nbsp;Liang Wang,&nbsp;Huaan Du,&nbsp;Hang Liu,&nbsp;Zhiyu Ling,&nbsp;Yuehui Yin","doi":"10.1155/2022/5694127","DOIUrl":"https://doi.org/10.1155/2022/5694127","url":null,"abstract":"<p><p>Sympathetic overactivation is one of the main contributors to development and progress of hypertension. Renal denervation (RDN) has been evidenced by series of clinical trials for its efficacy and safety to treat overactivated sympathetic nervous system induced diseases. However, the results were inconsistent and not all patients benefited from RDN. Appropriate patient selection and intraoperative factors to improve the efficacy of RDN need to be solved urgently. Over the decade, research studies on the correlations between indicators and the antihypertensive effects have been conducted and made a fairly well progress. Herein, we comprehensively reviewed the research studies on how to make RDN more predictable or improve the efficacy of RDN and summarized these potential indicators or devices which might be applied in clinical settings.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":" ","pages":"5694127"},"PeriodicalIF":1.9,"publicationDate":"2022-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9391193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40415800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Prediction Nomogram Combining Epworth Sleepiness Scale and Other Clinical Parameters to Predict Obstructive Sleep Apnea in Patients with Hypertension.","authors":"Lin Wang,&nbsp;Dongsheng Sun,&nbsp;Jianhong Xie,&nbsp;Li Zhang,&nbsp;Dibo Lao,&nbsp;Shaokun Xu","doi":"10.1155/2022/3861905","DOIUrl":"https://doi.org/10.1155/2022/3861905","url":null,"abstract":"Background Obstructive sleep apnea (OSA) is common in patients with hypertension. Nonetheless, OSA is underdiagnosed despite considerable evidence of the association between OSA and adverse health outcomes. This study developed and validated a clinical nomogram to predict OSA in patients with hypertension based on the Epworth Sleepiness Scale (ESS) score and OSA-related parameters. Methods A total of 347 hypertensive patients with suspected OSA were retrospectively enrolled and randomly assigned to a training set and a validation set at 70 : 30 (N = 242/N = 105) ratio. OSA was diagnosed through sleep monitoring and was defined as an apnea-hypopnea index ≥5 events/h. Using the least absolute shrinkage and selection operator regression model, we identified potential predictors of OSA and constructed a nomogram model in the training set. The predictive performance of the nomogram was assessed and validated by discrimination and calibration. The nomogram was also compared with ESS scores according to decision curve analysis (DCA), integrated discrimination index (IDI), and net reclassification index (NRI). Results ESS scores, body mass index, neck circumference, snoring, and observed apnea predicted OSA are considered. The nomogram showed similar discrimination between the training set (AUC: 0.799, 95% CI: 0.743–0.847) and validation set (AUC: 0.766, 95% CI: 0.673–0.843) and good calibration in the training (P=0.925 > 0.05) and validation (P=0.906 > 0.05) sets. Compared with the predictive value of the ESS, the nomogram was clinically useful and significantly improved reclassification accuracy (NRI: 0.552, 95% CI: 0.282–0.822, P < 0.001; IDI: 0.088, 95% CI: 0.045–0.133, P < 0.001) at a probability threshold of >42%. Conclusions We developed a novel OSA prediction nomogram based on ESS scores and OSA-related parameters. This nomogram may help improve clinical decision-making, especially in communities and primary clinics, where polysomnography is unavailable.","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":" ","pages":"3861905"},"PeriodicalIF":1.9,"publicationDate":"2022-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9411005/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33443800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trajectories of Blood Pressure in Patients with Established Coronary Artery Disease over 20 years.","authors":"Piotr Jankowski,&nbsp;Paweł Kozieł,&nbsp;Grzegorz Bilo,&nbsp;Jarosław Pinkas,&nbsp;Danuta Czarnecka,&nbsp;Kalina Kawecka-Jaszcz,&nbsp;Andrzej Pająk","doi":"10.1155/2022/2086515","DOIUrl":"https://doi.org/10.1155/2022/2086515","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate changes in blood pressure (BP) values in patients with established coronary artery disease (CAD) over 20 years (1997-2017).</p><p><strong>Materials and methods: </strong>Consecutive patients aged <71 years and hospitalized for acute coronary syndrome or myocardial revascularization procedures were recruited and interviewed 6-18 months after their discharge from the hospital. BP was measured in 1997-1998, 1999-2000, 2006-2007, 2011-2013, and 2016-2017. The same five hospitals took part in the surveys at each time point.</p><p><strong>Results: </strong>We examined 412 patients in 1997-1998, 427 in 1999-2000, 422 in 2006-2007, 462 in 2011-2013, and 272 in 2016-2017. The proportion of patients with BP at the recommended goal was 49.2% in 1997-98, 44.5% in 1999-2000, 44.7% in 2006-07, 51.1% in 2011-13, and 58.8% in 2016-17 (<i>p</i> < 0.001). Mean systolic and diastolic BP decreased significantly independent of age, sex, and education (systolic BP: 137.9 ± 21.4 mmHg in 1997-98, 139.5 ± 21.6 mmHg in 1999-2000, 136.1 ± 20.3 mmHg in 2006-07, 134.8 ± 22.0 mmHg in 2011-13, and 134.2 ± 18.6 mmHg in 2016-17, <i>p</i> < 0.001; diastolic BP: 83.4 ± 11.0 mmHg in 1997-98, 84.8 ± 12.0 mmHg in 1999-2000, 85.2 ± 11.0 mmHg in 2006-07, 80.9 ± 12.5 mmHg in 2011-13, and 81.1 ± 10.4 mmHg in 2016-17; <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>The analysis of five multicenter surveys provides evidence of a decrease in BP in patients with established CAD over two decades. This trend is independent of age, sex, and the education level of the patients.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":" ","pages":"2086515"},"PeriodicalIF":1.9,"publicationDate":"2022-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9550506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33504017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}