International Journal of Hypertension最新文献

{"title":"Electrocardiography in Hypertensive Patients without Cardiovascular Events: A Valuable Predictor Tool?","authors":"J Ricardo Pires, M Teixeira, F Ferreira, I Viseu, V Afreixo, C Neves","doi":"10.1155/2022/7038894","DOIUrl":"10.1155/2022/7038894","url":null,"abstract":"<p><strong>Background: </strong>Hypertension is an important risk factor of cardiovascular (CV) disease. An early diagnosis of target organ damage could prevent major CV events. Electrocardiography (ECG) is a valuable clinical technique, with wide availability and high specificity, used in evaluation of hypertensive patients. However, the use of ECG as a predictor tool is controversial given its low sensitivity. This study aims to characterise ECG features in a hypertensive population and identify ECG abnormalities that could predict CV events.</p><p><strong>Methods: </strong>We studied 175 hypertensive patients without previous CV events during a follow-up mean of 4.0 ± 2.20 years. ECGs and pulse wave velocity were performed in all patients. Clinical characteristics and ECG abnormalities were evaluated and compared between the patients as they presented CV events.</p><p><strong>Results: </strong>Considering the 175 patients (53.14% male), the median age was 62 years. Median systolic blood pressure was 140  mmHg and diastolic blood pressure was 78 mmHg. Median PWV was 9.8 m/s. Of the patients, 39.4% were diabetic, 78.3% had hyperlipidaemia, and 16.0% had smoking habits. ECG identified left ventricular (LV) hypertrophy in 29.71% of the patients, and a LV strain pattern was present in 9.7% of the patients. Twenty-nine patients (16.57%) had a CV event. Comparative analyses showed statistical significance for the presence of a LV strain pattern in patients with CV events (<i>p</i>=0.01). Univariate and multivariate analysis confirmed that a LV strain pattern was an independent predictor of CV event (HR 2.66, 95% IC 1.01-7.00). In the survival analysis, the Kaplan-Meier curve showed a worse prognosis for CV events in patients with a LV strain pattern (<i>p</i>=0.014).</p><p><strong>Conclusion: </strong>ECG is a useful daily method to identify end-organ damage in hypertensive patients. In our study, we also observed that it may be a valuable tool for the prediction of CV events.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":" ","pages":"7038894"},"PeriodicalIF":1.9,"publicationDate":"2022-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9334108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40660816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood Pressure Trajectories for 16 Years and the Development of Left Ventricular Hypertrophy and Increased Left Atrial Size: The Korean Genome and Epidemiology Study.","authors":"Seong Hwan Kim,&nbsp;Ju-Mi Lee,&nbsp;Seung Ku Lee,&nbsp;Chol Shin,&nbsp;Jae-Hyeong Park","doi":"10.1155/2022/6750317","DOIUrl":"https://doi.org/10.1155/2022/6750317","url":null,"abstract":"<p><strong>Background: </strong>Elevated single blood pressure (BP) measurement can be associated with the development of hypertension-mediated target organ damage including left ventricular hypertrophy (LVH) and left atrial (LA) enlargement (LAE). However, long-term patterns of BP and their effects on LVH and LAE are poorly understood. We evaluated the association between the BP trajectories and the presence of LVH and LAE.</p><p><strong>Methods: </strong>We analyzed a total of 2,565 participants (1,267 males, 47.8 ± 6.7 years old) from the first biennial examination (2001-2002) of the Korean Genome and Epidemiology Study. The presence of LVH and LAE was identified by echocardiography performed at the 8^th biennial examination (2015-2016). Latent mixture modeling was used to identify trajectories in mid-BP ((systolic BP + diastolic BP)/2) over time. Linear logistic regression was used for assessing BP trajectories with the outcomes.</p><p><strong>Results: </strong>We identified 4 distinct mid-BP trajectories: group 1 (lowest, 20.9%, <i>n</i> = 536), group 2 (36.2%, <i>n</i> = 928), group 3 (32.3%, <i>n</i> = 828), and group 4 (highest, 10.6%, <i>n</i> = 273). Compared with the lowest group, trajectories with elevated mid-BP had greater odds ratios having LVH and LAE by multivariable-adjusted regression models. Adjusted odd ratios for LVH were 2.033 (95% CI = 1.462-2.827, <i>P</i> < 0.001) for group 2, 3.446 (95% CI = 2.475-4.797, <i>P</i> < 0.001) for group 3, and 4.940 (95% CI = 3.318-7.356, <i>P</i> < 0.001) for group 4. Adjusted odd ratios for LAE were 1.200 (95% CI = 0.814-1.769, <i>P</i> = 0.358) for group 2, 1.599 (95% CI = 1.084-2.360, <i>P</i> = 0.018) for group 3, and 1.944 (95% CI = 1.212-3.118, <i>P</i> = 0.006) for group 4.</p><p><strong>Conclusions: </strong>Higher long-term mid-BP was an independent risk factor of cardiac structural changes such as LVH and LAE among middle-aged population.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":" ","pages":"6750317"},"PeriodicalIF":1.9,"publicationDate":"2022-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9313986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40651121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence to Self-Care among Patients with Hypertension in Ethiopia: A Systematic Review and Meta-Analysis.","authors":"Afework Edmealem,&nbsp;Sewunet Ademe,&nbsp;Sisay Gedamu","doi":"10.1155/2022/5962571","DOIUrl":"https://doi.org/10.1155/2022/5962571","url":null,"abstract":"Background Self-care adherence for hypertensive patients is a cornerstone for the control of it and prevention of its complications. However, there are inconsistent findings for self-care adherence of hypertensive patients in Ethiopia. Thus, this systematic review and meta-analysis was done to determine the pooled estimate self-care adherence. Methods This systematic review and meta-analysis was reported based on the Preferred Reporting Items for Systematic Review and Meta-Analysis guideline. An intensive search of online databases such as PubMed (MEDLINE), CINHAL, Google Scholar, and advanced Google search was made to access both published and unpublished articles that report self-care adherence among hypertensive patients in Ethiopia. The pooled estimate was done with STATA version 11 metan commands in a 95% confidence interval. The presence of heterogeneity and publication bias were detected by I2 and Egger's test, respectively. A random-effect model was obtained, and subgroup analysis was done for the management of heterogeneity. Result A total of 24 articles with a total of 7224 participants were included in the final systematic review and meta-analysis. The pooled estimate of overall self-care adherence among hypertensive patients was 36.98% (95% CI: 27.13–46.83). In subgroup analysis, the highest overall self-care adherence was observed in the Amhara region at 53% (95% CI: 46.54, 59.47). The pooled estimate of self-care dimensions such as medication adherence, low-salt diet, physical activity, smoking abstinence, alcohol abstinence, and weight management was 62.71%, 65.96%, 47.28%, 92.53%, 67.59%, and 52.54%, respectively. Conclusion The pooled estimate of good self-care adherence among hypertensive patients was low. From the dimensions of self-care, the lowest level was in physical activity and the highest level was in smoking abstinence. Comparing all regions, the lowest level of overall self-care adherence was observed in Addis Ababa, Tigray region, and South Nations and Nationalities of Ethiopia. Screening of adherence to self-care and health education should be provided to every patient during every visit.","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":" ","pages":"5962571"},"PeriodicalIF":1.9,"publicationDate":"2022-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40537703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibrosis-4 Index Is Closely Associated with Arterial Damage and Future Risk of Coronary Heart Disease in Type 2 Diabetes.","authors":"Kentaro Watanabe,&nbsp;Noe Takakubo,&nbsp;Taro Saigusa,&nbsp;Akiko Nagasawa,&nbsp;Midori Yamana,&nbsp;Midori Ojima,&nbsp;Wataru Kameda,&nbsp;Shinji Susa,&nbsp;Kenichi Ishizawa,&nbsp;Hisamitsu Ishihara","doi":"10.1155/2022/2760027","DOIUrl":"https://doi.org/10.1155/2022/2760027","url":null,"abstract":"This study evaluated the association between fibrosis-4 (FIB 4) index and arterial damage or future risk of coronary heart disease (CHD) in type 2 diabetes. The study subjects were 253 patients with type 2 diabetes. The FIB4 index, as a marker of hepatic fibrosis based on age, aspartate aminotransferase and alanine aminotransferase levels, and platelet count, was calculated for all subjects. Carotid intima-media thickness (IMT), carotid artery calcification (CAC), and aortic arch calcification (AAC) grade (0–2) were assessed as atherosclerotic variables. The Suita score was calculated as the future risk of coronary heart disease (CHD). We assessed whether the FIB4 index was associated with both atherosclerotic variables and the Suita score. FIB4 index was significantly associated with IMT (r = 0.241, P < 0.001) and Suita score (r = 0.291, P < 0.001). Subjects with CAC showed a significantly higher FIB4 index score compared to subjects without (1.70 ± 0.74 and 1.24 ± 0.69, respectively, P < 0.001), whereas the FIB4 index was significantly elevated with a higher grade of AAC (1.24 ± 0.74, 1.56 ± 0.66, and 1.79 ± 0.71, respectively, P < 0.001). Linear regression analysis adjusted for clinical characteristics indicated that the FIB4 index was positively associated with IMT, Suita score, CAC, and AAC grade (β = 0.241, P=0.004; β = 2.994, P < 0.001; β = 0.139, P=0.001; and β = 0.265, P < 0.001, respectively). FIB4 index is closely associated with arterial damage and future risk of CHD in type 2 diabetes.","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":" ","pages":"2760027"},"PeriodicalIF":1.9,"publicationDate":"2022-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9550504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33504016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergent Anthropometric Indices in Differential Prediction of Prehypertension and Hypertension in Mexican Population: Results according to Age and Sex.","authors":"Oscar Zaragoza-García, Ilse Adriana Gutiérrez-Pérez, Pedro Delgado-Floody, Isela Parra-Rojas, Daniel Jerez-Mayorga, Christian Campos-Jara, Iris Paola Guzmán-Guzmán","doi":"10.1155/2022/4522493","DOIUrl":"10.1155/2022/4522493","url":null,"abstract":"<p><strong>Background: </strong>Hypertension (HTN) is recognized as a significant public health problem in the world. The objective of this study is to evaluate emergent anthropometric indices as predictors of preHTN and HTN according to age and sex in a sample of Mexican adults.</p><p><strong>Methods: </strong>A cross-sectional study was conducted in 1,150 participants aged 18-80 years old. Anthropometric data and blood pressure measurements were analyzed. Comparisons between men and women were carried out by independent analysis. Cutoff points for each emergent anthropometric index were obtained using the values' upper second and third tertiles. Logistic regression models and receiver operating characteristics curve analyses were used to assess the association and the predictive value of several emergent anthropometric indices with the presence of preHTN and HTN.</p><p><strong>Results: </strong>The prevalence of preHTN and HTN was 29.74% and 14.35%, respectively. In a logistic regression analysis adjusted by age and sex, the body roundness index (BRI) (OR = 2.08, <i>p</i> < 0.001) and conicity index (CI) (OR = 1.37, <i>p</i>=0.044) were associated with preHTN, while CI (OR = 2.47, <i>p</i> < 0.001) and waist to height squared (W/Ht²) (OR = 2.19, <i>p</i> < 0.001) were associated with HTN. Furthermore, in both sexes, BRI was the main predictor of preHTN (AUC: 0.634 and 0.656, respectively). Particularly, according to sex and age range, the predictive emergent anthropometric indices in men were the body shape index (ABSI) and waist to height cubic (W/Ht³) (AUC = 0.777 and 0.771, respectively), whereas in women, the predictors were CI and ABSI (AUC = 0.737 and 0.729, respectively). In men ≤40 years old, central body fat indices were predictors of preHTN and HTN, but in men >40 years old, the predictor indices were W/Ht³ and W/Ht². In women ≤40 years, the pulse mass index (PMI) was the best main predictor (AUC = 0.909) of HTN.</p><p><strong>Conclusion: </strong>CI, PMI, W/Ht³, W/Ht², and ABSI could represent differential predictors of preHTN and HTN between men and women according to age range.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":" ","pages":"4522493"},"PeriodicalIF":1.9,"publicationDate":"2022-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9283069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40512109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender Differences in Cardiovascular Risk Factors, Clinical Presentation, and Outcome of Patients Admitted with a Hypertensive Crisis at the Buea Regional Hospital, Cameroon.","authors":"Clovis Nkoke,&nbsp;Ahmadou Musa Jingi,&nbsp;Jean Jacques Noubiap,&nbsp;Denis Teuwafeu,&nbsp;Cyrille Nkouonlack,&nbsp;Ronald Gobina,&nbsp;Siddikatou Djibrilla,&nbsp;Ali Abas,&nbsp;Anastase Dzudie","doi":"10.1155/2022/3062526","DOIUrl":"https://doi.org/10.1155/2022/3062526","url":null,"abstract":"<p><strong>Background: </strong>Several recent studies have shown differences in the risk profile and outcome of cardiovascular diseases between men and women, with a dearth of data from African populations. This study aimed to examine gender differences in a group of patients from Cameroon hospitalized with a hypertensive crisis.</p><p><strong>Methods: </strong>We conducted a cross-sectional study from June 2018 until June 2019. The criteria to define a hypertensive crisis (HC) were systolic and/or diastolic blood pressure should be ≥180/110 mmHg. We compared the clinical presentation and outcome of males versus females.</p><p><strong>Results: </strong>Out of the 1536 patients admitted, 95 (6.2%) had an HC. There were 49 (51.6%) men. There was no significant age difference between men and women (52.7 years vs. 49.3 years, <i>p</i> = 0.28). Alcohol consumption (<i>p</i> < 0.0001), previous stroke (<i>p</i> = 0.04), and smoking (<i>p</i> = 0.03) were significantly higher in men compared to women. Men had a higher proportion of psychomotor agitation (<i>p</i> = 0.05). There was an equal proportion of men and women with hypertensive emergencies. Although acute left ventricular failure was most frequent in women (46.4% vs 42.9%), cerebral infarction (14.3% vs 17.9%), and acute coronary syndrome (0% vs 7.1%) were higher in men, the differences were not statistically significant (all <i>p</i> > 0.05). Case fatality was also higher in men compared to women but the difference was not statistically significant.</p><p><strong>Conclusions: </strong>Men admitted for an HC had a significantly higher cardiovascular risk burden and higher psychomotor agitation. However, there were no significant differences in the types of hypertensive emergencies and outcomes between men and women.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":" ","pages":"3062526"},"PeriodicalIF":1.9,"publicationDate":"2022-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9256455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40572090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Blood Pressure Variability between 24 h Ambulatory Monitoring and Office Blood Pressure in Diabetics and Nondiabetic Patients: A Cross-Sectional Study.","authors":"Ana Lídia Rouxinol-Dias,&nbsp;Marta Lisandra Gonçalves,&nbsp;Diogo Ramalho,&nbsp;Jose Silva,&nbsp;Loide Barbosa,&nbsp;Jorge Polónia","doi":"10.1155/2022/1022044","DOIUrl":"https://doi.org/10.1155/2022/1022044","url":null,"abstract":"<p><strong>Background: </strong>Evidence regarding blood pressure (BP) variability (BPV) and its independent association with adverse outcomes has grown. Diabetic patients might have increased BPV, but there is still an evidence gap regarding relation between BPV and type 2 diabetes beyond mean values of BP.</p><p><strong>Objective: </strong>To examine the relationship between 24 h ambulatory BP monitoring (ABPM, short-term variability) and visit-to-visit in-office BPV (OBP, long-term variability), in diabetics (<i>D</i>) and nondiabetics (ND), and to explore BPV relation with estimated glomerular filtration rate (eGFR), and pulse wave velocity (PWV) as indicators of target organ lesion.</p><p><strong>Materials and methods: </strong>We conducted a single-center cross-sectional study in an outpatient BP unit, including adult patients consecutively admitted from 1999 to 2019. Multivariate was performed to compare BPV between <i>D</i> and ND adjusted for clinical variables. Pearson's correlation was performed to evaluate relation of BPV with eGFR and PWV.</p><p><strong>Results: </strong>A total of 1123 patients with ABPM and OBP measurements were included. Values of eGFR and PWV were worse in <i>D</i> than in ND. Measurements of OBPV did not differ between groups. Of ABPM BPV, the coefficient of variation and standard deviation for daytime systolic BP were higher in <i>D</i> compared to ND, but only in ND did BPV correlated with both eGFR and PWV.</p><p><strong>Conclusion: </strong>We found that diabetes is associated with higher variability of daytime BP than nondiabetics along with worse damage of vascular and renal function. However, in contrast to nondiabetics, in diabetics eGFR and PWV may not be dependent on BP variability, suggesting that other mechanisms might explain more rigorously the greater damage of target organ lesion markers.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":" ","pages":"1022044"},"PeriodicalIF":1.9,"publicationDate":"2022-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40462212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Sucrose Ingestion during a Critical Period of Vessel Development Promotes the Synthetic Phenotype of Vascular Smooth Muscle Cells and Modifies Vascular Contractility Leading to Hypertension in Adult Rats.","authors":"Vicente Castrejón-Téllez,&nbsp;María Esther Rubio-Ruiz,&nbsp;Agustina Cano-Martínez,&nbsp;Israel Pérez-Torres,&nbsp;Leonardo Del Valle-Mondragón,&nbsp;Elizabeth Carreón-Torres,&nbsp;Verónica Guarner-Lans","doi":"10.1155/2022/2298329","DOIUrl":"https://doi.org/10.1155/2022/2298329","url":null,"abstract":"<p><p>Cardiometabolic diseases, including hypertension, may result from exposure to high sugar diets during critical periods of development. Here, we studied the effect of sucrose ingestion during a critical period (CP) between postnatal days 12 and 28 of the rat on blood pressure, aortic histology, vascular smooth muscle phenotype, expression of metalloproteinases 2 and 9, and vascular contractility in adult rats and compared it with those of adult rats that received sucrose for 6 months and developed metabolic syndrome (MS). Blood pressure increased to a similar level in CP and MS rats. The diameter of lumen, media, and adventitia of aortas from CP rats was decreased. Muscle fibers were discontinuous. There was a decrease in the expression of alpha-actin in CP and MS rat aortas, suggesting a change to the secretory phenotype in vascular smooth muscle. Metalloproteinases 2 and 9 were decreased in CP and MS rats, suggesting that phenotype remains in an altered steady stationary state with little interchange of the vessel matrix. Aortic contraction to norepinephrine did not change, but aortic relaxation was diminished in CP and MS aortas. In conclusion, high sugar diets during the CP increase predisposition to hypertension in adults.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":" ","pages":"2298329"},"PeriodicalIF":1.9,"publicationDate":"2022-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40462213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Associated Factors of Hypertension among Women in Southern Ghana: Evidence from 2014 GDHS.","authors":"Cyprian Issahaku Dorgbetor,&nbsp;Kwamena Sekyi Dickson,&nbsp;Edward Kwabena Ameyaw,&nbsp;Kenneth Setorwu Adde","doi":"10.1155/2022/9700160","DOIUrl":"https://doi.org/10.1155/2022/9700160","url":null,"abstract":"<p><strong>Background: </strong>Hypertension, coupled with prehypertension and other hazards such as high blood pressure, is responsible for 8·5 million deaths from stroke, ischaemic heart disease, other vascular diseases, and renal disease worldwide. Hypertension is the fifth commonest cause of outpatient morbidity in Ghana. Some evidence have illustrated geographical variation in hypertension and it seems to have a heavy toll on women in southern Ghana compared to the north. This study seeks to determine the prevalence and associatedfactors of hypertension among women in southern Ghana using the most recent demographic and health survey (DHS) data set.</p><p><strong>Materials and methods: </strong>This study used data of 5,662 women from the current DHS data from Ghana that was conducted in 2014. Data were extracted from the women's file of the 2014 Ghana DHS. The outcome variable of this current study was hypertension and it was measured by blood pressure, according to guidelines of the Joint National Committee Seven (JNC7). Multivariable binary logistic regression analyses were performed to establish the factors associated with hypertension at the individual and community levels.</p><p><strong>Results: </strong>Prevalence of hypertension among women in southern Ghana was 16%. Women aged 40-44 years (aOR = 8.04, CI = 4.88-13.25) and 45-49 years (aOR = 13.20, CI = 7.96-21.89] had the highest odds of hypertension relative to women aged 15-19 years. Women with two births (aOR = 1.45, CI = 1.01-2.07) and those with three births (aOR = 1.47, CI = 1.01-2.15) had a higher likelihood of being hypertensive. Greater Accra women had higher odds (aOR = 1.35, CI = 1.02-1.79) of being hypertensive relative to the reference category, women from the Western region. Women of Guan ethnicity had a lesser likelihood (aOR = 0.54, CI = 0.29-0.98) of being hypertensive. Women who engaged in agriculture had the least likelihood (aOR = 0.72, CI = 0.52-0.99) of being classified hypertensive compared to unemployed women.</p><p><strong>Conclusion: </strong>This study has revealed the prevalence of hypertension among women in southern Ghana. The associated factors include age, parity, region, and occupation. As a result, existing interventions need to be appraised in the light of these factors. Of essence is the need for Ghana Health Service to implement wide-embracing health promotion initiatives that accommodate the nutritional, exercise, and lifestyle needs of women in southern Ghana. Having more children is associated with higher propensity of hypertension and consequently, women need to limit childbearing to reduce their chances of being hypertensive. It will also be advisable for women in the Greater Accra region to have frequent hypertension screening, as women in the region exhibited higher hypertension prospects.</p>","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":" ","pages":"9700160"},"PeriodicalIF":1.9,"publicationDate":"2022-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9236813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40407220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination of Oxalobacter Formigenes and Veillonella Parvula in Gastrointestinal Microbiota Related to Bile-Acid Metabolism as a Biomarker for Hypertensive Nephropathy","authors":"Xin Li, Li Wang, Shaojun Ma, Shaohui Lin, Chunyan Wang, Hai-yun Wang","doi":"10.1155/2022/5999530","DOIUrl":"https://doi.org/10.1155/2022/5999530","url":null,"abstract":"The human microbiome is a mixed group of microorganisms, which individually consists of 10–100 trillion symbiotic microbial cells. The relationship between gastrointestinal microbiota and blood pressure has been verified and the intestinal microbiota of chronic kidney disease (CKD) patients in the distribution of bacterial species is different from the flora of people with no CKD. The purpose of this research is to study the different intestinal microbiota of hypertensive patients with and without nephropathy and to find possible biomarkers of hypertensive nephropathy (H-CKD). The subjects of this research were divided into three groups, healthy control group, hypertension group, and hypertensive nephropathy group. Sequencing, bioinformatics, and statistical analysis were performed on the 16S rRNA gene of the subjects' stool samples. This research study showed the differences of intestinal flora as biomarkers in hypertension patients with and without nephropathy; it investigated the relationship of the differences in the intestinal microbiota with bile-acid metabolism; it also explored bile-acid metabolism mechanism of intestinal microbiota differences in hypertension with or without nephropathy. In summary, the difference in the combination of O. formigenes and V. parvula in the gastrointestinal microbiota is related to bile-acid metabolism in hypertensive patients and can be one of the factors causing CKD. It is the first time to report such a biomarker or pathogenic factor of H-CKD in the world.","PeriodicalId":14132,"journal":{"name":"International Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2022-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44698540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}