International Journal of Medical Research and Health Sciences最新文献_第3页

Anti-Leishmanial drug Pentostam induced histological changes to liver and kidney in male BALB/c wild mice 抗利什曼药物戊妥斯坦诱导雄性BALB/c野生小鼠肝脏和肾脏组织学改变

International Journal of Medical Research and Health Sciences Pub Date : 2021-01-01 DOI: 10.53626/jimrhs.2021.1202

Nouara Elazirg Elammari, Salem Ramadan Sariti

{"title":"Anti-Leishmanial drug Pentostam induced histological changes to liver and kidney in male BALB/c wild mice","authors":"Nouara Elazirg Elammari, Salem Ramadan Sariti","doi":"10.53626/jimrhs.2021.1202","DOIUrl":"https://doi.org/10.53626/jimrhs.2021.1202","url":null,"abstract":"Leishmaniasis is still a complex disease of (sub) tropical regions of the world caused by Leishmania spp. Antimonial pentostam is an anti-leishmaniasis drug used medically and it is the primary drug employed against leishmaniasis in Libya. It has multiple acute and chronic adverse effects which can be minimized by using the lowest effective dose. This work aimed to investigate the histological changes in the liver and kidneys affected by different doses of pentostam. Adult male of BALB/c wild mice was divided into four groups, 6 mice of each, and i.p. injected with 10mg/kg, 20mg/kg, and 40mg/kg pentostam in addition to a control group. After 28 therapeutic days and finishing the histological procedure to examine the collected tissue specimens, the obtained results of the liver tissue ranged from demonstrating cytoplasmic vacuoles, to hydropic degeneration, focal and hepatocytic necrosis, and lastly irregular area of hepatocytes with condensed pyknotic nuclei (hepatocyte necrosis). As well, the histological examination of kidney tissue ranged between demonstrating mild cloudy swelling (reversible hydropic degeneration), showed stromal aggregates of inflammatory cells (nephritis), and lastly showed renal tubule casts and necrosis. In a final conclusion, there are clear histological changes in the liver and kidneys, which had been seen in this study, which are dose-dependent changes.","PeriodicalId":14122,"journal":{"name":"International Journal of Medical Research and Health Sciences","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82297891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Water Content in Food Drink and IL-10 Level 食品、饮料中水分含量与IL-10水平

International Journal of Medical Research and Health Sciences Pub Date : 2021-01-01 DOI: 10.53626/jimrhs.2021.1205

R. Lelyana

{"title":"Water Content in Food Drink and IL-10 Level","authors":"R. Lelyana","doi":"10.53626/jimrhs.2021.1205","DOIUrl":"https://doi.org/10.53626/jimrhs.2021.1205","url":null,"abstract":"Introduction: Water affects IL-10 levels in the body. Many people do not understand that water is very important and needed by the body for influencing IL-10 levels. The purpose of writing this paper is to be able to understand the importance of water for the body on IL-10 levels in order to avoid various conditions that interfere with health. Method: Review study. Results: The simplest but most important source of nutrients is water. The water content in the body is about 60-70%, and a loss of about 10% of the water will cause death. Water balance is obtained through food, drink, and the body's metabolic processes. Various components of food and beverages consumed such as coffee drinks, vegetable soups/fruit juices contain water and affect IL-10 levels in the body. Likewise, the water content in bath water and various other daily activities affect IL-10 levels in the body. Discussion: Vegetables, even drinks such as coffee contain water so that they can fulfill the body's health functions, both for skin health, all body organs and body tissues and cells, as well as for metabolic functions and avoiding dehydration conditions. The water content in the food we drink and the water we use greatly affects the condition of the body so that it also affects the body's immune response. This is related to the presence of IL-10 levels where the increase and decrease in IL-10 levels are strongly influenced by the components of the food or drink contained in the water or the water content contained in the food and drink. In fact, bathwater containing sulfur also affects IL-10 levels. So water plays an important role in IL-10 levels in the body. Conclusions: Body health is influenced by water and water also affect IL-10 levels in the body so that it is beneficial for body health related to the immune system.","PeriodicalId":14122,"journal":{"name":"International Journal of Medical Research and Health Sciences","volume":"74 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91552413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioefficacy of local Lantana camara (Verberneae) plant extracts against the 3rd instar larva and adult stages of Anopheles gambiae senso lato (Giles). 马鞭草植物提取物对冈比亚按蚊3龄幼虫和成虫的生物药效研究

International Journal of Medical Research and Health Sciences Pub Date : 2020-12-13 DOI: 10.15520/jmrhs.v3i12.214

W. Yana, Enda Corinna Andu, K. H. Tofel, A. Henri

{"title":"Bioefficacy of local Lantana camara (Verberneae) plant extracts against the 3rd instar larva and adult stages of Anopheles gambiae senso lato (Giles).","authors":"W. Yana, Enda Corinna Andu, K. H. Tofel, A. Henri","doi":"10.15520/jmrhs.v3i12.214","DOIUrl":"https://doi.org/10.15520/jmrhs.v3i12.214","url":null,"abstract":"\u0000Resistance of malaria vectors to synthetic chemicals with high operational cost and environmental pollution has been a great challenge to scientists. Alternative approaches such as the use of natural plant products which are environmentally friendly are put in place to control malaria vectors. This study was focused on testing the effectiveness of three solvent extracts of Lantana camara on the 3rd instar larvae and adults of Anopheles gambiae s. l. These extracts were obtained by maceration. Bioassays test were carried out by WHO’s method for determination of larvicidal and adulticidal efficacy. The results show that, larval mortality increased significantly with the concentration and exposure time. Lethal concentrations 50 (LC50) and 95 (LC95) after 24 hours of larvae exposure time are respectively 0.31 g/mL and 1.53 g/mL while within 48 h they are 0.27 g/mL and 0.79 g/mL for hexane extract; 1.45 g/mL and 2.0 g/mL (24 h exposure), 0.84 g/mL and 1.55 g/mL (48 h exposure) for acetone extract; 1.96 g/mL and no lethal concentration causing 95% mortality was determined; 0.40 g/mL and 2.20 g/mL (48 h) for aqueous extract. The efficacy of hexane and aqueous extract on the adult knock down and mortality were not significant even with the increasing extract concentrations and exposure time whereas with acetone extract, the adult LC50 after 24 h was 2.4 g/mL but with 95% mortality lethal concentration was not determined. According to the results, hexane extract showed high larvicidal efficacy of An. gambiae and acetone extract showed significant adult mortality. Those two extracts of L. camara can be used to fight against An. gambiae as alternative malaria vector control to replace conventional insecticides.","PeriodicalId":14122,"journal":{"name":"International Journal of Medical Research and Health Sciences","volume":"209 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84266299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Essential Treatment of Covid19 Patients covid - 19患者的必要治疗

International Journal of Medical Research and Health Sciences Pub Date : 2020-12-02 DOI: 10.15520/jmrhs.v3i12.294

Gerry A. Smith

引用次数: 2

The Assessment of Immunomolecular expression and prognostic role of TLR7 among patients with Prostatitis 前列腺炎患者TLR7免疫分子表达及预后评价

International Journal of Medical Research and Health Sciences Pub Date : 2020-11-07 DOI: 10.15520/jmrhs.v3i11.278

I. Alsaimary, Hussein Naeem Aldhaheri, M. Almusafer

{"title":"The Assessment of Immunomolecular expression and prognostic role of TLR7 among patients with Prostatitis","authors":"I. Alsaimary, Hussein Naeem Aldhaheri, M. Almusafer","doi":"10.15520/jmrhs.v3i11.278","DOIUrl":"https://doi.org/10.15520/jmrhs.v3i11.278","url":null,"abstract":"The Aim of this study was to determine Immunogenetic expression of Toll-like receptor gene clusters related to prostatitis, to give acknowledge about Role of TLR in prostatitis immunity in men. A case–control study included 135 confirmed prostatitis patients And 50 persons as a control group. Data about age, marital status, working, infertility, family history and personal information like (Infection, Allergy, Steroid therapy, Residency, Smoking, Alcohol Drinking, Blood group, Body max index (BMI) and the clinical finding for all patients of Prostatitis were collected , The molecular expression study include extracting DNA from blood of Prostatitis patients , Prostitis patients and Control group by using specific primers for conventional PCR and Real Time PCR , the amplification of all extracted DNA from blood samples was preform and confirm by using electrophoresis with (100volt/30min). PCR product was 149bp for TLR7 on agarose gel (1%), (50voltage for 1hour) with a presence 100%. The results of the present study indicate that the Toll like receptor alleles associated with risk of prostatitis.","PeriodicalId":14122,"journal":{"name":"International Journal of Medical Research and Health Sciences","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91233218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The Estimation of prostate specific antigen (PSA) concentrations in patients with prostatitis by fully automated ELISA technique. 全自动ELISA技术测定前列腺炎患者前列腺特异性抗原(PSA)浓度。

International Journal of Medical Research and Health Sciences Pub Date : 2020-11-07 DOI: 10.15520/jmrhs.v3i11.279

Hussein Naeem Aldhaheri, I. Alsaimary, M. Almusafer

引用次数: 5

Risk Factor of Intra-Uterine Fetal Death in Gaza Governmental Hospitals:Case-Control Study (2018-2019). 加沙政府医院子宫内胎儿死亡的危险因素:病例对照研究(2018-2019)

International Journal of Medical Research and Health Sciences Pub Date : 2020-10-25 DOI: 10.15520/jmrhs.v3i10.275

A. ElShanti, Bothyna Bassyoni EL syed Etewa, A. Dhair, Naema Mohammed Salem Abo Samra

引用次数: 1

SOME WORDS ABOUT FRACTURES OF RADIAL HEAD 关于桡骨头骨折的几点介绍

International Journal of Medical Research and Health Sciences Pub Date : 2020-10-05 DOI: 10.15520/jmrhs.v3i10.261

B. Saccomanni

引用次数: 1

The Effectiveness of Assertiveness Training on Bullying, Competitive State Anxiety and Performance Under Pressure in Futsal Players 自信训练对五人制足球运动员欺凌、竞争状态焦虑和压力下表现的影响

International Journal of Medical Research and Health Sciences Pub Date : 2020-09-01 DOI: 10.32598/jrh.10.5.21.7.98

Reza Aliyar Najafabadi, Z. Meshkati, R. Badami

引用次数: 4

The Prevalence of Vitamin D Deficiency and Its Related Factors Among Female Staff of Gonabad University of Medical Sciences, Gonabad City, Iran, in 2019 2019年伊朗戈纳巴德市戈纳巴德医科大学女性员工维生素D缺乏症患病率及相关因素调查

International Journal of Medical Research and Health Sciences Pub Date : 2020-08-10 DOI: 10.32598/JRH.10.5.1783.1

S. Niazi, Abdulghader Taene, M. Kianmehr, A. Abbasnezhad, M. Matlabi

{"title":"The Prevalence of Vitamin D Deficiency and Its Related Factors Among Female Staff of Gonabad University of Medical Sciences, Gonabad City, Iran, in 2019","authors":"S. Niazi, Abdulghader Taene, M. Kianmehr, A. Abbasnezhad, M. Matlabi","doi":"10.32598/JRH.10.5.1783.1","DOIUrl":"https://doi.org/10.32598/JRH.10.5.1783.1","url":null,"abstract":"Background: Vitamin D (VitD) plays a significant role in human health, survival, and fertility. It is necessary for calcium absorption and bone growth and the regulation of the immune system. This study aims to determine the prevalence of VitD deficiency and the factors affecting it in women working in the campus of Gonabad University of Medical Sciences, Gonabad City, Iran. Methods: In this cross-sectional analytical study, 70 women working on the campus of Gonabad University of Medical Sciences in 2019 were selected by the census method. After obtaining their consent forms, the researcher-made checklist was completed by the participants. The serum levels of 25-hydroxycholecalciferol (25-OH D3) were the index for measuring VitD. The significance level is set below 0.05. Results: The Mean±SD level of VitD in the research units was 13.67±22.5 ng/mL. About 12.85% of the samples had severe deficiency (less than 10 ng/mL), 32.85% had moderate deficiency (10-20 ng/mL) and 31.42% had mild deficiency (20-30 ng/mL). The prevalence of VitD deficiency was lower in people with a history of physical activity, and those with a history of taking supplements. Also, the highest VitD deficiency was observed in the age group of older than 40 years. Conclusion: According to the results, the prevalence of VitD deficiency in the study population was high because 45.7% of the subjects had severe and moderate VitD deficiency.","PeriodicalId":14122,"journal":{"name":"International Journal of Medical Research and Health Sciences","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83567834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0