International journal of neuropharmacology最新文献_第5页

A stereotaxic atlas of the brain of the baboon 狒狒大脑的立体定位图谱

International journal of neuropharmacology Pub Date : 1969-05-01 DOI: 10.1016/0028-3908(69)90053-7

F.E. Bloom

引用次数: 30

An examination of the effects of stimulant and depressant drugs on escape/avoidance conditioning in strains of rats selectively bred for emotionality/non-emotionality: Intertrial activity 在选择性饲养的情绪性/非情绪性大鼠中，兴奋剂和抑制剂对逃避/回避条件反射的影响的研究:试验间活动

International journal of neuropharmacology Pub Date : 1969-05-01 DOI: 10.1016/0028-3908(69)90043-4

B.D. Gupta, H.C. Holland

引用次数: 10

The effects of 6-azauridine on the peripheral nervous system—II. The action on neuromuscular transmission and on striated muscle 6-氮脲对周围神经系统的影响[j]。对神经肌肉传递和横纹肌的作用

International journal of neuropharmacology Pub Date : 1969-05-01 DOI: 10.1016/0028-3908(69)90048-3

V. Bauer, R. Cˇapek

{"title":"The effects of 6-azauridine on the peripheral nervous system—II. The action on neuromuscular transmission and on striated muscle","authors":"V. Bauer, R. Cˇapek","doi":"10.1016/0028-3908(69)90048-3","DOIUrl":"10.1016/0028-3908(69)90048-3","url":null,"abstract":"<div><p>The effects of 6-azauridine, a cancerostatic agent, on striated muscle and on neuromuscular transmission, were studied in the isolated phrenic nerve hemidiaphragm preparation of the rat. In the directly stimulated and curarized preparation, 6-azauridine in a concentration of 2 × 10<sup>−6</sup> to 2 × 10<sup>−4</sup> g/ml caused a late increase in contractions. Higher concentrations (2 × 10<sup>−3</sup> to 2 × 10<sup>−2</sup>) resulted in an initial increase in muscle contractions followed by inhibition of the contractions which developed gradually. The concentration of 6 × 10<sup>−2</sup> led to a decrease in muscle contractions only. In the indirectly stimulated preparation, low concentrations of the drug (2 × 10<sup>−6</sup> to 8 × 10<sup>−5</sup>) led to a slight increase in muscle contractions. The concentration from 8 × 10<sup>−4</sup> up to 6 × 10<sup>−2</sup> caused an inhibition or blockade of muscle contractions. It was possible to overcome this inhibition temporarily with physostigmine (1 × 10<sup>−5</sup>) or tetanic stimulation. The effects of 6-azauridine on the contractile mechanism of striated muscle correspond to the action on smooth muscle described previously, both being biphasic, depending on the dose. The action of 6-azauridine on neuromuscular transmission was inhibitory in the concentrations having an opposite effect on directly stimulated muscle. It is concluded that this curare-like action of 6-azauridine is non-depolarizing.</p></div>","PeriodicalId":14111,"journal":{"name":"International journal of neuropharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1969-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0028-3908(69)90048-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15415002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comparison of effects of some 6-azapyrimidines with and without antimetabolite activity on the central nervous system 一些具有和不具有抗代谢活性的6-氮杂嘧啶对中枢神经系统影响的比较

International journal of neuropharmacology Pub Date : 1969-05-01 DOI: 10.1016/0028-3908(69)90040-9

M. Krsˇiak, I. Janku˚

{"title":"A comparison of effects of some 6-azapyrimidines with and without antimetabolite activity on the central nervous system","authors":"M. Krsˇiak, I. Janku˚","doi":"10.1016/0028-3908(69)90040-9","DOIUrl":"10.1016/0028-3908(69)90040-9","url":null,"abstract":"<div><p>The activities of 6-azauridine, 6-azauracil, some of 5-alkyl derivatives of 6-azauracil and 1-phenyl derivatives of 6-azauracil in producing a neurological impairment (estimated by dropping off a reversed wire mesh) and behavioural changes (measured on the intensity of exploratory activity) were compared in mice.</p><p>The substitution by an alkyl group on C-5 of 6-azauracil, which decrease the antimetabolite activity, increases the intensity and the rapidity of dropping off the mesh parallel to the prolongation of the alkyl chain. On the other hand there was no intensification in depression of exploratory activity with prolongation of alkyl chain. Effective inhibitors of orotidylic acid decar☐ylase—6-azauridine and 6-azauracil—produced depression of exploratory activity in doses ten times lower than those producing dropping off the mesh. Compounds lacking antimetabolite activities—5-alkyl derivatives of 6-azauracil and 1-phenyl derivatives of 6-azauracil—caused the depression of exploratory activity only in doses inducing falling off the mesh suggesting an unspecific character of this effect. In 6-azauridine and 6-azauracil the peak of the falling off the mesh was attained 1 hr after the injection of both substances, while the maximal depression of exploratory activity occurred after 4–5 hr, i.e. at the time when the former effect has already disappeared.</p><p>On the basis of this findings it is supposed that the central effects of 6-azauridine and 6-azauracil may be induced both by direct action of their substituted asym-triazine structure (the neurological disturbances) as well as by their specific antimetabolite action (behavioural changes).</p></div>","PeriodicalId":14111,"journal":{"name":"International journal of neuropharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1969-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0028-3908(69)90040-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16892375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The effect of dopamine and other compounds on the activity of neurones ofHelix aspersa; Structure-activity relationships 多巴胺等化合物对螺旋树神经元活性的影响结构活性关系

International journal of neuropharmacology Pub Date : 1969-05-01 DOI: 10.1016/0028-3908(69)90049-5

G.N. Woodruff, R.J. Walker

{"title":"The effect of dopamine and other compounds on the activity of neurones ofHelix aspersa; Structure-activity relationships","authors":"G.N. Woodruff, R.J. Walker","doi":"10.1016/0028-3908(69)90049-5","DOIUrl":"10.1016/0028-3908(69)90049-5","url":null,"abstract":"<div><p>The effect of a series of phenylethylamine and related compounds has been investigated on the activity of specific neurones from the isolated brain of the snail,<em>Helix aspersa</em>. Dopamine and Epinine were the most potent of the compounds tested. Both compounds inhibited the spontaneous activity of the neurones and hyperpolarized the cell membrane potential. (−)-Noradrenaline and (−)-adrenaline were respectively twenty-five and ninety-two times less potent than dopamine. Isoprenaline had no effect on neurone activity.</p><p>Evidence is presented for a dopamine receptor as distinct from an action of dopamine on either an α or β adrenaline receptor. There are two specific requirements for this dopamine receptor: (a) two hydroxyl groups on the 3 and 4 position of the benzene ring; (b) the presence of a terminal nitrogen either unsubstituted or with one methyl group. The presence of an ethyl or an isopropyl group on the terminal nitrogen of dopamine reduces activity. Ethyldopamine and isopropyldopamine are respectively 106 and 193 times less potent than dopamine. The presence of a hydroxyl group β to the terminal nitrogen reduces dopamine-like activity.</p></div>","PeriodicalId":14111,"journal":{"name":"International journal of neuropharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1969-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0028-3908(69)90049-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"16868846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 77

Alteration of a learned response of the squirrel monkey by hallucinogens 致幻剂对松鼠猴学习反应的改变

International journal of neuropharmacology Pub Date : 1969-05-01 DOI: 10.1016/0028-3908(69)90045-8

Edward T. Uyeno

引用次数: 16

The effects of 6-azauridine on the peripheral nervous system—I. The action on ganglionic transmission 6-氮脲对周围神经系统的影响[j]。对神经节传导的作用

International journal of neuropharmacology Pub Date : 1969-05-01 DOI: 10.1016/0028-3908(69)90047-1

V. Bauer, R. Cˇapek

{"title":"The effects of 6-azauridine on the peripheral nervous system—I. The action on ganglionic transmission","authors":"V. Bauer, R. Cˇapek","doi":"10.1016/0028-3908(69)90047-1","DOIUrl":"10.1016/0028-3908(69)90047-1","url":null,"abstract":"<div><p>The action on ganglionic transmission of 6-azauridine, an antimetabolite of pyrimidine nucleotides, was studied in the sympathetic superior cervical ganglion of the cat. The action potential evoked by preganglionic stimulation and asynchronous discharge caused by close intra-arterial injections of acetylcholine were recorded from postganglionic fibers. The administration of low doses of 6-azauridine (50–70 μg) resulted in an increase in action potential amplitude and in prolongation of the asynchronous discharge. Medium doses (200–500 μg), caused an initial decrease in amplitude of both the action potential and asynchronous discharge, followed by a delayed increase in action potential amplitude and prolongation of the asynchronous discharge. After the administration of higher doses (1–5 mg) preganglionic stimulation or acetylcholine administration failed for several hours to evoke any response. After administration of low and medium doses of 6-azauridine, hexamethonium (0·5–2·0 mg) ord-tubocurarine(0·4 mg) completely blocked the prolonged asynchronous discharge. However, atropine (1–2 μg) caused the disappearance of the prolongation of asynchronous discharge alone. Tetanic stimulation and physostigmine administration were not capable of restoring the responses blocked by high doses of 6-azauridine. It is suggested that the facilitatory action of 6-azauridine might be due to an unmasking of muscarinic cholinergic receptors in the ganglion. The inhibitory effects might be due to the blocking of nicotinic receptors alone after administration of medium doses, and to the blocking of both nicotinic and muscarinic receptors after the administration of high doses of 6-azauridine.</p></div>","PeriodicalId":14111,"journal":{"name":"International journal of neuropharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1969-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0028-3908(69)90047-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15415001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Failure to detect a synergist for pentylenetetrazol in the blood of psychotic children 未能在精神病儿童的血液中检测到戊四氮的增效剂

International journal of neuropharmacology Pub Date : 1969-05-01 DOI: 10.1016/0028-3908(69)90052-5

C.J. Brackenridge

引用次数: 1

Effects of diphenylaminoethanol and lidocaine on central inhibition 二苯胺乙醇和利多卡因对中枢抑制的影响

International journal of neuropharmacology Pub Date : 1969-05-01 DOI: 10.1016/0028-3908(69)90042-2

Ronald D. Huffman, George K.W. Yim

引用次数: 12

Pharmacological studies on inhibition in the cuneate nucleus of the cat 猫楔形细胞核抑制作用的药理学研究

International journal of neuropharmacology Pub Date : 1969-05-01 DOI: 10.1016/0028-3908(69)90051-3

N.R. Banna , S.J. Jabbur

引用次数: 56