An examination of the effects of stimulant and depressant drugs on escape/avoidance conditioning in strains of rats selectively bred for emotionality/non-emotionality: Intertrial activity

B.D. Gupta, H.C. Holland
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引用次数: 10

Abstract

It is suggested that intertrial activity, which is highly correlated with escape/avoidance conditionability, may be enhanced or reduced by central and autonomic nervous system drugs. Furthermore, it is claimed that these drugs produce their effects in entirely different ways.

By employing animals which differed constitutionally in their levels of reactivity, and drugs which were assumed to act differentially upon the mechanisms underlying fear and activation, a systematic examination of these views has been possible. It is shown that a complex interaction exists between the level of emotionality, drugs, and dosage. Some of the parameters of this interaction are outlined and discussed.

在选择性饲养的情绪性/非情绪性大鼠中,兴奋剂和抑制剂对逃避/回避条件反射的影响的研究:试验间活动
提示与逃避/回避条件性高度相关的庭间活动可能通过中枢和自主神经系统药物增强或减弱。此外,据称这些药物以完全不同的方式产生作用。通过使用在体质上反应水平不同的动物,以及被认为对潜在的恐惧和激活机制起不同作用的药物,对这些观点进行系统的检查已经成为可能。结果表明,情绪水平、药物和剂量之间存在复杂的相互作用。本文概述并讨论了这种相互作用的一些参数。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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