International Journal of Mental Health and Addiction最新文献

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Controlled Use of Cannabis Among Young Adults in Los Angeles Across Changes in Cannabis Policies. 大麻政策变化对洛杉矶年轻人大麻使用的控制。
IF 2.8 3区 医学
International Journal of Mental Health and Addiction Pub Date : 2025-12-20 DOI: 10.1007/s11469-025-01608-w
Stephen E Lankenau, Janna Ataiants, Mark Prince, Ekaterina Fedorova, Bridgid M Conn, Emily Ansell, Carolyn F Wong
{"title":"Controlled Use of Cannabis Among Young Adults in Los Angeles Across Changes in Cannabis Policies.","authors":"Stephen E Lankenau, Janna Ataiants, Mark Prince, Ekaterina Fedorova, Bridgid M Conn, Emily Ansell, Carolyn F Wong","doi":"10.1007/s11469-025-01608-w","DOIUrl":"10.1007/s11469-025-01608-w","url":null,"abstract":"<p><p>The availability of cannabis has increased due to expanding legalization of cannabis across the USA. Controlled use of cannabis - rules by cannabis users that limit use - is a significant but understudied area in the present policy environment, particularly among young adults. A prospective Los Angeles-based cohort aged 18-26 who used cannabis in the past 90 days was assessed during eight survey waves across 9 years. Four discrete waves were analyzed: wave 1 (2014-2015/medical only policy, <i>n</i> = 366), wave 4 (2017-2018/transition to adult use policy, <i>n</i> = 275), wave 5 (2019-2020/adult use policy, <i>n</i> = 241), and wave 8 (2022-2023/adult use policy, <i>n</i> = 193). Five rules of controlled cannabis use were used as indicators in a latent class analysis. Two discrete latent classes - Controlled and Uncontrolled - emerged and became more distinct over time. The Uncontrolled class was a majority across all waves. Probabilities for two rules of controlled use - \"no school/work\" or \"no driving\" under the influence - increased overtime, and one rule - \"stopping cannabis use\" - decreased during the transition to legalized adult use. The Controlled class, which consistently practiced more rules, used less cannabis across all waves and had lower problematic cannabis use in waves 1, 4, and 5 compared to the Uncontrolled class.</p>","PeriodicalId":14083,"journal":{"name":"International Journal of Mental Health and Addiction","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12799194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145970843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mental Health Care for Patients with Opioid Use Disorder and Methamphetamine Use in Methadone Maintenance Treatment: Experiences and Perspectives. 阿片类药物使用障碍和美沙酮维持治疗中甲基苯丙胺使用患者的精神卫生保健:经验和观点
IF 2.8 3区 医学
International Journal of Mental Health and Addiction Pub Date : 2025-12-19 DOI: 10.1007/s11469-025-01616-w
Huyen Pham, Chunqing Lin, Diep Bich Nguyen, Larissa J Mooney, Giang Minh Le, Steven J Shoptaw, Hai Van Truong, Yih-Ing Hser
{"title":"Mental Health Care for Patients with Opioid Use Disorder and Methamphetamine Use in Methadone Maintenance Treatment: Experiences and Perspectives.","authors":"Huyen Pham, Chunqing Lin, Diep Bich Nguyen, Larissa J Mooney, Giang Minh Le, Steven J Shoptaw, Hai Van Truong, Yih-Ing Hser","doi":"10.1007/s11469-025-01616-w","DOIUrl":"10.1007/s11469-025-01616-w","url":null,"abstract":"<p><p>Untreated co-occurring mental health disorders (MHD) and substance use disorders (SUD) are associated with negative treatment outcomes. This study explored the experiences and perspectives of patients with opioid use disorder (OUD) who were using methamphetamine while undergoing methadone maintenance treatment (MMT) regarding barriers and facilitators to accessing MHD services. We conducted 30 in-depth interviews with MMT participants with varying levels of MHD severity, assessed using the 21-item Depression, Anxiety, Stress Scale (DASS-21). Barriers to seeking MHD services included lack of awareness, fear of additional stigma and extra burden to families, unaddressed poly-substance use, and lack of specialized professionals. Benefits of integrating MHD services into MMT clinics included improved diagnosis, streamlined referrals, and reduced logistical challenges. Key facilitators identified included supportive family members, healthcare professionals, and digital platforms. Integrating MHD care into MMT, emphasizing family involvement, staff training, and digital platforms, holds promise to improve MHD diagnosis, referral, and treatment.</p>","PeriodicalId":14083,"journal":{"name":"International Journal of Mental Health and Addiction","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12811026/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145998272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Examining the Roles of Psychological Inflexibility and Distress Tolerance on Cigarette Dependence and Binge Drinking among Individuals who Co-use Cannabis for Therapeutic Purposes. 在共同使用大麻治疗目的的个体中,检查心理不灵活性和痛苦耐受对香烟依赖和酗酒的作用。
IF 2.8 3区 医学
International Journal of Mental Health and Addiction Pub Date : 2025-11-21 DOI: 10.1007/s11469-025-01594-z
Silvana Agterberg, Mary Barna Bridgeman, Benjamin Billingsley, Rachel L Rosen, Thomas W O'Kane, Marc L Steinberg
{"title":"Examining the Roles of Psychological Inflexibility and Distress Tolerance on Cigarette Dependence and Binge Drinking among Individuals who Co-use Cannabis for Therapeutic Purposes.","authors":"Silvana Agterberg, Mary Barna Bridgeman, Benjamin Billingsley, Rachel L Rosen, Thomas W O'Kane, Marc L Steinberg","doi":"10.1007/s11469-025-01594-z","DOIUrl":"10.1007/s11469-025-01594-z","url":null,"abstract":"<p><p>The aims of this study were to examine associations between psychological inflexibility and (1) cigarette dependence among individuals who co-use cannabis and combustible cigarettes, and (2) binge drinking among individuals who co-use cannabis and alcohol. Adults attending a medical marijuana dispensary (N = 697) completed a survey examining cannabis use, cigarette smoking, binge drinking, psychological inflexibility, and distress tolerance. Psychological inflexibility was associated with greater cigarette dependence (<i>β</i> = .325, <i>p</i> = .013) and binge drinking (<i>β</i> = .303, <i>p</i> < .001). In linear but not zero-inflated negative binomial models, distress tolerance moderated the relationship between psychological inflexibility and binge drinking frequency (<i>β</i> = .160, <i>p</i> = .003), though not the relationship between psychological inflexibility and cigarette dependence. Findings highlight the role of psychological inflexibility in the use of cigarettes and alcohol among people who co-use cannabis for therapeutic purposes. This population may benefit from interventions aimed at reducing psychological inflexibility and improving distress tolerance.</p>","PeriodicalId":14083,"journal":{"name":"International Journal of Mental Health and Addiction","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13166164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147928998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gender Differences in Cannabis as a Mediator Between Distress Factors and Non-Fatal Suicidal Behaviors. 大麻作为焦虑因素和非致命性自杀行为中介的性别差异。
IF 2.8 3区 医学
International Journal of Mental Health and Addiction Pub Date : 2025-10-29 DOI: 10.1007/s11469-025-01570-7
Nawar Nayeem, McKenna Walsh, Jennifer Bello-Kottenstette, Erick Messias, Ping-I Lin
{"title":"Gender Differences in Cannabis as a Mediator Between Distress Factors and Non-Fatal Suicidal Behaviors.","authors":"Nawar Nayeem, McKenna Walsh, Jennifer Bello-Kottenstette, Erick Messias, Ping-I Lin","doi":"10.1007/s11469-025-01570-7","DOIUrl":"10.1007/s11469-025-01570-7","url":null,"abstract":"<p><p>Emerging evidence suggests gender-based heterogeneity in suicide risk associated with cannabis use, while the role of cannabis in gender-dependent suicide risk is elusive. The objective of the present study is to determine whether cannabis use contributes differently to the pathway from depression or pain conditions to non-fatal suicidal behaviors (e.g., suicidal ideation, plans, or attempts) in men versus women. We analyzed the data that was extracted from the National Survey of Drug Use and Health (NSDUH) from 2020 to 2022 during the COVID-19 pandemic. Mediation analysis was conducted using a causal framework to assess the mediating role of cannabis in the association between depression, pain conditions, and suicide ideation/plan/attempt in two gender groups. A sample of 93,743 individuals aged 18-50 years participated in the NSDUH survey. Mediation analysis revealed that cannabis use mediated a greater proportion of the effect of depression on suicidal ideation (2.3%) and attempts (1.7%) in women compared to men (1.2% and 1.0%, respectively). Similarly, cannabis appears to mediate 12.5% (95% CI 0.081-0.272) of the effect of pain conditions on suicidal ideation in women versus 5.9% (95% CI 0.038-0.128) in men. These findings suggest that cannabis has a greater mediating impact in non-fatal suicidal behaviors for women than men, particularly in the context of depression and pain conditions. Tailored interventions addressing cannabis use as a self-medication strategy, especially for women, are critical for suicide prevention.</p>","PeriodicalId":14083,"journal":{"name":"International Journal of Mental Health and Addiction","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12858094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146105362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How Does Poverty Stigma Affect Depression Symptoms for Women Living with HIV? Longitudinal Mediating and Moderating Mechanisms. 贫困耻辱如何影响艾滋病毒感染妇女的抑郁症状?纵向中介和调节机制
IF 2.5 3区 医学
International Journal of Mental Health and Addiction Pub Date : 2025-04-01 Epub Date: 2023-08-31 DOI: 10.1007/s11469-023-01147-2
Bulent Turan, Mirjam-Colette Kempf, Deborah Konkle-Parker, Tracey E Wilson, Phyllis C Tien, Gina Wingood, Torsten B Neilands, Mallory O Johnson, Carmen H Logie, Sheri D Weiser, Janet M Turan
{"title":"How Does Poverty Stigma Affect Depression Symptoms for Women Living with HIV? Longitudinal Mediating and Moderating Mechanisms.","authors":"Bulent Turan, Mirjam-Colette Kempf, Deborah Konkle-Parker, Tracey E Wilson, Phyllis C Tien, Gina Wingood, Torsten B Neilands, Mallory O Johnson, Carmen H Logie, Sheri D Weiser, Janet M Turan","doi":"10.1007/s11469-023-01147-2","DOIUrl":"10.1007/s11469-023-01147-2","url":null,"abstract":"<p><strong>Purpose: </strong>In a sample of women living with HIV, we examined whether individual traits fear of negative evaluation and resilience moderate the internalization of poverty stigma that these women experience from others. We also examined the downstream effects of these processes on depression symptoms using moderated serial mediation analyses.</p><p><strong>Methods: </strong>Data were collected annually for 4 years (2016-2020; T1, T2, T3, and T4) from 369 women living with HIV at 4 US cities using validated measures. Moderation effects were evaluated examining simple slopes at one standard deviation above and below the mean of the moderator. In all mediation analyses utilizing bootstrapping, we used the independent variable measured at T1, the mediators measured at subsequent visits (T2 and T3), and the outcome at the last visit (T4) to preserve the temporal sequence among the independent variable, mediators, and outcome variable. We also adjusted for T1 values of all mediators and outcome variables in analyses.</p><p><strong>Results: </strong>Women with stronger fears of negative evaluation by others or lower dispositional resilience had stronger associations between experienced poverty stigma and internalized poverty stigma. Internalized poverty stigma (T2) mediated the association between experienced poverty stigma (T1) and depression symptoms (T4); this mediated association was moderated by fear of negative evaluation and resilience (T1). Finally, internalized poverty stigma (T2) and avoidance coping (T3) were serial mediators in the association between experienced poverty stigma (T1) and depression symptoms (T4), moderated by fear of negative evaluation and resilience.</p><p><strong>Conclusions: </strong>Understanding factors that minimize internalization of stigma and buffer its negative effects on mental health can inform interventions to improve health outcomes of individuals with stigmatized conditions.</p>","PeriodicalId":14083,"journal":{"name":"International Journal of Mental Health and Addiction","volume":" ","pages":"946-963"},"PeriodicalIF":2.5,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12311801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42329527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hazardous Drinking and Cannabis Use in Military Veterans: Comparative Associations with Risk for Suicidal and Non-Suicidal Self-Injury. 退伍军人危险饮酒和大麻使用:与自杀和非自杀自伤风险的比较关联。
IF 2.8 3区 医学
International Journal of Mental Health and Addiction Pub Date : 2025-02-07 DOI: 10.1007/s11469-025-01453-x
Jeremy L Grove, Jean C Beckham, Patrick S Calhoun, Eric A Dedert, Mary J Pugh, Nathan A Kimbrel
{"title":"Hazardous Drinking and Cannabis Use in Military Veterans: Comparative Associations with Risk for Suicidal and Non-Suicidal Self-Injury.","authors":"Jeremy L Grove, Jean C Beckham, Patrick S Calhoun, Eric A Dedert, Mary J Pugh, Nathan A Kimbrel","doi":"10.1007/s11469-025-01453-x","DOIUrl":"10.1007/s11469-025-01453-x","url":null,"abstract":"<p><strong>Objective: </strong>Alcohol and cannabis use are each associated with suicidal thoughts and behaviors and nonsuicidal self-injury (NSSI) in military veterans, but less is known with regard to concurrent use. The present study compared U.S. veterans (<i>N</i> = 1098; 78% male, 67% White) who in the past year engaged in hazardous drinking (HD only), cannabis use (CU only), or concurrent use (HD + CU), or used neither substance (comparison group), on past-year suicidal ideation, elevated risk for suicidal behavior, and past-year NSSI.</p><p><strong>Method: </strong>Veterans completed questionnaires on sociodemographics, psychiatric and substance use history, and self-directed violence via a mailed self-report survey.</p><p><strong>Results: </strong>Independent of covariates, HD + CU related to greater odds of past-year suicidal ideation relative to the CU only and comparison group, and greater odds of elevated risk for suicidal behavior relative to all groups. The HD only group related to greater odds of past-year suicidal ideation relative to the comparison group. Contrary to expectations, CU only did not relate to greater odds of any suicide-related outcomes. As for NSSI, both CU only and HD + CU related to greater odds of past-year NSSI relative to the HD only and comparison group.</p><p><strong>Conclusions: </strong>Concurrent use may increase odds of suicide-related outcomes in veterans relative to single use alone, whereas cannabis use may confer risk for NSSI regardless of if used concurrently with alcohol. These differential associations may suggest distinct mechanisms of risk for self-directed violence in veterans based on substance type (e.g., alcohol vs. cannabis) and use practice (single vs. concurrent use).</p>","PeriodicalId":14083,"journal":{"name":"International Journal of Mental Health and Addiction","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12382343/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144953297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patterns of Substance Use Among Street-Involved Children and Youth in Kenya: the Roles of Street-Exposure, Migratory Factors, Family Deprivation, and Geographic Sub-location. 肯尼亚街头儿童和青少年的物质使用模式:街头暴露、迁移因素、家庭剥夺和地理亚位置的作用
IF 3.2 3区 医学
International Journal of Mental Health and Addiction Pub Date : 2025-02-01 Epub Date: 2023-07-19 DOI: 10.1007/s11469-023-01115-w
Michael L Goodman, Sarah Seidel, Andrew Springer, Christine Markham, Aaron Godoy, Lauren Raimer-Goodman, Kelvin Munene, Stanley Gitari
{"title":"Patterns of Substance Use Among Street-Involved Children and Youth in Kenya: the Roles of Street-Exposure, Migratory Factors, Family Deprivation, and Geographic Sub-location.","authors":"Michael L Goodman, Sarah Seidel, Andrew Springer, Christine Markham, Aaron Godoy, Lauren Raimer-Goodman, Kelvin Munene, Stanley Gitari","doi":"10.1007/s11469-023-01115-w","DOIUrl":"10.1007/s11469-023-01115-w","url":null,"abstract":"<p><p>Substance use among street-involved children and youth (SICY) in low- and middle-income countries is common. Using data abstracted from program intake forms (2016-2022) for an intervention to reintegrate SICY with their communities, we assess which individual, family, and geographic characteristics are predictive of substance use, and specifically inhalant use and non-inhalant use among a sample of 227 SICY in Meru County, Kenya. Assessed determinants include age, geographic location of home community, years on street, family deprivation prior to street-migrating, motivation for street migrating, abuse experiences on the street, and activities on the street. Number of years lived on the street, experiencing abuse on the street, and citing peer-self relations as the reason for street migration were all associated with significantly higher odds of reporting substance use, and inhalant use specifically. Inhalant use was also significantly associated with peer socialization and specific street activities. Further research should explore the role of peer-self dynamics in substance use among SICY and how it can inform approaches to reintegrating children from street situations and sustaining their development in non-street environments.</p>","PeriodicalId":14083,"journal":{"name":"International Journal of Mental Health and Addiction","volume":" ","pages":"329-343"},"PeriodicalIF":3.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11957461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44049759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of Continuous Theta Burst Stimulation to the Pre-supplementary Motor Area in Gambling Disorder: a Randomized Double-Blind Controlled Trial. 连续θ波爆发刺激对赌博障碍前辅助运动区的效果:一项随机双盲对照试验
IF 2.8 3区 医学
International Journal of Mental Health and Addiction Pub Date : 2025-02-01 Epub Date: 2023-07-21 DOI: 10.1007/s11469-023-01120-z
Stefano Pallanti, Joan A Camprodon, Michele Di Ponzio, Nikos Makris
{"title":"Efficacy of Continuous Theta Burst Stimulation to the Pre-supplementary Motor Area in Gambling Disorder: a Randomized Double-Blind Controlled Trial.","authors":"Stefano Pallanti, Joan A Camprodon, Michele Di Ponzio, Nikos Makris","doi":"10.1007/s11469-023-01120-z","DOIUrl":"10.1007/s11469-023-01120-z","url":null,"abstract":"<p><p>Gambling disorder (GD) is a condition constituting a public health concern due to its impactful detrimental consequences for affected individuals and its very high social costs. Given the lack of FDA-approved treatments, novel non-pharmacological interventions are warranted. In this double-blind randomized controlled trial, we aimed to investigate the effects of continuous Theta Burst Stimulation (cTBS) in patients with GD. Twenty-nine patients with a diagnosis of GD were included and randomly assigned to active or sham condition. In the active condition, participants received 10 sessions of cTBS over pre-SMA bilaterally. Patients were evaluated at baseline and at the end of treatment with the Pathological Gambling version of the Yale-Brown Obsessive-Compulsive Scale (PG-YBOCS) as primary outcome measure, and with the following secondary measures: Hamilton Anxiety Scale (HAM-A), Hamilton Depression Scale (HAM-D), Gambling Urges Scale (GUS), Barratt Impulsiveness Scale (BIS-11), Sheehan Disability Scale (SDS), Fagerstrom Test for Nicotine Dependence (FTND). A two-way repeated measures ANOVA revealed a significant \"group\" × \"time\" interaction for PG-YBOCS and GUS measures. Within group comparisons revealed that PG-YBOCS scores (<i>p</i><.001) and GUS scores (<i>p</i><.001) improved significantly in the group receiving the active stimulation, and positively correlated with a reduction of gambling-related disability, as measured with the SDS. This study shows that cTBS could be an effective treatment for GD, since it reduces one of its main dimensions: craving. Trial registration: ClinicalTrials.gov Identifier: NCT03669315.</p>","PeriodicalId":14083,"journal":{"name":"International Journal of Mental Health and Addiction","volume":" ","pages":"410-419"},"PeriodicalIF":2.8,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13089355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48973583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Management of Amphetamine and Methamphetamine Use Disorders: A Systematic Review and Network Meta-analysis of Randomized Trials. 安非他明和甲基苯丙胺使用障碍的管理:随机试验的系统回顾和网络荟萃分析。
IF 2.5 3区 医学
International Journal of Mental Health and Addiction Pub Date : 2025-01-01 Epub Date: 2024-09-20 DOI: 10.1007/s11469-024-01379-w
Malahat Khalili, Behnam Sadeghirad, Paxton Bach, Alexis Crabtree, Sara Javadi, Erfan Sadeghi, Sara Moradi, Fatemeh Mirzayeh Fashami, Mehran Nakhaeizadeh, Sahar Salehi, Ahmad Sofi-Mahmudi, Naser Nasiri, Soheil Mehmandoost, Soroush Moallef, Shahryar Moradi Falah Langeroodi, Jessica Moe, Mark Lysyshyn, Dan Werb, Jane A Buxton, Mohammad Karamouzian
{"title":"Management of Amphetamine and Methamphetamine Use Disorders: A Systematic Review and Network Meta-analysis of Randomized Trials.","authors":"Malahat Khalili, Behnam Sadeghirad, Paxton Bach, Alexis Crabtree, Sara Javadi, Erfan Sadeghi, Sara Moradi, Fatemeh Mirzayeh Fashami, Mehran Nakhaeizadeh, Sahar Salehi, Ahmad Sofi-Mahmudi, Naser Nasiri, Soheil Mehmandoost, Soroush Moallef, Shahryar Moradi Falah Langeroodi, Jessica Moe, Mark Lysyshyn, Dan Werb, Jane A Buxton, Mohammad Karamouzian","doi":"10.1007/s11469-024-01379-w","DOIUrl":"10.1007/s11469-024-01379-w","url":null,"abstract":"<p><p>The current evidence regarding effective management of methamphetamine and amphetamine (MA/A) use disorders is inconclusive. Therefore, we assessed the comparative benefits and tolerability of pharmacological, psychosocial, and harm reduction interventions for management of MA/A use disorders. We searched six electronic databases for randomized controlled trials of any pharmacological, psychosocial, or harm reduction interventions in adults with MA/A use disorders. We performed a random-effects frequentist network meta-analysis and used the GRADE approach to assess the certainty of evidence. We included 72 randomized trials (6836 participants). Low certainty evidence suggests quetiapine may extend abstinence compared to placebo [risk ratio (RR) 3.17 (95% confidence intervals (CI), 1.24 to 8.07)] and weekly average proportion of patients with negative urine samples [mean difference (MD) 32.17 (95% CI, 14.08 to 50.26)]. Low certainty evidence also suggested that riluzole may be associated with a higher weekly average proportion of patients with negative urine samples [MD 24.10 (95% CI, 5.54 to 42.66)]. Very low certainty evidence suggests methylphenidate alone [compared to placebo MD 10.24 (95% CI, 3.49 to 16.99)] or in combination with matrix model [MD 23.55 (95% CI, 7.64 to 39.46)] may be associated with an increased weekly average proportion of patients with negative urine samples. Compared to placebo, contingency management alone [MD 21.20 (95% CI, 11.39 to 31.00), very low certainty] or in combination with cognitive behavioural therapy [MD 34.85 (95% CI, 19.63 to 50.08), very low certainty] may be associated with longer duration of abstinence. Compared to placebo, venlafaxine [RR 0.27 (95% CI 0.08 to 0.90), low certainty] and citicoline [RR 0.69 (95% CI 0.49 to 0.99), lowcertainty] may be among the most tolerable interventions. Very few interventions may be associated with slight improvement in certain outcomes, but no intervention showed moderate- to high-certainty evidence for important changes across any patient-important outcomes.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1007/s11469-024-01379-w.</p>","PeriodicalId":14083,"journal":{"name":"International Journal of Mental Health and Addiction","volume":"23 6","pages":"4768-4786"},"PeriodicalIF":2.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12698752/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145756650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Technology-based substance use interventions for emerging adults and college students: A systematic review and meta-analysis. 新兴成人和大学生基于技术的物质使用干预:系统回顾和荟萃分析。
IF 2.8 3区 医学
International Journal of Mental Health and Addiction Pub Date : 2024-12-26 DOI: 10.1007/s11469-024-01433-7
Audrey Hang Hai, Laura Curran, Jocelyn N Simons, Kate B Carey, Patrick S Bordnick
{"title":"Technology-based substance use interventions for emerging adults and college students: A systematic review and meta-analysis.","authors":"Audrey Hang Hai, Laura Curran, Jocelyn N Simons, Kate B Carey, Patrick S Bordnick","doi":"10.1007/s11469-024-01433-7","DOIUrl":"10.1007/s11469-024-01433-7","url":null,"abstract":"<p><strong>Objective: </strong>To synthesize randomized controlled trial evidence on technology-based interventions' (TBIs) effectiveness for substance use among emerging adults (EA)/college students (CS).</p><p><strong>Methods: </strong>Nine electronic databases were searched. Two reviewers independently screened studies, extracted data, and assessed evidence quality. We used robust variance estimation in meta-regression for effect size synthesis and moderator analysis.</p><p><strong>Results: </strong>Based on 130 studies, the overall between-group effect size was 0.23 (95% CI= 0.18, 0.28). The effect sizes for comparing TBIs with no treatment, standard care, and non-technology interventions were 0.25 (CI=0.19, 0.31), 0.23 (CI=0.15, 0.32), and 0.12 (CI= -0.02, 0.25), respectively. Older participants showed significantly larger effect sizes, and interventions using multiple technologies had larger effects than smartphone-based ones.</p><p><strong>Conclusion: </strong>TBIs are effective in reducing substance use in EA/CS, with outcomes comparable to non-technology interventions and advantages over no treatment and standard care. Future research should address drug-related outcomes, multi-technology approaches, age-appropriate designs, and cultural diversity.</p>","PeriodicalId":14083,"journal":{"name":"International Journal of Mental Health and Addiction","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12456661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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