International Journal of Fertility & Sterility最新文献

{"title":"Therapeutic Effects of <i>Cynodon dactylon (C. dactylon)</i> against Polycystic Ovary Syndrome Induced by Letrozole in Adult Rats: Ovarian and Uterine Aspects.","authors":"Masoumeh Ahmadi, Afshin Zare, Mohammad Reza Jafarzadeh Shirazi, Samaneh Askari, Arezoo Khoradmehr, Nadiar M Mussin, Asset A Kaliyev, Farzad Mohammad Rezazadeh, Saman Saedi, Mohammad Dadpasand Taromsari, Alidad Boostani, Nader Tanideh, Kulyash R Zhilisbayeva, Ramazon Safarzoda Sharofiddin, Amin Tamadon","doi":"10.22074/ijfs.2024.2020015.1608","DOIUrl":"https://doi.org/10.22074/ijfs.2024.2020015.1608","url":null,"abstract":"<p><strong>Background: </strong><i>Cynodon dactylon</i> traditionally employed or treating hormonal problems in women. Therefore, this study aimed to assess the effect of <i>C. dactylon</i> hydroalcoholic extract of on letrozole-induced polycystic ovary syndrome (PCOS) in adult rats.</p><p><strong>Materials and methods: </strong>In this experimental study, hydroalcoholic extract was prepared from the whole plant except the root. Then, 16 female Sprague-Dawley rats were divided into four groups. In the control group, the PCOS model was not induced and no treatment was performed. The PCOS-induced groups received 1 mg/kg of body-weight letrozole daily by gavage for 21 days. In the PCOS-induced groups two groups were orally treated with 250 mg/kg body weight daily metformin or 500 mg/kg body weight daily <i>C. dactylon</i> extract, 28 days after PCOS induction. Hormonal, histopathologic, and histomorphometric analyses were performed. Molecular docking also done to evaluate effect of <i>C. dactylon</i> extract on receptors involved in the pathophysiology of PCOS.</p><p><strong>Results: </strong><i>C. dactylon</i> had a remarkable positive effect on estrous cycles and also led to a significant reduction in the weight of PCOS rats. Moreover, <i>C. dactylon</i> extract mitigates PCOS-induced hormonal imbalances including a significant decrease in testosterone and estrogen levels, as well as increased progesterone levels. Ovarian and uterine structures were improved including reducing theca layer thickness, enhancing antral follicular areas, and a significant decrease in the luminal area of the perimetrial layer, endometrial glands, and the total uterine area when compared to the PCOS group. Besides, molecular docking analysis showed that Ar-tumerone, Tumerone, Tricyclo[6.3.0.0(1,5)] undec-2-en-4-one, 2,3,5,9- tetramethyl, Curlone, and 3-Tert-butyl-4-hydroxyanisole showed the most binding affinity to the receptors that play crucial role in the pathophysiology of PCOS.</p><p><strong>Conclusion: </strong><i>C. dactylon</i> extract could display positive effects on both the ovary and uterus of letrozole-induced PCOS rats. Therefore, <i>C. dactylon</i> had therapeutic effects on the ovary and uterus of PCOS-induced rat models.</p>","PeriodicalId":14080,"journal":{"name":"International Journal of Fertility & Sterility","volume":"19 2","pages":"200-218"},"PeriodicalIF":2.3,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is There An Association between Dyslipidemia and The Risk of Ovarian Hyperstimulation Syndrome in A Population of Non-Obese Polycystic Ovary Syndrome Patients? A Cross-Sectional Study.","authors":"Jamileh Jahangirian, Rahil Jannatifar, Maryam Hafezi, Hoora Amozegar, Roya Hosseini, Nahid Nasiri, Maryam Mohammadi, Poopak Eftekhari-Yazdi","doi":"10.22074/ijfs.2024.2024542.1643","DOIUrl":"https://doi.org/10.22074/ijfs.2024.2024542.1643","url":null,"abstract":"<p><strong>Background: </strong>This research delves into exploring the nexus between lipid profiles and pro-inflammatory cytokines in both blood and follicular fluid (FF). It examines their impact on assisted reproductive technology (ART) outcomes and the propensity for ovarian hyperstimulation syndrome (OHSS) in non-obese polycystic ovary syndrome (PCOS) patients.</p><p><strong>Materials and methods: </strong>One hundred and thirty-one PCOS patients with intracytoplasmic sperm injection (ICSI) indication, participated in this cross-sectional study. Based on plasma fasting lipids, patients were divided into two groups, dyslipidemia group (n=79) was defined as patients with triglyceride (TG) ≥150 mg/dl or/and total cholesterol (TC) ≥200 mg/dl. Patients with lower levels of lipids were included in the normal lipid group (n=51). All patients underwent the antagonist protocol to stimulate ovulation for ICSI. Blood and FF samples collected on the ovum pick-up (OPU) day. The concentrations of lipids in serum and FF, including TC and TG using Colorometry method, and also, high-density lipoprotein (HDL) using turbidimetric method. The lowdensity lipoprotein (LDL) level was calculated by the formula: LDL= TC-TG/5- HDL. Serum tumor necrosis factor-alpha (TNF-α) and interleukin-18 (IL-18) were measured with ELISA kit. ART outcomes encompassed retrieved oocytes, metaphase II oocytes (MII), and rates of fertilization, cleavage, blastocyst development, and chemical and clinical pregnancy.</p><p><strong>Results: </strong>FF level of LDL-C in the dyslipidemia group was markedly higher than the normal lipid group (P=0.007). Serum TNFα levels (P<0.001) and FF levels of TNF-α and IL-18 were significantly elevated in the dyslipidemia group (P=0.005, P<0.001, respectively). A robust correlation between FF inflammatory cytokines and ART outcomes emerged in PCOS patients, independent of lipid status. Notably, the normal lipid group exhibited a significantly higher risk of OHSS than the dyslipidemia group (P=0.034).</p><p><strong>Conclusion: </strong>The present study underscored the association between lipid metabolic disorders in PCOS and heightened inflammatory cytokine levels, correlating with ART outcomes but not with OHSS risk.</p>","PeriodicalId":14080,"journal":{"name":"International Journal of Fertility & Sterility","volume":"19 2","pages":"193-199"},"PeriodicalIF":2.3,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Value of Serum Progesterone Levels on The Day of Frozen-Thawed Embryo Transfer in Determining Pregnancy Outcomes in Infertile Women: A Cohort Prospective Study.","authors":"Saeideh Dashti, Nasim Tabibnejad, Farimah Shamsi, Behnaz Gandom","doi":"10.22074/ijfs.2024.2032890.1720","DOIUrl":"https://doi.org/10.22074/ijfs.2024.2032890.1720","url":null,"abstract":"<p><strong>Background: </strong>Hormone replacement therapy (HRT) is the preferred protocol for endometrial preparation. Progesterone is important for successful implantation and the outcome of assisted reproductive techniques (ART). The impact of serum progesterone concentration on pregnancy outcomes has been extensively studied; however, there are conflicting results for dosage and route of administration. This study investigates the association between serum progesterone levels on embryo transfer day and assisted reproductive technique outcomes in frozen-thawed embryo transfer (FET).</p><p><strong>Materials and methods: </strong>This prospective cohort study was conducted on women who underwent FET. Participants received HRT with 6 mg of oestradiol valerate and 400 mg of micronized vaginal progesterone, along with 50 mg of intramuscular (IM) progesterone for endometrial preparation. Serum progesterone was assessed before embryo transfer. The primary outcome was live birth rate (LBR).</p><p><strong>Results: </strong>Overall, 190 infertile women underwent cleavage FET and were categorised according to the presence (group I: n=38) or absence (group II: n=152) of live birth. Group I women had significantly higher progesterone levels on the transfer day (34.48 ± 8.95 ng/ml) compared to group II women (29.83 ± 11.076 ng/ml, P=0.008). We divided the serum progesterone values into quartiles and observed significantly lower clinical pregnancy rates in the Q1 quartile (progesterone ≤23.84 ng/ml). Receiver operating characteristic (ROC) curve analysis indicated a significant threshold for progesterone level on the day of embryo transfer in terms of LBR, with an area under the curve (AUC) of 0.64 [95% confidence interval (CI): 0.54-0.73, P<0.001]. The estimated threshold was 26.95 ng/ml, with a sensitivity of 82% and a specificity of 43%.</p><p><strong>Conclusion: </strong>The present study showed a significant positive association between serum progesterone levels on transfer day and LBR in FET cycles after patients received a combination of vaginal and IM progesterone supplements. Monitoring of serum progesterone in FET cycles are recommended.</p>","PeriodicalId":14080,"journal":{"name":"International Journal of Fertility & Sterility","volume":"19 2","pages":"219-225"},"PeriodicalIF":2.3,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotics and Uterine Flushing versus Antibiotics Alone for Chronic Endometritis with Thin Endometrium in Assisted Reproductive Technology: A Single-Center Retrospective Cohort Study.","authors":"Vyacheslav Lokshin, Yenglik Askar, Anasstasya Rybina, Aigerim Abshekenova, Sholpan Karibayeva, Ravil Valiev, Almas Saduakas","doi":"10.22074/ijfs.2024.2014586.1565","DOIUrl":"https://doi.org/10.22074/ijfs.2024.2014586.1565","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to investigate whether uterine cavity flushing combined with antibiotic administration, improves the outcomes of assisted reproductive technology for patients with thin endometrium (<7 mm) associated with chronic endometritis.</p><p><strong>Materials and methods: </strong>A retrospective cohort study was conducted, including 202 patients. Subsequently, a single frozen-thawed embryo of high morphological quality (≥4AB) was transferred either in an artificial cycle or on day 7 after the luteinizing hormone (LH) peak in the natural cycle. The parameters measured included the number of CD138-positive plasma cells in the endometrial stroma, endometrial thickness on the day of embryo transfer, clinical pregnancy rate (CPR), and live birth rate (LBR).</p><p><strong>Results: </strong>Following treatment with endometrial flushing and antibiotics (group 1), there was a significant increase in endometrial thickness compared to antibiotics alone (group 2): 9.93 ± 1.37 mm vs. 8.2 ± 0.4 mm (P<0.001). Additionally, there was a significant reduction in the number of CD138-positive plasma cells in the endometrial stroma: 0.4 ± 0.8 vs. 4.1 ± 5.2 (P<0.001). The CPR with high-quality ET was 68.6 vs. 48%, respectively (P=0.016). The take-home baby rate was 60.8 vs. 39%, respectively (P=0.002).</p><p><strong>Conclusion: </strong>Therapy for chronic endometritis, which includes uterine flushing along with antibacterial treatment, when compared with the standard treatment method, resulted in a significant reduction in the clinical symptoms of chronic endometritis (CE) and can enhance the effectiveness of assisted reproductive technology treatments.</p>","PeriodicalId":14080,"journal":{"name":"International Journal of Fertility & Sterility","volume":"19 2","pages":"186-192"},"PeriodicalIF":2.3,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mesenchymal Stem Cell-Derived Small Extracellular Vesicle as A Novel Therapeutic Approach for Chemotherapy-Induced Male Infertility: A Review Article.","authors":"Maryam Taher, Hanieh Jalali, Homa Mohseni Kouchesfehani, Gholamreza Kaka","doi":"10.22074/ijfs.2024.2031240.1705","DOIUrl":"https://doi.org/10.22074/ijfs.2024.2031240.1705","url":null,"abstract":"<p><p>Small extracellular vesicles (sEVs) have been recognized as a promising therapeutic modality due to their low immunogenicity, and the ability to penetrate biological barriers. They contain significant amounts of lipids, proteins, and microRNAs, effectively participating in intra- and inter-cellular communications. sEVs derived from mesenchymal stem cells (MSCs) are being explored as a potential therapeutic option due to their immunomodulatory, anti-inflammatory, antioxidant, and regenerative properties, offering advantages over stem cell transplantationbased treatments. Chemotherapy induces side effects on various organs, particularly those with high proliferative capacity, such as testicular tissue. Exposure to some groups of chemotherapeutic agents, such as cyclophosphamide, cisplatin, and doxorubicin can cause DNA damage and induce apoptosis in spermatogonia and primary spermatocytes. Chemotherapy has been shown to induce cellular stress in testicles, leading to testicular dysfunction and the activation of apoptotic pathways in response to external and internal stress. The current research aims to review the potential therapeutic advantages of sEVs derived from MSCs in addressing sperm abnormalities and male infertility resulting from chemotherapy. Several lines of evidence indicate that treatment with sEVs can reduce testicular tissue damage caused by chemotherapy by decreasing oxidative stress and inflammatory responses. sEVs boost the growth and motility of spermatogenic cells and protect them from apoptosis by activating internal pathways. Therefore, as a non-invasive approach, they have shown promising results in regenerating damaged spermatozoa and restoring spermatogenesis.</p>","PeriodicalId":14080,"journal":{"name":"International Journal of Fertility & Sterility","volume":"19 2","pages":"110-119"},"PeriodicalIF":2.3,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ovarian Activation Surgical Techniques for Women with Premature Ovarian Insufficiency or Poor Ovarian Response: A Systematic Review.","authors":"Antonio D'Amato, Antonio Simone Laganà, Amerigo Vitagliano, Antonio Stanziano, Anna Maria Caringella, Clementina Cantatore, Giuseppe D'Amato, Giovanni Buzzaccarini, Andrea Etrusco","doi":"10.22074/ijfs.2024.2021822.1622","DOIUrl":"https://doi.org/10.22074/ijfs.2024.2021822.1622","url":null,"abstract":"<p><strong>Background: </strong><i>In vitro</i> fertilization (IVF) with egg donation often stands as the sole treatment option for women with premature ovarian insufficiency (POI) or poor ovarian response (POR); for this reason, alternative techniques are being developed, among which stand surgical techniques for ovarian activation. The aim of the present study was to evaluate the effectiveness of surgical techniques for ovarian activation in patients affected by POI or POR.</p><p><strong>Materials and methods: </strong>In this systematic review study, a comprehensive search of the literature was carried out on the principal databases. Only original studies reporting the treatment of POI or POR using surgical techniques for ovarian activation in human subjects were deemed eligible for inclusion in this qualitative analysis.</p><p><strong>Results: </strong>Overall, 187 patients with POI and 65 patients with POR were treated with experimental surgical techniques. Among the POI patients, 10 pregnancies and 8 live births were achieved. In the POR group, 18 pregnancies were reported with 14 live births.</p><p><strong>Conclusion: </strong>Ovarian fragmentation (OF) appears to be a promising method for treating POI, although large sample randomized controlled trials (RCTs) are necessary to confirm this hypothesis. Regarding POR, surgical techniques do not improve IVF outcomes, and thus should not be proposed, although they may lead to a slight increase in ovarian reserve markers as compared with before treatment. Both clinical and basic science studies are highly demanded to better understand the molecular mechanisms underlying some partially promising results, with the aim of improving currently available techniques.</p>","PeriodicalId":14080,"journal":{"name":"International Journal of Fertility & Sterility","volume":"19 2","pages":"133-143"},"PeriodicalIF":2.3,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling The Impact of Viral Infections on Sperm Genetic Stability: A Scoping Review.","authors":"Yasaman Hajiesmaeili, Fahimeh Mollaahmadi, Parnaz Borjian Boroujeni, Anahita Mohseni Meybodi, Kaveh Haratian","doi":"10.22074/ijfs.2024.2026567.1661","DOIUrl":"https://doi.org/10.22074/ijfs.2024.2026567.1661","url":null,"abstract":"<p><p>Despite the apparent resilience of the male reproductive system, various viruses have been found to impact male fertility by causing testicular inflammation, hormonal imbalances, and sperm abnormalities. The integrity of the genome is vital for cell function, and its instability, influenced by various factors including viral infections, may contribute to age-related conditions such as cancer and neurodegenerative disorders. This scoping review aims to investigate the relationship between viral infections and sperm genetic stability, exploring their interactions and potential impact on male reproductive health and fertility. In order to conduct this scoping review, PubMed, MEDLINE (OVID), ScienceDirect, Google Scholar, and Cochrane databases were explored to find the relevant articles using a search strategy developed in collaboration with a medical librarian. Two independent reviewers screened titles and abstracts of the relevant papers, followed by full-text screening. Studies focusing on infertile males with viral infections, compared to fertile males, examining DNA damage and sperm abnormalities were included. Thirty-four studies were included in the current review. This review will provide valuable information to healthcare professionals in addressing virusinduced sperm genetic instability and its implications for reproductive health. Furthermore, it highlights the socioeconomic and public health aspects of preventing and managing viral infections.</p>","PeriodicalId":14080,"journal":{"name":"International Journal of Fertility & Sterility","volume":"19 2","pages":"120-132"},"PeriodicalIF":2.3,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Cumulus Cells for The Immature Oocyte Undergoing In Vitro Maturation Rescue: A Retrospective Analysis.","authors":"Yudha Sudewo, Binarwan Halim, Diana Novi, Ichwaniul Adenin, Henry Salim Siregar, Muhammad Fidel Ganis Siregar, Muharam Natadisastra, Muhammad Rizki Yaznil, Irwin Lamtota Lumbanraja","doi":"10.22074/ijfs.2024.2014638.1561","DOIUrl":"https://doi.org/10.22074/ijfs.2024.2014638.1561","url":null,"abstract":"<p><strong>Background: </strong>Lack of matured oocytes after ovarian stimulation for in vitro fertilization (IVF) is one problem affecting the number of good-quality embryos. In vitro maturation (IVM) rescue is one way that can be done to rescue the immature oocytes retrieved after ovarian stimulation. It has been proven that cumulus cells (CCs) play an essential role in the growth and development of oocytes. However, their role in immature oocytes undergoing IVM rescue still needs to be improved. To assess the role of CCs in immature oocytes after controlled ovarian stimulation (COS) that underwent IVM rescue followed by intra cytoplasmic sperm injection (ICSI).</p><p><strong>Materials and methods: </strong>A retrospective study consists of 200 immature oocytes with normal morphology obtained from IVF patients who had undergone ovarian stimulation. They were randomly divided into a control group (complete denudation, n=100) and a study group (non-denudation, n=100). Both groups then underwent IVM rescue for 24 hours. Oocytes that mature through IVM rescue were followed by ICSI. Our primary outcome is the number of good-quality embryos. Other intermediate outcomes such as oocyte maturation rate, fertilization rate, embryo cleave and rate, and embryo quality were also analyzed.</p><p><strong>Results: </strong>The two groups had no significant difference in oocyte maturation rate 71 vs. 73% (P=0.875). However, significant differences were found in the fertilization rate 38.1 vs. 61.6% and embryo cleave rates 37.1 vs. 62.2% (P=0.006 and 0.005, respectively). In addition, immature oocytes that underwent IVM rescue with attached CCs produced more good embryos compared to IVM rescue of denuded oocytes 20 vs. 35.7% (P=0.003).</p><p><strong>Conclusion: </strong>Current research indicates that IVM rescue of immature oocytes with attached CCs may produce more good-quality embryos.</p>","PeriodicalId":14080,"journal":{"name":"International Journal of Fertility & Sterility","volume":"19 2","pages":"230-235"},"PeriodicalIF":2.3,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined Effects of Chrysin Supplementation and Exercise Training on Diabetes-Induced Oxidative Stress and Apoptosis in Rat Testicular Tissue.","authors":"Shiva Cheraghi Abajlou, Asghar Tofighi, Javad Tolouei Azar, Amir Afshin Khaki, Mazdak Razi","doi":"10.22074/ijfs.2024.2019906.1606","DOIUrl":"https://doi.org/10.22074/ijfs.2024.2019906.1606","url":null,"abstract":"<p><strong>Background: </strong>Diabetes mellitus (DM), one of the most pervasive and enduring metabolic diseases, has been demonstrated to adversely impact male fertility. Conversely, both exercise training and Chrysin have been identified as potential interventions capable of mitigating the deleterious effects of diabetes on spermatogenesis. Thus, the current study aims to explore the individual and combined influences of Chrysin supplementation and running exercise on oxidative stress and germ cell apoptosis in the testicular tissue of diabetic adult rats.</p><p><strong>Materials and methods: </strong>In this experimental study, the DM was induced by streptozotocin (STZ,50 mg/kg). Rats were divided into control (received STZ solvent), DM-sole, Chrysin-sole (50 mg/kg, daily), moderate-intensity running exercise training (MIRET-sole, warm-up, 5 minutes at 30% of Smax1 (Maximum speed); Moderate intensity exercise, 60 minutes at 60% of Smax1, and recovery, 5 minutes to 30% of Smax1), DM+Chrysin, DM+MIRET, and DM+MIRET+Chrysin. Following 8 weeks, the histopathological changes (Johnson's score, epithelial height, and tubular diameter), testicular malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPX), and the mRNA levels of anti-apoptotic gene Bcl-2 and pro-apoptotic gene Bax was analyzed.</p><p><strong>Results: </strong>Chrysin solely and simultaneous with MIRET could remarkably (P=0.001) improve the DM-induced histopathological damages, increase the testicular SOD and GPx levels, and decline the DM-increased MDA content. Moreover, our results showed that Chrysin solely and more simultaneously with MIRET could significantly (P=0.001) decrease the mRNA expression of <i>Bax</i> and improve the <i>Bcl-2</i> expression and rebalance the <i>Bax/Bcl-2</i> balance.</p><p><strong>Conclusion: </strong>Our findings showed that co-administration of Chrysin along with MIRET can significantly ameliorate the DM-induced histopathological, and biochemical impairments and reduce the pro-apoptotic impact of DM on testicular tissue.</p>","PeriodicalId":14080,"journal":{"name":"International Journal of Fertility & Sterility","volume":"19 1","pages":"88-95"},"PeriodicalIF":2.3,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11744208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143004864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Embryo Donation Technology on Child Psychological Adjustment and parenting styles: A Comparative Study.","authors":"Mahya Kaveh, Seyed Hamzeh Hosseini, Hamid Sharif Nia, Sepideh Peyvandi","doi":"10.22074/ijfs.2024.2016523.1581","DOIUrl":"10.22074/ijfs.2024.2016523.1581","url":null,"abstract":"<p><strong>Background: </strong>Despite the remarkable advancements in the use of embryo donation, concerns have arisen regarding its potential effects on the psychological well-being of children conceived through this assisted reproductive technology and their parent-child relationships. The aim of the study is to evaluate children's psychological adjustment and parenting style in families with donor-conceived children and compare them with the normal population.</p><p><strong>Materials and methods: </strong>A historical cohort study was conducted to assess the psychological adjustment of 31 children aged 3 to 7 years born via embryo donation and to compare the results with those of 30 age-matched children from families who conceived naturally using the Strengths and Difficulties Questionnaire. The sample size was determined using G power, and the samples were selected using a convenient sampling method. Parenting styles within these families were also evaluated using the Baumrind Parenting Styles Inventory through clinical interviews.</p><p><strong>Results: </strong>Although 8 out of 31 children born through embryo donation (25.8%) and 3 out of 30 children from families with natural conception exhibited psychological maladjustment, this difference was not statistically significant (P=0.249). Furthermore, there were no significant differences in parenting styles between the two groups (P values for permissive, authoritarian, and authoritative parenting styles were 0.424, 0.656, and 0.219, respectively).</p><p><strong>Conclusion: </strong>The lack of genetic parent-child relationships does not seem to be a dominant factor affecting the psychological adjustment of children or parenting styles.</p>","PeriodicalId":14080,"journal":{"name":"International Journal of Fertility & Sterility","volume":"19 1","pages":"96-103"},"PeriodicalIF":2.3,"publicationDate":"2025-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11744203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}