International Journal of Impotence Research最新文献_第9页

The impact of cannabis use on erectile dysfunction and sex hormones: a Mendelian randomization analysis. 使用大麻对勃起功能障碍和性激素的影响：孟德尔随机分析。

IF 2.6 3区医学

International Journal of Impotence Research Pub Date : 2024-06-04 DOI: 10.1038/s41443-024-00925-3

Youqian Zhang, Yue Su, Zitian Tang, Lin Li

{"title":"The impact of cannabis use on erectile dysfunction and sex hormones: a Mendelian randomization analysis.","authors":"Youqian Zhang, Yue Su, Zitian Tang, Lin Li","doi":"10.1038/s41443-024-00925-3","DOIUrl":"https://doi.org/10.1038/s41443-024-00925-3","url":null,"abstract":"Previous study has highlighted an association between cannabis use (CU) and an increased risk of erectile dysfunction (ED), potentially due to indirect effects on sex hormonal balance. However, the evidence remains controversial, and the causal relationship is unclear. This study utilized genome-wide association study (GWAS) data to investigate the causal relationships between cannabis use disorder (CUD), lifetime cannabis use (LCU), and ED, as well as levels of sex hormones including estradiol (E2), bioavailable testosterone (BT), follicle-stimulating hormone (FSH), and luteinizing hormone (LH) through Mendelian randomization (MR) analysis. The primary method of analysis was the inverse variance weighted (IVW) method. Data from the FinnGen and UK Biobank were used for replication and meta-analysis. The results indicated no causal relationship between genetically predicted CUD (OR = 0.97, 95% CI 0.87-1.10, P = 0.66) and LCU (OR = 1.13, 95% CI 0.84-1.50, P = 0.42) with the risk of ED. The meta-analysis provided consistent evidence (P > 0.05). No causal relationships were found between CUD and LCU with E2(CUD: β = 0.00, 95% CI 0.00-0.01, P = 0.37; LCU: β = 0.00, 95% CI -0.02-0.01, P = 0.62), BT (CUD: β = 0.00, 95% CI -0.03-0.02, P = 0.90; LCU: β = 0.02, 95% CI -0.04-0.09, P = 0.46), FSH (CUD: β = 0.01, 95% CI -0.18-0.20, P = 0.92; LCU: β = 0.01, 95% CI -0.44-0.47, P = 0.95), and LH (CUD: β = 0.01, 95% CI -0.18-0.21, P = 0.90; LCU: β = 0.13, 95% CI -0.22-0.49, P = 0.46). Sensitivity analyses detected no evidence of horizontal pleiotropy or heterogeneity, ensuring the robustness of the results. In conclusion, this MR analysis did not provide evidence supporting a causal relationship between CU and ED or sex hormone levels.","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141248054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond the prescription: trends and challenges in erectile dysfunction medications among young adult men. 处方之外：年轻成年男性勃起功能障碍用药的趋势和挑战。

IF 2.6 3区医学

International Journal of Impotence Research Pub Date : 2024-06-03 DOI: 10.1038/s41443-024-00902-w

Jonathan A Aguiar, Daniel R Greenberg, Robert E Brannigan, Joshua A Halpern, Justin M Dubin

{"title":"Beyond the prescription: trends and challenges in erectile dysfunction medications among young adult men.","authors":"Jonathan A Aguiar, Daniel R Greenberg, Robert E Brannigan, Joshua A Halpern, Justin M Dubin","doi":"10.1038/s41443-024-00902-w","DOIUrl":"https://doi.org/10.1038/s41443-024-00902-w","url":null,"abstract":"We sought to assess erectile dysfunction (ED) medication use among males aged 18-40. Between June and July 2023, a cross-sectional survey on Qualtrics (Provo, UT) was disseminated via Research Match. Among 210 respondents, ED prevalence was 57.1% with 39.0% reporting prior ED medication use. Black or African American race (OR = 3.54, p < 0.001), Hispanic or Latino ethnicity (OR = 3.32, p = 0.01), and Medicare or Medicaid insurance status (OR = 6.07, p < 0.001) were associated with increased medication utilization. Income >$200,000 was associated with decreased medication usage (OR 0.23, p = 0.04). ED severity significantly correlated with higher medication usage. Primary care providers were the most common source of acquisition (47.6%), followed by online direct to consumer (DTC) platforms (31.7%) and personal connections (19.5%). Privacy (n = 51, 62.2%) and cost (n = 45, 54.9%) were key considerations in obtaining medications. Despite 73.2% of individuals receiving counseling regarding risks/benefits and 84.1% receiving instructions for proper use, only 28.0% correctly identified essential aspects of proper/appropriate use. Overall, we found a high ED prevalence and medication utilization rate. The preference for privacy in procuring medications suggests ongoing stigma around men's sexual health. Despite extensive counseling, a significant knowledge gap remains indicating a pressing need for enhanced patient education.","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141237466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on: does time of intraoperative exposure to the aerobiome increase microbial growth on inflatable penile prostheses? 评论：术中暴露于空气生物群的时间是否会增加充气阴茎假体上微生物的生长？

IF 2.8 3区医学

International Journal of Impotence Research Pub Date : 2024-06-01 DOI: 10.1038/s41443-024-00909-3

Britney L Atwater, Martin S Gross, Steven K Wilson

引用次数: 0

Comparing risk of post infection erectile dysfunction following SARS Coronavirus 2 stratified by acute and long COVID, hospitalization status, and vasopressor administration: a U.S. large claims database analysis. 按急性和长期 COVID、住院状态和使用血管加压药分层比较 SARS 冠状病毒 2 感染后勃起功能障碍的风险：美国大型索赔数据库分析。

IF 2.6 3区医学

International Journal of Impotence Research Pub Date : 2024-05-31 DOI: 10.1038/s41443-024-00913-7

Aurora J Grutman, Kelli Gilliam, Ankith P Maremanda, Corey Able, Una Choi, Mark N Alshak, Taylor P Kohn

{"title":"Comparing risk of post infection erectile dysfunction following SARS Coronavirus 2 stratified by acute and long COVID, hospitalization status, and vasopressor administration: a U.S. large claims database analysis.","authors":"Aurora J Grutman, Kelli Gilliam, Ankith P Maremanda, Corey Able, Una Choi, Mark N Alshak, Taylor P Kohn","doi":"10.1038/s41443-024-00913-7","DOIUrl":"https://doi.org/10.1038/s41443-024-00913-7","url":null,"abstract":"No study has yet assessed the risk of developing erectile dysfunction (ED) after a diagnosis of long COVID, defined by the Centers for Disease Control and Prevention as the persistence or presence of new symptoms at least 4 weeks after initial SARS-CoV-2 infection, when compared to those diagnosed with acute COVID or cases in which more severe treatment is required. To assess these risks, we queried the TriNetX COVID-19 Research Network from December 1st 2020 through June 2023. Men aged ≥ 18 diagnosed with long COVID were compared to those diagnosed with acute COVID and analyses were performed to compare men who were/were not hospitalized within 1 month of acute COVID diagnosis and men who did/did not need vasopressors. Cohorts were propensity score matched and compared for differences in new ED diagnosis and/or prescription of phosphodiesterase-5 inhibitors (PDE5i). After propensity score matching, the long and acute COVID cohorts included 2839 men with an average age of 54.5±16.7 and 55.1±17.1 years respectively (p = 0.21). Men with long COVID were more likely to develop ED or be prescribed PDE5i (3.63%) when compared to men with only acute COVID infections (2.61%) [RR 1.39; 95% CI 1.04, 1.87]. There was no statistically significant risk of developing ED or being prescribed PDE5i for individuals who received vasopressors [RR 0.92; 95% CI 0.77,1.10] or were hospitalized [RR 0.93; 95% CI 0.82,1.06].","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":null,"pages":null},"PeriodicalIF":2.6,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141184001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on: Does time of intraoperative exposure to the aerobiome increase microbial growth on inflatable penile prostheses? 评论术中暴露于空气生物群的时间是否会增加充气阴茎假体上微生物的生长？

IF 2.6 3区医学

International Journal of Impotence Research Pub Date : 2024-05-31 DOI: 10.1038/s41443-024-00907-5

John J Mulcahy

引用次数: 0

Search traffic for inflatable penile prosthesis increased following the COVID-19 pandemic in the United States: a Google Trends analysis. COVID-19 在美国大流行后，充气阴茎假体的搜索流量增加：谷歌趋势分析。

IF 2.8 3区医学

International Journal of Impotence Research Pub Date : 2024-05-30 DOI: 10.1038/s41443-024-00922-6

Elia Abou Chawareb, Hana Nakamura, Muhammed A M Hammad, Jake A Miller, Supanut Lumbiganon, Babak K Azad, Faysal A Yafi

{"title":"Search traffic for inflatable penile prosthesis increased following the COVID-19 pandemic in the United States: a Google Trends analysis.","authors":"Elia Abou Chawareb, Hana Nakamura, Muhammed A M Hammad, Jake A Miller, Supanut Lumbiganon, Babak K Azad, Faysal A Yafi","doi":"10.1038/s41443-024-00922-6","DOIUrl":"10.1038/s41443-024-00922-6","url":null,"abstract":"We aimed to determine the impact of the COVID-19 pandemic on search trends for inflatable penile implants in the US. Search trends for inflatable penile implants ranging from 2016 through 2023 were analyzed utilizing Google Trends. Associations between search trends and US Census Bureau data, including average household income and per capita income, were analyzed. Pre- and post- COVID-19, the interest in inflatable penile implants has been steadily increasing on average in the US. The average household income for counties with the highest interest in inflatable penile implants during the pre-COVID era was $53,136, whereas for the counties with the highest interest in inflatable penile implants in the post-COVID era, the average decreased to $50,940. Similarly, the average per capita median decreased from $35,209 to $34,547. Search traffic for inflatable penile prosthesis increased following the pandemic in the US. Nevertheless, post-pandemic, individuals with lower income levels showed no change in interest in penile implant searches compared to the pre-pandemic period. Understanding this steadiness in interest can inform healthcare professionals and policymakers to tailor interventions and educational efforts to reach a broader audience, ensuring equitable access to information and healthcare resources.","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141179466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Marfan's syndrome is associated with a greater risk of Peyronie's disease: a case-control study of the TriNetX database. 马凡氏综合征与罹患佩罗尼氏病的更大风险相关：TriNetX 数据库的病例对照研究。

IF 2.6 3区医学

International Journal of Impotence Research Pub Date : 2024-05-30 DOI: 10.1038/s41443-024-00923-5

Kaushik P Kolanukuduru, Asher L Mandel, Rishabh K Simhal, Tamir N Sholklapper, Kelly Sun, Maria Poluch, Kerith R Wang, Yash B Shah, Paul H Chung

引用次数: 0

Top-cited articles in andrology journals from 2013-2022: a bibliometric analysis. 2013年至2022年期间在男性学期刊上被引用次数最多的文章：文献计量学分析。

IF 2.8 3区医学

International Journal of Impotence Research Pub Date : 2024-05-28 DOI: 10.1038/s41443-024-00908-4

James Dornbush, Roei Golan, Aaron A Gurayah, Manish Kuchakulla, Hasan Jhaveri, Ely Kresch, Aditya Sathe, Pranay Manda, Kevin Campbell, Ranjith Ramasamy

{"title":"Top-cited articles in andrology journals from 2013-2022: a bibliometric analysis.","authors":"James Dornbush, Roei Golan, Aaron A Gurayah, Manish Kuchakulla, Hasan Jhaveri, Ely Kresch, Aditya Sathe, Pranay Manda, Kevin Campbell, Ranjith Ramasamy","doi":"10.1038/s41443-024-00908-4","DOIUrl":"10.1038/s41443-024-00908-4","url":null,"abstract":"Bibliometric analyses serve to identify influential articles that have shaped medical practice and fostered new research ideas. Over the past decade, research in andrology has witnessed exponential growth, with an increasing number of academic publications, collaborations, and research innovations. However, there is a lack of literature that has identified the top-cited andrology articles. We conducted a bibliometric analysis to identify the top 1000 citations in andrology journals, with a focus on the top funding agencies, authors, institutions, countries/regions, and journals. To perform this analysis, we identified the top-cited articles in andrology journals as indexed in the Web of Science Core Collection. From 2013 through 2022, we found a total of 9827 articles published in andrology journals. The top publishers included \"Andrology,\" the \"Asian Journal of Andrology,\" and \"Andrologia.\" The top affiliations contributing to research include the Cleveland Clinic Foundation (269 publications), Egyptian Knowledge Bank (EKB) (265), and Shanghai Jiao Tong University (202). Funding was primarily provided by notable agencies such as the National Natural Science Foundation of China (905 grants), United States Department of Health Human Services (321), and National Institutes of Health (NIH USA) (317). The present bibliometric analysis highlights andrology research from 2013 through 2022, offering key insights into leading contributors, influential authors, prominent funding sources, and major trends in the field.","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141161582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endocrine effect of phthalate metabolites and a butterfly effect of prenatal exposure to androgens on qualitative aspects of female sexual response- an initial survey. 邻苯二甲酸酯代谢物的内分泌效应和产前接触雄激素对女性性反应定性方面的蝴蝶效应--初步调查。

IF 2.8 3区医学

International Journal of Impotence Research Pub Date : 2024-05-28 DOI: 10.1038/s41443-024-00919-1

Branislav Kolena, Henrieta Hlisníková, Miroslava Nagyová, Katarína Orendáčová, Mária Vondráková, Ida Petrovičová, Miloš Mlynček, Petr Weiss, James G Pfaus

{"title":"Endocrine effect of phthalate metabolites and a butterfly effect of prenatal exposure to androgens on qualitative aspects of female sexual response- an initial survey.","authors":"Branislav Kolena, Henrieta Hlisníková, Miroslava Nagyová, Katarína Orendáčová, Mária Vondráková, Ida Petrovičová, Miloš Mlynček, Petr Weiss, James G Pfaus","doi":"10.1038/s41443-024-00919-1","DOIUrl":"10.1038/s41443-024-00919-1","url":null,"abstract":"There is growing evidence that endocrine disruptive chemicals have deleterious effects on sexual and reproductive function. To examine subjective sexual functions in human females and their relationship to postnatal phthalate exposure and perinatal androgenization, a Sexuality Score (SS) was established from a first-stage survey questionnaire of subjective sexual function filled out by female university students (n = 68; average age 25.23 ± 5.17 years; rural 25.51 ± 6.74 vs. urban 25.85 ± 1.43 years). Seventeen phthalate metabolites in urine samples were analyzed by high-performance liquid chromatography (HPLC) and tandem mass spectrometry (MS/MS). Females were also assessed for the 2D:4D digit ratio as an index of perinatal androgenization. The mean age of menarche was 12.82 ± 1.35 years (rural 12.59 ± 1.39 vs. urban 13.18 ± 1.27; p = 0.01). The mean age at first sexual intercourse was 14.88 ± 6.89 years (rural 14.62 ± 7.20 vs. urban 15.24 ± 6.55), and as the age of first sexual intercourse increases, the SS score tends to increase as well, albeit moderately (r = 0.25, p = 0.037). Mono-iso-butyl phthalate, mono(2-ethyl-5-carboxypentyl) phthalate, mono(hydroxy-n-butyl) phthalate, mono(2-ethyl-5-oxohexyl) phthalate (p ≤ 0.05) and mono(2-carboxymethylhexyl) phthalate (p ≤ 0.01) were negatively associated with SS. A compounding butterfly effect of prenatal exposure to androgens was observed with disruptive effects of mono(2-ethyl-5-oxohexyl) phthalate and mono(2-ethyl-5-carboxypentyl) phthalate on sexual function. Exposure to phthalates in adult females may lead to disruption of subjective sexual function, especially concerning sexual desire and sexual satisfaction, and perinatal androgenization could augment these effects.","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141161574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on: Prior COVID-19 infection associated with increased risk of newly diagnosed erectile dysfunction 评论曾感染COVID-19与新诊断出勃起功能障碍的风险增加有关

IF 2.8 3区医学

International Journal of Impotence Research Pub Date : 2024-05-25 DOI: 10.1038/s41443-024-00912-8

Sirpi Nackeeran, Ranjith Ramasamy

引用次数: 0