International Journal of Impotence Research最新文献

{"title":"Response to Comment on: Hard-flaccid syndrome: a report of two case.","authors":"Karl H Pang, Yan Zhang","doi":"10.1038/s41443-025-01113-7","DOIUrl":"10.1038/s41443-025-01113-7","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of vacuum erectile device in refractory erectile dysfunction: a systematic review and meta-analysis.","authors":"Fuxun Zhang, Zhirong Luo, Qi Xue, Xuyan Guo, Wei Zhang, Yang Xiong, Uzoamaka Adaobi Okoli, Geng Zhang, Yong Jiao","doi":"10.1038/s41443-025-01102-w","DOIUrl":"10.1038/s41443-025-01102-w","url":null,"abstract":"<p><p>Vacuum erection device (VED) as one of the approved therapies for erectile dysfunction (ED) is widely used. However, available evidence of VED efficacy on refractory ED, a condition often unresponsive to phosphodiesterase type 5 (PDE5) inhibitors, is limited. A literature search was performed using PubMed, EMBASE, and the Cochrane Library to identify all clinical trials up to December 2024. The primary outcome was efficacy defined as successful intercourse or intercourse satisfaction after VED intervention, and the secondary outcome was the incidence of most common side effects. The pooled rate with 95% confidence intervals (CI) was selected as the effect size. Heterogeneity was assessed by Cochran's Q test and the I² test. Sensitivity analyses, subgroup analyses and meta-regression were used to explore the sources of heterogeneity. Publication bias was assessed by funnel plots and Egger's test. Data from 1065 patients across 18 studies were analyzed in this meta-analysis. The pooled effect size of VED efficacy was 0.80 (95% CI: 0.76-0.84). Among the different subgroups, the efficacy of VED in ED patients with mixed etiologies, diabetes mellitus, spinal cord injury and radical prostatectomy were 82.9, 73.0, 71.8 and 84.5%, respectively. The most common side effect was penile bruising with a pooled incidence of 24.3%. ED patients with spinal cord injury may have a higher risk of penile bruising (31.4%). Meta-regression suggested that the publication date and patients' age may affect the outcome. No significant publication bias was detected. In conclusion, VED is an effective adjunct for improving the intercourse success rate and patient satisfaction in refractory ED. Future large randomized controlled trials with standardized objective measurements and longer follow-up durations are warranted.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144336470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Penile sympathetic skin response in patients with non-organic erectile dysfunction: a Cross-Sectional Study.","authors":"Qingqiang Gao, Xuechao Han, Youfeng Han, Bin Wang, Yutian Dai, Baibing Yang, Xiaozhi Zhao","doi":"10.1038/s41443-025-01096-5","DOIUrl":"https://doi.org/10.1038/s41443-025-01096-5","url":null,"abstract":"<p><p>This study evaluated the clinical value of penile sympathetic skin response (PSSR) in patients with non-organic erectile dysfunction (ED) and its correlation with psychological status. Based on the results of the nocturnal penile tumescence and rigidity (NPTR) test, the study included 68 patients with non-organic ED, 30 patients with organic ED, and 120 matched control subjects with normal erectile function. All subjects underwent PSSR testing to measure PSSR latency, International Index of Erectile Function-5 (IIEF-5) scores, and self-rating anxiety scale (SAS) scores. The results showed that the PSSR latency in patients with non-organic ED was significantly shorter than that in patients with organic ED and normal controls (NCs) (1179.12 ± 145.38 vs. 1420.00 ± 145.97 vs. 1382.00 ± 179.68 ms, p < 0.001). Furthermore, PSSR latency in patients with non-organic ED was negatively correlated with the SAS anxiety score (p < 0.001, r = -0.681) and positively correlated with the IIEF-5 score (p < 0.001, r = 0.493). Our study results suggest that patients with non-organic ED have excessive sympathetic excitation, and PSSR can be used as an objective electrophysiological indicator to assess autonomic nerve dysfunction, providing a rapid, non-invasive auxiliary tool for clinical differential diagnosis. This study is the first to reveal a significant association between PSSR latency and psychological anxiety, suggesting that enhanced sympathetic nerve activity may be an important pathological mechanism of non-organic ED.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-orgasmic illness syndrome and its effects on self esteem and relationships: a survey.","authors":"Luke N Maietta, Isaac Bronson, Michael Cabral, Cameron Stokes, Karla Radillo Mendoza, Olivia Johnson, Dipavo Banerjee, Anthony J Rothschild, Rachel S Rubin","doi":"10.1038/s41443-025-01103-9","DOIUrl":"10.1038/s41443-025-01103-9","url":null,"abstract":"<p><p>Post-Orgasmic Illness Syndrome (POIS) is a rare medical condition characterized by a range of distressing physical and cognitive symptoms that occur following ejaculation in affected individuals. Little is known about the complex interaction between self-esteem and relationship factors that affect those living with POIS. This study investigated the impact of POIS on intimate relationships and feelings of isolation and stigmatization, including questions related to personal and partner control over symptoms. Furthermore, it aims to provide a clinical framework for addressing the psychosocial concerns of this patient population and their partners. Eighty-three patients (76.3% white, 37.5% with Bachelor's degree, 73.8% middle income or higher) with POIS completed the Sexual Dysfunction Attribution Scale (SDAS) as part of the larger survey study. Surveys were distributed via social media, online groups, and forums including the subreddit: \"POIS\", Twitter, and \"POISCENTER\" and were completed between 05/21/24-06/09/24. Descriptive, exploratory, and demographic data of the participants are provided from this survey. Patients with POIS were likely to report feeling no personal control over their symptoms (81.9%), feeling that their symptoms would \"always be present\" (96.4%), and feeling that they were personally to blame for their sexual dysfunction (60.2%). Overall, 80.7% reported that their symptoms negatively affected their relationships, and 37.3% reported not having sex within the past year. Our results can help providers to understand the experiences of patients with POIS and equip them to recommend the appropriate resources. Further research may use advanced analytical and qualitative techniques to better elucidate this population's challenges.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144309922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Astaxanthin mitigates radiation-induced erectile dysfunction: protective effects on corpus cavernosum in a rat model.","authors":"Gunal Ozgur, Bahadir Sahin, Beste Melek Atasoy, Canberk Tomruk, Cansin Sirin Tomruk, Hasan Huseyin Tavukcu, Ali Yaman, Cemile Ceylan, Deniz Mukaddes Turet, Sehkar Oktay, Yigit Uyanikgil, Gonca Haklar, Haydar Kamil Cam","doi":"10.1038/s41443-025-01106-6","DOIUrl":"10.1038/s41443-025-01106-6","url":null,"abstract":"<p><p>The objective of this study was to evaluate the effects of ionizing radiation (iR) on corpus cavernosum and the potential of astaxanthin (AST) in preventing radiation-induced erectile dysfunction (RiED). Male Wistar Albino rats (10-12 week, 250-300 g) were divided-into four groups: sham (SH, n = 8), radiotherapy (RT, n = 8), vehicle-administered (olive oil (OO); RT + OO, n = 12), and astaxanthin (RT + AST, n = 12). The RT-group received 12-Gy prostate-targeted iR. The vehicle-administered (OO) group received iR with daily 1 ml OO via oral gavage, while the AST-group received iR with 50 mg/kg AST dissolved in OO. After the treatment-period (12-week), intracavernosal pressure to mean arterial pressure (ICP/MAP) ratios in the RT [0.28(0.14-0.65)] and OO groups [0.26(0.19-0.64)] were significantly lower than in the SH [0.6(0.43-0.72)] and AST [0.53(0.35-0.64)] groups (p < 0.05). iR caused narrowing of the cavernous sinusoids (RT:95.38 (84.62-110.05) vs SH:132.33 (113.27-155.86), AST:124.44 (112.11-131.97) µm, p < 0.001). Alpha smooth muscle actin (SH:165 (136.25-188.75) vs RT:100 (87.5-112.5), AST:137.5 (107.5-155), p < 0.001), endothelial nitric-oxide synthase (NOS) (SH:127.5 (115-167.5) vs RT:92.5 (81.25-98.75), AST:115 (86.25-128.75), p = 0.002) and neuronal NOS (SH:152.5 (133.75-163.75) vs RT:95 (81.25-103.75), AST:135 (125-140), p < 0.001) were diminished in the RT-group and preserved in the AST-group according to immunohistochemical scoring. Biochemical measurements of the corpus cavernosum revealed that the level of cGMP was significantly higher (93.15 (71.22-103.38) vs 70.8 (65-72.35) pmol/ml) in the AST-group, while lipid peroxidation was significantly higher (32.38 (29.07-36.98) vs 20.14 (17.85-21.04) nmol.mda/g) in the RT-group (p = 0.004, p < 0.001). This trial showed that AST preserved ICP/MAP values and histopathological-biochemical parameters after exposure to iR.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Penile prosthesis implantation: a systematic review of intraoperative and postoperative complications.","authors":"Andrea Cocci, Paolo Capogrosso, Suks Minhas, Carlo Bettocchi, Luca Boeri, Joana Carvalho, Nusret Can Cilesiz, Giovanni Corona, Konstantinos Dimitropoulos, Murat Gül, Georgios Hatzichristodoulou, Thomas Hugh Jones, Ates Kadioglu, Juan Ignatio Martínez Salamanca, Uros Milenkovic, Vaibhav Modgil, Giorgio Ivan Russo, Ege Can Serefoglu, Tharu Tharakan, Paolo Verze, Marco Falcone, Andrea Salonia","doi":"10.1038/s41443-025-01108-4","DOIUrl":"https://doi.org/10.1038/s41443-025-01108-4","url":null,"abstract":"<p><p>Erectile dysfunction (ED) is the most frequently reported male sexual dysfunction. Penile prosthesis implantation (PPI) is an effective solution for patients with medically refractory ED. Despite advancements in surgical techniques and device technology, detailed evidence on PPI complication rates is limited. A systematic review was conducted following PRISMA guidelines, including literature from Medline, Embase, Cochrane Libraries, and clinicaltrial.gov from 2000 to October 2024. Eligible studies included randomized controlled trials (RCTs), non-randomized comparative studies, and case series with ≥5 participants. Adult male patients (≥18 years) undergoing PPI for ED, Peyronie's disease, or priapism were considered. Eligible interventions included malleable and hydraulic (two- or three-piece) prosthesis implantation, device explantation and reimplantation, and PPI combined with penile curvature correction. Primary outcomes were intraoperative and postoperative complication rates. Of the 1370 studies initially identified, 151 met inclusion criteria, encompassing a total of 92,777 patients. Device infections were reported in 103 studies, with rates ranging from 0.03-14.3%, predominantly under 5%. Erosion rates spanned 0.02-32.5%, with most studies reporting rates below 5%. Mechanical failure rates were highly variable, exceeding 15% in about half the studies with follow-up periods of 5 to 11 years. Intraoperative complications such as urethral injury and corporeal perforation were uncommon but occurred more frequently in patients with severe fibrosis, including those with priapism. Neurological comorbidities were associated with an elevated risk of mechanical failure, while diabetic patients did not exhibit a significantly increased infection risk compared to the general population. Modern techniques and coated devices have reduced infection and erosion rates. However, mechanical failure remains a concern, emphasizing the need for technological advancements. Tailored device selection and comprehensive pre- and postoperative management are critical to reducing revision rates and improving outcomes. Future research should address gaps in surgical approach optimization and complication management.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: Awareness of Monkeypox virus among sexual medicine experts is low: a multi-institutional survey.","authors":"Rashed Rowaiee, Ahmed AlBlooshi, Saleh M Hassan, Omer A Raheem","doi":"10.1038/s41443-025-01109-3","DOIUrl":"https://doi.org/10.1038/s41443-025-01109-3","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-reported outcome measures in penile cancer: a narrative review","authors":"Oluwatobi Adegboye,&nbsp;Arie Parnham,&nbsp;Vijay Sangar","doi":"10.1038/s41443-025-01031-8","DOIUrl":"10.1038/s41443-025-01031-8","url":null,"abstract":"Penile cancer is a relatively rare cancer globally. The cancer itself and its surgical excision can have detrimental physical and psychosocial implications on patients. Patients can share assessments of their health and quality of life using patient-reported outcome measures. These questionnaires are associated with more dynamic, patient-centred clinical decision-making, better patient symptom control and reduced need for hospitalisation. There is a drive for increased implementation and digitalisation of patient-reported outcome measures, especially in surgical settings, to allow real-time monitoring and adjustment of patient management. Consequently, this narrative review provides a contemporary exploration of the usage of patient-reported outcome measures in patients with penile cancer.","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":"37 9","pages":"751-758"},"PeriodicalIF":2.5,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41443-025-01031-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrophilic inflatable penile prosthesis surface coatings readily rebind antibiotics and maintain antimicrobial efficacy ex vivo.","authors":"Brian H Im, Aaron R Hochberg, Analyse H Giordano, Rachel Evans, Andrzej Fertala, Jolanta Fertala, Noreen J Hickok, Paul H Chung","doi":"10.1038/s41443-025-01104-8","DOIUrl":"https://doi.org/10.1038/s41443-025-01104-8","url":null,"abstract":"<p><p>Hydrophilic penile prosthesis (PP) surfaces removed during revision surgery may potentially rebind antiseptics and maintain antimicrobial efficacy ex vivo. Coloplast Titan reservoirs and cylinders were retrieved during revision surgery for mechanical failure. Congo Red staining and contact angle measurements were performed to evaluate the integrity of the hydrophilic surface. Fluorescent antibiotic binding was performed by submerging discs for 3 min in either fluorescein-isothiocyanate (FITC) labeled or unlabeled vancomycin at 2 mg/mL. Fluorescence was quantified via ImageJ. 8 mm discs were submerged for 3 min in normal saline (NS), 0.05% chlorhexidine gluconate, or a 2 mg/mL vancomycin and 160 μg/mL gentamicin (VG) antibiotic, then incubated with 10⁵ colony-forming units per milliliter of methicillin-sensitive Staphylococcus aureus ATCC25923 for 48 h then counted. Mann-Whitney U and one-way ANOVA tests were performed to compare outcomes, p < 0.05 considered significant. All PP tested for binding with FITC-vancomycin showed significant increases in fluorescence relative to unlabeled vancomycin controls (p < 0.0001). All explanted and control PP exhibited significant decreases in bacterial counts on VG-treated surfaces relative to NS controls (p < 0.01). The hydrophilic surface of the reservoir and cylinders maintain their integrity based on Congo Red staining and rebind VG antibiotics effectively based on microbiology and fluorescent binding studies.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144274807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low opioid fill rates continue after termination of a financial incentive for opioid-free vasectomies.","authors":"Catherine S Nam, Yen-Ling Lai, Hsou Mei Hu, Arvin K George, Tudor Borza, Susan Linsell, Stephanie Ferrante, Michael P Thompson, Chad M Brummett, Jennifer F Waljee, James M Dupree","doi":"10.1038/s41443-025-01105-7","DOIUrl":"https://doi.org/10.1038/s41443-025-01105-7","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}