{"title":"Response to Comment on: Reservoir placement and surgical considerations: a narrative review.","authors":"Benjamin Dalkin, Bryce Baird","doi":"10.1038/s41443-026-01303-x","DOIUrl":"https://doi.org/10.1038/s41443-026-01303-x","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Leonidas Karapanos, Daniel Porres, Axel Heidenreich, Luisa Halbe, Marc Busche
{"title":"Partial glans necrosis following complex Peyronie's disease surgery salvaged by novel glans lipofilling using autologous adipose tissue (microfat).","authors":"Leonidas Karapanos, Daniel Porres, Axel Heidenreich, Luisa Halbe, Marc Busche","doi":"10.1038/s41443-026-01305-9","DOIUrl":"10.1038/s41443-026-01305-9","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Priapism: an overview and update","authors":"Wai Gin Lee, David Ralph","doi":"10.1038/s41443-026-01301-z","DOIUrl":"10.1038/s41443-026-01301-z","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":"38 7","pages":"505-506"},"PeriodicalIF":2.5,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41443-026-01301-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Beyond surgery: the international masterclass in andrology and reconstructive surgery (iMARS) and the value of global collaboration in reconstructive urology and sexual medicine.","authors":"Andrea Cocci, Marco Capece, Marco Falcone","doi":"10.1038/s41443-026-01298-5","DOIUrl":"https://doi.org/10.1038/s41443-026-01298-5","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Data-Driven symptom clustering identifies four potential phenotypes of self-reported postorgasmic illness syndrome: findings from a large Chinese online survey.","authors":"Lun Li, Jia Yin","doi":"10.1038/s41443-026-01261-4","DOIUrl":"https://doi.org/10.1038/s41443-026-01261-4","url":null,"abstract":"<p><p>Postorgasmic illness syndrome (POIS) is a rare and heterogeneous condition characterized by local and/or systemic symptoms following ejaculation. However, whether distinct clinical phenotypes exist remains unclear. We aimed to identify symptom-dominant phenotypes among men with self-reported POIS-like symptoms and to explore variations in the history of allergic diseases across the resulting phenotypes. An online cross-sectional survey was conducted via social media from December 2020 to August 2021 using the WenJuanXing web application. A two-step cluster analysis was performed using 26 variables from POIS-related symptoms and history of allergic diseases. A total of 2,443 men completed the survey, including 770 with self-reported POIS-like symptoms. A four-cluster solution (BIC = 39,404.98; ratio of distance measures = 1.42; ratio of BIC changes = 0.34) was selected. Cluster 1 represented the generalized type (81 patients, 10.5%) characterized by longer spontaneous recovery time with widespread disorders, including mental, flu-like, head, muscle symptoms and mostly reported atopic status. Cluster 2 represented the neuropsychiatric type (235 patients, 30.5%) comprised subjects with fewer atopic symptoms and predominantly mental symptoms, particularly concentration and memory difficulties. Cluster 3, or the nasal type (185 patients, 24.0%) mainly showed atopic and nasal symptoms, while cluster 4, or the oligosymptomatic type (269 patients, 34.9%) had fewer symptoms, faster symptom onset after ejaculation, shorter spontaneous recovery time, and fewer atopic symptoms. All 26 variables included in the clustering model differed significantly across clusters (P <0.001). Recruitment via social media may have introduced selection bias, potentially limiting the generalizability of these findings. The four identified phenotypes reflect the clinical variability of POIS and offer a preliminary framework for future phenotype-based investigations.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comment on: Long-term outcomes and risk factors for erectile dysfunction and penile curvature after surgical penile fracture repair","authors":"Roshan Ajeet Singh, Elaine Redmond","doi":"10.1038/s41443-026-01297-6","DOIUrl":"10.1038/s41443-026-01297-6","url":null,"abstract":"","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":"38 8","pages":"1-2"},"PeriodicalIF":2.5,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Augustus E Anderson Iv, Dev Shah, Maia Van Dyke M, Charles Klose C, Allen F Morey, Bryce A Baird
{"title":"Reservoir placement and surgical considerations: A narrative review.","authors":"Augustus E Anderson Iv, Dev Shah, Maia Van Dyke M, Charles Klose C, Allen F Morey, Bryce A Baird","doi":"10.1038/s41443-026-01285-w","DOIUrl":"10.1038/s41443-026-01285-w","url":null,"abstract":"<p><p>The evolution of inflatable penile prosthesis reservoir design and placement techniques has significantly impacted patient outcomes and surgical practices. Recent advancements in reservoir design have improved device safety, durability, and surgical adaptability, which has built on decades of innovation. Concurrently, surgical techniques have evolved to accommodate anatomical variations, reduce complications, and expand options for both traditional and ectopic reservoir placement. Novel approaches, such as high submuscular reservoir placement with counter-incision, exemplify the trend toward safer and more reproducible solutions in complex cases. By synthesizing these developments, this review aims to provide a comprehensive understanding of how patient-centered care and mastery of diverse techniques can optimize outcomes and address challenges in prosthetic urology.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148204911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Dacron ingrowth during penile prosthesis revision: presentation, outcomes, and surgical management.","authors":"Ming-Yeah Y Hu, Mariela Martinez, Aaron C Lentz","doi":"10.1038/s41443-026-01299-4","DOIUrl":"https://doi.org/10.1038/s41443-026-01299-4","url":null,"abstract":"<p><p>The Boston Scientific American Medical Systems 700™ (AMS 700™, Boston Scientific Corporation, United States of America) inflatable penile prostheses feature an inner Dacron layer that facilitates controlled expansion. Over time, outer silicone rupture exposes the Dacron, allowing for tissue ingrowth and complicating explantation. We herein describe our experience managing this situation in a retrospective, single-surgeon case series. Operative reports of all AMS 700™ inflatable penile prostheses explants from 2011 to 2025 (CPT 54406, 54410, 54411, 54416, 54417) of a single surgeon at one institution were screened for \"Dacron\" and \"ingrowth\". Eleven (5.5%) of 200 AMS 700™ penile prostheses explants had Dacron ingrowth. Median implant age was 15.4 years (IQR 12.8-24.4). Ten (91%) implants were removed for mechanical failure. Median operative time was 154 min (IQR 116.5-180). Five (45%) patients had bilateral ingrowth; six (55%) had unilateral involvement. Ten (91%) cases required extended corporotomies. Three (27%) required distal penile incisions for cylinder removal. Four (67%) of six patients with unilateral ingrowth underwent immediate replacement with an inflatable penile prosthesis, one (17%) who later required Mulcahy salvage for infection. All patients with bilateral ingrowth received malleable prostheses for staged reimplantation; one (20%) patient required revision for cylinder crossover of the malleable. Overall, Dacron ingrowth is a rare but technically complex finding during long-standing AMS 700™ penile prostheses explants. Surgeons should anticipate increased operative time, potential for additional incisions, and elevated infection risk. When dissection is extensive, staged reconstruction offers a practical and safe strategy.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148156447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maurizio D'Anna, Lluis Peri Cusí, Antonio Alcaraz Asensio, Josep Torremadé Barreda
{"title":"Top ten surgical tricks-surgical management of adult acquired buried penis.","authors":"Maurizio D'Anna, Lluis Peri Cusí, Antonio Alcaraz Asensio, Josep Torremadé Barreda","doi":"10.1038/s41443-026-01293-w","DOIUrl":"https://doi.org/10.1038/s41443-026-01293-w","url":null,"abstract":"<p><p>Adult acquired buried penis is an increasingly prevalent condition, commonly associated with obesity, in which a normally sized penis becomes concealed by suprapubic adipose tissue. It has a negative impact on quality of life, causing urinary and sexual dysfunction, and recurrent infections. Chronic inflammation may further lead to urethral stricture, lichen sclerosus, and penile malignancy. Surgical repair is the definitive treatment, but it requires a structured reconstructive approach. This article describes ten key principles to optimize outcomes in the surgical repair of an adult acquired buried penis. These include appropriate patient selection and preoperative optimization, accurate standing-position marking, a wide transverse incision, and dissection to the aponeurosis with preservation of the spermatic cords. Penile skin must be carefully assessed to determine the need for grafts or scrotal flaps. Restoration of the penopubic angle using anchoring sutures is essential to prevent recurrence, while adjunctive lipectomy or liposuction may improve contour. Proper drainage, layered wound closure, and meticulous postoperative care are critical to minimize complications. These principles provide a practical framework for reconstructive urologists performing adult acquired buried penis repair, facilitating functional recovery, improved aesthetic outcomes, and sustained improvement in patient quality of life.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148156434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Koenraad Van Renterghem, Alvaro Yebes, Glenn Lamers, Josep Torremadé, Carlo Bettocchi, Borja Garcia-Gomez, Wai Gin Lee, Christien Caris, Wim Witjes, Ignacio Moncada, David Ralph
{"title":"Predictors of penile prosthesis length: results from the PHOENIX registry.","authors":"Koenraad Van Renterghem, Alvaro Yebes, Glenn Lamers, Josep Torremadé, Carlo Bettocchi, Borja Garcia-Gomez, Wai Gin Lee, Christien Caris, Wim Witjes, Ignacio Moncada, David Ralph","doi":"10.1038/s41443-026-01294-9","DOIUrl":"https://doi.org/10.1038/s41443-026-01294-9","url":null,"abstract":"<p><p>Penile prosthesis implantation (PPI) is an effective treatment for refractory erectile dysfunction (ED), but changes in penile length after surgery remain a major determinant of patient satisfaction. We aimed to identify patient- and surgery-related factors associated with final penile length, measured as total implanted device length. We analysed prospectively collected data from the PHOENIX registry, a multicenter cohort including consecutive PPI cases from 29 centers between November 2021 and August 2024 (ClinicalTrials.gov NCT03849586). Baseline demographics and surgical variables were recorded. Variables significant at p < 0.05 in univariate analysis and clinically relevant covariates were entered into a multivariate linear regression model. After exclusions, 1033 patients were included (mean age 60.9 ± 9.06 years). Mean total device length was 20.0 ± 2.36 cm (range 6-28). In multivariate analysis, shorter total device length was independently associated with diabetes mellitus (adjusted coefficient -0.59 cm; 95% CI -0.97 to -0.22; p = 0.002), history of radical prostatectomy (-0.45 cm; 95% CI -1.01 to -0.11; p = 0.04), prior pelvic radiotherapy (-1.42 cm; 95% CI -2.42 to -0.51; p = 0.002), Peyronie's disease (-0.83 cm; 95% CI -1.32 to -0.34; p < 0.001), previous intracavernosal injections (-0.68 cm; 95% CI -0.99 to -0.37; p < 0.001). Avoidance of sequential corporal dilation was associated with a modest increase in device length (+0.15 cm; 95% CI 0.01 to 0.50; p = 0.04). Loss of penile length is a well-established cause of patient and partner dissatisfaction following PPI. Pre-operative counselling and management of expectations is critical to the success of the procedure. In this large prospective multicenter cohort different factors were found to be associated with greater or lesser length. Among them, and following multivariate analysis, diabetes, radical prostatectomy, radiotherapy, Peyronie's disease and prior intracavernosal injections were associated with shorter implanted device length, whereas no corporal dilation was associated with longer device length. These findings can inform preoperative counselling and surgical planning.</p>","PeriodicalId":14068,"journal":{"name":"International Journal of Impotence Research","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148143450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}