International Journal of Geriatric Psychiatry最新文献

{"title":"Correction to Pre-Stroke and Early Post-Stroke Apathy Is Associated With Increased Risk of Dementia 3 Months After Stroke","authors":"","doi":"10.1002/gps.70062","DOIUrl":"https://doi.org/10.1002/gps.70062","url":null,"abstract":"<p>Lopatkiewicz AM, Slowik A, Dziedzic T. Pre-stroke and early post-stroke apathy is associated with increased risk of dementia 3 months after stroke. <i>Int J Geriatr Psychiatry</i>. 2023 Dec;38(12):e6043.</p><p>In the Table 1, information that scores of NPI-apathy, AES-C, NPI-depression and PHQ-9 are shown as <i>n</i> (%) is incorrect. These scores are expressed as mean (standard deviation).</p><p>We apologize for this error.</p>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 3","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/gps.70062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143497113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attitudes and Preferences Towards Screening for Dementia From the Perspectives of Healthcare Professionals: An Updated Systematic Review","authors":"Ríona Mc Ardle,&nbsp;Abigail Dsouza,&nbsp;Alexander Hagan,&nbsp;Amani Al-Oraibi,&nbsp;Matilda Hanjari,&nbsp;Blossom C. M. Stephan,&nbsp;Carol Brayne,&nbsp;Louise Lafortune,&nbsp;Manpreet Bains,&nbsp;Nadeem Qureshi,&nbsp;Louise Robinson","doi":"10.1002/gps.70057","DOIUrl":"https://doi.org/10.1002/gps.70057","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Approximately 55 million people are living with dementia globally. Global policies have suggested that screening for dementia in asymptomatic populations may support risk-reduction approaches to stem the rising numbers of people with the condition. A previous systematic review of literature up to 2012 indicated that healthcare professionals negatively view dementia screening; however, the research and clinical landscape has made significant advances in the last decade. Therefore, the aim of this systematic review is to re-examine the attitudes and preferences of healthcare professionals since 2012 regarding primary and community care-based dementia screening.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This review was pre-registered on PROSPERO (CRD42024531455) and followed PRISMA guidelines. Key terms relevant to the aim were input into six databases, and articles between 2012 and 2024 were considered. Titles, abstracts and full texts were independently screened by two reviewers. Articles were eligible for inclusion if peer-reviewed, written in English, considered primary or community care-based dementia screening and included healthcare perspectives from either quantitative or qualitative methods.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>From 18,732 identified titles, 19 articles were included in this review. Seventeen studies presented perspectives from primary care practitioners. Key findings suggest that healthcare professionals have mixed views regarding their willingness to conduct dementia screening, although limited studies suggest an interest in engaging in dementia risk reduction. Common influences on perspectives included knowledge, skills and training; resource provision; access to a dedicated screening service and referral pathways; and stigma.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings suggest that healthcare professionals' perspectives and resource are not aligned with international policies promoting dementia screening. When considering implementing evidence-based dementia screening in the future, a dedicated screening service is recommended.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 2","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/gps.70057","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143455797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the Numbers of Dementia in Brazil: A Delphi Consensus Study","authors":"Márlon Juliano Romero Aliberti,&nbsp;Claudia Kimie Suemoto,&nbsp;Jerson Laks,&nbsp;Paulo Caramelli,&nbsp;Sonia Maria Dozzi Brucki,&nbsp;Nicolas Farina,&nbsp;Daniel Apolinario,&nbsp;Einstein Francisco Camargos,&nbsp;Eleonora d'Orsi,&nbsp;Gilberto Sousa Alves,&nbsp;Karolina Gouveia César-Freitas,&nbsp;Luís Fernando Rangel,&nbsp;Márcia Lorena Fagundes Chaves,&nbsp;Marcos Antonio Lopes,&nbsp;Marcus Vinicius Della Coletta,&nbsp;Matheus Ghossain Barbosa,&nbsp;Norberto Anizio Ferreira Frota,&nbsp;Ricardo Nitrini,&nbsp;Cleusa Pinheiro Ferri","doi":"10.1002/gps.70055","DOIUrl":"https://doi.org/10.1002/gps.70055","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>As the global dementia crisis intensifies, especially in low-and middle-income countries (LMICs), there is a pressing need for comprehensive prevalence data across diverse regions, including Brazil, where studies have been predominantly limited to affluent urban centers. This study aimed to conduct an expert consensus to determine the prevalence of all-cause dementia in Brazil, considering various age groups, sexes, and geographical areas.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A Delphi consensus process with clinical and academic experts from across Brazil was conducted to provide dementia prevalence estimates in people aged ≥ 60 years living throughout Brazil for 2019. Each round consisted of answering structured questionnaires that incorporated information from the literature. A priori criteria were used to ascertain the point in which consensus was achieved for &gt; 70% of the 15 prevalence estimates—for (1) total, (2) women and men, and (3) the five Brazilian macro-regions. The current and projected dementia cases in Brazil were calculated based on age and sex population distributions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Fifteen experts, with a mean professional experience of 25 ± 10 years, reached a consensus in the fourth round. Experts agreed with a mean all-cause dementia prevalence of 8.5% among Brazilians aged ≥ 60 years, which comprised 2.46 million people in 2019 in this age. They reported higher dementia rates in women (9.1%) than men (7.7%); the highest total prevalence was in those over 80 where it exceeds 20%. Regional variations were also noted, with lower prevalence in the South (7.3%) and higher in the North (8.9%) and Northeast (10.1%). Projections estimate that considering Brazil’s rapidly aging population, dementia cases will rise to 8.89 million by 2060.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This Delphi study estimated that dementia already affects roughly 1 in 12 older Brazilians aged 60 and above, with slightly higher prevalence in women and significant geographical variations. These results underscore the urgency for targeted public health strategies in Brazil and offer a framework for similar challenges in other LMICs, especially given that dementia cases are projected to increase by approximately 3.6 times in 4 decades.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 2","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143397064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Incidence and Prevalence of Dementia Among Ontario Adults With and Without Intellectual and Developmental Disabilities","authors":"Prachi Patel,&nbsp;Winnie Sun,&nbsp;Andrea Mataruga,&nbsp;Kinwah Fung,&nbsp;Robert Balogh","doi":"10.1002/gps.70050","DOIUrl":"https://doi.org/10.1002/gps.70050","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>There are more than 66,000 Ontario adults living with intellectual and developmental disabilities (IDD). While the risk of dementia is well established among those with Down Syndrome (DS), there is limited research in persons with IDD excluding DS (Non-DS IDD). This study aimed to compare the incidence and prevalence of dementia in Ontario adults with and without IDD over time and by demographic information.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Administrative data were used to calculate and compare the annual age- and sex-adjusted cumulative incidence and period prevalence of dementia from fiscal years 2011/12 to 2020/21 in three cohorts: (1) Non-DS IDD, (2) DS, and (3) No IDD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Compared to persons without IDD, cumulative incidence of dementia was on average 4.27 and 5.33 times higher in persons with Non-DS IDD and DS respectively and period prevalence of dementia was on average 4.87 and 5.93 times higher in persons with Non-DS IDD and DS respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Given the increased rates of dementia within the IDD population, it is imperative that early dementia screening take place, appropriate health and social services are implemented and more actions are taken to delay the onset of dementia, while considering the needs of this population.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 2","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/gps.70050","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143396907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost-Effectiveness of the Tailored Activity Programme for Person With Dementia-Caregiver Dyads: A Markov Model","authors":"Brenda Gannon,&nbsp;Vinh Vo,&nbsp;Laura N. Gitlin,&nbsp;Sally Bennett","doi":"10.1002/gps.70049","DOIUrl":"https://doi.org/10.1002/gps.70049","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The Tailored Activity Programme (TAP) is a home-based programme with compelling outcomes for reducing behavioural and psychological symptoms of dementia and functional decline. We conducted a cost-utility analysis of TAP compared to usual care, for the person with dementia and their caregiver.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We developed a Markov Model, from the healthcare sector perspective. Using parameters from the dementia care literature. Base-case and probabilistic sensitivity analyses were applied to handle uncertainty.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Given the growing need for cost-effective dementia care, understanding the cost-effectiveness of TAP is crucial for health service design and its implementation into healthcare settings. Our study shows that TAP is cost-effective for both males and females with dementia and their caregivers. The most favourable cost-effectiveness acceptability curves were found in men and women with dementia, aged 50 to 70, with lower costs and higher QALYs compared to those over 80. The probability of TAP being cost-effective rises with public higher willingness-to-pay thresholds, especially for people with dementia in the age group of 50–70.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings indicate TAP is highly cost-effective for individuals living with dementia compared to usual home care, which provides evidence for policy makers towards their decisions on resource allocation and for implementing TAP in Australia.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 2","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/gps.70049","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143380164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Longitudinal Trajectories of Physical Frailty With Dementia Status in Older Adults: A National Cohort Study","authors":"Fen Ye,&nbsp;Weijiao Zhou,&nbsp;Junlan Pu,&nbsp;Haobo Chen,&nbsp;Xiurong Wang,&nbsp;Jung Jae Lee","doi":"10.1002/gps.70051","DOIUrl":"https://doi.org/10.1002/gps.70051","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background and Objectives&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;The longitudinal patterns of change in physical frailty and their associations with the subsequent dementia risk remain unclear. This study aimed to (1) explore the long-term trajectories of physical frailty over a 6-year period in older adults without dementia at baseline; (2) identify the socio-demographic and health-related factors associated with different physical frailty trajectories; and (3) examine the longitudinal relationships between different physical frailty trajectories and subsequent risk of dementia.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Research Design and Methods&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This national cohort study used data from the National Health and Aging Trends Study (NHATS) conducted in the United States from 2015 to 2021 and included adults aged ≥ 65 without dementia (&lt;i&gt;n&lt;/i&gt; = 2245) at baseline in 2015. Group-based trajectory modeling was used to describe the longitudinal changes. Socio-demographic and health-related characteristics were compared across the identified physical frailty trajectories using bivariate analyses, employing Rao–Scott chi-square tests for categorical variables and design-based F-tests for continuous variables. Multinomial logistic regression analyses were conducted to examine the relationships between different frailty trajectories and subsequent dementia status.&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Results&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;Three frailty trajectories were identified: low-stable (74.00%), low-increasing (21.14%), and high-level (4.86%). Participants in the low-increasing and high-level groups were predominantly older, female, minorities, unmarried, and less educated and had a lower income, more comorbidities, and greater anxiety and depression symptoms (&lt;i&gt;p&lt;/i&gt; &lt; 0.001). Compared with the low-stable group, older adults in the low-increasing group had higher risk of possible dementia (RRR: 2.37, 95% CI: 1.41–3.97, &lt;i&gt;p&lt;/i&gt; &lt; 0.001) and probable dementia (RRR: 1.71, 95% CI: 1.08–2.73, &lt;i&gt;p&lt;/i&gt; = 0.02); similarly, older adults in the high-level group had higher risks of possible dementia (RRR: 4.24, 95% CI: 1.74–10.36, &lt;i&gt;p&lt;/i&gt; &lt; 0.001) and probable dementia (RRR: 2.99, 95% CI: 1.32–6.76, &lt;i&gt;p&lt;/i&gt; = 0.01). No significant differences were found in the risk of dementia between the high-level frailty group and the low-increasing frailty group (&lt;i&gt;p&lt;/i&gt; &gt; 0.05).&lt;/p&gt;\u0000 &lt;/section&gt;\u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Conclusion and Implications&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study highlighted the importance of regular frailty monitoring for early detection and informed future interventions that could delay frailty progress","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 2","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/gps.70051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143111153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of a Dementia Diagnosis on Clinical Decision-Making in Dysphagia Management","authors":"Angela J. Van Sickle,&nbsp;Ed M. Bice","doi":"10.1002/gps.70048","DOIUrl":"10.1002/gps.70048","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The main objective of this survey was to determine the effects of a dementia diagnosis on dysphagia management by speech-language pathologists (SLP).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A survey of SLPs interested and/or working with individuals with dysphagia was conducted via a website. The SLPs viewed two written cases of patients with dysphagia, one with dementia and one without dementia. Both cases included a video capture of the patients' swallows. SLPs answered specific questions related to each case and video.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Frequency counts, McNemar's Test, and descriptive analysis of responses showed that participants were less likely to initiate dysphagia therapy (<i>p</i> &lt; 0.001) or use rehabilitative swallowing strategies (<i>p</i> = 0.008) for individuals with dysphagia and a dementia diagnosis than for an individual with dysphagia without a dementia diagnosis. In addition, SLPs overidentified impairments and chose treatment targets not present.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Based on the current survey, SLPs displayed a bias when the diagnosis of dementia was present. The bias appears to exist regardless of experience or education. Not initiating treatment or not providing rehabilitative strategies may have detrimental effects on the health and quality-of-life of individuals with dementia.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 2","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11785825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recorded Loneliness and Adverse Outcomes in Older Acute Care Inpatients Receiving Psychiatric Assessment","authors":"Moyenda Joseph,&nbsp;Kate Lockie,&nbsp;Agnes Mbazira,&nbsp;Robert Stewart","doi":"10.1002/gps.70052","DOIUrl":"10.1002/gps.70052","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>We investigated the prevalence of loneliness recorded during assessment of general hospital inpatients by older adult liaison psychiatry services and its associations with level of subsequent hospitalisation, emergency presentation and mortality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data were drawn from a large south London mental healthcare provider of older adult liaison psychiatry services to four acute general hospitals. The sample comprised all patients receiving assessments from these services from 2007–2017. Recorded loneliness was ascertained from text fields via a bespoke natural language processing algorithm and, via a linkage with national hospitalisation data, was investigated as a risk factor for repeat emergency department (ED) attendance, inpatient days in the subsequent 12 months, and mortality.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In 11,631 patients assessed, loneliness was recorded in 11.2%. After adjustment for a range of demographic and health covariates, recorded loneliness was associated with an increased risk of ED attendance, but with lower mortality and, in survivors, with fewer hospitalisation days over a 12-month follow-up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Loneliness is recorded in over 10% of inpatients assessed by older adult liaison services and is likely to be present in substantially more. Lack of recording in more severe illness and/or cognitive disorders may explain associations with lower mortality and hospitalisation days. Its association with higher likelihood of repeat ED attendance suggests that loneliness should be considered more routinely in clinical assessments, possibly with formal screening.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 2","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11781905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143065370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ApoE Genotype, Age, and Cognitive Decline in Old Chinese Individuals Without Dementia: A Population-Based Study With Five-Year Follow-Up","authors":"Hao Wu,&nbsp;Xingzhong Gu,&nbsp;Shuai Liu,&nbsp;Pan Wang,&nbsp;Hui Lu,&nbsp;Yalin Guan,&nbsp;Zhihong Shi,&nbsp;Yong Ji","doi":"10.1002/gps.70045","DOIUrl":"10.1002/gps.70045","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Apolipoprotein E (ApoE) ε4 genotype is a well-known risk factor for Alzheimer's disease (AD). However, its effect on predicting cognitive decline in individuals without dementia and its association with age are unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To investigate the relationship between ApoE polymorphism and risk of cognitive decline and dementia incidence in the elderly without dementia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This population-based prospective study was conducted between 2011 and 2016. The study involved 767 dementia-free individuals who had undergone ApoE genotype analysis, were aged ≥ 60 years, and lived in rural China. Participants were divided into three ApoE groups: E3 (genotype 3/3), E4 (genotypes 3/4 and 4/4), and E2 (genotype 2/3) groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>After 5 years, 666 (86.8%) individuals were followed up. The rate of change in MMSE score was faster in the E4 group than in the E3 and E2 groups (5.0 ± 4.4 vs. 3.5 ± 3.8 vs. 3.9 ± 3.9, <i>p</i> = 0.001), after adjusting for age, sex, educational level and baseline MMSE scores, especially in the 70–79 years age group. In the same age group, the incidence rate of dementia was higher in the E4 group than in the E3 group (OR = 2.850; 95% CI: 1.146–7.090). After adjusting for age, sex, hypertensive status, educational level, marital status, engagement in social activities, and past history of stroke, the ApoE ε4 allele remained an independent risk factor for dementia incidence (OR = 3.070; 95% CI: 1.162–8.110) in individuals aged 70–79 years after follow-up.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>ApoE ε4 carriers with age ≥ 60 years had faster cognitive decline. The ApoE ε4 allele was an independent risk factor for dementia incidence in extremely old individuals.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Housing Relocation and Residential Satisfaction After Relocation: Effects of Dwelling Condition Changes on Older Adults in the Community","authors":"Gum-Ryeong Park,&nbsp;Bo Kyong Seo,&nbsp;Eun Ha Namkung","doi":"10.1002/gps.70044","DOIUrl":"10.1002/gps.70044","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>This study seeks to analyze the trajectories of residential satisfaction among older adults before and after relocation and explore the variability in the relationship between relocation and residential satisfaction based on changes in housing conditions during the relocation process.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Utilizing a nationally representative longitudinal dataset of older adults (<i>N</i> = 2718), this study employs individual-level fixed effect regression models to estimate the association between the timing of relocation and residential satisfaction. Stratified analyses are also conducted to explore how this association varies based on changes in housing conditions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Residential satisfaction tends to decrease before relocation, peaks at the time of relocation, and maintain higher levels as older adults adapt to their new environment. This adaptation process varies depending on changes in dwelling conditions during relocation, with transitions from poor to non-poor housing conditions positively affecting psychological responses, while moves from non-poor to poor conditions can lead to increased psychological burden and prolonged adjustment periods.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion</h3>\u0000 \u0000 <p>Aging policies can prioritize programs that facilitate adjustment to new environments to improve residential satisfaction of older adults, thereby promoting healthy aging.</p>\u0000 </section>\u0000 </div>","PeriodicalId":14060,"journal":{"name":"International Journal of Geriatric Psychiatry","volume":"40 1","pages":""},"PeriodicalIF":3.6,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143005161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}