Yvonne C. M. Rensen, Corrie de Waal - Gordijn, Roy P. C. Kessels
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Finally, we assessed the convergent validity and investigated whether QUALIKO-SR scores were related to the severity of the cognitive impairments.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>The study took place in specialized long-term care facilities providing care for patients with KS. 116 patients with alcoholic KS participated in this study. The QUALIKO-SR was developed and validated against the QUALIKO-PV, the Manchester Short Assessment of Quality of Life (MANSA-16), and the Montreal Cognitive Assessment 8.1 (MoCA).</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Significant differences were found between self- and proxy reported QoL on the subscales Negative Affect, Social Isolation, and Feeling at Home. No significant differences were found on the other subscales. QUALIKO-SR scores did not significantly vary over time. However, caregivers reported significant improvements in Care Relationships, Autonomy, Restless Tense Behavior, Social Isolation, and Feeling at Home over time. A significant, positive association was found between the QUALIKO-SR and the MANSA-16. No significant correlations were found between the QUALIKO-SR and the MoCA.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>This study describes the development and validation of a self-report instrument for objectifying QoL in patients with KS living in 24-h care facilities, the QUALIKO-SR. Measuring QoL in patients with severe cognitive impairments, such as patients with KS, is complex and we advise to include both self-report and proxy-report measures in future studies as well as in clinical practice. 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引用次数: 0
摘要
评估（自我报告的）科萨科夫综合征（KS）患者的生活质量（QoL）对于深入了解这些患者的健康状况和优化他们在长期护理机构的护理非常重要。在本研究中，我们描述了qualko - self Report （QUALIKO-SR）的发展，这是一种客观化KS患者自我报告生活质量的工具。接下来，我们将QUALIKO-SR分数与QUALIKO-Proxy Version （QUALIKO-PV）分数进行比较，并检查生活质量随时间的变化。最后，我们评估了趋同效度，并研究了QUALIKO-SR评分是否与认知障碍的严重程度相关。方法本研究在专门为KS患者提供护理的长期护理机构中进行。116例酒精性KS患者参与了本研究。根据QUALIKO-PV、曼彻斯特生活质量短期评估（MANSA-16）和蒙特利尔认知评估8.1 （MoCA）开发并验证了QUALIKO-SR。结果自我和代理报告的生活质量在消极情绪、社会孤立和家的感觉三项量表上存在显著差异。在其他量表上没有发现显著差异。QUALIKO-SR评分随时间变化不显著。然而，护理人员报告说，随着时间的推移，他们在护理关系、自主性、不安紧张行为、社会隔离和家的感觉方面有了显著的改善。在QUALIKO-SR和MANSA-16之间发现了显著的正相关。QUALIKO-SR与MoCA之间无显著相关。本研究描述了一种自我报告工具的开发和验证，用于客观化生活在24小时护理机构的KS患者的生活质量，即QUALIKO-SR。测量严重认知障碍患者（如KS患者）的生活质量是复杂的，我们建议在未来的研究和临床实践中同时采用自我报告和代理报告的测量方法。QUALIKO-SR和QUALIKO-PV的可用性鼓励研究人员和临床医生在KS患者中这样做。
Validity and Sensitivity to Change of a Self-Report Quality of Life Measure in Patients With Korsakoff's Syndrome
Background
Assessing (self-reported) quality of life (QoL) in patients with Korsakoff's syndrome (KS) is important to gain insight into these patients' well-being and to optimize their care in long-term care facilities. In this study, we describe the development of the QUALIKO-Self Report (QUALIKO-SR), an instrument for objectifying self-reported QoL in patients with KS. Next, we compared the QUALIKO-SR scores with the scores on the QUALIKO-Proxy Version (QUALIKO-PV) and examined changes in QoL over time. Finally, we assessed the convergent validity and investigated whether QUALIKO-SR scores were related to the severity of the cognitive impairments.
Methods
The study took place in specialized long-term care facilities providing care for patients with KS. 116 patients with alcoholic KS participated in this study. The QUALIKO-SR was developed and validated against the QUALIKO-PV, the Manchester Short Assessment of Quality of Life (MANSA-16), and the Montreal Cognitive Assessment 8.1 (MoCA).
Results
Significant differences were found between self- and proxy reported QoL on the subscales Negative Affect, Social Isolation, and Feeling at Home. No significant differences were found on the other subscales. QUALIKO-SR scores did not significantly vary over time. However, caregivers reported significant improvements in Care Relationships, Autonomy, Restless Tense Behavior, Social Isolation, and Feeling at Home over time. A significant, positive association was found between the QUALIKO-SR and the MANSA-16. No significant correlations were found between the QUALIKO-SR and the MoCA.
Conclusions
This study describes the development and validation of a self-report instrument for objectifying QoL in patients with KS living in 24-h care facilities, the QUALIKO-SR. Measuring QoL in patients with severe cognitive impairments, such as patients with KS, is complex and we advise to include both self-report and proxy-report measures in future studies as well as in clinical practice. The availability of the QUALIKO-SR and QUALIKO-PV encourages researchers and clinicians to do so in patients with KS.
期刊介绍：
The rapidly increasing world population of aged people has led to a growing need to focus attention on the problems of mental disorder in late life. The aim of the Journal is to communicate the results of original research in the causes, treatment and care of all forms of mental disorder which affect the elderly. The Journal is of interest to psychiatrists, psychologists, social scientists, nurses and others engaged in therapeutic professions, together with general neurobiological researchers.
The Journal provides an international perspective on the important issue of geriatric psychiatry, and contributions are published from countries throughout the world. Topics covered include epidemiology of mental disorders in old age, clinical aetiological research, post-mortem pathological and neurochemical studies, treatment trials and evaluation of geriatric psychiatry services.
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