International Journal of Environmental Health Research最新文献

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The occurrence, concentration, and human health risk assessment of deoxynivalenol in beer: a global systematic review and meta-analysis.
IF 2.2 4区 医学
International Journal of Environmental Health Research Pub Date : 2025-03-22 DOI: 10.1080/09603123.2025.2482073
Denis A Nikolenko, Yadolah Fakhri, Fereshteh Mehri, Amirhossein Mahmoudizeh, Somayeh Dehghani, Behnam Khodadoust, Amin Mousavi Khaneghah
{"title":"The occurrence, concentration, and human health risk assessment of deoxynivalenol in beer: a global systematic review and meta-analysis.","authors":"Denis A Nikolenko, Yadolah Fakhri, Fereshteh Mehri, Amirhossein Mahmoudizeh, Somayeh Dehghani, Behnam Khodadoust, Amin Mousavi Khaneghah","doi":"10.1080/09603123.2025.2482073","DOIUrl":"https://doi.org/10.1080/09603123.2025.2482073","url":null,"abstract":"<p><p>This study examined the concentration and occurrence of deoxynivalenol (DON) in beer and calculated the health risk to consumers using the target hazard quotient (THQ). The analysis considered the country and type of DON subgroups. Searches were performed in databases including Scopus, Web of Science, Embase, and PubMed from 1 January 2000, to 20 February 2024. Our study included 26 papers with 154 data reports. The rank order of DON types based on occurrence was DON (67.38%) > DON-3-Glc (61.45%) > DON-15-Ac (3.43%) > DON-3-Ac (2.58%). Based on concentration, DON (14.658 µg L⁻¹) > DON-3-Glc (14.190 µg L-1) > DON-15-Ac (13.023 µg L⁻¹) > DON-3-Ac (7.550 µg L⁻¹). The highest concentrations of DON, DON-3-Ac, DON-15-Ac, and DON-3-Glc in beer were observed in Cameroon (227.797 µg L⁻¹), Nigeria (27.000 µg L⁻¹), Nigeria (30.000 µg L⁻¹), and the Czech Republic (44.050 µg L⁻¹), respectively. The meta-regression reveals a significant decrease in the occurrence of DON in beer over time (C: -0.014; p-value = 0.016). Despite the higher health risk in Cameroon, Brazil, and Latvia compared to other countries, the health risk assessment revealed no significant non-carcinogenic risk for consumers.</p>","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"1-13"},"PeriodicalIF":2.2,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Short-term exposure to PM2.5 and its components and type 2 diabetes-related hospital admissions, length of stay, and hospital costs in Shanghai.
IF 2.2 4区 医学
International Journal of Environmental Health Research Pub Date : 2025-03-19 DOI: 10.1080/09603123.2025.2477582
Hongyu Liang, Wenyong Zhou, Zexuan Wen, Jing Wei, Weibing Wang, Jun Li
{"title":"Short-term exposure to PM<sub>2.5</sub> and its components and type 2 diabetes-related hospital admissions, length of stay, and hospital costs in Shanghai.","authors":"Hongyu Liang, Wenyong Zhou, Zexuan Wen, Jing Wei, Weibing Wang, Jun Li","doi":"10.1080/09603123.2025.2477582","DOIUrl":"https://doi.org/10.1080/09603123.2025.2477582","url":null,"abstract":"<p><p>The short-term influence of particles with an aerodynamic diameter ≤2.5 μm (PM<sub>2.5</sub>) and its individual elements on hospital costs, the length of hospital stay (LOS), and hospital admissions caused by type 2 diabetes remains unclear. A generalized additive model (GAM) with quasi-Poisson distribution was utilized to assess the association of individual pollutants and mixtures. For every 10 μg/m<sup>3</sup> rise in PM<sub>2.5</sub> and a per-SD increase in NH<sub>4</sub><sup>+</sup>at lag0, hospital admissions increased by 0.93% (95% CI: 0.68, 1.19) and 2.81% (95% CI: 2.20, 3.42); hospital costs rose by 24.58 thousands of CNY (95% CI: 5.95, 43.22) and 77.06 thousands of CNY (95% CI: 33.07, 121.04); LOS increased by 9.53 days (95% CI: 0.44, 18.62) and 27.80 days (95% CI: 6.34, 49.27), respectively. Factor analysis showed that mixed-source particulate pollution was significantly associated with an increase in hospital admissions (0.27%, 95% CI: (0.20, 0.34)), LOS (2.87 days, 95% CI: (0.35, 5.40)), and hospital costs (71.68 thousands of CNY, 95% CI: (19.89,123.46)). These findings suggested that short-term exposure to elevated levels of PM<sub>2.5</sub> as well as its components increased the risk of hospital costs, LOS, and hospital admissions due to type 2 diabetes.</p>","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"1-14"},"PeriodicalIF":2.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of ambient fine particulate matter on the exacerbation of psychiatric disorders in southern Taiwan: a case-crossover study. 环境细颗粒物对台湾南部精神疾病恶化的影响:病例交叉研究。
IF 2.2 4区 医学
International Journal of Environmental Health Research Pub Date : 2025-03-19 DOI: 10.1080/09603123.2025.2480853
Su-Lun Hwang, Yu-Ching Lin, Chieh-Mo Lin, Miao-Ching Chi
{"title":"Effects of ambient fine particulate matter on the exacerbation of psychiatric disorders in southern Taiwan: a case-crossover study.","authors":"Su-Lun Hwang, Yu-Ching Lin, Chieh-Mo Lin, Miao-Ching Chi","doi":"10.1080/09603123.2025.2480853","DOIUrl":"https://doi.org/10.1080/09603123.2025.2480853","url":null,"abstract":"<p><p>This study investigated the impact of short-term exposures to ambient fine particulate matter 2.5 (PM<sub>2.5</sub>) on the exacerbation of psychiatric disorders (PDs) in southern Taiwan between 2014 and 2020. Data on emergency room visits (ERVs) for PDs and air pollutant levels were obtained from the Chang Gung Research Database and the Environmental Protection Administration, respectively. A time-stratified case-crossover design was adopted to estimate the risks of ERVs for PDs. At lag4 days, a 10-μg/m<sup>3</sup> increase in PM<sub>2.5</sub> was associated with significant increases in ERVs in both single- and multi-pollutant models, with odds ratio (OR) of 1.18 [95% confidence interval (95% CI): 1.00, 1.38] (PM<sub>2.5</sub>), 1.20 (95% CI: 1.00, 1.43) (PM<sub>2.5</sub> + SO<sub>2</sub>), 1.23 (95% CI: 1.03, 1.46) (PM<sub>2.5</sub> + O<sub>3</sub>), and 1.25 (95% CI: 1.03, 1.52) (PM<sub>2.5</sub> + SO<sub>2</sub> + O<sub>3</sub>). For cumulative lags (lag0-6), a 10-μg/m<sup>3</sup> increase in PM<sub>2.5</sub> was associated with significant increases in ERVs only for multi-pollutant model (PM<sub>2.5</sub> + SO<sub>2</sub>), with OR of 1.41 (95% CI: 1.03, 1.93). Among males, significant increases in ERVs were observed at lag4 and lag0-6 days; however, no significant associations were observed in females. In conclusion, short-term exposure to PM<sub>2.5</sub> increased the risk of PDs exacerbation, exhibiting both delayed and cumulative effects, with male patients found to be more sensitive.</p>","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"1-12"},"PeriodicalIF":2.2,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human health risk assessment of dietary metal intake through commonly consumed vegetables in Gaya District, Bihar, India.
IF 2.2 4区 医学
International Journal of Environmental Health Research Pub Date : 2025-03-17 DOI: 10.1080/09603123.2025.2478243
Jayprabha Singh, Nighat Parveen, Ankita Singh, Soma Giri, Abhay Kumar Singh
{"title":"Human health risk assessment of dietary metal intake through commonly consumed vegetables in Gaya District, Bihar, India.","authors":"Jayprabha Singh, Nighat Parveen, Ankita Singh, Soma Giri, Abhay Kumar Singh","doi":"10.1080/09603123.2025.2478243","DOIUrl":"https://doi.org/10.1080/09603123.2025.2478243","url":null,"abstract":"<p><p>This study assessed the concentration of Al, As, Cd, Co, Cr, Cu, Fe, Mn, Ni, Pb, Se, and Zn in commonly grown vegetables collected from the Gaya district of Bihar. Metals were determined using Inductively Coupled Plasma Mass Spectrometry following sample preparation and digestion. As, Cr, Ni, Pb and Zn exceeded the maximum allowable concentration of Food and Agricultural Organization in some of the vegetable samples. Non-carcinogenic human health risk assessment due to ingestion of vegetables was estimated using Hazard Quotient (HQ) and Hazard Index (HI) which revealed that non-carcinogenic risks were primarily due to Co, followed by Cr and Fe. The risk was higher in the leafy and underground vegetables as compared to the fruit vegetables. Of all the locations, the highest risk was estimated for Fatehpur, followed by Manpur and Bodhgaya, which was attributed to the anthropogenic activities of the locations. The HI exceeded unity in 64.3% of the vegetable samples, indicating potential health risks to the consumers and suggesting that vegetables from some locations in the Gaya district might have food safety issues. Periodic soil testing, irrigation water management, and avoidance of leafy vegetables from polluted sites are suggested to lower the health risks associated with vegetable consumption.</p>","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"1-15"},"PeriodicalIF":2.2,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparative analysis of lipid profiles and antioxidant potential of Coriandrum sativum fruit oils from Tunisia and Canada: influence of extraction methods.
IF 2.2 4区 医学
International Journal of Environmental Health Research Pub Date : 2025-03-16 DOI: 10.1080/09603123.2025.2480855
Jazia Sriti, Baya Mhamdi, Gaith Hamdaoui, Thierry Talou, Muriel Cerny, Kamel Msaada
{"title":"Comparative analysis of lipid profiles and antioxidant potential of <i>Coriandrum sativum</i> fruit oils from Tunisia and Canada: influence of extraction methods.","authors":"Jazia Sriti, Baya Mhamdi, Gaith Hamdaoui, Thierry Talou, Muriel Cerny, Kamel Msaada","doi":"10.1080/09603123.2025.2480855","DOIUrl":"https://doi.org/10.1080/09603123.2025.2480855","url":null,"abstract":"<p><p>This study investigated the lipid profiles and free radical scavenging potential of <i>Coriandrum sativum</i> fruit oils from Tunisia and Canada, utilizing three extraction methods: single screw, twin screw, and solvent extraction. Significant differences (<i>p</i> < 0.05) were found in the concentrations of essential fatty acids, including petroselinic, linoleic, oleic, and palmitic acids, between oils from the two regions. Notably, the twin screw extraction method applied to Tunisian coriander oils resulted in higher phytochemical content and superior free radical scavenging activity. The twin screw method demonstrated the highest efficacy, achieving an IC<sub>50</sub> value of 1.4 mg/ml for the stable DPPH radical, while the solvent extraction method yielded an IC<sub>50</sub> of 4 mg/ml for the same oil. These findings highlight the influence of geographic origin and extraction techniques on the nutritional and antioxidant properties of coriander oils.</p>","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"1-11"},"PeriodicalIF":2.2,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterizing air pollution exposure methodologies in rhinology: a scoping review.
IF 2.2 4区 医学
International Journal of Environmental Health Research Pub Date : 2025-03-13 DOI: 10.1080/09603123.2025.2477585
Conner J Massey, Benton Tullis, Colin Johnson, Gretchen Oakley, Richard Orlandi, Jeremiah Alt, Abigail Pulsipher, Amarbir Gill, John Horel, Kristine Smith
{"title":"Characterizing air pollution exposure methodologies in rhinology: a scoping review.","authors":"Conner J Massey, Benton Tullis, Colin Johnson, Gretchen Oakley, Richard Orlandi, Jeremiah Alt, Abigail Pulsipher, Amarbir Gill, John Horel, Kristine Smith","doi":"10.1080/09603123.2025.2477585","DOIUrl":"https://doi.org/10.1080/09603123.2025.2477585","url":null,"abstract":"<p><p>ABST RACTCharacterization of air pollution assessment methodologies in rhinologic disease research is lacking. A scoping review was thus conducted to survey exposure methods in studies examining common rhinologic conditions: allergic rhinitis (AR) and chronic rhinosinusitis (CRS). Several medical databases were queried for variables relating to (1) adults with a diagnosis of CRS or AR and (2) air pollution exposure. Data was extracted for pollutants assessed, method of quantifying exposure, assessment of residential stability, inclusion of authors with expertise in environmental exposure assessment, and disease-related outcomes. Thirty-four articles were included for analysis - 16 for AR and 18 for CRS. Fifteen studies originated from East Asia, 10 from North America, and 6 from Europe. The most common pollutant studied was PM2.5 (28 studies), with most studies investigating multiple pollutants. Twenty-one studies used a nearby air monitor to quantify exposure, 9 studies reported whether subjects had residential stability for the period assessed, and 17 studies included authors with climate science background. Timeframes included both acute and chronic exposure. Current methods to quantify air pollution exposure in rhinology vary considerably and inconsistently employ expertise from environmental scientists. Future investigations may benefit from multidisciplinary collaboration, reporting of residential stability, and standardized reporting metrics.</p>","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"1-16"},"PeriodicalIF":2.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Changes in access to household handwashing facility and hygiene practice in Kanyama peri-urban, Zambia - a repeated cross-sectional study.
IF 2.2 4区 医学
International Journal of Environmental Health Research Pub Date : 2025-03-13 DOI: 10.1080/09603123.2025.2478249
Jessy Zgambo, Sikopo Nyambe, Taro Yamauchi
{"title":"Changes in access to household handwashing facility and hygiene practice in Kanyama peri-urban, Zambia - a repeated cross-sectional study.","authors":"Jessy Zgambo, Sikopo Nyambe, Taro Yamauchi","doi":"10.1080/09603123.2025.2478249","DOIUrl":"https://doi.org/10.1080/09603123.2025.2478249","url":null,"abstract":"<p><p>Hand hygiene is an essential behaviour that significantly enhances public health, especially in resource-limited settings with inadequate water supply and sanitation services. However, hand hygiene practices and access to facilities remain a challenge. We aimed to assess handwashing facilities and practice of hand hygiene in a peri-urban community of Zambia - Southern Africa. A repeated cross-sectional survey was conducted in Lusaka in 2018 and 2022 on 318households for both surveys. Data were collected using a Water Sanitation and Hygiene (WASH) questionnaire and checklist on household and handwashing facility characteristics, participants' sociodemographic characteristics and methods of hand hygiene practice. Descriptive analysis, chi-square and logistic regression tests were used to analyse the data. Households without handwashing facilities increased by 20%, while those with handwashing facilities with soap and water reduced from 14% to 0%. Using soap and water was higher in 2018 than 2022 (<i>p</i> ≤ 0.05). The chances of handwashing with soap and water were reduced in males, those over 40 years old, married/living with a partner, and employed. The study revealed a decline in access to handwashing facilities and hygiene practices, indicating the need for strategies to enhance hand hygiene in peri-urban areas and individuals of all demographics.</p>","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"1-14"},"PeriodicalIF":2.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of ethylene oxide exposure with all-cause mortality risk among adult population with different stages of diabetes progression.
IF 2.2 4区 医学
International Journal of Environmental Health Research Pub Date : 2025-03-13 DOI: 10.1080/09603123.2025.2478620
Yi-Xiong Gao, Xin Tan
{"title":"Association of ethylene oxide exposure with all-cause mortality risk among adult population with different stages of diabetes progression.","authors":"Yi-Xiong Gao, Xin Tan","doi":"10.1080/09603123.2025.2478620","DOIUrl":"https://doi.org/10.1080/09603123.2025.2478620","url":null,"abstract":"<p><p>The actual effects of ethylene oxide (EO) exposure on diabetes population are unknown. This prospective study aimed to examine the association of EO with all-cause mortality risk among adults with different stages of diabetes progression. Study participants were selected from NHANES 2013-2018. The mortality was ascertained through linkage to National Death Index files. Data were analyzed using weighted Cox proportional regressions to examine the associations of hemoglobin adducts of EO (HbEO) with all-cause mortality risk. Restricted cubic spline was applied to flexibly model the non-linear association. Results showed the median of follow-up period was 48.0 months. The participants with diabetes had the highest mortality (<i>p</i> = 0.001). The association of all-cause mortality risk with HbEO was overall positive among diabetes (weighted covariates-adjusted HR: 1.089, 95% CI: 1.028-1.155) but not non-diabetes participants. Among diabetes participants, the association was non-linear (p for non-linearity test: 0.023) and was non-significant when the HbEO level was higher than 310.24 pmol/g Hb. In conclusion, EO may increase the mortality risk among diabetes population through aggravating the diabetes-mediated metabolic disorders. The non-linear association found for the first time may reflect the complex physiological effects of the enzymes that contribute to EO endogenous formation or metabolism.</p>","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"1-10"},"PeriodicalIF":2.2,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Staphylococcus aureus detachment from linoleum surface: influence of liquid flow rate and cleaner type.
IF 2.2 4区 医学
International Journal of Environmental Health Research Pub Date : 2025-03-12 DOI: 10.1080/09603123.2024.2424968
A Zore, M Jevšnik, L Roblek, G Štefanić, M Modic, J Čáslavský, P Trebše, M Bavcon Kralj, A Abram, D Kovačević, P Raspor, K Bohinc, L Mravcová
{"title":"<i>Staphylococcus aureus</i> detachment from linoleum surface: influence of liquid flow rate and cleaner type.","authors":"A Zore, M Jevšnik, L Roblek, G Štefanić, M Modic, J Čáslavský, P Trebše, M Bavcon Kralj, A Abram, D Kovačević, P Raspor, K Bohinc, L Mravcová","doi":"10.1080/09603123.2024.2424968","DOIUrl":"https://doi.org/10.1080/09603123.2024.2424968","url":null,"abstract":"<p><p>The aim of this research is to analyse the impact of surface cleaner type and hydrodynamic flow on bacterial detachment. For that purpose, a new liquid flow chamber was constructed and applied. In experiments, <i>Staphylococcus aureus</i> was grown on linoleum surfaces that are used in health care institutions. The bare surfaces were characterized by contact angle, zeta potential and surface roughness measurements. Material element analysis of linoleum was made. The main object is to determine how efficient different clearner type and strength of the liquid flow remove adhered bacteria from the linoleum surface. Bacterial detachment from linoleum surface was studied by turbulent liquid flow of cleaning solutions at room temperature. The impact of different surface cleaners on bacterial detachment was examined and compared to the effect of distilled water. For this reason, the exact identification of cleaner constituents was performed. Very realistic cleaning technique based on multiple swiping with a cloth was also applied. Results show that the turbulent flow can remove a significant number of bacteria adhered to the linoleum surface. The effect increases with the liquid flow rate and is cleaner specific.</p>","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"1-13"},"PeriodicalIF":2.2,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143614893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The mitigation mechanism of morin on PM2.5-induced apoptosis by inhibiting mitochondrial damage via the ROS/ERK signaling pathway in human HaCaT keratinocytes.
IF 2.2 4区 医学
International Journal of Environmental Health Research Pub Date : 2025-03-11 DOI: 10.1080/09603123.2025.2472999
Herath Mudiyanselage Udari Lakmini Herath, Mei Jing Piao, Kyoung Ah Kang, Pincha Devage Sameera Madushan Fernando, Changlim Hyun, Suk Ju Cho, Jin Won Hyun
{"title":"The mitigation mechanism of morin on PM<sub>2.5</sub>-induced apoptosis by inhibiting mitochondrial damage via the ROS/ERK signaling pathway in human HaCaT keratinocytes.","authors":"Herath Mudiyanselage Udari Lakmini Herath, Mei Jing Piao, Kyoung Ah Kang, Pincha Devage Sameera Madushan Fernando, Changlim Hyun, Suk Ju Cho, Jin Won Hyun","doi":"10.1080/09603123.2025.2472999","DOIUrl":"https://doi.org/10.1080/09603123.2025.2472999","url":null,"abstract":"<p><p>Particulate matter 2.5 (PM<sub>2.5</sub>) can penetrate the human skin, causing inflammatory disease, senescence, and carcinogenesis. This study assessed the effects of morin on PM<sub>2.5</sub>-induced apoptosis of HaCaT human keratinocytes. According to our results, morin at concentrations up to 12 µg/mL did not exhibit any harmful effects on cells and effectively reduced the generation of reactive oxygen species induced by PM<sub>2.5</sub>. Furthermore, morin significantly inhibited PM<sub>2.5</sub>-induced macromolecular damage, mitochondrial damage, and expression of pro-apoptotic proteins. Moreover, the cytoprotective effects of morin correlated with the activation of the transcription factor nuclear factor erythroid 2-related factor 2 and heme oxygenase-1 expression. The results of our experiments using a mitogen-activated protein kinase kinase inhibitor indicated that morin protected cells from apoptosis by the extracellular signal-regulated kinase pathway. Morin mitigated skin damage caused by PM<sub>2.5</sub> via attenuation of oxidative stress, mitochondrial dysfunction, and apoptosis.</p>","PeriodicalId":14039,"journal":{"name":"International Journal of Environmental Health Research","volume":" ","pages":"1-16"},"PeriodicalIF":2.2,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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