International Journal of Medical Physics, Clinical Engineering and Radiation Oncology最新文献

{"title":"Dosimetric Comparison between Three Dimensional Conformal Radiation Therapy (3DCRT) & Intensity Modulated Radiation Therapy (IMRT) in Mid-Lower Oesophageal Carcinoma","authors":"A. N. Taher, Rasha A. Elawady, A. Amin","doi":"10.4236/IJMPCERO.2019.82011","DOIUrl":"https://doi.org/10.4236/IJMPCERO.2019.82011","url":null,"abstract":"Purpose: To investigate if intensity modulated radiation therapy (IMRT) offers a better planning target volume (PTV) coverage and/or lower dose to normal thoracic structures in comparison to three dimensional conformal radiation therapy (3DCRT) in the treatment of mid and lower oesophageal carcinoma patients. Materials and Methods: A prospective study in the period from 2014 till 2015 was held in the radiation therapy department of the National Cancer Institute, Cairo University, in which 20 locally advanced or inoperable mid and lower oesophageal cancer patients were treated by chemo-radiation using 3DCRT technique. IMRT plans were generated for those 20 patients. The 3DCRT and IMRT plans were compared as regards PTV coverage and doses to critical organs at risk. Results: All plans had produced satisfactory PTV coverage with no significant differences noted. The lung V20 for both lungs in 3DCRT was 16.94% ± 4.2% which was increased to 21.42% ± 3.6% in IMRT (p = 0.017). The mean dose to the heart and V30 were higher in IMRT plans while the mean dose to the spinal cord was higher with 3DCRT plans, yet that didn’t reach a statistically significant level (p = 0.156). The dose delivered to the liver didn’t pose any difference between both techniques. Conclusion: 3DCRT remains to be a feasible cost effective treatment delivery option for mid and lower oesophageal cancer cases with a lower optimization and delivery time than that for IMRT. Moreover, that calls for further dosimetric studies and clinical trials to assess IMRT technique. In our study, IMRT using nine fields didn’t prove to be superior to 3DCRT.","PeriodicalId":14028,"journal":{"name":"International Journal of Medical Physics, Clinical Engineering and Radiation Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82258877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of Error Detection Capabilities of Various Patient-Specific Intensity Modulated Radiotherapy Quality Assurance Devices","authors":"T. Sanghangthum, S. Z. Lat, S. Suriyapee","doi":"10.4236/IJMPCERO.2019.81003","DOIUrl":"https://doi.org/10.4236/IJMPCERO.2019.81003","url":null,"abstract":"The capability of error detection of patient-specific QA tools plays an important role in verifying MLC motion accuracy. The goal of this study was to investigate the capability in error detection of portal dosimetry, MapCHECK2 and MatriXX QA tools in IMRT plans. The 9 fields IMRT for 4 head and neck plans and 7 fields IMRT for 4 prostate plans were selected for the error detection of QA devices. The measurements were undertaken for the original plan and the modified plans, where the known errors were introduced for increasing and decreasing of prescribed dose (±2%, ±4% and ±6%) and position shifted in X-axis and Y-axis (±1, ±2, ±3 and ±5 mm). After measurement, the results were compared between calculated and measured values using gamma analysis at 3%/3 mm criteria. The average gamma pass for no errors introduced in head and neck plans was 96.9%, 98.6%, and 98.8%, while prostate plans presented 99.4%, 99.0%, and 99.7%, for portal dosimetry, MapCHECK2 and MatriXX system, respectively. In head and neck plan, the shifted error detections were 1 mm for portal dosimetry, 2 mm for MapCHECK2, and 3 mm for MatriXX system. In prostate plan, the shifted error detections were 2 mm for portal dosimetry, 3 mm for MapCHECK2, and 5 mm for MatriXX system. For the dose error detection, the portal dosimetry system could detect at 2% dose deviation in head and neck and 4% in prostate plans, while other two devices could detect at 4% dose deviation in both head and neck and prostate plans. Portal dosimetry shows slightly more capability to detect the error compared with MapCHECK2 and MatriXX system, especially in the complicated plan. It may be due to higher resolution of the detector; however, all three-detector types can detect various errors and can be used for patient-specific IMRT QA.","PeriodicalId":14028,"journal":{"name":"International Journal of Medical Physics, Clinical Engineering and Radiation Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77321675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological Dose Comparison between a Fixed RBE and a Variable RBE in SFO and MFO IMPT with Various Multi-Beams for Brain Cancer","authors":"R. Kohno, W. Cao, P. Yepes, Xuemin Bai, F. Poenisch, D. Grosshans, T. Akimoto, R. Mohan","doi":"10.4236/IJMPCERO.2019.81004","DOIUrl":"https://doi.org/10.4236/IJMPCERO.2019.81004","url":null,"abstract":"IMPT plans with various multi-angle beams were planned by the Varian Eclipse treatment planning system for one case of brain cancer. Dose distributions for each plan, along with the associated linear energy transfer distributions, were recomputed using an in-house fast Monte Carlo dose calculator with a FRBE of 1.1 or with a previously published VRBE model. We then compared dosimetric parameters obtained by the VRBE with those obtained by the FRBE. Biological doses obtained by the VRBE for the clinical target volume in all plans were 1% - 2% larger than those obtained by the FRBE. The minimum dose obtained by the VRBE for the right optic nerve in the MFO IMPT with 4 fields was 70% larger than that obtained by the FRBE, but the difference was only 18.1 cGy (RBE). The difference in maximum dose for the right optic nerve in the MFO IMPT with 5 fields was less than 10.4%, but the difference was 131.8 cGy (RBE). The mean difference in maximum dose was less than 2% for all other organs at risk. We found that biological dose with the FRBE had any dose errors in IMPT with various multi-angle beams.","PeriodicalId":14028,"journal":{"name":"International Journal of Medical Physics, Clinical Engineering and Radiation Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88142506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of Image Contrast Recovery Coefficient (CRC) of a Large Ring PET Scanner","authors":"M. M. Ahasan, S. Akter, R. Khatun, M. F. Uddin, M. Islam, H. M. Jamil, A. N. Monika, M. A. Rahman, Rasel Das, M. Rahman, R. Sharmin, M. N. Khanam","doi":"10.4236/IJMPCERO.2019.81005","DOIUrl":"https://doi.org/10.4236/IJMPCERO.2019.81005","url":null,"abstract":"Image contrast recovery coefficient (CRC) of a large ring PET scanner “macroPET” was studied with septa and without septa configuration by ac-quiring data from a laboratory made 35.7 cm square phantom filled with 18-F. Images were reconstructed with simple 2D filtered back projection using Hann, Hamming and Parsen filters with different cut-off frequencies aiming to investigate the influence of filter and cut-off frequency on image contrast with septa and without septa mode. Results indicate that the CRC, for both hot and cold lesions, is excellent for diameters ≥ 3 cm using cut-off frequencies > 0.4. For a 2 cm hot lesion CRC is around 0.8 to 0.9. CRC for 1 cm hot and cold lesions is ~0.3, as expected. There is surprisingly little difference between results with and without septa. For hot lesions, septa appear to improve CRC slightly, but for cold lesions CRC is slightly poorer using septa.","PeriodicalId":14028,"journal":{"name":"International Journal of Medical Physics, Clinical Engineering and Radiation Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73348055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Winston-Lutz-Gao Test on the True Beam STx Linear Accelerator","authors":"Jun-fang Gao, Xiaoqian Liu","doi":"10.4236/IJMPCERO.2019.81002","DOIUrl":"https://doi.org/10.4236/IJMPCERO.2019.81002","url":null,"abstract":"In the linear accelerator-based stereotactic radio surgery (SRS) and stereotactic body radiotherapy (SBRT) programs, single isocenter-multiple metastases’ treatment has become more and more popular due to their high efficiency in treatment time. However, the absence of a comprehensive quality assurance program is still the challenge for medical physicists. The Winston-Lutz-Gao test, which we developed two years ago, was performed for the first time on a True Beam STx (Varian Medical System) linear accelerator in this study. Beams were designed by Eclipse with gantry, collimator, and couch full rotations, and a 200-pound weight was placed on the couch to mimic real treatment. The “frameless SRS QA target pointer” from the Brainlab company, with a 3.5-mm metallic ball embedded in the center, was used as a phantom. Images were acquired by the portal imager built-in linear accelerator and analyzed directly by the Image browser in ARIA. We found that the farther the metastases were from the linac isocenter, the worse the congruence was between the beam mechanical and the radiation center. The farthest metastases should be within 6 cm from the linac isocenter per the AAPM TG-142 and American Society for Radiation Oncology (ASTRO) white paper criteria. To the best of our knowledge, this is the first off-isocenter Winston-Lutz test performed on a True Beam STx linear accelerator.","PeriodicalId":14028,"journal":{"name":"International Journal of Medical Physics, Clinical Engineering and Radiation Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73902908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiation Shielding Analysis and Design of tof PET-CT Facility at Institute of Nuclear Medical Physics under Bangladesh Atomic Energy Commission, Bangladesh","authors":"M. F. Uddin, R. Khatun, S. Akter, H. M. Jamil, A. N. Monika, Mansur Rahaman, Rasel Das, R. Sharmin, M. Rahman, M. M. Ahasan","doi":"10.4236/IJMPCERO.2019.81001","DOIUrl":"https://doi.org/10.4236/IJMPCERO.2019.81001","url":null,"abstract":"High \u0000resolution (4 mm) tof PET-CT (positron emission tomography-computed tomography) from Philips of model Ingenuity TF is newly installed at Institute \u0000of Nuclear Medical Physics (INMP). 128 slice CT component incorporated with PET \u0000provides comparatively lower dose than the 511 keV annihilation photons \u0000associated with positron decay from PET scan. So, for designing shielding in \u0000our PET-CT facility, only 511 keV annihilation photons energy has been \u0000considered. The main objective of this paper is to show what measures have been \u0000taken to protect patients, occupational workers as well as environment from \u0000PET-CT radiation hazard through a cost effective design that satisfy the \u0000national regulatory demand. In this paper, AAPM (American Associations of \u0000Physicists in Medicine) Task group 108 analysis for PET and PET-CT shielding \u0000requirements is followed for our PET-CT facility shielding design. From theoretical calculation as shielding \u0000requirement, 1.1 cm Pb thickness or, 13 cm concrete thicknesses are \u0000found. Practically, all walls and ceiling are of 30.48 cm (1 foot) thick made \u0000of concrete with density 2.35 gcm-3 for more safety. As x-ray from \u0000CT is not \u0000taken into account for shielding analysis, Bangladesh Atomic Energy Commission \u0000(BAEC) conducted an extensive radiation survey at controlled, supervised and \u0000public area for CT. The report that is found meets the national regulatory \u0000requirements.","PeriodicalId":14028,"journal":{"name":"International Journal of Medical Physics, Clinical Engineering and Radiation Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73623353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of High Spatial Resolution Working Modes for Clinical PET Scanner","authors":"Kelin Wang","doi":"10.4236/IJMPCERO.2018.74045","DOIUrl":"https://doi.org/10.4236/IJMPCERO.2018.74045","url":null,"abstract":"Contemporary PET scanners for clinical use have spatial-resolution of 4 - 5 mm, caused by fundamental factors in medical imaging: detector sizes, free path of positrons, and non-colinearity uncertainty of annihilation photon-pairs. The drawback in resolution significantly restrained the sensitivity of PET in imaging small lesions, which could be either early-stage cancers or small metastasis. In this study, the principle for a novel scanning mode to acquire high spatial-resolution images is proposed for clinical PET scanners. The concept of equivalent position was first proposed as different angular orientations of the scanner ring, at which comparable images could be achieved. Due to this concept, a typical static PET scan can be separated into m (m ≥ 2) equivalent sub-scans at different equivalent positions, when the scanner ring is systematically adjusted to m equivalent-positions of equal distance within one detector size. In this case each detector is virtually divided into m equal sub-detectors, without physical minimizing the detector size, and imaging contributions from every 1/m part of the detector can be determined by an analytically matrix, since there are m variables and m sub-scans. This novel concept is quite feasible to contemporary design because the high spatial resolution working modes (m ≥ 2) only demand the scanner to be slightly adjustable to other angular orientations. Adding high spatial resolutions modes to the scanner only has trifling influence on contrast resolutions as all imaging events at each sub-scan are independent. The time for performing a high-resolution scan could be comparable to a typical PET scan, as long as the Poisson noises are insignificant to low-uptake voxels. As a result, for a typical scanner design e.g. 80 cm in diameter with 18F as tracers, the spatial resolution of double sub-scans (m = 2) is 2.56 mm, and 2.19 mm for triple sub-scans (m = 3), which are significant improvements. The novelty of high spatial resolution design is compatible to digital PET or any other technological evolutions.","PeriodicalId":14028,"journal":{"name":"International Journal of Medical Physics, Clinical Engineering and Radiation Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74229327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multicomponent Assessment of the Geometrical Uncertainty and Consequent Margins in Prostate Cancer Radiotherapy Treatment Using Fiducial Markers","authors":"P. Castro, M. Roch, A. Zapatero, D. Büchser, J. Garayoa, C. Ansón, D. Hernández, C. Huerga, M. Chevalier, S. González, L. Pérez","doi":"10.4236/ijmpcero.2018.74043","DOIUrl":"https://doi.org/10.4236/ijmpcero.2018.74043","url":null,"abstract":"The aim is to compute all sources of geometrical uncertainty in prostate radiotherapy using fiducial markers and determine the safety treatment margins. Based on the markers position, correlations between prostate rotation/deformation and rectal and bladder fillings as well as changes in prostate volume during the treatment course are analyzed. The study includes 375 pre-treatment CBCT images from 15 prostate cancer patients treated with hypofractionated radiotherapy. The position coordinates of the markers were obtained from each image acquisition. In addition, rectum and bladder were outlined on CBCTs. The intrafractional error was estimated by an additional post-treatment CBCT acquired on alternate days. Tau-Kendall analysis was performed to correlate organ fillings with prostate rotation/deformation. Delineation uncertainty was assessed from contours of 10 patients performed by two radiation oncologists and repeated twice. The CT contouring was assisted by a multiparametric MR approach combining a T2-weighted with diffusion-weighted imaging, and a gradient recalled echo for fiducial marker identification. Uncertainty associated to treatment unit was estimated from phantom measurements. The obtained clinical margins were 4.4, 7.3, 5.1 mm in the Left-Right, Superior-Inferior, and Anterior-Posterior directions, respectively, being the contouring the most important contribution. The mechanical limitations of the beam delivery system and the associated imaging device entailed errors of the same order as prostate motion, rotation or deformation. Weak correlations between variation of the rectal volume and the presence of rotations/deformations were found (correlation coefficient 0.182, p = 0.001 for rotations around lateral axis; correlation coefficients 0.1, p < 0.05 for deformations). The distance between markers decreased with session number, becoming more pronounced from fraction 13 and reaching 1 - 1.8 mm at the end of the treatment. In summary we have determined the optimal treatment margins based on geometrical uncertainty assessment using van Herk formalism. An appropriate preparation of rectum and bladder involves minimizing the effect of prostate rotations/deformations. The prostate tends to decrease in size during the treatment which could influence treatment re-planning strategies.","PeriodicalId":14028,"journal":{"name":"International Journal of Medical Physics, Clinical Engineering and Radiation Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73042831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Variance Component Analysis (ANOVA) in Setup Errors and PTV Margins for Lung Cancer with Stereotactic Body Radiation Therapy (SBRT)","authors":"Xiaotian Huang, Jun Zhang, C. Xie, Yunfeng Zhou, H. Quan","doi":"10.4236/IJMPCERO.2018.74044","DOIUrl":"https://doi.org/10.4236/IJMPCERO.2018.74044","url":null,"abstract":"Purpose: To investigate the feasibility of applying ANOVA newly proposed by Yukinori to verify the setup errors, PTV (Planning Target Volume) margins, DVH for lung cancer with SBRT. Methods: 20 patients receiving SBRT to 50 Gy in 5 fractions with a Varian iX linear acceleration were selected. Each patient was scanned with kV-CBCT before the daily treatment to verify the setup position. Two other error calculation methods raised by Van Herk and Remeijer were also compared to discover the statistical difference in systematic errors (Σ), random errors (σ), PTV margins and DVH. Results: Utilizing two PTV margin calculation formulas (Stroom, Van Herk), PTV calculated by Yukinori method in three directions were (5.89 and 3.95), (5.54 and 3.55), (3.24 and 0.78) mm; Van Herk method were (6.10 and 4.25), (5.73 and 3.83), (3.51 and 1.13) mm; Remeijer method were (6.39 and 4.57), (5.98 and 4.10), (3.69 and 1.33) mm. The volumes of PTV using Yukinori method were significantly smaller (P 0.05) among three methods. Conclusions: In lung SBRT treatment, due to fraction reduction and high level of dose per fraction, ANOVA was able to offset the effect of random factors in systematic errors, reducing the PTV margins and volumes. However, no distinct dose distribution improvement was founded in target volume and organs at risk.","PeriodicalId":14028,"journal":{"name":"International Journal of Medical Physics, Clinical Engineering and Radiation Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84966050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dosimetric Comparison of Amorphous Silicon EPID and 2D Array Detector for Pre-Treatment Verification of Intensity Modulated Radiation Therapy","authors":"Ayman G. Ibrahim, Ismail E. Mohamed, H. M. Zidan","doi":"10.4236/ijmpcero.2018.74037","DOIUrl":"https://doi.org/10.4236/ijmpcero.2018.74037","url":null,"abstract":"Purpose: To study the dosimetric characteristics of amorphous silicon Electronic Portal Imaging Device EPID and 2D array detector for dose verification of radiotherapy treatment plans, and the quality assurance QA testing of IMRT was investigated. Materials and methods: All measurements were done with Varian IX linear accelerator, aSi-1000 EPID and 2D array detector. The dose linearity, reproducibility, output factors, dose rate, SDD and response with slap phantom thickness have been measured and compared against those measured by ion chamber. Results: The characteristics of EPID and 2D array: the response of EPID agreed with 2D array and ion chamber 0.6cc. EPID and 2D array showed short-term output reproducibility with SD = 0.1%. The dose rates of 2D array SD = ±0.7%, EPID = ±0.4% compared with a 0.6 cc SD = ±0.5%. Output factor measurements for the central chamber of the EPID and 2D array showed no considerable deviation from ion chamber measurements. Measurement of beam profiles with the EPID and 2D array matched very well with the ion chamber measurements in the water phantom. The EPID is more sensitive to lower energy photons by increasing solid water phantom thickness. The mean and standard deviation passing rates (γ%≤1) for film, 2D array and EPID for 30 IMRT fields of five patients were 95.93 ± 0.96%, 99.05 ± 0.24%, and 99.37 ± 0.12%, respectively. Conclusion: The study shows that EPID and 2D array are a reliable and accurate dosimeter and a useful tool for quality assurance. We found that the EPID was more accurate compared with both 2D array and ion chamber. The gamma criterion of 3%/3 mm is the most suitable criteria for IMRT plans of QA.","PeriodicalId":14028,"journal":{"name":"International Journal of Medical Physics, Clinical Engineering and Radiation Oncology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2018-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83170067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}