International Journal of Inflammation最新文献

{"title":"Neutrophil Extracellular Trap Production in Patients with Colorectal Cancer In Vitro.","authors":"J J R Richardson,&nbsp;C Hendrickse,&nbsp;F Gao-Smith,&nbsp;D R Thickett","doi":"10.1155/2017/4915062","DOIUrl":"https://doi.org/10.1155/2017/4915062","url":null,"abstract":"<p><strong>Purpose: </strong>Neutrophil Extracellular Traps (NETs) are extracellular neutrophil derived DNA webs which have been implicated in cancer progression and in the development of metastases. NETs production in patients with colorectal cancer was investigated to elucidate their role and prognostic significance.</p><p><strong>Methods: </strong>Systemic neutrophils were isolated from consecutive patients with colorectal cancer and from age-matched healthy volunteers. Neutrophils were stimulated to produce NETs which were quantified by a measure of the fluorescence of the extracellular DNA. The impact of cancer location, tumour stage, and patient outcomes (complications, length of stay, and mortality) on NET production was investigated.</p><p><strong>Results: </strong>Quantification of NET formation was performed in patients with colorectal cancer (<i>n</i> = 45) and in well-matched healthy individuals (<i>n</i> = 20). Significant increases in NETs production in response to no stimulant (9,735 AFU versus 11347 AFU, <i>p</i> = 0.0209), IL-8 (8,644 AFU versus 11,915 AFU, <i>p</i> = 0.0032), and LPS (10,576 AFU versus 12,473 AFU, <i>p</i> = 0.0428) were identified in patients with colorectal cancer. A significant increase in NETs production in response to fMLP was detected in patients who developed significant postoperative complications (11,760 AFU versus 18,340 AFU, <i>p</i> = 0.0242) and who had a prolonged hospital recovery (9,008 AFU versus 12,530 AFU, <i>p</i> = 0.0476). An increase in NETs production was also observed in patients who died, but this did not reach statistical significance. Cancer location and tumour stage did not appear to affect preoperative NETs production.</p><p><strong>Conclusions: </strong>Patients with colorectal cancer have significantly increased NETs production in vitro when compared to healthy volunteers, possibly implicating them in cancer development. Adverse patient outcomes were associated with increased preoperative NETs production, which highlights them as potential therapeutic targets.</p>","PeriodicalId":14004,"journal":{"name":"International Journal of Inflammation","volume":"2017 ","pages":"4915062"},"PeriodicalIF":2.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/4915062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35338123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impaired mRNA Expression of the Migration Related Chemokine Receptor CXCR4 in Mesenchymal Stem Cells of COPD Patients.","authors":"K Karagiannis,&nbsp;A Proklou,&nbsp;E Tsitoura,&nbsp;I Lasithiotaki,&nbsp;C Kalpadaki,&nbsp;D Moraitaki,&nbsp;I Sperelakis,&nbsp;G Kontakis,&nbsp;K M Antoniou,&nbsp;N Tzanakis","doi":"10.1155/2017/6089425","DOIUrl":"https://doi.org/10.1155/2017/6089425","url":null,"abstract":"<p><p>Defective tissue repair and remodeling are main aspects of Chronic Obstructive Pulmonary Disease (COPD) pathophysiology. Bone marrow mesenchymal stem cells (BM-MSCs) have been implicated in this direction, as their functional impairment and recruitment could possibly contribute to disease development and progression. The present study characterizes for the first time the expression of migration related chemokine receptors and their ligands in BM-MSCs from COPD patients. CXCR4/SDF1a and CCR7/CCL19-CCL21 mRNA levels were evaluated in BM-MSCs obtained from twelve COPD patients and seven healthy donors. SDF1a protein levels in sera and BM-MSCs' conditioned media were also evaluated. CXCR4, SDF1a, CCL19, and CCL21 mRNA levels were significantly reduced in COPD BM-MSCs while CCR7 levels were undetectable. Notably, SDF1a protein levels were marginally elevated in both patient sera and BM-MSCs' conditioned media while the increase in SDF1a serum levels significantly correlated with disease severity in COPD. Our findings show posttranscriptional regulation of SDF1a levels in BM-MSCs of COPD patients and significant downregulation of SDF1a and CXCR4 mRNA indicating an involvement of the SDF1a signaling pathway in the disease pathophysiology.</p>","PeriodicalId":14004,"journal":{"name":"International Journal of Inflammation","volume":"2017 ","pages":"6089425"},"PeriodicalIF":2.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/6089425","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35410623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HMGB1 and Histones Play a Significant Role in Inducing Systemic Inflammation and Multiple Organ Dysfunctions in Severe Acute Pancreatitis.","authors":"Runkuan Yang,&nbsp;Jyrki Tenhunen,&nbsp;Tor Inge Tonnessen","doi":"10.1155/2017/1817564","DOIUrl":"https://doi.org/10.1155/2017/1817564","url":null,"abstract":"Severe acute pancreatitis (SAP) starts as a local inflammation of pancreatic tissue that induces the development of multiple extrapancreatic organs dysfunction; however, the underlying mechanisms are still not clear. Ischemia-reperfusion, circulating inflammatory cytokines, and possible bile cytokines significantly contribute to gut mucosal injury and intestinal bacterial translocation (BT) during SAP. Circulating HMGB1 level is significantly increased in SAP patients and HMGB1 is an important factor that mediates (at least partly) gut BT during SAP. Gut BT plays a critical role in triggering/inducing systemic inflammation/sepsis in critical illness, and profound systemic inflammatory response syndrome (SIRS) can lead to multiple organ dysfunction syndrome (MODS) during SAP, and systemic inflammation with multiorgan dysfunction is the cause of death in experimental SAP. Therefore, HMGB1 is an important factor that links gut BT and systemic inflammation. Furthermore, HMGB1 significantly contributes to multiple organ injuries. The SAP patients also have significantly increased circulating histones and cell-free DNAs levels, which can reflect the disease severity and contribute to multiple organ injuries in SAP. Hepatic Kupffer cells (KCs) are the predominant source of circulating inflammatory cytokines in SAP, and new evidence indicates that hepatocyte is another important source of circulating HMGB1 in SAP; therefore, treating the liver injury is important in SAP.","PeriodicalId":14004,"journal":{"name":"International Journal of Inflammation","volume":"2017 ","pages":"1817564"},"PeriodicalIF":2.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/1817564","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34832953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Sensitive C-Reactive Protein Levels in a Group of Syrian University Male Students and Its Associations with Smoking, Physical Activity, Anthropometric Measurements, and Some Hematologic Inflammation Biomarkers.","authors":"Wafika Zarzour,&nbsp;Nada Dehneh,&nbsp;Mazen Rajab","doi":"10.1155/2017/7326527","DOIUrl":"https://doi.org/10.1155/2017/7326527","url":null,"abstract":"<p><p>In Syria, health risk data on young males are limited. Hence, the aim of the present study was to evaluate cardiovascular disease (CVD) risk factors along with C-reactive protein levels measured by high-sensitive method (hsCRP) in a group of healthy males of university students (<i>n</i> = 101, 18-25 years old). Participants' anthropometric characteristics; alcohol drinking, smoking, and physical activity habits; parents medical history; and some inflammatory biomarkers were inspected for their associations with hsCRP. <i>Results</i>. Regarding hsCRP level, 19 participants were at average (1-3 mg/L) and 13 were at high (>3 mg/L) risk of CVD. Nonparametric statistical tests (<i>p</i> value < 0.05) revealed that hsCRP level was higher in participants who had high body mass index (BMI), had high BMI with high waist-to-hip ratio (WHR), or did not practice sport frequently. Unexpectedly, it did not vary between smokers and nonsmokers. In general, it correlated positively with anthropometric and erythrocyte sedimentation rate (ESR) measurements. Nevertheless, it negatively correlated with sports practicing in overall and nonsmoker groups and in participants whose parents were without medical history. Finally, when participants with high BMI were smokers, did not practice sport frequently, or had a parent with medical history, their hsCRP levels were higher than others who had the same circumstances but with low BMI.</p>","PeriodicalId":14004,"journal":{"name":"International Journal of Inflammation","volume":"2017 ","pages":"7326527"},"PeriodicalIF":2.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/7326527","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34982129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of a Novel Alternatively Spliced Form of Inflammatory Regulator SWAP-70-Like Adapter of T Cells.","authors":"Marie Hashimoto,&nbsp;Jun-Ichi Nagao,&nbsp;Shojiro Ikezaki,&nbsp;Sonoko Tasaki,&nbsp;Ken-Ichi Arita-Morioka,&nbsp;Yuka Narita,&nbsp;Tamaki Cho,&nbsp;Kenji Yuasa,&nbsp;Amnon Altman,&nbsp;Yoshihiko Tanaka","doi":"10.1155/2017/1324735","DOIUrl":"https://doi.org/10.1155/2017/1324735","url":null,"abstract":"<p><p>Activation of naive CD4⁺ T cells results in the development of several distinct subsets of effector Th cells, including Th2 cells that play a pivotal role in allergic inflammation and helminthic infections. SWAP-70-like adapter of T cells (SLAT), also known as Def6 or IBP, is a guanine nucleotide exchange factor for small GTPases, which regulates CD4⁺ T cell inflammatory responses by controlling Ca²⁺/NFAT signaling. In this study, we have identified a novel alternatively spliced isoform of SLAT, named SLAT2, which lacks the region encoded by exons 2-7 of the <i>Def6</i> gene. SLAT2 was selectively expressed in differentiated Th2 cells after the second round of in vitro stimulation, but not in differentiated Th1, Th17, or regulatory T (Treg) cells. Functional assays revealed that SLAT2 shared with SLAT the ability to enhance T cell receptor- (TCR-) mediated activation of NFAT and production of IL-4 but was unable to enhance TCR-induced adhesion to ICAM-1. Ectopic expression of SLAT2 or SLAT in Jurkat T cells resulted in the expression of distinct forms of filopodia, namely, short versus long ones, respectively. These results demonstrate that modulating either SLAT2 or SLAT protein expression could play critical roles in cytokine production and actin reorganization during inflammatory immune responses.</p>","PeriodicalId":14004,"journal":{"name":"International Journal of Inflammation","volume":"2017 ","pages":"1324735"},"PeriodicalIF":2.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/1324735","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35010168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Toll-Like Receptors in Autoimmune Diseases through Failure of the Self-Recognition Mechanism.","authors":"Mark Farrugia,&nbsp;Byron Baron","doi":"10.1155/2017/8391230","DOIUrl":"https://doi.org/10.1155/2017/8391230","url":null,"abstract":"<p><p>Toll-like receptors (TLRs), part of the innate immune system that recognises molecular signatures, are important in the recognition of pathogenic components. However, when specific cellular contexts develop in which TLRs are inappropriately activated by self-components, this may lead to sterile inflammation and result in the occurrence of autoimmunity. This review analyses the available data regarding TLR biochemistry, the specific mechanisms which are brought about by TLR activation, and the importance of these mechanisms in the light of any existing and potential therapies in the field of autoimmunity.</p>","PeriodicalId":14004,"journal":{"name":"International Journal of Inflammation","volume":"2017 ","pages":"8391230"},"PeriodicalIF":2.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/8391230","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35037285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alleviating Promotion of Inflammation and Cancer Induced by Nonsteroidal Anti-Inflammatory Drugs.","authors":"Anthony M Kyriakopoulos,&nbsp;Markus Nagl,&nbsp;Stella Baliou,&nbsp;Vasilleios Zoumpourlis","doi":"10.1155/2017/9632018","DOIUrl":"https://doi.org/10.1155/2017/9632018","url":null,"abstract":"<p><strong>Clinical relevance: </strong>Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) including aspirin are of intensive use nowadays. These drugs exert their activity via the metabolism of arachidonic acid (AA) by cyclooxygenase inhibition. Though beneficial for health in some instances, both unspecific and specific cyclooxygenase inhibitor activity interfere with AA metabolism producing also proinflammatory lipids that may promote cancer.</p><p><strong>Materials and methods: </strong>This review is based on available literature on clinical uses, biochemical investigations, molecular medicine, pharmacology, toxicity, and epidemiology-clinical studies on NSAIDs and other drugs that may be used accordingly, which was collected from electronic (SciFinder, Medline, Science Direct, and ACS among others) and library searches of books and journals.</p><p><strong>Results: </strong>Relevant literature supports the notion that NDSAID use may also promote proinflammatory biochemical events that are also related to precancerous predisposition. Several agents are proposed that may be employed in immediate future to supplement and optimize treatment with NSAIDs. In this way serious side effects arising from promotion of inflammation and cancer, especially in chronic NSAID users and high risk groups of patients, could be avoided.</p>","PeriodicalId":14004,"journal":{"name":"International Journal of Inflammation","volume":"2017 ","pages":"9632018"},"PeriodicalIF":2.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/9632018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35054609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptional and Molecular Pathways Activated in Mesenteric Adipose Tissue and Intestinal Mucosa of Crohn's Disease Patients.","authors":"Andressa Coope,&nbsp;Lívia Bitencourt Pascoal,&nbsp;Francesca Aparecida Ramos da Silva,&nbsp;José Diego Botezelli,&nbsp;Maria de Lourdes Setsuko Ayrizono,&nbsp;Marciane Milanski,&nbsp;Michel Gardere Camargo,&nbsp;Núria Planell,&nbsp;Mariana Portovedo,&nbsp;Cilene Bicca Dias,&nbsp;João José Fagundes,&nbsp;Raquel Franco Leal","doi":"10.1155/2017/7646859","DOIUrl":"https://doi.org/10.1155/2017/7646859","url":null,"abstract":"<p><p>Crohn's disease (CD) is a chronic inflammatory disorder, characterized by cytokine imbalance and transcription signaling pathways activation. In addition, the increase of mesenteric adipose tissue (MAT) near the affected intestinal area is a hallmark of CD. Therefore, we evaluated the transcription signaling pathways and cytokines expression in intestinal mucosa and MAT of active CD patients. Ten patients with ileocecal CD and eight with noninflammatory diseases were studied. The biopsies of intestinal mucosa and MAT were snap-frozen and protein expression was determined by immunoblotting. RNA levels were measured by qPCR. The pIkB/IkB ratio and TNF<i>α</i> level were significantly higher in intestinal mucosa of CD when compared to controls. However, STAT1 expression was similar between intestinal mucosa of CD and controls. Considering the MAT, the pIkB/IkB ratio was significantly lower and the anti-inflammatory cytokine IL10 was significantly higher in CD when compared to controls. Finally, the protein content of pSTAT1 was higher in MAT of CD compared to controls. These findings reinforce the predominance of the proinflammatory NF-kB pathway in CD intestinal mucosa. For the first time, we showed the activation of STAT1 pathway in MAT of CD patients, which may help to understand the physiopathology of this immune mediated disease.</p>","PeriodicalId":14004,"journal":{"name":"International Journal of Inflammation","volume":"2017 ","pages":"7646859"},"PeriodicalIF":2.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/7646859","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34982130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Mycobacterium avium</i> Subsp. <i>paratuberculosis</i> Induces Specific IgE Production in Japanese People with Allergies.","authors":"D Cossu,&nbsp;S Otsubo,&nbsp;Y Otsubo,&nbsp;S Eda,&nbsp;T Suzuki,&nbsp;Y Iwao,&nbsp;T Kuribayashi,&nbsp;S Yamamoto,&nbsp;L A Sechi,&nbsp;E Momotani","doi":"10.1155/2017/7959154","DOIUrl":"https://doi.org/10.1155/2017/7959154","url":null,"abstract":"<p><p><i>Background</i>. The prevalence of allergies is steadily increasing worldwide; however, the pathogenesis is still unclear. We hypothesized that <i>Mycobacterium avium</i> subsp. <i>paratuberculosis</i> (MAP) may contribute to allergy development. This organism can be present in dairy foods, it can elicit an immunomodulatory switch from a Th1 to a Th2 response, and it has been speculated that it is linked to several human autoimmune diseases. To determine the contribution, sera from 99 individuals with various atopic disorders and 45 healthy nonallergic controls were assessed for total IgE levels and successively for MAP-specific IgE by ELISA. <i>Results</i>. The mean total serum IgE level in allergic patients was 256 ± 235 IU/mL, and in the healthy controls it was 62 ± 44 IU/mL (AUC = 0.88; <i>p</i> < 0.0001). Among the patient groups, 50 of the 99 subjects had increased IgE total level ≥ 150 IU/mL, while 49 subjects had IgE ≤ 150 IU/mL (mean level: 407 ± 256 IU/mL versus 106 ± 16 IU/mL; <i>p</i> < 0.0001). Additionally, 6 out of 50 subjects (12%) with IgE ≥ 150 IU/mL and none (0%) with IgE ≤ 150 IU/mL were positive for specific MAP IgE (AUC = 0.63; <i>p</i> = 0.03). <i>Conclusion.</i> The present study revealed that MAP has the ability to induce specific IgE and might contribute to the induction of allergic inflammation in genetically predisposed individuals.</p>","PeriodicalId":14004,"journal":{"name":"International Journal of Inflammation","volume":"2017 ","pages":"7959154"},"PeriodicalIF":2.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/7959154","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35010169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is Neutrophil-to-Lymphocyte Ratio a Predictor of Coronary Artery Disease in Western Indians?","authors":"Kamal Sharma,&nbsp;Alap K Patel,&nbsp;Komal H Shah,&nbsp;Ashwati Konat","doi":"10.1155/2017/4136126","DOIUrl":"https://doi.org/10.1155/2017/4136126","url":null,"abstract":"<p><strong>Introduction: </strong>The current study was designed to evaluate the association of neutrophil-to-lymphocyte ratio (NLR) with coronary artery disease (CAD) presence. We also aimed to propose a suitable cut-off of NLR for diagnosis of CAD in Western Indians.</p><p><strong>Methods: </strong>Total 324 patients undergoing coronary angiography were enrolled and were subdivided into two groups: group 1 (<i>n</i> = 99; population without CAD) and group 2 (<i>n</i> = 225; population with CAD).</p><p><strong>Results: </strong>The results indicated significant (<i>p</i> < 0.05) positive association between elevated levels of WBC, neutrophil, monocyte, NLR, hs-CRP, CPK-MB, and troponin I and disease presence. According to subgroup analysis, the association was more profound in male and older population. Among all the markers NLR showed the strongest predictive potential for CAD with highest odds ratio (1.495; 95% CI: 0.942-2.371; <i>p</i> < 0.048). Optimum cut-off of NLR for diagnosis of CAD was 2.13 (AUC-0.823; <i>p</i> < 0.001; sensitivity: 83.64%; specificity: 63.46%). Association of NLR with other biochemical markers such as hs-CRP, CPK-MB, and troponin I was also observed in quartile analysis.</p><p><strong>Conclusion: </strong>NLR is a simple indicator that could be effectively used for the diagnosis of CAD with a cut-off of 2.13 in Western Indian population.</p>","PeriodicalId":14004,"journal":{"name":"International Journal of Inflammation","volume":"2017 ","pages":"4136126"},"PeriodicalIF":2.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/4136126","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35273752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}