International Journal of Inflammation最新文献_第9页

Psoriatic Arthritis Is an Indicator of Significant Renal Damage in Patients with Psoriasis: An Observational and Epidemiological Study. 银屑病关节炎是银屑病患者肾损害的一个指标:一项观察性和流行病学研究。

IF 2

International Journal of Inflammation Pub Date : 2017-01-01 Epub Date: 2017-03-22 DOI: 10.1155/2017/5217687

Abidullah Khan, Iqbal Haider, Maimoona Ayub, Mohammad Humayun

{"title":"Psoriatic Arthritis Is an Indicator of Significant Renal Damage in Patients with Psoriasis: An Observational and Epidemiological Study.","authors":"Abidullah Khan, Iqbal Haider, Maimoona Ayub, Mohammad Humayun","doi":"10.1155/2017/5217687","DOIUrl":"https://doi.org/10.1155/2017/5217687","url":null,"abstract":"Background. Psoriasis affects joints in around 30% of the patients. Recent studies have demonstrated an increased risk of essential hypertension, ischemic heart disease, and stroke in psoriatic patients. However, the prevalence of renal disease in patients with psoriasis has not been evaluated properly. Objectives. Objectives were to evaluate renal functions in patients with psoriasis and to assess any possible relationship of renal failure with psoriasis and psoriatic arthritis. Methods. In this cross-sectional study, 30 participants were recruited into the following three groups: group-A, psoriatic arthritis; group-B, psoriasis without arthritis; and group-C, healthy subjects. Renal function tests were performed for every participant of each group. The data was analyzed by using SPSS version 16. Chi-squared and one-way ANOVA tests were applied, considering a P value of less than 0.05 as a standard criterion. Results. Serum creatinine, urea, and phosphate were the highest in group-A, higher in group-B, and normal in group-C, P < 0.05. Similarly, GFR was the lowest in group-A, lower in group-B, and normal in group-C. The difference in mean GFR values was statistically significant, F(2) = 355, P < 0.001. Moreover, proteinuria (gm/day) was seen in 96.7% of the patients with psoriatic arthritis, (M = 1.18 ± 0.55, P < 0.05) against 10% of the psoriatic patients without arthritis (M = 0.41 ± 0.10, P < 0.05). Conclusion. Derangement of renal function is more prevalent in psoriatic patients, especially in those with concomitant psoriatic arthritis. Therefore, each psoriatic patient must be routinely screened for an underlying renal failure.","PeriodicalId":14004,"journal":{"name":"International Journal of Inflammation","volume":"2017 ","pages":"5217687"},"PeriodicalIF":2.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/5217687","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34922944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Curcumin Inhibits NTHi-Induced MUC5AC Mucin Overproduction in Otitis Media via Upregulation of MAPK Phosphatase MKP-1. 姜黄素通过上调MAPK磷酸酶MKP-1抑制nthi诱导的中耳炎MUC5AC粘蛋白过量产生

IF 2

International Journal of Inflammation Pub Date : 2017-01-01 Epub Date: 2017-04-12 DOI: 10.1155/2017/4525309

Anuhya Sharma Konduru, Shingo Matsuyama, Byung-Cheol Lee, Kensei Komatsu, Jian-Dong Li

{"title":"Curcumin Inhibits NTHi-Induced MUC5AC Mucin Overproduction in Otitis Media via Upregulation of MAPK Phosphatase MKP-1.","authors":"Anuhya Sharma Konduru, Shingo Matsuyama, Byung-Cheol Lee, Kensei Komatsu, Jian-Dong Li","doi":"10.1155/2017/4525309","DOIUrl":"https://doi.org/10.1155/2017/4525309","url":null,"abstract":"Otitis media (OM), characterized by the presence of mucus overproduction and excess inflammation in the middle ear, is the most common childhood infection. Nontypeable Haemophilus influenzae (NTHi) pathogen is responsible for approximately one-third of episodes of bacteria-caused OM. Current treatments for bacterial OM rely on the systemic use of antibiotics, which often leads to the emergence of multidrug resistant bacterial strains. Therefore there is an urgent need for developing alternative therapies strategies for controlling mucus overproduction in OM. MUC5AC mucin has been shown to play a critical role in the pathogenesis of OM. Here we show that curcumin derived from Curcuma longa plant is a potent inhibitor of NTHi-induced MUC5AC mucin expression in middle ear epithelial cells. Curcumin inhibited MUC5AC expression by suppressing activation of p38 MAPK by upregulating MAPK phosphatase MKP-1. Thus, our study identified curcumin as a potential therapeutic for inhibiting mucin overproduction in OM by upregulating MKP-1, a known negative regulator of inflammation.","PeriodicalId":14004,"journal":{"name":"International Journal of Inflammation","volume":"2017 ","pages":"4525309"},"PeriodicalIF":2.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/4525309","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34982128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

High Vitamin D Levels May Downregulate Inflammation in Patients with Behçet's Disease. 高维生素D水平可能下调behaperet病患者的炎症反应。

IF 2

International Journal of Inflammation Pub Date : 2017-01-01 Epub Date: 2017-06-04 DOI: 10.1155/2017/8608716

Fahd Adeeb, Maria Usman Khan, Xia Li, Austin G Stack, Joseph Devlin, Alexander D Fraser

{"title":"High Vitamin D Levels May Downregulate Inflammation in Patients with Behçet's Disease.","authors":"Fahd Adeeb, Maria Usman Khan, Xia Li, Austin G Stack, Joseph Devlin, Alexander D Fraser","doi":"10.1155/2017/8608716","DOIUrl":"https://doi.org/10.1155/2017/8608716","url":null,"abstract":"Vitamin D plays a significant role in the immune system modulation and may confer a protective role in autoimmune diseases. We conducted a case-control study to compare 25(OH)D levels in patients with BD who were managed at a regional rheumatology programme in the midwest region of Ireland compared to matched controls. Healthy controls were selected from the Irish health system and matched in 1 : 5 ratio for age, sex, and the month of the year. 25(OH)D levels <20 nmol/L were classified as deficient while levels between 20 and 40 nmol/L were classified as insufficient. Differences between groups were assessed using Mann-Whitney test and associations between cases and controls were expressed as odds ratios and 95% confidence intervals. Nineteen patients with BD were compared with 95 controls matched by age, sex, and month of blood draw. 25(OH)D levels were significantly higher in patients in BD than in matched controls (median values: 45 nmol/L versus 22 nmol/L, p < 0.005) and tended to be lower in patients with active disease than in those without (median values: 35 nmol/L (IQR: 22.75-47.25 nm/L) versus 50 nmol/L (IQR: 35-67 nmol/L), p = 0.11). Compared to controls, patients with BD were significantly less likely to have 25(OH)D deficiency or insufficiency (OR: 0.09, 95% CI: 0.03-0.28, p < 0.001). Our findings suggest a possible role for 25(OH)D in modifying the inflammatory response in BD and uncover a potential opportunity to assess whether correction of Vit D deficiency confers protective benefits.","PeriodicalId":14004,"journal":{"name":"International Journal of Inflammation","volume":"2017 ","pages":"8608716"},"PeriodicalIF":2.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/8608716","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35129071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Are Systematic Screening for Vitamin D Deficiency and Vitamin D Supplementation Currently Feasible for Ankylosing Spondylitis Patients? 对强直性脊柱炎患者进行维生素D缺乏和维生素D补充的系统筛查是否可行?

IF 2

International Journal of Inflammation Pub Date : 2017-01-01 DOI: 10.1155/2017/7840150

M. Essouma, J. Noubiap

{"title":"Are Systematic Screening for Vitamin D Deficiency and Vitamin D Supplementation Currently Feasible for Ankylosing Spondylitis Patients?","authors":"M. Essouma, J. Noubiap","doi":"10.1155/2017/7840150","DOIUrl":"https://doi.org/10.1155/2017/7840150","url":null,"abstract":"Beyond its role in calcium and phosphorus metabolism for healthy bone mineralization, there is increasing awareness for vitamin D contribution in modulation of immune reactions. Given that ankylosing spondylitis (AS) is a chronic inflammatory disease involving excess immune/inflammatory activity and posing great therapeutic challenges, it is conceivable to claim that vitamin D treatment may be a safe and effective treatment to influence or modify the primary disease and its related comorbidities. Nevertheless, consistent body of research supporting this hypothesis is still lacking. In this paper, we examine whether systematic screening and treatment for vitamin D deficiency are feasible at present. We will review the immunomodulatory role of vitamin D and its contribution in initiation and progression of AS, as well as how they would determine the occurrence of comorbid conditions. Our conclusion is that despite the overwhelmed interest about vitamin D treatment in AS patients, systematic screening and treatment for vitamin D deficiency of all AS patients are not feasible as yet. This stresses the need for further extensive well-designed research to prove vitamin D efficacy in AS beyond bone protection. And if utility is proven, personalized treatment regimes, duration of treatment, and threshold values for vitamin D should be provided.","PeriodicalId":14004,"journal":{"name":"International Journal of Inflammation","volume":"25 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88754981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

The Level of Oxidative Neutrophil Response When Determining Endotoxin Activity Assay: A New Biomarker for Defining the Indications and Effectiveness of Intensive Care in Patients with Sepsis. 测定内毒素活性测定时氧化中性粒细胞反应水平:确定脓毒症患者重症监护适应症和有效性的新生物标志物。

IF 2

International Journal of Inflammation Pub Date : 2017-01-01 Epub Date: 2017-04-12 DOI: 10.1155/2017/3495293

Michael Yaroustovsky, Ekaterina Rogalskaya, Marina Plyushch, Ludmila Klimovich, Nataliya Samsonova, Marina Abramyan

{"title":"The Level of Oxidative Neutrophil Response When Determining Endotoxin Activity Assay: A New Biomarker for Defining the Indications and Effectiveness of Intensive Care in Patients with Sepsis.","authors":"Michael Yaroustovsky, Ekaterina Rogalskaya, Marina Plyushch, Ludmila Klimovich, Nataliya Samsonova, Marina Abramyan","doi":"10.1155/2017/3495293","DOIUrl":"https://doi.org/10.1155/2017/3495293","url":null,"abstract":"Background. To analyse the clinical informativity of the neutrophil oxidative response level (\"Response\") during an Endotoxin Activity Assay (EAA) as a new biomarker defining the indications and effectiveness of intensive care in cardiac surgical patients with septic complications. Methods. Blood samples were taken from 198 adult patients who were admitted to the ICU after cardiac surgery (SIRS: 34, MODS: 36, and sepsis: 128). The composite of laboratory studies included CRP, PCT, EAA with \"Response\" level, and presepsin. Results. 83% of patients had a \"normal\" neutrophil response, 12% of patients had a low neutrophil response, and 5% of patients had a critically low neutrophil response. Patients with critically low responses had the lowest values of the EAA and the highest concentrations of PSP and D-dimer (p < 0.05). Conclusions. EAA results should be interpreted with the level of neutrophil response. \"Response\" > 0.5 has a negative predictive value; the EAA < 0.6 at \"Response\" < 0.5 may indicate a high level of endotoxaemia.","PeriodicalId":14004,"journal":{"name":"International Journal of Inflammation","volume":"2017 ","pages":"3495293"},"PeriodicalIF":2.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/3495293","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34981208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Ethanol-Induced Alterations of T Cells and Cytokines after Surgery in a Murine Infection Model. 小鼠感染模型术后乙醇诱导的T细胞和细胞因子的改变。

IF 2

International Journal of Inflammation Pub Date : 2017-01-01 Epub Date: 2017-11-20 DOI: 10.1155/2017/1067598

Nadine Lanzke, Mario Menk, Clarissa von Haefen, Lilit Sargsyan, Bianca Scharf, Klaus-Dieter Wernecke, Claudia D Spies

{"title":"Ethanol-Induced Alterations of T Cells and Cytokines after Surgery in a Murine Infection Model.","authors":"Nadine Lanzke, Mario Menk, Clarissa von Haefen, Lilit Sargsyan, Bianca Scharf, Klaus-Dieter Wernecke, Claudia D Spies","doi":"10.1155/2017/1067598","DOIUrl":"https://doi.org/10.1155/2017/1067598","url":null,"abstract":"Background: Interactions between alcohol, infection, and surgery and their effect on differentiation and functionality of T helper cells are not yet completely understood. We hypothesized that alcohol and surgery disturb differentiation of T helper cells and contribute to an impaired immune response.Methods: Mice were treated with alcohol for two weeks. Saline treatment served as control. Clinical performance and weight were assessed. On day 14, a median laparotomy was performed and animals were challenged with Klebsiella pneumoniae intranasally. Bacterial load was determined in lungs and blood. T helper cell subpopulations and the released cytokines were assessed in lungs, spleens, and plasma. Key transcription factors of T cell differentiation were evaluated.Results: Alcohol significantly impaired clinical appearance and body weight of animals with postsurgical infection (p < 0.05). Bacterial load was significantly higher after alcohol treatment (p < 0.05). T helper cell subsets and released cytokine levels were significantly altered in lung, but not in spleen. Expression of transcription factors of T helper cell lineage commitment did not translate into different counts of T helper cells.Conclusions: Alcohol and surgery lead to significant cellular and functional modulations of T helper cells during postsurgical infection. These effects may contribute to an impaired immune response after surgery.","PeriodicalId":14004,"journal":{"name":"International Journal of Inflammation","volume":"2017 ","pages":"1067598"},"PeriodicalIF":2.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/1067598","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35750319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Administration of Protein Kinase D1 Induces a Protective Effect on Lipopolysaccharide-Induced Intestinal Inflammation in a Co-Culture Model of Intestinal Epithelial Caco-2 Cells and RAW264.7 Macrophage Cells. 在肠上皮Caco-2细胞和RAW264.7巨噬细胞共培养模型中，蛋白激酶D1对脂多糖诱导的肠道炎症具有保护作用。

IF 2

International Journal of Inflammation Pub Date : 2017-01-01 Epub Date: 2017-10-26 DOI: 10.1155/2017/9273640

Ditte Søvsø Gundelund Nielsen, Marlene Fredborg, Vibeke Andersen, Stig Purup

{"title":"Administration of Protein Kinase D1 Induces a Protective Effect on Lipopolysaccharide-Induced Intestinal Inflammation in a Co-Culture Model of Intestinal Epithelial Caco-2 Cells and RAW264.7 Macrophage Cells.","authors":"Ditte Søvsø Gundelund Nielsen, Marlene Fredborg, Vibeke Andersen, Stig Purup","doi":"10.1155/2017/9273640","DOIUrl":"https://doi.org/10.1155/2017/9273640","url":null,"abstract":"Inflammatory bowel diseases (IBD) are chronic inflammatory diseases involving all or part of the gastrointestinal tract. The stress-activated serine-threonine protein kinase D1 (PKD1) protein has previously been implicated in intestinal immune regulation. The objective of this study was to evaluate the effects of human PKD1 in relation to intestinal inflammation, using a co-culture model of intestinal epithelial Caco-2 cells and RAW264.7 macrophages. An inflammatory response was induced in the macrophages by lipopolysaccharide (LPS), upregulating the expression of tumour necrosis factor alpha (TNF-α), interleukin- (IL-) 1β, and IL-6 besides increasing the secretion of TNF-α protein. The effect of administering PKD1 to Caco-2 was evaluated in relation to both amelioration of inflammation and the ability to suppress inflammation initiation. Administration of PKD1 (10-100 ng/ml) following induction of inflammation induced downregulation of TNF-α expression in RAW264.7 cells. In addition, PKD1 administered for 3 h prior to LPS stimulation reduced the subsequent inflammatory response through downregulation of TNF-α, IL-1β, and IL-6 in RAW264.7 cells. These results demonstrate a potential role of PKD1 in the intercellular communication between intestinal epithelial and immune cells, proposing a protective effect of PKD1 on the induction of an inflammatory response in macrophages, an important aspect during the pathogenesis of IBD.","PeriodicalId":14004,"journal":{"name":"International Journal of Inflammation","volume":"2017 ","pages":"9273640"},"PeriodicalIF":2.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/9273640","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35241752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Hyperexcitability in Spinal WDR Neurons following Experimental Disc Herniation Is Associated with Upregulation of Fractalkine and Its Receptor in Nucleus Pulposus and the Dorsal Root Ganglion 实验性椎间盘突出后脊髓WDR神经元的高兴奋性与髓核和背根神经节中裂肽及其受体的上调有关

IF 2

International Journal of Inflammation Pub Date : 2016-12-26 DOI: 10.1155/2016/6519408

D. Jacobsen, A. Moen, F. Haugen, J. Gjerstad

{"title":"Hyperexcitability in Spinal WDR Neurons following Experimental Disc Herniation Is Associated with Upregulation of Fractalkine and Its Receptor in Nucleus Pulposus and the Dorsal Root Ganglion","authors":"D. Jacobsen, A. Moen, F. Haugen, J. Gjerstad","doi":"10.1155/2016/6519408","DOIUrl":"https://doi.org/10.1155/2016/6519408","url":null,"abstract":"Introduction. Lumbar radicular pain following intervertebral disc herniation may be associated with a local inflammatory response induced by nucleus pulposus (NP) cells. Methods. In anaesthetized Lewis rats, extracellular single unit recordings of wide dynamic range (WDR) neurons in the dorsal horn and qPCR were used to explore the effect of NP application onto the dorsal nerve roots (L3–L5). Results. A clear increase in C-fiber response was observed following NP conditioning. In the NP tissue, the expression of interleukin-1β (IL-1β), colony stimulating factor 1 (Csf1), fractalkine (CX3CL1), and the fractalkine receptor CX3CR1 was increased. Minocycline, an inhibitor of microglial activation, inhibited the increase in neuronal activity and attenuated the increase in IL-1β, Csf1, CX3L1, and CX3CR1 expression in NP tissue. In addition, the results demonstrated an increase in the expression of TNF, CX3CL1, and CX3CR1 in the dorsal root ganglions (DRGs). Conclusion. Hyperexcitability in the pain pathways and the local inflammation after disc herniation may involve upregulation of CX3CL1 signaling in both the NP and the DRG.","PeriodicalId":14004,"journal":{"name":"International Journal of Inflammation","volume":"73 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2016-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86092696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

The Role of TLR2, TLR4, and TLR9 in the Pathogenesis of Atherosclerosis TLR2、TLR4和TLR9在动脉粥样硬化发病中的作用

IF 2

International Journal of Inflammation Pub Date : 2016-10-04 DOI: 10.1155/2016/1532832

Mohsin H. K. Roshan, Amos Tambo, N. Pace

{"title":"The Role of TLR2, TLR4, and TLR9 in the Pathogenesis of Atherosclerosis","authors":"Mohsin H. K. Roshan, Amos Tambo, N. Pace","doi":"10.1155/2016/1532832","DOIUrl":"https://doi.org/10.1155/2016/1532832","url":null,"abstract":"Toll-like receptors (TLRs) are key players in the pathogenesis of inflammatory conditions including coronary arterial disease (CAD). They are expressed by a variety of immune cells where they recognize pathogen-associated molecular patterns (PAMPs). TLRs recruit adaptor molecules, including myeloid differentiation primary response protein (MYD88) and TIRF-related adaptor protein (TRAM), to mediate activation of MAPKs and NF-kappa B pathways. They are associated with the development of CAD through various mechanisms. TLR4 is expressed in lipid-rich and atherosclerotic plaques. In TLR2−/− and TLR4−/− mice, atherosclerosis-associated inflammation was diminished. Moreover, TLR2 and TLR4 may induce expression of Wnt5a in advanced staged atheromatous plaque leading to activation of the inflammatory processes. TLR9 is activated by CpG motifs in nucleic acids and have been implicated in macrophage activation and the uptake of oxLDL from the circulation. Furthermore, TLR9 also stimulates interferon-α (INF-α) secretion and increases cytotoxic activity of CD4+ T-cells towards coronary artery tunica media smooth muscle cells. This review outlines the pathophysiological role of TLR2, TLR4, and TLR9 in atherosclerosis, focusing on evidence from animal models of the disease.","PeriodicalId":14004,"journal":{"name":"International Journal of Inflammation","volume":"139 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2016-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77417895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 127

Association of Alanine Aminotransferase and Periodontitis: A Cross-Sectional Analysis—NHANES 2009–2012 丙氨酸转氨酶与牙周炎的相关性:横断面分析- nhanes 2009-2012

IF 2

International Journal of Inflammation Pub Date : 2016-02-11 DOI: 10.1155/2016/3901402

R. Wiener, U. Sambamoorthi, R. Jurevic, Robert C Byrd

{"title":"Association of Alanine Aminotransferase and Periodontitis: A Cross-Sectional Analysis—NHANES 2009–2012","authors":"R. Wiener, U. Sambamoorthi, R. Jurevic, Robert C Byrd","doi":"10.1155/2016/3901402","DOIUrl":"https://doi.org/10.1155/2016/3901402","url":null,"abstract":"Objective. Alanine Aminotransferase is an enzyme associated with not only liver diseases, liver conditions, and metabolic syndrome, but also inflammation. Periodontitis is associated with increased cytokines and other markers of inflammation. The purpose of this study is to determine if an independent association between Alanine Aminotransferase and periodontitis exists. Methods. Data from the 2009-2010 and 2011-2012 National Health and Nutrition Surveys (NHANES) were combined. Data concerning periodontitis and Alanine Aminotransferase were extracted and analyzed with Rao Scott Chi-square and logistic regressions. Serum Alanine Aminotransferase was dichotomized at 40 units/liter, and periodontitis was dichotomized to the presence or absence of periodontitis. Results. In bivariate Chi-square analyses, periodontitis and Alanine Aminotransferase were associated (p = 0.0360) and remained significant in unadjusted logistic regression (OR = 1.30 [95% CI: 1.02, 1.65]). However, when other known risk factors of periodontitis were included in the analyses, the relationship attenuated and failed to reach significance (adjusted OR = 1.17 [95% CI: 0.85, 1.60]). Conclusion. Our study adds to the literature a positive but attenuated association of serum Alanine Aminotransferase with periodontitis which failed to reach significance when other known, strong risk factors of periodontitis were included in the analysis.","PeriodicalId":14004,"journal":{"name":"International Journal of Inflammation","volume":"17 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2016-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82696046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6