International Journal of Inflammation最新文献_第7页

A CFA-Induced Model of Inflammatory Skin Disease in Miniature Swine. cfa诱导的小型猪炎症性皮肤病模型。

IF 2

International Journal of Inflammation Pub Date : 2018-06-24 eCollection Date: 2018-01-01 DOI: 10.1155/2018/6916920

Nalú Navarro-Alvarez, Beatriz M M Gonçalves, Alec R Andrews, David H Sachs, Christene A Huang

{"title":"A CFA-Induced Model of Inflammatory Skin Disease in Miniature Swine.","authors":"Nalú Navarro-Alvarez, Beatriz M M Gonçalves, Alec R Andrews, David H Sachs, Christene A Huang","doi":"10.1155/2018/6916920","DOIUrl":"https://doi.org/10.1155/2018/6916920","url":null,"abstract":"Similarities between porcine and human skin make the pig an ideal model for preclinical studies of cutaneous inflammation and wound healing. Complete Freund's adjuvant (CFA) has been used to induce inflammation and to study inflammatory pain in several animal models. Here, we evaluated the inflammation caused by CFA injected in different layers of skin and subcutaneous (SC) tissue in a large-animal model. The degree of inflammation was evaluated at early and late time points by visual inspection and histopathologic analysis. In addition, the side effects of CFA injections were evaluated based on clinical findings, behavioral changes, physiologic state, and (histo)pathologic lesions. Pigs were injected with CFA at the back of the neck's skin at different depths. All animals showed histologic signs of inflammation at the injection site. Animals injected SC did not show any signs of pain or distress (loss of appetite, abnormal behavior) and did not require pain medication. Inflammation was followed by measuring the area of induration beneath the skin. Animals injected into the dermis and/or epidermis demonstrated a severe inflammatory response on the skin surface with massive swelling, redness within 12hrs of CFA injection, and severe skin necrosis within a week, preventing accurate induration measurements. In contrast to animals injected SC, animals receiving intradermal and/or intraepidermal injection of CFA showed signs of distress requiring pain medication. Conclusion. SC injection of CFA in swine induces an inflammatory response that can be measured accurately by induration without causing unnecessary discomfort, providing a useful preclinical large-animal model of inflammatory skin disease.","PeriodicalId":14004,"journal":{"name":"International Journal of Inflammation","volume":"2018 ","pages":"6916920"},"PeriodicalIF":2.0,"publicationDate":"2018-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/6916920","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36334114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

The Difference in Interleukin-19 Serum on Degrees of Acne Vulgaris Severity. 白细胞介素-19血清对寻常性痤疮严重程度的影响。

IF 2

International Journal of Inflammation Pub Date : 2018-04-01 eCollection Date: 2018-01-01 DOI: 10.1155/2018/4141579

Moerbono Mochtar, Alamanda Murasmita, M Eko Irawanto, Indah Julianto, Harijono Kariosentono, Fajar Waskito

{"title":"The Difference in Interleukin-19 Serum on Degrees of Acne Vulgaris Severity.","authors":"Moerbono Mochtar, Alamanda Murasmita, M Eko Irawanto, Indah Julianto, Harijono Kariosentono, Fajar Waskito","doi":"10.1155/2018/4141579","DOIUrl":"https://doi.org/10.1155/2018/4141579","url":null,"abstract":"Introduction: Acne vulgaris is a multifactorial disease. Recent study showed that inflammation does have a central role in the formation of both inflammatory and noninflammatory lesions in acne vulgaris. There are various findings of proinflammatory cytokines related to acne vulgaris, but no previous study correlate interleukin- (IL-) 19 to acne vulgaris. This pilot study aims to look at difference in IL-19 serum concentration on degrees of severity of acne vulgaris.Methods: This is an analytical observational cross-sectional study. Sample subjects were patients with acne vulgaris who met the inclusion criteria. Enzyme-linked immunosorbent assay (ELISA) study was applied to measure IL-19 serum.Result: Analysis test found statistically significant difference between IL-19 serum concentration of group of patients with mild acne vulgaris and that of group of patients with severe acne vulgaris. Moreover, analysis revealed significant difference between IL-19 serum concentration of group of patients with moderate acne vulgaris and that of group of patients with severe acne vulgaris.Conclusions: There are differences in serum levels of IL-19 on the severity of acne vulgaris. The significant difference might show that inflammation has a core role in severity of acne vulgaris, and IL-19 might potentially be related to acne vulgaris.","PeriodicalId":14004,"journal":{"name":"International Journal of Inflammation","volume":"2018 ","pages":"4141579"},"PeriodicalIF":2.0,"publicationDate":"2018-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/4141579","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36135406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

S-Equol, a Major Isoflavone from Soybean, Inhibits Nitric Oxide Production in Lipopolysaccharide-Stimulated Rat Astrocytes Partially via the GPR30-Mediated Pathway. 大豆主要异黄酮S-Equol通过gpr30介导的途径部分抑制脂多糖刺激大鼠星形胶质细胞一氧化氮的产生

IF 2

International Journal of Inflammation Pub Date : 2018-03-05 eCollection Date: 2018-01-01 DOI: 10.1155/2018/8496973

Mitsuaki Moriyama, Ayano Hashimoto, Hideyo Satoh, Kenji Kawabe, Mizue Ogawa, Katsura Takano, Yoichi Nakamura

{"title":"S-Equol, a Major Isoflavone from Soybean, Inhibits Nitric Oxide Production in Lipopolysaccharide-Stimulated Rat Astrocytes Partially via the GPR30-Mediated Pathway.","authors":"Mitsuaki Moriyama, Ayano Hashimoto, Hideyo Satoh, Kenji Kawabe, Mizue Ogawa, Katsura Takano, Yoichi Nakamura","doi":"10.1155/2018/8496973","DOIUrl":"https://doi.org/10.1155/2018/8496973","url":null,"abstract":"Cumulative evidence indicates that estrogen receptor (ER) agonists attenuate neuroinflammation. Equol, a major isoflavone from soybean, exhibits estrogen-like biological activity, but their effect on inflammatory response has not been well established. Here, we investigated the effect of S-equol on nitric oxide (NO) production, well-known inflammatory change in astrocytes stimulated by LPS. S-Equol attenuated LPS-induced NO production with a concomitant decrease in expression of inducible NO synthase (iNOS). S-Equol did not affect LPS-induced increase in intracellular ROS production. Intracellular ER blocker ICI 182.780 had no effect on S-equol-induced decrease in NO production. Addition of G-15, antagonist of G protein-coupled receptor 30 which is nongenomic ER and located on cell surface, partially recovered S-equol-induced attenuation of NO production. These findings suggest that attenuation of NO production by S-equol may mitigate LPS-induced neuroinflammation in astrocytes. S-Equol may exert a glioprotective effect, at least in part, via a nongenomic effect.","PeriodicalId":14004,"journal":{"name":"International Journal of Inflammation","volume":"2018 ","pages":"8496973"},"PeriodicalIF":2.0,"publicationDate":"2018-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/8496973","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36041547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Natural Products with Toll-Like Receptor 4 Antagonist Activity. 具有toll样受体4拮抗剂活性的天然产物

IF 2

International Journal of Inflammation Pub Date : 2018-03-01 eCollection Date: 2018-01-01 DOI: 10.1155/2018/2859135

Monica Molteni, Annalisa Bosi, Carlo Rossetti

引用次数: 58

Presenting a New Standard Drug Model for Turmeric and Its Prized Extract, Curcumin. 提出姜黄及其珍贵提取物姜黄素的新标准药物模型。

IF 2

International Journal of Inflammation Pub Date : 2018-01-15 eCollection Date: 2018-01-01 DOI: 10.1155/2018/5023429

Franco Cavaleri

{"title":"Presenting a New Standard Drug Model for Turmeric and Its Prized Extract, Curcumin.","authors":"Franco Cavaleri","doi":"10.1155/2018/5023429","DOIUrl":"10.1155/2018/5023429","url":null,"abstract":"Various parts of the turmeric plant have been used as medicinal treatment for various conditions from ulcers and arthritis to cardiovascular disease and neuroinflammation. The rhizome's curcumin extract is the most studied active constituent, which exhibits an expansive polypharmacology with influence on many key inflammatory markers. Despite the expansive reports of curcucmin's therapeutic value, clinical reliability and research repeatability with curcumin treatment are still poor. The pharmacology must be better understood and reliably mapped if curcumin is to be accepted and used in modern medical applications. Although the polypharmacology of this extract has been considered, in mainstream medicine, to be a drawback, a perspective change reveals a comprehensive and even synergistic shaping of the NF-kB pathway, including transactivation. Much of the inconsistent research data and unreliable clinical outcomes may be due to a lack of standardization which also pervades research standard samples. The possibility of other well-known curcumin by-products contributing in the polypharmacology is also discussed. A new flowchart of crosstalk in transduction pathways that lead to shaping of nuclear NF-kB transactivation is generated and a new calibration or standardization protocol for the extract is proposed which could lead to more consistent data extraction and improved reliability in therapy.","PeriodicalId":14004,"journal":{"name":"International Journal of Inflammation","volume":"2018 ","pages":"5023429"},"PeriodicalIF":2.0,"publicationDate":"2018-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35939083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impaired Inflammatory Response to LPS in Type 2 Diabetes Mellitus. 2型糖尿病患者对LPS的炎症反应受损。

IF 2

International Journal of Inflammation Pub Date : 2018-01-14 eCollection Date: 2018-01-01 DOI: 10.1155/2018/2157434

Lusine Khondkaryan, Sona Margaryan, David Poghosyan, Gayane Manukyan

{"title":"Impaired Inflammatory Response to LPS in Type 2 Diabetes Mellitus.","authors":"Lusine Khondkaryan, Sona Margaryan, David Poghosyan, Gayane Manukyan","doi":"10.1155/2018/2157434","DOIUrl":"https://doi.org/10.1155/2018/2157434","url":null,"abstract":"Type 2 diabetes mellitus (T2DM) is a severe health problem worldwide, reaching epidemic levels. High susceptibility to infections of T2DM patients indicates dysregulated immune responses to pathogens. However, innate immune responses, including monocyte functions, in T2DM are poorly investigated. Therefore, in this study we aimed to assess lipopolysaccharide- (LPS-) induced immune responses of circulating monocytes from T2DM patients. The results showed that monocytes from T2DM were hyporesponsive to LPS challenge as reflected by significantly suppressed secretion of TNFα (p < 0.01) and expression of CD11b (p < 0.001) and TLR4 (p < 0.001) compared to those in monocytes from healthy subjects. Furthermore, LPS-induced IL-10 levels were similar in diabetic and healthy supernatants, while expression levels of CD163 were found to be downregulated on monocytes from T2DM (p < 0.001) suggesting impaired ability of monocytes to switch their phenotype to anti-inflammatory. Taken together, our results suggest compromised function of monocytes in T2DM, which may explain, at least partly, high incidence of infection in these patients.","PeriodicalId":14004,"journal":{"name":"International Journal of Inflammation","volume":"2018 ","pages":"2157434"},"PeriodicalIF":2.0,"publicationDate":"2018-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/2157434","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35939678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23

Sterile Neuroinflammation and Strategies for Therapeutic Intervention 无菌性神经炎症及治疗干预策略

IF 2

International Journal of Inflammation Pub Date : 2017-01-03 DOI: 10.1155/2017/8385961

Manoj Banjara, C. Ghosh

{"title":"Sterile Neuroinflammation and Strategies for Therapeutic Intervention","authors":"Manoj Banjara, C. Ghosh","doi":"10.1155/2017/8385961","DOIUrl":"https://doi.org/10.1155/2017/8385961","url":null,"abstract":"Sterile neuroinflammation is essential for the proper brain development and tissue repair. However, uncontrolled neuroinflammation plays a major role in the pathogenesis of various disease processes. The endogenous intracellular molecules so called damage-associated molecular patterns or alarmins or damage signals that are released by activated or necrotic cells are thought to play a crucial role in initiating an immune response. Sterile inflammatory response that occurs in Alzheimer's disease (AD), Parkinson's disease (PD), stroke, hemorrhage, epilepsy, or traumatic brain injury (TBI) creates a vicious cycle of unrestrained inflammation, driving progressive neurodegeneration. Neuroinflammation is a key mechanism in the progression (e.g., AD and PD) or secondary injury development (e.g., stroke, hemorrhage, stress, and TBI) of multiple brain conditions. Hence, it provides an opportunity for the therapeutic intervention to prevent progressive tissue damage and loss of function. The key for developing anti-neuroinflammatory treatment is to minimize the detrimental and neurotoxic effects of inflammation while promoting the beneficial and neurotropic effects, thereby creating ideal conditions for regeneration and repair. This review outlines how inflammation is involved in the pathogenesis of major nonpathogenic neuroinflammatory conditions and discusses the complex response of glial cells to damage signals. In addition, emerging experimental anti-neuroinflammatory drug treatment strategies are discussed.","PeriodicalId":14004,"journal":{"name":"International Journal of Inflammation","volume":"24 1","pages":""},"PeriodicalIF":2.0,"publicationDate":"2017-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82202896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 60

From Inflammation to Current and Alternative Therapies Involved in Wound Healing. 从炎症到当前和替代疗法参与伤口愈合。

IF 2

International Journal of Inflammation Pub Date : 2017-01-01 Epub Date: 2017-07-25 DOI: 10.1155/2017/3406215

Mariana Barreto Serra, Wermerson Assunção Barroso, Neemias Neves da Silva, Selma do Nascimento Silva, Antonio Carlos Romão Borges, Iracelle Carvalho Abreu, Marilene Oliveira da Rocha Borges

引用次数: 142

Does Inhalation of Virgin Coconut Oil Accelerate Reversal of Airway Remodelling in an Allergic Model of Asthma? 在过敏性哮喘模型中吸入初榨椰子油是否会加速气道重塑的逆转？

IF 2

International Journal of Inflammation Pub Date : 2017-01-01 Epub Date: 2017-06-04 DOI: 10.1155/2017/8741851

N A Kamalaldin, S A Sulaiman, M R Yusop, B Yahaya

{"title":"Does Inhalation of Virgin Coconut Oil Accelerate Reversal of Airway Remodelling in an Allergic Model of Asthma?","authors":"N A Kamalaldin, S A Sulaiman, M R Yusop, B Yahaya","doi":"10.1155/2017/8741851","DOIUrl":"10.1155/2017/8741851","url":null,"abstract":"Many studies have been done to evaluate the effect of various natural products in controlling asthma symptoms. Virgin coconut oil (VCO) is known to contain active compounds that have beneficial effects on human health and diseases. The objective of this study was to evaluate the effect of VCO inhalation on airway remodelling in a rabbit model of allergic asthma. The effects of VCO inhalation on infiltration of airway inflammatory cells, airway structures, goblet cell hyperplasia, and cell proliferation following ovalbumin induction were evaluated. Allergic asthma was induced by a combination of ovalbumin and alum injection and/or followed by ovalbumin inhalation. The effect of VCO inhalation was then evaluated via the rescue or the preventive route. Percentage of inflammatory cells infiltration, thickness of epithelium and mucosa regions, and the numbers of goblet and proliferative cells were reduced in the rescue group but not in preventive group. Analysis using a gas chromatography-mass spectrometry found that lauric acid and capric acid were among the most abundant fatty acids present in the sample. Significant improvement was observed in rescue route in alleviating the asthma symptoms, which indicates the VCO was able to relieve asthma-related symptoms more than preventing the onset of asthma.","PeriodicalId":14004,"journal":{"name":"International Journal of Inflammation","volume":"2017 ","pages":"8741851"},"PeriodicalIF":2.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35129072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An In Vitro Model of Gastric Inflammation and Treatment with Cobalamin. 胃炎症的体外模型及钴胺素治疗。

IF 2

International Journal of Inflammation Pub Date : 2017-01-01 Epub Date: 2017-06-06 DOI: 10.1155/2017/5968618

T R Elliott, A L Guildford

{"title":"An In Vitro Model of Gastric Inflammation and Treatment with Cobalamin.","authors":"T R Elliott, A L Guildford","doi":"10.1155/2017/5968618","DOIUrl":"https://doi.org/10.1155/2017/5968618","url":null,"abstract":"Pernicious anaemia (PA) is an autoimmune condition where antibodies target intrinsic factor and parietal cells, reducing the patient's ability to absorb cobalamin promoting atrophic gastritis. Treatment guidelines are based on excretion data of hydroxocobalamin from healthy individuals obtained 50 years ago. This manuscript describes the use of phorbol 12-myristate 13-acetate (PMA) to stimulate low grade inflammation in an epithelial colorectal cell line to assess the efficacy of methylcobalamin and hydroxocobalamin. Nitric oxide increased significantly in cells exposed to higher doses of PMA (100 ng/ml, 150 ng/ml, and 200 ng/ml) accompanied by a loss of the characteristic cobblestone morphology with no negative effect on cell activity or viability. A significant reduction in nitric oxide production was associated with the addition of 200 pg/ml hydroxocobalamin, alongside a return to the characteristic cobblestone morphology. This study highlights the use of PMA to promote low grade inflammation in human cell lines to model gastric inflammation associated with autoimmunity; furthermore it raises questions regarding the concentration of cobalamin administered clinically to restore cell functionality, feasibly allowing the patient to receive reduced quantity of the vitamin more regularly, providing the patient with levels which are akin to dietary intake.","PeriodicalId":14004,"journal":{"name":"International Journal of Inflammation","volume":"2017 ","pages":"5968618"},"PeriodicalIF":2.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2017/5968618","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35141936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2