ACS Chemical Neuroscience最新文献

{"title":"Therapeutic Role of l-Theanine in Mitigating Cognitive Dysfunction and Neuropathology in Scopolamine-Treated Mice.","authors":"Eman M Elbaz, Sherehan M Ibrahim, Eman Rashad, Noha A E Yasin, Heba R Ghaiad, Noha A Mehana","doi":"10.1021/acschemneuro.5c00351","DOIUrl":"10.1021/acschemneuro.5c00351","url":null,"abstract":"<p><p>Memory decline is a prominent hallmark of Alzheimer's disease (AD). Scopolamine-induced amnesia is a pharmacological paradigm in AD research to model these cognitive insults. AD represents the most prevalent type of dementia among the elderly, depicted by impaired cognition and memory. AD pathogenesis is an interplay among cholinergic signaling disruption, neuroinflammation, and oxidative stress. Recently, autophagy modulation has been proven to display a beneficial effect against several diseases. l-Theanine (LTA), found in green tea, possesses neuroprotective, anti-inflammatory, antioxidant, and antiaging properties. Hence, this study investigated LTA's potential to alleviate AD symptoms, elaborating the role of autophagy. 45 mice were classified into five groups: the control, where animals received phosphate-buffered saline, while the other groups received scopolamine (Scop; 1 mg/kg; i.p.), inducing amnesia; then they were categorized as follows: group II represented the model one, group III was treated with donepezil (DON; 5 mg/kg; p.o.), while group IV was treated with LTA (20 mg/kg; p.o.), and group V received chloroquine (CQ; 10 mg/kg; p.o.), an autophagy blocker, followed by LTA. LTA stimulated AMP-activated protein kinase (AMPK), microtubule-associated protein-1 light chain-3II (LC3II), and beclin 1 but lowered phosphorylated levels of protein kinase B (p-AKT) and mammalian target of rapamycin (p-mTOR). Furthermore, LTA elevated the brain-derived neurotrophic factor (BDNF) and downregulated caspase-3 expression. Noteworthily, LTA increased glutathione and reduced malondialdehyde and tumor necrosis factor-alpha levels. In conclusion, LTA ameliorated histopathological changes, reduced amyloid-β, and enhanced learning and memory performance in novel object recognition, Y-maze, and Morris water maze. LTA boosted autophagy, promoted neuronal survival, and attenuated oxidative stress. LTA almost displayed similar effects to the DON group, while CQ abolished LTA-enhanced memory via blocking autophagy. Consequently, LTA-mediated autophagy represents a promising approach to alleviating Scop-induced amnesia in mice.</p>","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":" ","pages":"2528-2545"},"PeriodicalIF":4.1,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association between Body Mass Index, HbA1c Levels, and Tarsal Tunnel Syndrome: A Clinical and Neurophysiological Study.","authors":"Marwa Hanafy Abo Omirah, Marwa Kamal, Mohammed Gomaa, Abdelrahman Ahmed Ewais, Hayam Ali AlRasheed, Mostafa M Bahaa, Sherif Thabet, Hossam Mostafa Moawad, Mostafa M Magdy","doi":"10.1021/acschemneuro.5c00198","DOIUrl":"https://doi.org/10.1021/acschemneuro.5c00198","url":null,"abstract":"<p><p>Tarsal Tunnel Syndrome (TTS) is a focal compressive entrapment neuropathy affecting the posterior tibial nerve. While obesity and diabetes mellitus are known as systemic risk factors, their specific impact on TTS severity remains insufficiently investigated. We aimed to determine the association between body mass index (BMI), glycemic control (HbA1c level), and TTS severity. A cross-sectional study included 34 patients presented with signs and symptoms of TTS. For these patients, BMI was calculated, HbA1c levels were recorded, and clinical severity was evaluated using the Takakura scale and Mondelli's electrophysiological severity scale. There was a significant association between BMI, HbA1c level, and age with TTS severity both clinically and electrophysiologically (<i>p</i> < 0.05). Increases in age, BMI, and HbA1c levels were associated with a decrease in the rating scale and an increase in Mondelli's electrophysiological scale. There is a high prevalence of bilateral TTS. Higher BMI and elevated HbA1c levels are strongly associated with increased TTS severity. Obesity and diabetes are strongly correlated with the severity of TTS. Further studies are required to validate the correlations found.</p>","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144537389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal Neuroimaging for the PK/PD Profile of NLX-204: A Biased 5-HT_1A Receptor Agonist.","authors":"Violette Richin, Marco Valdebenito, Caroline Bouillot, Sandrine Bouvard, Sébastien Daligault, Benjamin Vidal, Adrian Newman-Tancredi, Wael Zeinyeh, Luc Zimmer","doi":"10.1021/acschemneuro.5c00342","DOIUrl":"https://doi.org/10.1021/acschemneuro.5c00342","url":null,"abstract":"<p><p>NLX-204, a highly selective biased agonist for serotonin 5-HT_1A receptors, demonstrates strong affinity and preferentially elicits ERK1/2 phosphorylation, a response linked to antidepressant activity. Preclinical studies in rodent models confirm its potential as an effective and rapid-acting treatment for depression. In the present study, we performed a pharmacokinetic and pharmacodynamic characterization of NLX-204 by means of neuroimaging techniques. Radiolabeling of NLX-204 with fluorine-18 was used to assess its brain distribution and labeling kinetics via PET microdosing imaging in rats. Its pharmacodynamics were further investigated through a dose-response study in awake, freely moving rats using functional ultrasound (fUS) imaging. This unique combination of PET and fUS brain imaging data demonstrates that NLX-204 specifically engages 5-HT_1A receptors in the rat brain, eliciting robust activation in specific cortical regions. These results support the potential of NLX-204 as a promising candidate for the treatment of mood disorders.</p>","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144525306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stereoisomers of Chiral Methyl-Substituted Symmetric and Asymmetric Aryl Piperazinium Compounds Exhibit Distinct Selectivity for α9 and α7 Nicotinic Acetylcholine Receptors.","authors":"Hina Andleeb, Roger L Papke, Katrin Richter, Veronika Grau, Arik J Hone, Andrew Kerr, J Michael McIntosh, Clare Stokes, Ganesh A Thakur","doi":"10.1021/acschemneuro.5c00204","DOIUrl":"https://doi.org/10.1021/acschemneuro.5c00204","url":null,"abstract":"<p><p>We have characterized families of phenylpiperazine (PP) compounds, studying their relative activity with α7 and α9* nicotinic acetylcholine receptors (nAChRs) and focusing on the effects of side groups on the phenyl ring (R₁) and the effects of different alkyl groups on the base nitrogen. In this study, we evaluated the impact of methyl substitution on the piperazine ring, which introduced a chiral center, enabling the generation and separation of stereoisomers. Methyl groups were added to either the C2 or C3 positions on the piperazine of the α9α10 agonist/α7 partial agonist PA-EMPP. Additions at the C3 position greatly reduced activity, while additions at the C2 position had selective effects on either α7 or α9/α10 activity. The 2-methyl <i>S</i> and <i>R</i> isomers of PA-EMPP contain a second chiral center at the nitrogen. Notably, replacing the terminal substitution with <i>N</i>,<i>N</i>-dimethyl abolished α9/α910 agonist activity, rendering the compound selective for α7. We also tested 2M isomers of the α9α10 agonist <i>p</i>CN-EMPP and obtained similar enantioselective activity as observed with the PA-EMPP isomers. Compounds were studied for their ability to reduce the ATP-dependent release of IL-1β from monocytes, one aspect of the cholinergic anti-inflammatory activity. Results were consistent with their apparent activation or antagonism of α9* receptors. These findings underscore the critical role of chirality and structural modifications in fine-tuning receptor selectivity, offering valuable insights for the rational design of selective nicotinic therapeutics.</p>","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144525308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phosphodiesterase 2A as a Therapeutic Target for Relieving Mechanical Allodynia and Modulating Microglial Polarization in Neuropathic Pain Models Following Spinal Cord Injury.","authors":"Wen-Jie Yang, Jie Han, Zhen-Xin Cao, Lei Yang, Jun-Nan Wang, Tao Sun","doi":"10.1021/acschemneuro.5c00169","DOIUrl":"https://doi.org/10.1021/acschemneuro.5c00169","url":null,"abstract":"<p><p>Spinal cord injury (SCI) is a severe clinical condition often accompanied by multiple complications, with neuropathic pain (NP) being one of the most persistent and difficult conditions to treat. The underlying mechanisms of NP remain unclear, and effective clinical treatments are lacking. Some studies suggest that phosphodiesterase 2A (PDE2A) may contribute to the development of NP. This study aims to investigate the role of PDE2A inhibitor Bay 60-7550 in alleviating NP in a rat model of SCI. Male Sprague-Dawley rats were randomly allocated into four groups: sham, SCI, SCI + Bay 60-7550, and SCI + vehicle. Mechanical thresholds were assessed using the von Frey test from 1 day prior to surgery through postoperative day 21. PDE2A expression in the spinal cord was quantified via qRT-PCR, Western blotting, and immunohistochemistry. Microglial polarization (M1/M2) was analyzed using flow cytometry and qRT-PCR. Downstream biomarkers, including IL-6, IL-1β, IL-10, TGF-β, CCL2, and CCL3, were also quantified via qRT-PCR. Additionally, enzyme-linked immunosorbent assay (ELISA) was performed to determine the levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). Intrathecal administration of the PDE2A inhibitor Bay 60-7550 significantly alleviated mechanical allodynia in rats following SCI. PDE2A expression was notably elevated in the spinal dorsal horn post-SCI, an effect that was suppressed by Bay 60-7550 treatment. In addition, Bay 60-7550 administration reduced the expression of pro-inflammatory cytokines (IL-6, IL-1β), increased anti-inflammatory cytokines (IL-10, TGF-β), and decreased mRNA levels of CCL2 and CCL3 in the spinal cord. Consistently, treatment with Bay 60-7550 elevated the levels of cGMP and cAMP in the spinal cord and shifted microglial polarization by increasing the proportion of M2-type cells while reducing M1-type cells in SCI rats. Inhibiting PDE2A overexpression may mitigate the progression of NP in rats following SCI by modulating microglial polarization. Therefore, PDE2A represents a promising therapeutic target for the management of neuropathic pain after SCI.</p>","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144525307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circadian and Age-Related Variations of Amino Acids Levels in <i>Drosophila</i> Brains: Correlations and Descriptive Dimensions.","authors":"Sandrine Parrot, Jacob Crehan, Chloé Aman, Philippe De Deurwaerdère, Matthew Thimgan, Laurent Seugnet","doi":"10.1021/acschemneuro.5c00052","DOIUrl":"https://doi.org/10.1021/acschemneuro.5c00052","url":null,"abstract":"<p><p>A comprehensive view of whole-brain amino acid levels holds the potential to provide valuable insights into the brain's state, given the mutual interconnections through metabolism, food intake, and neurotransmission. We tested this concept by evaluating free amino acid levels in single <i>Drosophila</i> brains across 24 h and at two different ages. A large proportion of these amino acids displayed time-of-day variations, and a subset exhibited age-dependent variations. Cross-correlation analysis of the data sets confirmed broad time-of-day and age dependent interconnections between amino acids. Factor Analysis of Mixed Data revealed further data structuration along key amino acids. For example, 50% of the variance could be accounted for by an inverse coupling between gamma-aminobutyric acid and several essential amino acids during the active phase, linking food intake and sleep. This proof of concept emphasizes the value of combining multivariate analysis to whole-brain amino acid level evaluation, shedding potentially new light on sleep-wake regulation and aging.</p>","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and Pharmacology of a Morphinan-Derived Dual Mu-Kappa Opioid Receptor Agonist Analgesic.","authors":"Balazs R Varga, Rajendra Uprety, Barnali Paul, Alexis Knoll, Nokomis Ramos-Gonzalez, Kevin Appourchaux, Tori Taylor, Bengisu Turgutalp, Ryosuke Shinouchi, Shainnel O Eans, Ashai K Williams, Steven G Vasquez-Grinnell, Saheem Zaidi, Antonina L Nazarova, Andras Varadi, Valerie Le Rouzic, Taylor G Brown, Shani Martinez, Michael Ansonoff, Rebecca Notis Dardashti, Amanda Hunkele, Joan Subrath, Matthew Welch, Jin Xu, Grace C Rossi, John Pintar, Gavril W Pasternak, Vsevolod Katritch, Jay P McLaughlin, Ying Xian Pan, Susruta Majumdar","doi":"10.1021/acschemneuro.5c00312","DOIUrl":"10.1021/acschemneuro.5c00312","url":null,"abstract":"<p><p>We present the synthesis and pharmacological characterization of 3'-iodobenzoylamido epoxymorphinans, with a saturated ring C and devoid of 14-OH, based on a dihydronormorphine backbone with various <i>N</i>-17 alkyl substitutions. All synthesized compounds were characterized pharmacologically in radioligand binding assays, [³⁵S]GTPγS functional assays, and for antinociception in mice. Among these analogues, <b>MP1202</b>, a pan-opioid receptor analogue, was characterized further in β-arrestin1/2 studies, G-protein recruitment and Gα-subtype profiling, as well as by evaluation of opioid-mediated effects in mice. <b>MP1202</b> exhibits potent antinociceptive effects in mice without causing typical opioid side effects, such as respiratory depression and physical dependence. However, it displays conditioned place preference and aversion behaviors similar to those of classical mu and kappa agonists.</p>","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biased Signaling Agonists of Dopamine D3 Receptor Differentially Regulate the Effects of Cocaine On Dopamine Transporter Function.","authors":"Sophie R Cohen, Wei Xu, Nastaran F Aziz, Rodrigo A España, Sandhya Kortagere","doi":"10.1021/acschemneuro.5c00076","DOIUrl":"https://doi.org/10.1021/acschemneuro.5c00076","url":null,"abstract":"<p><p>Cocaine use disorder is a major healthcare issue with no effective FDA-approved treatments. Cocaine exerts its effects - in part - by blocking dopamine transporters (DAT) and subsequently dysregulating DAT function. Several molecular targets have been identified as key regulators of DAT function and expression including dopamine D3 receptors (D3R) that are highly expressed in the mesolimbic dopamine pathway. Although D3R partial agonists and antagonists have been shown to influence cocaine seeking in rodents, effects have been inconsistent with studies reporting varying outcomes on cocaine-associated behavior. In this study, we tested the effects of SK609, a novel G-protein biased D3R agonist, and pramipexole, an unbiased agonist of D3R, on DAT expression and function and cocaine-seeking behavior. Results indicated that SK609 reduced phosphorylation of DATs following cocaine and the uptake inhibition effects of cocaine on dopamine transmission in <i>in vitro</i> and <i>ex vivo</i> studies, respectively. By comparison, pramipexole augmented the effects of cocaine on DAT phosphorylation, enhanced dopamine levels, and increased cocaine seeking in rats. These results suggest that unbiased D3R activation promotes the effects of cocaine and that limiting D3R agonists to G-protein signaling pathways may have the potential to reduce these effects.</p>","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcium-Dependent S100A8 Amyloid Fibril Formation via S100A1-Mediated Transient Interaction.","authors":"Viktorija Karalkevičiu̅tė, Ieva Baronaitė, Aistė Peštenytė, Dominykas Veiveris, Gediminas Usevičius, Mantas Šimėnas, Mantas Žiaunys, Vytautas Smirnovas, Darius Šulskis","doi":"10.1021/acschemneuro.5c00086","DOIUrl":"https://doi.org/10.1021/acschemneuro.5c00086","url":null,"abstract":"<p><p>The S100 family consists of calcium-binding proteins that are largely known for their contribution to neuroinflammatory processes. These proteins are associated with various cardiac and neurological functions as well as related diseases. A few S100 proteins can form unspecific or amyloid aggregates in neuropathologies and thus play a part in dementia pathogenesis. Among all S100 proteins, S100B and S100A9 aggregation properties are the most investigated; however, there is a lack of studies regarding other S100 members. In particular, S100A1 and S100A8 are also associated with neurological pathologies, but their interactions and aggregation are poorly understood. Therefore, in this study, we explored whether S100A1 and S100A8 proteins can form heterodimers, interact, or coaggregate. Our results revealed that S100A1 and S100A8 interactions and S100A8 amyloid aggregation are driven by calcium ions. We observed that while S100A1 remains mostly stable, S100A8 forms various types of spherical or unspecific aggregates. While they do not form stable heterodimers like calprotectin, their transient interactions facilitate the formation of worm-like amyloid fibrils, and the process is regulated by different calcium ion concentrations. At calcium ion saturation, both proteins are stabilized, leading to inhibition of aggregation. Overall, by employing a diverse range of techniques from amyloid and protein-specific fluorescence detection to electron-electron double resonance spectroscopy, we elucidated interactions between S100 proteins that might otherwise be overlooked, enhancing our understanding of their aggregation behavior.</p>","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiofluorinated Analogs of NCS-382 as Potential PET Tracers for Imaging the CaMKIIα Hub Domain.","authors":"Ludovica S Sirocchi, Sophie Stotz, Marius Müller, Nadia Billesborg Pedersen, Louise Thiesen, Simona Mattiussi, Christos Avgerinos, Vladimir Shalgunov, Petrine Wellendorph, Bente Fro̷lund, Matthias M Herth","doi":"10.1021/acschemneuro.4c00778","DOIUrl":"https://doi.org/10.1021/acschemneuro.4c00778","url":null,"abstract":"<p><p>The Ca²⁺/calmodulin-dependent protein kinase II alpha (CaMKIIα) is a key regulator of calcium signaling in the central nervous system and is suggested to play a crucial role in neurodegenerative diseases and stroke. The CaMKIIα hub domain was recently identified as a high-affinity binding site for γ-hydroxybutyric acid (GHB), representing a new target for neurological research and therapy. In this study, we synthesized and evaluated two novel radiofluorinated GHB analogs, [¹⁸F]<b>6</b> and [¹⁸F]<b>9</b>, to visualize CaMKIIα via this domain in vivo using positron emission tomography (PET). In vitro autoradiography demonstrated specific binding of [¹⁸F]<b>6</b> to CaMKIIα-rich brain regions, whereas [¹⁸F]<b>9</b> exhibited apparent nonspecific myelin binding. In vivo, [¹⁸F]<b>6</b> crossed the blood-brain barrier but did not exhibit effective PET imaging of CaMKIIα presumably due to a too low affinity. Despite this limitation, the brain penetrance of the compound suggests that further chemical modifications could enhance its suitability for neuroimaging. This work provides a foundation for future radiotracer development targeting CaMKIIα.</p>","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144493135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}