ACS Chemical Neuroscience最新文献

{"title":"Purinergic Receptor P2Y1 Modulates Catecholamine Signaling in Murine Mesenteric Lymph Nodes.","authors":"Alexandra K Brooke, Sarbeshwar Ojha, Daniel P Murrow, Ashley E Ross","doi":"10.1021/acschemneuro.4c00435","DOIUrl":"https://doi.org/10.1021/acschemneuro.4c00435","url":null,"abstract":"<p><p>Neuroimmune communication is crucial for the body's response to physiological challenges, homeostasis, and immune stress response. Adrenergic and purinergic neurotransmission in the sympathetic nervous system is vital for this communication. This study achieves the first co-detection of adenine-based purines and catecholamines in mesenteric lymph nodes via fast-scan cyclic voltammetry. Additionally, we reveal that manipulating an ATP receptor can impact catecholamine signaling in the lymph node for the first time. The G-protein-coupled receptor P2Y1, which controls intracellular Ca²⁺ levels, was targeted with the antagonist MRS2179. MRS2179 decreased catecholamine concentrations, increased inter-event times, and prolonged event durations. These results suggest that events became smaller, less frequent, and longer-lasting, possibly attributable to decreased intracellular Ca²⁺ levels. These findings indicate that ATP release in the lymph node can partially regulate norepinephrine signaling, providing mechanistic insight into sympathetic neuronal neurotransmitter control. A deeper understanding of more complicated neuroimmune mechanisms could potentially influence the development of therapeutic strategies in immunology and neurobiology.</p>","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"M₄ Positive Allosteric Modulator VU0467154 Impacts Amphetamine Sensitization and Spontaneous Locomotion in Male Mice.","authors":"Anna Berezovskaia, Craig Lindsley, Anders Fink-Jensen, Gitta Wörtwein","doi":"10.1021/acschemneuro.4c00795","DOIUrl":"https://doi.org/10.1021/acschemneuro.4c00795","url":null,"abstract":"<p><p>This study investigates the effects of the muscarinic acetylcholine receptor subtype 4 (M₄) positive allosteric modulator (PAM) VU0467154 on the development, incubation, and expression of amphetamine sensitization in mice, the expression of immediate early genes in the medial prefrontal cortex after induction and expression of sensitization, as well as on spontaneous locomotion and several aspects of sensorimotor function. Mice were pretreated with VU0467154 during the induction phase, before the challenge test, or both. A separate cohort was treated during the incubation period. Tests of spontaneous locomotion and sensorimotor function were conducted after VU0467154 administration to evaluate potential side effects. Treatment with VU0467154 inhibited the development and expression of amphetamine sensitization. This was paralleled by effects on immediate early gene expression in the medial prefrontal cortex. Additionally, previous pretreatment with VU0467154 during the induction phase attenuated the expression of sensitization after a two-week incubation period. However, treatment with VU0467154 during the incubation period did not affect the expression of a sensitized response. VU0467154 significantly reduced spontaneous locomotion without impairing other aspects of sensorimotor function, as assessed by the mesh, adhesive removal, horizontal bar, and negative geotaxis tests. Global M₄ knockout mice confirmed that the inhibitory effect on spontaneous locomotion was specific to M₄ receptors. Our findings provide new insights into the therapeutic potential of M₄ PAMs in modulating the neuroadaptations associated with psychostimulant abuse. Collectively, these results suggest that activation of M₄ receptors could be a promising strategy for modulating dopaminergic signaling and reducing some behaviors associated with substance use disorder.</p>","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery of ONO-2920632 (VU6011887): A Highly Selective and CNS Penetrant TREK-2 (TWIK-Related K+ Channel 2) Preferring Activator <i>In Vivo</i> Tool Compound.","authors":"Kentaro Yashiro, Yuzo Iwaki, Hirohito Urata, Masaya Kokubo, Takahiro Mori, Yoko Sekioka, Koichi Isami, Junya Kato, Joshua Wieting, Kevin M McGowan, Thomas M Bridges, Olivier Boutaud, Darren W Engers, Jerod S Denton, Haruto Kurata, Craig W Lindsley","doi":"10.1021/acschemneuro.5c00032","DOIUrl":"https://doi.org/10.1021/acschemneuro.5c00032","url":null,"abstract":"<p><p>Herein we describe our initial work on the K₂P family of potassium ion channels with the chemical optimization and characterization of a novel series of TWIK-Related K+ Channel (TREK)-1/2 dual activators and TREK-2 preferring activators derived from a high-throughput screening hit. The exercise provided TREK activators with good CNS penetration and others with low CNS exposure to enable exploration of both central and peripheral TREK activation. From this, ONO-2920632 (VU6011887 = <b>19b</b>) emerged as a reasonably potent (human Tl⁺; TREK-1 EC₅₀ = 2.8 μM (95% <i>E</i>_max), TREK-2 EC₅₀ = 0.30 μM (184% <i>E</i>_max)), first-generation CNS penetrant (rat K_p = 0.37) <i>in vivo</i> tool compound with selectivity versus the other K₂P channels (>91-fold selective vs TASK1, TASK2, TASK3, TRAAK, TWIK2, and 31-fold selective vs TRESK) and no significant activity in a large ancillary pharmacology panel. ONO-2920632 (VU6011887) displayed robust, dose dependent efficacy when dosed orally in a mouse pain model (acetic acid writhing assay), where it was equipotent at 3 mg/kg to the assay standard indomethacin at 10 mg/kg. The therapeutic potential of TREK channel activation has long been hampered by a lack of selective, small molecule tools, and this work provides a variety of <i>in vivo</i> tool compounds for the community.</p>","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced Cognitive and Memory Functions via Gold Nanoparticle-Mediated Delivery of Afzelin through Synaptic Modulation Pathways in Alzheimer's Disease Mouse Models.","authors":"Ju Hee Mun, Min Jun Jang, Won Seok Kim, Seong-Seop Kim, Bonggi Lee, HyunSeon Moon, Soo-Jin Oh, Cheol-Hui Ryu, Kyung Su Park, Ik-Hyun Cho, Gyu-Sang Hong, Chun Whan Choi, Changhyuk Lee, Min Soo Kim","doi":"10.1021/acschemneuro.4c00766","DOIUrl":"https://doi.org/10.1021/acschemneuro.4c00766","url":null,"abstract":"<p><p>Gold nanoparticles (AuNPs) are valuable tools in pharmacological and biological research, offering unique properties for drug delivery in the treatment of neurodegenerative diseases. This study investigates the potential of gold nanoparticles loaded with afzelin, a natural chemical extracted from <i>Ribes fasciculatum</i>, to enhance its therapeutic effects and overcome the limitations of using natural compounds regarding low productivity. We hypothesized that the combined treatment of AuNPs with afzelin (AuNP-afzelin) would remarkably enforce neuroprotective effects compared with the single treatment of afzelin. Central administration of AuNP-afzelin (10 ng of afzelin) indicated improvements in cognition and memory-involved assessments of behavioral tests, comparing single treatments of afzelin (10 or 100 ng of afzelin) in scopolamine-induced AD mice. AuNP-afzelin also performed superior neuroprotective effects of rescuing mature neuronal cells and recovered cholinergic dysfunction compared to afzelin alone, according to further investigations of BDNF-pCREB-pAkt signaling, long-term potentiation, and doublecortin (DCX) expression in the hippocampus. This study highlights the potential of afzelin with gold nanoparticles as a promising therapeutic approach for mitigating cognitive impairments associated with neurodegenerative diseases and offers a new avenue for future research and drug development.</p>","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143456258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optical Spectroscopy of Cerebral Blood Flow for Tissue Interrogation in Ischemic Stroke Diagnosis.","authors":"Bakr Ahmed Taha, Ahmed C Kadhim, Ali J Addie, Qussay Al-Jubouri, Ahmad S Azzahrani, Adawiya J Haider, Ali Najem Alkawaz, Norhana Arsad","doi":"10.1021/acschemneuro.4c00809","DOIUrl":"https://doi.org/10.1021/acschemneuro.4c00809","url":null,"abstract":"<p><p>Ischemic stroke remains a leading cause of morbidity and mortality worldwide, and early diagnosis is critical for improving clinical outcomes. This paper presents an optical design framework combining speckle contrast optical spectroscopy (SCOS) with multiwavelength reflectance spectroscopy to monitor subtle changes in cerebral blood flow during ischemic events. The research aims to enable precise tissue interrogation using high-resolution, low-scatter imaging. Key to the system's accuracy is a 1.55 μm small beam waist, a grating density of 1300 grooves/mm, and a 15.53 μm depth of focus. The calculated effective focal length of 8333.33 μm enhances the resolution to 4.07 μm, improving the detection of minor changes in tissue optical properties. We investigate the sensitivity of various near-infrared wavelengths (660, 785, 800, and 976 nm) to ischemic-induced changes, with particular emphasis on the 976 nm wavelength, which demonstrates superior tissue penetration and increased sensitivity to variations in blood perfusion and tissue density during ischemia. Optical markers such as spot-size widening, spatial intensity shifts, and central intensity decrease are identified as reliable indicators of ischemia. Our findings suggest that multiwavelength reflectance analysis, particularly in the near-infrared range, provides a practical, noninvasive approach for continuously monitoring ischemic strokes. This technique indicates potential for improving early diagnosis and real-time monitoring of cerebral perfusion, which allows for continuous, noninvasive monitoring of cerebral perfusion and management of ischemic strokes, improving patient outcomes and clinical decision-making.</p>","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":" ","pages":""},"PeriodicalIF":4.1,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Treatment with Salvianolic Acid A Produces Neuroprotection in Stroke Models by Inducing Excitatory Long-Term Synaptic Depression.","authors":"Jinnan Li, Niya Wang, Qi Huang, Chunxiang Jiao, Weilin Liu, Chunxian Yang, Xun Tang, Rongrong Mao, Qixin Zhou, Yuqiang Ding, Baoci Shan, Lin Xu","doi":"10.1021/acschemneuro.4c00720","DOIUrl":"10.1021/acschemneuro.4c00720","url":null,"abstract":"<p><p>Acute ischemic stroke (AIS) is a significant brain disease with a high mortality and disability rate. Additional therapies for AIS are urgently needed, and neuroplasticity mechanisms by agents are expected to be neuroprotective for AIS. As a major active component of Salvia miltiorrhiza, salvianolic acid A (SAA) has shown potential for preventing cardiovascular diseases. However, there is no evidence of the long-term effect of SAA on ischemic injury or its mechanism. Therefore, using rats and mice, we systematically investigated the impact of SAA on AIS from the perspective of neuroprotective and neuroplasticity. Here, we report that SAA induces a long-term depression (LTD)-like process in synapses. This antiexcitotoxicity action supports the SAA effect, including alleviating infarction and promoting blood circulation in photothrombosis and middle cerebral artery occlusion (MCAO) models. Furthermore, repeated positron emission tomography/computed tomography (PET/CT) imaging and behavioral assessments two months after AIS induction reveal that acute treatment of SAA promotes recovery from disrupted whole-brain glucose metabolism and impaired spatial memory. These data suggest that acute treatment of SAA is neuroprotective by improving long-term functional outcomes through a synaptic LTD-like process, providing a promising adjunct to current therapies to enable better recovery for AIS.</p>","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":" ","pages":"659-672"},"PeriodicalIF":4.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143062114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sapphire-Based Optrode for Low Noise Neural Recording and Optogenetic Manipulation.","authors":"Yanyan Xu, Ben-Zheng Li, Xinlong Huang, Yuebo Liu, Zhiwen Liang, Xien Yang, Lizhang Lin, Liyang Wang, Yu Xia, Matthew Ridenour, Yujing Huang, Zhen Yuan, Achim Klug, Sio Hang Pun, Tim C Lei, Baijun Zhang","doi":"10.1021/acschemneuro.4c00602","DOIUrl":"10.1021/acschemneuro.4c00602","url":null,"abstract":"<p><p>Electrophysiological recording of neurons in deep brain regions using optogenetic stimulation is a powerful method for understanding and regulating the role of complex neural activity in biological behavior and cognitive function. Optogenetic techniques have significantly advanced neuroscience research by enabling the optical manipulation of neural activities. Because of the significance of the technique, constant advancements in implantable optrodes that integrate optical stimulation with low-noise, large-scale electrophysiological recording are in demand to improve the spatiotemporal resolution for various experimental designs and future clinical applications. However, robust and easy-to-use neural optrodes that integrate neural recording arrays with high-intensity light emitting diodes (LEDs) are still lacking. Here, we propose a neural optrode based on Gallium Nitride (GaN) on sapphire technology, which integrates a high-intensity blue LED with a 5 × 2 recording array monolithically for simultaneous neural recording and optogenetic manipulation. To reduce the noise interference between the recording electrodes and the LED, which is in close physical proximity, three metal grounding interlayers were incorporated within the optrode, and their ability to reduce LED-induced artifacts during neural recording was confirmed through both electromagnetic simulations and experimental demonstrations. The capability of the sapphire optrode to record action potentials has been demonstrated by recording the firing of mitral/tuft cells in the olfactory bulbs of mice in vivo. Additionally, the elevation of action potential firing due to optogenetic stimulation observed using the sapphire probe in medial superior olive (MSO) neurons of the gerbil auditory brainstem confirms the capability of this sapphire optrode to precisely access neural activities in deep brain regions under complex experimental designs.</p>","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":" ","pages":"628-641"},"PeriodicalIF":4.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of Trends Underlying Aspartic Acid Isomerization in Intact Proteins Reveals Unusually Rapid Isomerization of Tau.","authors":"Thomas A Shoff, Brielle Van Orman, Vivian C Onwudiwe, Joseph C Genereux, Ryan R Julian","doi":"10.1021/acschemneuro.4c00721","DOIUrl":"10.1021/acschemneuro.4c00721","url":null,"abstract":"<p><p>Spontaneous chemical modifications in long-lived proteins can potentially change protein structure in ways that impact proteostasis and cellular health. For example, isomerization of aspartic acid interferes with protein turnover and is anticorrelated with cognitive acuity in Alzheimer's disease. However, few isomerization rates have been determined for Asp residues in intact proteins. To remedy this deficiency, we used protein extracts from SH-SY5Y neuroblastoma cells as a source of a complex, brain-relevant proteome with no baseline isomerization. Cell lysates were aged <i>in vitro</i> to generate isomers, and extracted proteins were analyzed by data-independent acquisition (DIA) liquid chromatography-mass spectrometry (LC-MS). Although no Asp isomers were detected at day 0, isomerization increased over time and was quantifiable for 105 proteins by day 50. Data analysis revealed that the isomerization rate is influenced by both primary sequence and secondary structure, suggesting that steric hindrance and backbone rigidity modulate isomerization. Additionally, we examined lysates extracted under gentle conditions to preserve protein complexes and found that protein-protein interactions often slow isomerization. Base catalysis was explored as a means to accelerate Asp isomerization due to findings of accelerated asparagine deamidation. However, no substantial rate enhancement was found for isomerization, suggesting fundamental differences in acid-base chemistry. With an enhanced understanding of Asp isomerization in proteins in general, we next sought to better understand Asp isomerization in tau. <i>In vitro</i> aging of monomeric and aggregated recombinant tau revealed that tau isomerizes significantly faster than any similar protein within our data set, which is likely related to its correlation with cognition in Alzheimer's disease.</p>","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":" ","pages":"673-686"},"PeriodicalIF":4.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143062117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative Analysis of Neuropeptide Y (NPY) and C-Terminal Glycine-Extended NPY by Mass Spectrometry and Their Localization in the Developing and Sexual Adult Mouse Brains.","authors":"Tohru Yamagaki, Tomohiro Osugi, Yohei Shinmyo, Hiroshi Kawasaki, Honoo Satake","doi":"10.1021/acschemneuro.4c00545","DOIUrl":"10.1021/acschemneuro.4c00545","url":null,"abstract":"<p><p>Neuropeptide Y (NPY), a central stimulator of food intake and an energy balance controlling hormone, was quantitatively analyzed in developing brains at birth using microflow liquid chromatography (LC) and triple-quadrupole tandem mass spectrometry (MS/MS). We detected and identified endogenous C-terminal glycine-extended NPY (NPY-Gly 1-37) first, an intermediate of NPY before amidation in the mouse brain using high-resolution Fourier-transform Orbitrap MS and MS/MS. NPY-Gly was present in the fetal brain (E16) at almost the same levels as NPY of 1.92 pmol/g-brain tissue. After birth, NPY in postnatal 2-day brains (P2) was elevated drastically at 11.02 pmol/g-brain (<i>p</i> < 0.05 vs E16) and remained at a high level for the first 10 postnatal days, an important period for the formation of the NPY neural circuit in the brain. Immunohistochemistry unexpectedly showed that the localizations of NPY and NPY-Gly in the hypothalamus were completely different: NPY was localized in the arcuate nucleus, whereas NPY-Gly was already located at pars tuberalis during brain development from a fetus to a neonate to a sexual adult.</p>","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":" ","pages":"588-594"},"PeriodicalIF":4.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143121663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrochemical Sensing of Dopamine with an Implantable Microelectrode Array Microprobe Including an On-Probe Iridium Oxide Reference Electrode.","authors":"Dmitriy A Ruckodanov, Nigel T Maidment, Harold G Monbouquette","doi":"10.1021/acschemneuro.4c00658","DOIUrl":"10.1021/acschemneuro.4c00658","url":null,"abstract":"<p><p>Inclusion of an on-probe iridium oxide (IrOx) reference electrode on an implantable microelectrode array (MEA) microprobe enabled dopamine (DA) sensing with high sensitivity, an ultralow limit of detection, and high selectivity against common electroactive interferents. The monitoring of DA signaling in vivo is important for the study of brain disorders such as Parkinson's disease and substance abuse. A postfabrication method for electrochemical deposition of an IrOx film onto a targeted microelectrode enabled integration of an IrOx reference electrode (RE) onto the same MEA as the DA sensing, working electrode (WE). The on-probe IrOx RE is an attractive alternative to commonly used external Ag/AgCl wire REs, which can be unstable and can cause inflammatory responses in vivo. The on-probe IrOx RE was tested for support of DA sensing performance in two-electrode (i.e., WE and RE) and three-electrode (i.e., WE, RE and counter electrode) configurations. The sensitivities of the integrated and externally referenced DA sensing microprobes were comparable at ∼2500 nA/(μM·cm²), however the integrated three-electrode configuration exhibited a 6-fold lower limit of detection of ∼9 nM due to an 82% reduction in baseline noise. In addition, excellent 1000:1 selectivity against common electroactive interferents makes these DA sensing microprobes attractive for implementation in vivo.</p>","PeriodicalId":13,"journal":{"name":"ACS Chemical Neuroscience","volume":" ","pages":"642-648"},"PeriodicalIF":4.1,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}