International Journal of Endocrinology最新文献

{"title":"Vitamin D Deficiency and the Presentation of Primary Hyperparathyroidism: A Mini Review","authors":"Niharika Yedla, Hyon Kim, Anupa Sharma, Xiangbing Wang","doi":"10.1155/2023/1169249","DOIUrl":"https://doi.org/10.1155/2023/1169249","url":null,"abstract":"The clinical presentation of primary hyperparathyroidism (PHPT) has evolved over the years from a symptomatic disorder to a predominantly asymptomatic condition. Altered vitamin D metabolism seems to play a role in the presentation of PHPT and may exacerbate the severity of disease. The epidemiology of PHPT differs in the developing versus the developed world, where more severe phenotypes occur in regions where vitamin D deficiency is common. Although it has been validated that patients with PHPT should be vitamin D sufficient, the threshold to supplement in relation to the severity of PHPT and the degree of vitamin D deficiency remains controversial. This review will highlight some of the controversy regarding vitamin D deficiency and the different phenotypes of PHPT.","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":"11 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2023-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138569599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress in Prevention and Treatment of Acute Bone Loss in Orthopedics","authors":"Haoran Wang, Ji Wu, Boyao Wang, Hu Qin, Lei Fan, Yunhua Wang, Bin He","doi":"10.1155/2023/9373043","DOIUrl":"https://doi.org/10.1155/2023/9373043","url":null,"abstract":"Orthopedic patients need to perform limb immobilization for several days to several weeks due to fracture or other special circumstances. When the function of a certain part or the whole body is restricted, the activity of osteoclasts will be enhanced and its life activity will surpass that of osteoblasts, so local or even whole body bone loss will occur. Acute bone loss usually occurs within a few weeks after the immobilization of limbs. At this stage, the patient’s bone mass will decrease sharply, and the patient is prone to osteoporotic refracture. After that, the bone mass will gradually recover, but the speed of bone formation and bone absorption is difficult to reach a balanced state, and the bone mass of patients will continue to decline after it has recovered to a certain degree. After acute progressive bone loss, a large number of bones were lost and the strength of bones decreased. It is often difficult to recover to the level before fracture for a long time, which undoubtedly increases the risk of osteoporosis and related refractures. According to this common phenomenon of bone loss, clinical treatment varies greatly. After a series of research and practice, clinicians summed up some rules and put forward some feasible suggestions, thus strengthening clinicians’ understanding of the treatment of acute bone loss, effectively improving the treatment effect of acute bone loss, having far-reaching significance for preventing and treating osteoporosis, reducing the risk of fracture, and improving the long-term prognosis of patients.","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":"235 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138515938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Sleep Duration and Left Ventricular Hypertrophy for Patients with Type 2 Diabetes Mellitus","authors":"Lin Mu, Chao Li, Wenying Zhao, Aihua Li, Dong Zhao, Baoyu Zhang","doi":"10.1155/2023/5532778","DOIUrl":"https://doi.org/10.1155/2023/5532778","url":null,"abstract":"<i>Objective</i>. In this study, we aimed to estimate the impact of sleep duration on left ventricular hypertrophy (LVH) in type 2 diabetes mellitus (T2DM). <i>Methods</i>. Consecutive patients with T2DM undergoing transthoracic echocardiography (TTE) in our center from October 2017 to February 2021 were analyzed. The association of the risk of LVH in T2DM patients was evaluated using univariable and multivariable logistic regression analyses. <i>Results</i>. This study finally included 2689 adult patients (mean age 51.8 ± 12.5 years, 56.2% men, mean sleep duration 7.6 ± 1.4 hours per day). Of all patients, 655 (24.4%) patients were diagnosed with LVH and 2034 did not have LVH. All patients were adults and were diagnosed with T2DM. In the univariate and multivariate regression analyses, gender, sleep duration, body mass index (BMI), waist, hemoglobin (Hb), blood creatinine (Cr), and high-density lipoprotein cholesterol (HDL-c) were associated with LVH. In the restricted cubic spline (RCS) model, the cut-off points of sleep duration given refer to the group of patients with T2DM and LVH were 8 hours per day. With the cut-off points, the multivariable analysis demonstrated that, for diabetic patients, LVH was significantly correlated with a sleep duration of 8 hours per day, hemoglobin, blood urea nitrogen (BUN), and HDL-c. <i>Conclusion</i>. For patients with T2DM, long sleep duration (&gt;8 hours per day), hemoglobin, BUN, and HDL-c were independently associated with LVH. This trial is registered with NCT03811470.","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":"9 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138515935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variations in the Urinary Iodine Concentration and Urinary Iodine/Creatinine Ratio among Preschool Children","authors":"Dong An, Rui Yang, Yuping Du, Xuan Wang, Ying Yang, Wenxing Guo, Junhong Yang, Dongmei Meng, Weiwei Gao, Jiayi Zhang, Wen Chen, Wanqi Zhang","doi":"10.1155/2023/6779094","DOIUrl":"https://doi.org/10.1155/2023/6779094","url":null,"abstract":"Variations in different urinary measurements for evaluating iodine status are concerning to clinicians and researchers. The present study aimed to analyze the interindividual and intraindividual variations in the urinary iodine concentration (UIC) and urinary iodine/creatinine (UI/Cr) ratio and evaluate their application in assessing the iodine nutrition of preschool children. Four repeated spot urine samples were collected from 163 children at different times within one day. The urinary iodine concentration (UIC) and urinary creatinine concentration (UCr) were measured, and the UI/Cr ratio was calculated. The UIC (<svg height=\"8.68572pt\" style=\"vertical-align:-0.0498209pt\" version=\"1.1\" viewbox=\"-0.0498162 -8.6359 8.15071 8.68572\" width=\"8.15071pt\" xmlns=\"http://www.w3.org/2000/svg\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><g transform=\"matrix(.013,0,0,-0.013,0,0)\"></path></g></svg> &lt; 0.001) and urinary iodine/creatinine ratio (<svg height=\"8.68572pt\" style=\"vertical-align:-0.0498209pt\" version=\"1.1\" viewbox=\"-0.0498162 -8.6359 8.15071 8.68572\" width=\"8.15071pt\" xmlns=\"http://www.w3.org/2000/svg\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><g transform=\"matrix(.013,0,0,-0.013,0,0)\"><use xlink:href=\"#g113-81\"></use></g></svg> = 0.019) of multiple measurements were significantly different. The UIC of morning urine was highest (99.83 <i>μ</i>g/L) and then gradually decreased with collection time (<svg height=\"8.68572pt\" style=\"vertical-align:-0.0498209pt\" version=\"1.1\" viewbox=\"-0.0498162 -8.6359 8.15071 8.68572\" width=\"8.15071pt\" xmlns=\"http://www.w3.org/2000/svg\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><g transform=\"matrix(.013,0,0,-0.013,0,0)\"><use xlink:href=\"#g113-81\"></use></g></svg> &lt; 0.001). In contrast, the UI/Cr ratio of morning urine samples increased with collection time. By computing the mean intraindividual and interindividual coefficients of variance (CV), the intraindividual variation of the UI/Cr ratio (68%) was significantly lower than that of the UIC (86%). Nevertheless, the interindividual variation was lowest in the UIC (78.62%) of morning urine. In addition, the UIC and UI/Cr ratio showed moderate correlations (<i>r</i> = 0.52, <svg height=\"8.68572pt\" style=\"vertical-align:-0.0498209pt\" version=\"1.1\" viewbox=\"-0.0498162 -8.6359 8.15071 8.68572\" width=\"8.15071pt\" xmlns=\"http://www.w3.org/2000/svg\" xmlns:xlink=\"http://www.w3.org/1999/xlink\"><g transform=\"matrix(.013,0,0,-0.013,0,0)\"><use xlink:href=\"#g113-81\"></use></g></svg> &lt; 0.001), with kappa values of 0.42 in assessing iodine nutrition. The UIC of morning urine samples taken at 8:00–10:00 am was perhaps more stable and reliable in evaluating the iodine nutrition of preschool children at the population level. The UI/Cr ratio showed lower intraindividual variation and may be more suitable for assessing individual iodine nutrition.","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":"12 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2023-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138515952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Accuracy of the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC): An Institution Experience.","authors":"Karima Rai, Joseph Park, Shamika Gokhale, Fatima Irshaidat, Gurdeep Singh","doi":"10.1155/2023/9615294","DOIUrl":"https://doi.org/10.1155/2023/9615294","url":null,"abstract":"<p><p>The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) is a standardized system which is used to classify results of thyroid fine-needle aspiration (FNA). This system is used to evaluate and determine which patients should get thyroid surgery. It was created in order to reduce the number of patients requiring surgery. The question remains as to whether this reporting system is accurate in determining those nodules that have malignant potential and those that do not. This study is a retrospective analysis of patients in one institution who have undergone FNA and then thyroid surgery based on TBSRTC. The outcome of the pathology reports after surgery was analyzed to determine the accuracy of TBSRTC in our institution (Lourdes Hospital, Binghamton, NY). The results from our institution were compared with similar studies in other institutions to determine accuracy and reproducibility. Our results indicated that the risk of malignancy in each Bethesda category was similar to the risk percentages described for most categories in the 2017 TBSRTC update.</p>","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":"2023 ","pages":"9615294"},"PeriodicalIF":2.8,"publicationDate":"2023-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665099/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138459797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes Mellitus across the Arabo-Islamic World: A Revolution","authors":"Mohamad Fleifel, Bassem Fleifel, Andrew El Alam","doi":"10.1155/2023/5541808","DOIUrl":"https://doi.org/10.1155/2023/5541808","url":null,"abstract":"Background. Mankind continues to suffer from the ever-growing diabetes epidemic and the rapid rise of type 2 diabetes mellitus (T2DM). This metabolic disease has been studied since ancient civilizations. The Arabo-Islamic civilization excelled in establishing some of the most notable discoveries and teachings that remained the blueprint for years to come in the field of diabetology. Aim. This article aimed to review the ancient history of diabetes mellitus, with its main focus on the Arabo-Islamic civilization, and to report our subjective views and analysis of some of the past recommendations based on modern-day findings. Discussion. It is natural to have the teachings of medicine dynamically inspired by one civilization to another, as various fields continue to expand and evolve. This also applies to diabetology as the Arabo-Islamic world used the outlines of prior civilizations to revolutionize the understanding of the disease. Al-Razi and Ibn Sina are probably two of the most renowned polymaths in history, and their contributions to diabetology are well documented. Ibn Maymun’s postulation about the higher prevalence of diabetes in Egypt as compared to Andalusia is something to be carefully studied. It could be that diabetes mellitus’ underdiagnosis and late-stage detection are some of the major reasons for the disparity between the two mentioned regions. Modern-day Arabo-Islamic scholars continue to excel in revolutionizing diabetology. Conclusion. The Arabo-Islamic world houses an impressive bout of scholars who have contributed since the ancient times to diabetology. This scientific locomotion shows no signs of stopping, as it continues to shine during the present day, and likely in the future.","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":"85 5","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135092423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association between Visit-to-Visit Variability of Blood Pressure and the Risk of Metabolic Syndrome: The Moderating Effect of Weight","authors":"Ruxue Li, Wuai Zhou, Xue Cai, Dan Luo, Huijing Zhang, Mingzi Li","doi":"10.1155/2023/8156084","DOIUrl":"https://doi.org/10.1155/2023/8156084","url":null,"abstract":"Aims. Metabolic syndrome (MetS) affects approximately one-third of the global population. Visit-to-visit variability of blood pressure (VVV-BP) constitutes a substantial risk factor for numerous chronic conditions. Thus, this study aimed to assess the relationship between VVV-BP and MetS and identify potential moderating factors between these. Methods. Data were obtained from the China Health and Retirement Longitudinal Study, a nationally representative study. Multiple logistic regression analyses were utilized to explore the association between VVV-BP and MetS while incorporating moderation analyses. MetS was defined according to the criteria outlined in the Joint Interim Statement. VVV-BP was expressed by the standard deviation, coefficient of variation, average real variability, and root mean square error. Results. Individuals with the highest levels of VVV of systolic blood pressure (SBP) exhibited a 70% increased risk of MetS compared to those with the lowest levels (OR = 1.70, 95% CI = 1.31–2.21). In addition, they had a 41% increased risk of VVV of diastolic blood pressure (DBP) (OR = 1.41, 95% CI = 1.09–1.81). Notably, weight change status significantly influenced the relationship between VVV-BP and MetS (Pinteraction = 0.01). Conclusions. VVV-BP is a significant contributor to the risk of developing MetS. Importantly, individuals who experienced weight loss during the follow-up period did not face a significantly higher risk of developing MetS.","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":"BC-28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136234141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated with Vitamin D Deficiency and Their Relative Importance among Indian Adolescents: An Application of Dominance Analysis.","authors":"Akif Mustafa,&nbsp;Chander Shekhar","doi":"10.1155/2023/4209369","DOIUrl":"10.1155/2023/4209369","url":null,"abstract":"<p><p>Vitamin D deficiency is a serious issue in developing nations, including India. This study investigates the determinants of vitamin D deficiency among Indian adolescents and assesses their relative importance using dominance analysis. Data from the Comprehensive National Nutrition Survey (CNNS) conducted between 2016 and 2018 were utilized in this study. Vitamin D levels were assessed based on serum 25-hydroxyvitamin D concentration, with a sample size encompassing 13,065 adolescents aged between 10 and 19 years. Backward stepwise multivariate logistic regression was used to identify the correlates of vitamin D deficiency, and the relative importance of these factors was assessed using dominance analysis. The study identified nine predictors that were significantly associated with vitamin D deficiency at a 1% level of significance (<i>α</i> = 0.001). Among these factors, sex was found to be the most significant predictor, with female adolescents being 2.66 (95% CI: 95% CI: 2.39-2.96) times more likely to be vitamin D deficient compared to male adolescents. Lifestyle and behavioral factors, such as \"sex,\" \"wealth index,\" and \"place of residence,\" were more dominant in predicting vitamin D deficiency than biological indicators like \"BMI\" and \"serum creatinine.\" This underscores the vital role of sunlight exposure in maintaining sufficient vitamin D levels. In summary, this study sheds light on the multifaceted factors contributing to vitamin D deficiency among Indian adolescents, emphasizing the significance of targeted interventions and public health awareness campaigns to mitigate this pressing issue.</p>","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":"2023 ","pages":"4209369"},"PeriodicalIF":2.8,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10597726/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50161504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Subclinical Thyroid Dysfunction and Metabolic Abnormality in 28568 Healthy People.","authors":"Yan Xie,&nbsp;Zhixue Wang,&nbsp;Zongtao Chen","doi":"10.1155/2023/5216945","DOIUrl":"10.1155/2023/5216945","url":null,"abstract":"<p><p>We analyzed the detection rates of metabolic syndrome (MetS) and subclinical thyroid dysfunction, including subclinical hyperthyroidism (SCHyper) and subclinical hypothyroidism (SCH), in healthy people, as well as their relationship. Clinical data were collected from 28,568 healthy individuals who underwent physical examinations. The detection rates of SCHyper, SCH, and MetS, as well as in different genders and ages, were analyzed. The detection rate of SCHyper and SCH in females was significantly higher than that in males (<i>P</i> < 0.001), but that of MetS in males was significantly higher than that in females (<i>P</i> < 0.001). In each age group, the detection rate of SCH in females was higher than that in males (<i>P</i> < 0.001). The detection rate of SCH was significantly different in different age groups (<i>P</i> < 0.001). The detection rates of hyperlipidemia (<i>P</i> < 0.001), obesity (<i>P</i> = 0.004), hypertension (<i>P</i> = 0.009), and hyperglycemia (<i>P</i> < 0.001) in the female SCH group were significantly higher than those in the normal group. The detection rates of hyperlipidemia (<i>P</i> = 0.006), obesity (<i>P</i> = 0.04), and hypertension (<i>P</i> = 0.04) in the male SCH group were higher than those in the normal group. The males with SCHyper were more prone to hyperlipidemia (<i>P</i> = 0.02) and obesity (<i>P</i> = 0.03). In addition, the female SCHyper group was not significantly different from the normal group (<i>P</i> > 0.05). Conclusively, the detection rate of SCHyper and SCH in females is higher than that in males, which increases with age. Attention should be paid to subclinical thyroid dysfunction in elderly people, especially females. Early individualized screening and early intervention should be carried out for people with abnormal metabolism.</p>","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":"2023 ","pages":"5216945"},"PeriodicalIF":2.8,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10593554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50157869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sildenafil Enhances the Therapeutic Effect of Islet Transplantation for Diabetic Peripheral Neuropathy via mTOR/S6K1 Pathway.","authors":"Xiandong Zhu,&nbsp;Shangjing Xie,&nbsp;Jiawei Chen,&nbsp;Qiaohong Lu,&nbsp;Xiaowu Wang,&nbsp;Feixiang Duan,&nbsp;Sinian Xu,&nbsp;Yan Zhang,&nbsp;Hongjian Huang,&nbsp;Yongqiang Wang,&nbsp;Hongwei Wang,&nbsp;Bicheng Chen,&nbsp;Huanjie Huang","doi":"10.1155/2023/8199029","DOIUrl":"10.1155/2023/8199029","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to investigate the potential mechanism underlying the therapeutic effect of sildenafil in combination with islet transplantation for diabetic peripheral neuropathy.</p><p><strong>Methods: </strong>A streptozotocin-induced diabetic mouse model was established to evaluate the effects of islet transplantation and sildenafil intervention. The mice were subjected to different interventions for 6 weeks, and histopathological staining and immunohistochemistry techniques were employed to examine the pathological changes and protein expressions of BDNF, MBP, and cleaved caspase-3 in the sciatic nerve tissue. Moreover, RSC96 cells were cocultured with islet cells and sildenafil under high glucose conditions to investigate the potential involvement of the mTOR/S6K1 pathway, BDNF, and MBP proteins. Western blotting was used to detect protein expression in each group.</p><p><strong>Results: </strong>The results showed that islet transplantation can restore sciatic nerve injury in diabetic mice, and sildenafil can enhance the therapeutic effect of islet transplantation. In addition, the combination of sildenafil and islet cells significantly upregulated the expression levels of mTOR/S6K1, BDNF, and MBP in RSC96 cells under high glucose conditions.</p><p><strong>Conclusions: </strong>Islet transplantation can reverse sciatic nerve injury in diabetic mice, and islet cells exhibit a protective effect on RSC96 cells under high glucose conditions via the activation of the mTOR/S6K1 pathway. Sildenafil enhances the therapeutic effect of islet transplantation, which may represent a potential treatment strategy for diabetic peripheral neuropathy.</p>","PeriodicalId":13966,"journal":{"name":"International Journal of Endocrinology","volume":"2023 ","pages":"8199029"},"PeriodicalIF":2.8,"publicationDate":"2023-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10576648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41235143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}