{"title":"Multiple Pruritic Penile Papules and Nodules as a Highly Specific Clinical Sign of Scabies in Men Patients: A Two-Center Retrospective Study.","authors":"Murat Durdu, Mehmet Metehan Karacan, Soner Uzun","doi":"10.1111/ijd.70757","DOIUrl":"https://doi.org/10.1111/ijd.70757","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149244433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Derek Maas, Archie Spindler, Isabella Zappi, Jolie Kantor, Margaret Cote, Sarah Go, Esha Patel, Jerry Shapiro, Kristen I Lo Sicco
{"title":"Bridging Therapy and Safety of Low-Dose Oral Minoxidil: A Novel Investigation of a Common Approach.","authors":"Derek Maas, Archie Spindler, Isabella Zappi, Jolie Kantor, Margaret Cote, Sarah Go, Esha Patel, Jerry Shapiro, Kristen I Lo Sicco","doi":"10.1111/ijd.70752","DOIUrl":"https://doi.org/10.1111/ijd.70752","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149244404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Albert Young, Joshua Vazhappilly, Xiaohan Zhan, José Labrador Pino, Kelsey Scott, Rania Djemil, Lauren Bradford, Andrea Dai, Rhea Raut, Li Zhou, Qing-Sheng Mi
{"title":"Therapeutic Drug Monitoring of Infliximab in Hidradenitis Suppurativa: A Retrospective Cohort Study.","authors":"Albert Young, Joshua Vazhappilly, Xiaohan Zhan, José Labrador Pino, Kelsey Scott, Rania Djemil, Lauren Bradford, Andrea Dai, Rhea Raut, Li Zhou, Qing-Sheng Mi","doi":"10.1111/ijd.70751","DOIUrl":"https://doi.org/10.1111/ijd.70751","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149266837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marco Spadafora, Gerardo Palmisano, Claudio Conforti, Luca Ambrosio, Alessandro Di Stefani, Ketty Peris, Giovanni Pellacani, Caterina Longo
{"title":"The Role of Line-Field Confocal Optical Coherence Tomography in the Diagnosis of Melanoma and Melanocytic Lesions: A Systematic Review.","authors":"Marco Spadafora, Gerardo Palmisano, Claudio Conforti, Luca Ambrosio, Alessandro Di Stefani, Ketty Peris, Giovanni Pellacani, Caterina Longo","doi":"10.1111/ijd.70736","DOIUrl":"https://doi.org/10.1111/ijd.70736","url":null,"abstract":"<p><p>Line-field confocal optical coherence tomography (LC-OCT) is an emerging non-invasive imaging technique that provides real-time vertical, horizontal, and three-dimensional visualization of the skin at near-cellular resolution. We systematically reviewed the available evidence on LC-OCT in melanocytic lesions to identify diagnostic features associated with melanoma and to clarify its current clinical role. MEDLINE/PubMed, Scopus, Embase, and Web of Science were searched from inception to September 2026 in accordance with PRISMA recommendations. Thirty-two studies were included, encompassing cutaneous melanoma, lentigo maligna, and facial pigmented lesions, benign and atypical melanocytic lesions, and mucosal melanoma. Across studies, melanoma-associated findings included irregular or disorganized epidermal architecture, numerous or pleomorphic pagetoid cells, disruption or blurring of the dermoepidermal junction, atypical dermal nests, and clefting. In lentigo maligna and facial melanoma, peri-adnexal atypia and follicular involvement emerged as particularly relevant features, whereas mucosal melanoma was characterized by diffuse pagetoid spread, epithelial disarray, atypical junctional cells, and discohesive melanocytic nests. Benign lesions more often showed preserved epidermal architecture, a well-defined junction, organized nests, and a regular wave-like dermal pattern. However, substantial overlap was observed with atypical nevi, spitzoid lesions, blue nevi, melanosis, and other intermediate entities. Although selected studies reported promising diagnostic performance, the evidence remains heterogeneous and is largely based on small, descriptive cohorts. LC-OCT may therefore serve as a useful adjunct in clinically or dermoscopically equivocal melanocytic lesions, but prospective multicenter validation and assessment of reproducibility are required before widespread routine implementation.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149266873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"AI-to-AI Cross-Checks for Error Detection in Dermatology.","authors":"Mohamad Goldust, Marina Landau, Jane M Grant-Kels","doi":"10.1111/ijd.70762","DOIUrl":"https://doi.org/10.1111/ijd.70762","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149244386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Beyond Classical Atopic Dermatitis: Rethinking Head-Neck Flares in the Era of Targeted Therapies.","authors":"Kerem Balan, Deniz Tatar","doi":"10.1111/ijd.70763","DOIUrl":"https://doi.org/10.1111/ijd.70763","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149244456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Skin Tone Representation in Dermatologic Images of a Board Preparation Resource: A Multi-Edition Content Analysis.","authors":"Salma Shire, Aisha Ayub, Brittany Dulmage","doi":"10.1111/ijd.70738","DOIUrl":"https://doi.org/10.1111/ijd.70738","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149244421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clio Dessinioti, Ruggero Moro, Mihaella Plaka, Ioannis A Stratigos, Celia Requena, Katerina Kypreou, Victor Traves, Irene Stefanaki, Eduardo Nagore
{"title":"Nevus Counts, Sun Exposure and Phenotypic Characteristics in Invasive Versus In Situ Non-Lentigo Maligna/Non-Acral Lentiginous Melanoma.","authors":"Clio Dessinioti, Ruggero Moro, Mihaella Plaka, Ioannis A Stratigos, Celia Requena, Katerina Kypreou, Victor Traves, Irene Stefanaki, Eduardo Nagore","doi":"10.1111/ijd.70737","DOIUrl":"https://doi.org/10.1111/ijd.70737","url":null,"abstract":"<p><strong>Background: </strong>Evidence on phenotypic features and nevus counts for melanoma in situ (MIS) is lacking.</p><p><strong>Methods: </strong>This is a retrospective study in patients diagnosed with invasive SSM or MIS, from 1999 to 2025, in melanoma referral centers in Greece and Spain. Our aim was to investigate phenotypic characteristics and nevus counts in non-lentigo maligna/non-acral lentiginous MIS versus invasive superficial spreading melanoma (SSM).</p><p><strong>Results: </strong>In 3026 patients (2399 with invasive SSM, 627 with MIS), age did not differ between patients with invasive SSM and those with MIS. In multivariable analysis, patients who reported a history of severe sunburn were less likely to be diagnosed with invasive SSM than with MIS (odds ratio [OR]: 0.77, 95% confidence interval [95% CI]: 0.64-0.93, p = 0.007). No consistent association was observed with hair, eye color, or phototype between the two groups, both of which had predominantly dark hair and eyes. Compared with patients with few nevi, those with some or many nevi were significantly less likely to be diagnosed with invasive SSM compared to MIS (OR: 0.76, 95% CI: 0.62-0.93, and OR: 0.60, 95% CI 0.42-0.86, respectively).</p><p><strong>Conclusions: </strong>The similar age at diagnosis of MIS and invasive SSM does not support an obligate progression model. The association of higher nevus counts with MIS suggests that MIS may represent a marker of proneness to melanocytic proliferation or may be preferentially diagnosed in nevus-prone individuals undergoing closer surveillance. Further studies in phenotypically diverse populations are warranted.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149244381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
José Molina-Espinosa, Jorge Juan Vega-Castillo, Aurelio Marcos Martín-Castro, Ricardo Ruiz-Villaverde
{"title":"Persistent Truncal Eruption With Hematologic Disease.","authors":"José Molina-Espinosa, Jorge Juan Vega-Castillo, Aurelio Marcos Martín-Castro, Ricardo Ruiz-Villaverde","doi":"10.1111/ijd.70755","DOIUrl":"https://doi.org/10.1111/ijd.70755","url":null,"abstract":"<p><p>We present a clinicopathological challenge involving a persistent truncal eruption in a patient with Waldenström macroglobulinemia. Clinical examination showed erythematous to violaceous macules and plaques, and biopsy demonstrated a dermal lymphoplasmacytic infiltrate with IgM/κ restriction. Molecular analysis identified MYD88 L265P in the cutaneous specimen. Integration of the clinical history, immunophenotype, clonality studies, and molecular findings supported secondary cutaneous lymphoplasmacytic lymphoma rather than cutaneous macroglobulinosis, primary cutaneous marginal zone lymphoma, or drug eruption.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":4.2,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149266802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}