International Journal of Dermatology最新文献

{"title":"Widespread Verrucous Nodules in a Child With Wilsons Disease.","authors":"James Gaston, Anthony Moussa, Rosemary Sutton, David Orchard","doi":"10.1111/ijd.70076","DOIUrl":"https://doi.org/10.1111/ijd.70076","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"A Comparative Case-Control Study of Diagnostic Criteria for Atopic Dermatitis and Proposal of New Diagnostic Criteria From Tunisia\".","authors":"","doi":"10.1111/ijd.70073","DOIUrl":"https://doi.org/10.1111/ijd.70073","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145064594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatal Toxic Epidermal Necrolysis-Like Lupus Erythematosus in a Patient With Metastatic Histiocytic Sarcoma.","authors":"Carlo Alberto Maronese, Federica Derlino, Davide Termini, Stefano Buffon, Luisa Sarno, Giovanni Genovese, Francesca Laura Boggio, Angelo Valerio Marzano","doi":"10.1111/ijd.70072","DOIUrl":"https://doi.org/10.1111/ijd.70072","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145053092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Venous Lakes of Glans and Penis: A Case Report of Two Unusual Cases.","authors":"Qing Wang, Xiangyu Hu, Jizhen Zhong, Maolin Yao, Lin Feng","doi":"10.1111/ijd.70037","DOIUrl":"https://doi.org/10.1111/ijd.70037","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145053163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cutaneous Immune-Related Adverse Events and Efficacy of Immune Checkpoint Inhibitors for Patients With Advanced Solid Organ Malignancies.","authors":"David O'Reilly, Gregg Murray, Orla M Fitzpatrick, Hebatalla Ismail, Gavin P Dowling, Gargi Roy, David Synnott, Maggie O'Connor, Bryan T Hennessy, Oscar Breathnach, Liam Grogan, Megan Greally, Adrian Murphy, Patrick G Morris, Karen Eustace, Muireann Roche, Stephen Madden, Jarushka Naidoo","doi":"10.1111/ijd.70061","DOIUrl":"https://doi.org/10.1111/ijd.70061","url":null,"abstract":"<p><strong>Introduction: </strong>Immune checkpoint inhibitors (ICIs) have significantly improved outcomes for patients with advanced solid tumors. While low-grade immune-related adverse events (irAEs) are associated with prolonged survival, high-grade irAEs have been associated with poorer survival. Cutaneous immune-related adverse events (cirAEs) affect up to 20%-40% of patients treated with ICIs. We investigated the association between cirAES and the outcomes of progression-free survival (PFS) and overall survival (OS) in advanced solid organ malignancies.</p><p><strong>Methods: </strong>A retrospective analysis of patients receiving ICIs for stage IV solid organ malignancies was conducted at Beaumont RCSI Cancer Centre, Dublin, Ireland, between January 1, 2012, and June 30, 2020. Eligible participants included those who commenced therapy during this period, having received at least one cycle of ICI treatment, with or without chemotherapy, for histologically confirmed advanced solid organ malignancies.</p><p><strong>Results: </strong>Among 278 analyzed patients, 19% (53/278) experienced any cirAES. The most common cirAEs included psoriasis (23%) and pruritus (15%). cirAES were associated with significantly improved PFS (median 47.3 months vs. 18.3 months, p < 0.01) and OS (median 60.0 months vs. 26.0 months, p < 0.01). Patients with prior systemic therapy had a decreased risk of cirAES (odds ratio = 0.44, p = 0.02), and multivariate analysis confirmed that cirAES was independently associated with improved PFS and OS.</p><p><strong>Conclusion: </strong>Our study supports that cirAES may be associated with improved patient outcomes and that prior systemic therapy may be associated with a reduced risk of cirAES. Future research should focus on multi-institutional collaborations based on prospective irAE data to better understand the impact of specific irAEs on clinical outcomes.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145040211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aquagenic Wrinkling of the Cutaneous Lip: A Case Report.","authors":"Aria Trager, Negar Esfandiari, Viktor Goncharuk, Terenia Custer, Darius Mehregan","doi":"10.1111/ijd.70077","DOIUrl":"https://doi.org/10.1111/ijd.70077","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145053046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic Review of Accelerated Epigenetic Aging in Chronic Inflammatory Dermatology Conditions.","authors":"Ajay S Dulai, Aditya Joshi, Mildred Min, Vivian Y Shi, Raja K Sivamani","doi":"10.1111/ijd.70055","DOIUrl":"https://doi.org/10.1111/ijd.70055","url":null,"abstract":"<p><p>Although dermatologic conditions primarily manifest on the skin, an increasing amount of evidence demonstrates that these inflammatory conditions can have a deeper impact on our systemic health. The use of epigenetics to measure biological age, instead of chronological age, can give us insight into the systemic burden of these diseases on aging. We aimed to understand the degree to which each dermatological condition affects biological aging. A systematic review was performed of PubMed, Embase, and Web of Science to identify all publications that measured biological age in dermatological patients using epigenetic clocks. Six articles involved the following conditions: atopic dermatitis (AD) (1), hidradenitis suppurativa (HS) (1), and psoriasis (PsO) (4). Notably, patients with psoriatic arthritis, but not psoriasis alone, demonstrated significantly increased epigenetic aging compared to controls. Pediatric AD patients had an increase in the rate of biological aging as measured by the Horvath, Skin and Blood, PhenoAge, and GrimAge clocks. HS patients were found to have an increased biological age when assessing tissue from affected skin. Further research is needed to investigate correlations between disease severity and epigenetic aging, and for expansion into other dermatological diseases. Additionally, epigenetic clocks need to be developed that utilize different subsets of inflammation more broadly and skin biomarkers to provide a more accurate estimation for chronic inflammatory dermatological conditions.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145053095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary and Secondary Grzybowski's Generalized Eruptive Keratoacanthoma: A New Perspective on Management, Clinical Features, and Prognosis.","authors":"Nicholas Florin Kormos, Carina Maria Petrenciu, Alin Stefan Vizitiu, Raluca Ghețe, Umer Nadir, Adrian Lucian Baican, Stanislav N Tolkachjov","doi":"10.1111/ijd.70063","DOIUrl":"https://doi.org/10.1111/ijd.70063","url":null,"abstract":"<p><p>Grzybowski's generalized eruptive keratoacanthoma (GEKA) is a rare variant of keratoacanthomas, characterized by hundreds to thousands of lesions, accompanied by pruritus, mucosal involvement, and comorbidities. Our aim was to analyze the clinical presentation, associated comorbidities, treatment strategies, and outcomes of GEKA. We conducted a literature review of all published cases between 1950 and 2024, following the Preferred Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting guidelines. A total of 143 articles were screened; 58 were included, yielding 64 cases. Of these, 24 were associated with severe comorbidities, while 40 were not. Cases without associated conditions were more likely to exhibit a worse prognosis, greater therapeutic resistance, and distinct clinical features. In contrast, cases associated with malignancy, systemic diseases, or other comorbidities tended to show better treatment responses and fewer complications. Pruritus remained the predominant symptom in both groups, with similar lesion morphology. The rarity of GEKA leads to a paucity of literature. Reporting bias and limited cases may lead to less generalizability. Based on our review and considering the differences in clinical presentation, demographics, associated comorbidities, complications, and prognosis, GEKA may be classified as primary or secondary to a malignancy, systemic disease, or other comorbidity, encouraging clinicians to have a high index of suspicion during evaluation and treatment for an underlying trigger.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Dermocosmetics in Acne Management: A Middle East-North Africa Consensus.","authors":"Sameer Zimmo, Hesham Zaher, Amal Said, Eman El Morsy, Noureddine Litaiem, Anwar Al Hammadi, Amal El Sayed, Martin Steinhoff","doi":"10.1111/ijd.70070","DOIUrl":"https://doi.org/10.1111/ijd.70070","url":null,"abstract":"<p><strong>Background: </strong>Acne in the Middle East and Northern Africa (MENA) is associated with high rates of post-inflammatory hyperpigmentation and scarring, resulting from relatively high frequencies of darker or oily skin types, environmental factors, perceptions, and knowledge of acne and its treatment. Dermocosmetics, over-the-counter products with bioactive ingredients, can enhance acne management. The aim of this consensus was to provide recommendations for the integration of dermocosmetics into acne management plans in the MENA region.</p><p><strong>Methods: </strong>A group of eight key opinion leaders from the MENA region generated three consensus recommendations supporting the role of dermocosmetics in acne management using the Delphi methodology. Information on cases relating to the use of dermocosmetics as adjuncts in acne management was also presented.</p><p><strong>Results: </strong>Consensus was reached for all three recommendations relating to the use of dermocosmetics in acne management, including the use of dermocosmetics as monotherapy for mild acne cases and as adjuncts to acne medications to improve tolerability and efficacy of medications and to enhance treatment adherence. The two illustrative cases presented support the use of dermocosmetics as adjuncts in acne management.</p><p><strong>Conclusions: </strong>Cleansers, moisturizers, and photoprotection are important aspects of acne management, and both clinicians and patients should be aware of the benefits they can provide. Dermocosmetics are recommended to be used as monotherapy for mild acne or maintenance following active treatment as well as adjuncts to acne medications to improve effectiveness and tolerance of acne treatment. Education and awareness are key to the successful incorporation of appropriate dermocosmetics into acne management.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Dermoscopic Characterization of Scalp Cutaneous Metastases From Breast Carcinoma: A Multicenter Study of the EADV Task Force on Hair Diseases.","authors":"Andrea Sechi, Jacopo Tartaglia, Monica Ponzano, Christian Ciolfi, Stefano Piaserico, Adriana Rakowska, Lidia Rudnicka, Aimilios Lallas, Zoe Apalla, Azael Freites-Martinez, Luca Rapparini, Valentina Guaneri, Bianca Maria Piraccini, Michela Starace","doi":"10.1111/ijd.70059","DOIUrl":"https://doi.org/10.1111/ijd.70059","url":null,"abstract":"<p><strong>Introduction: </strong>Cutaneous scalp metastases from breast carcinoma (CMBC) represent an uncommon manifestation of metastatic disease, with heterogeneous clinical presentations, including nodular or infiltrative lesions and scarring alopecia (alopecia neoplastica). The absence of standardized diagnostic criteria, particularly for alopecic phenotypes, poses challenges to early recognition of CMBC, which may represent either the first indication of neoplastic progression or a late recurrence.</p><p><strong>Materials and methods: </strong>We retrospectively analyzed a multicenter cohort of 15 patients with histologically confirmed CMBC. Demographic, clinical, molecular, and trichoscopic data were collected and correlated with the main clinical phenotypes: patchy alopecia (alopecia neoplastica) versus nodules/plaques. The statistical analyses we performed were the Mann-Whitney test for group comparisons and Fisher's exact test for categorical variables.</p><p><strong>Results: </strong>The median age at CMBC diagnosis was 64 years. Alopecia neoplastica was the most frequent phenotype (53.3%). Patients with alopecia neoplastica showed a longer median interval between primary tumor diagnosis and metastasis onset compared to those with nodules/plaques (73.5 months vs. 59.5 months; p = 0.11). Trichoscopic analysis revealed significant differences in the distribution of features between the alopecia neoplastica group and the nodular/plaque group. Statistically significant differences were found among the two groups, including linear-irregular vessels (87.5% vs. 28.6%, p = 0.041), polymorphic vessels (87.5% vs. 28.6%, p = 0.041), pili torti (75% vs. 14.3%, p = 0.041), follicular hyperkeratosis and follicular plugging (87.5% vs. 14.3%, p = 0.01). Overall, the trichoscopic pattern in alopecia neoplastica appeared more variable and heterogeneous compared to that observed in the nodular/plaque phenotype.</p><p><strong>Conclusion: </strong>Alopecia neoplastica, often underestimated in clinical practice, emerges as the predominant CMBC phenotype in our cohort and is associated with a distinct trichoscopic profile. The complexity of the alopecic phenotype may reflect intrinsic biological differences compared to nodular lesions. Larger prospective studies are needed to validate these findings and incorporate trichoscopic profiles into standard diagnostic pathways.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}