International Journal of Dermatology最新文献

{"title":"Double Trouble: A Case Series on Dual Morphology Cutaneous Immune-Related Adverse Events in Cancer Patients Treated With Immune Checkpoint Inhibitors.","authors":"Joseph Ebriani, Mike Westmeijer, Bethany Brumbaugh, Allison Holt, Baraa Hijaz, Kevin Sheng-Kai Ma, Kerry L Reynolds, Yevgeniy R Semenov, Steven T Chen","doi":"10.1111/ijd.17737","DOIUrl":"https://doi.org/10.1111/ijd.17737","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generative Artificial Intelligence (AI) in Chronic Dermatophytosis Patient Counseling: A Viable Alternative?","authors":"Varniraj Patel, Zahbi Hasan, Meet Kachhadia, Yashdeep Singh Pathania","doi":"10.1111/ijd.17739","DOIUrl":"https://doi.org/10.1111/ijd.17739","url":null,"abstract":"<p><p>Dermatophytosis pose a significant burden on patients leading to recurrence and decreased quality of life owing to inadequate patient education and non-compliance to the treatment. There is a potential role of generative Artificial Intelligence (AI) in enhancing patient counseling by providing personalized, accessible, and consistent information and can support physician-led counseling, ultimately improving treatment adherence and outcomes.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"TikTok as a Source of Information on Retinol: A Cross-Sectional Analysis.","authors":"Anagha Srivatsa, Wasey Rehman, Rafey Rehman, Meena Moossavi, Darius Mehregan","doi":"10.1111/ijd.17741","DOIUrl":"https://doi.org/10.1111/ijd.17741","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Upadacitinib in the Treatment of Chronic Hand Eczema and Nail-Associated Changes in a Patient With Atopic Dermatitis.","authors":"Laura Bonzano, Alberico Motolese, Caterina Longo, Giovanni Pellacani, Alessia Paganelli","doi":"10.1111/ijd.17673","DOIUrl":"https://doi.org/10.1111/ijd.17673","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nail Changes in Thymoma-Associated Multiorgan Autoimmunity.","authors":"Supisara Wongdama, Penvadee Pattanaprichakul, Waranya Boonchai","doi":"10.1111/ijd.17746","DOIUrl":"https://doi.org/10.1111/ijd.17746","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety Profile of Baricitinib in Patients With Severe Alopecia Areata: A Prospective Study.","authors":"Isotta Giunipero di Corteranzo, Eleonora Bongiovanni, Stephano Cedirian, Michela Starace, Bianca Maria Piraccini, Luca Mastorino, Pietro Quaglino, Simone Ribero, Giuseppe Gallo","doi":"10.1111/ijd.17732","DOIUrl":"https://doi.org/10.1111/ijd.17732","url":null,"abstract":"<p><strong>Introduction: </strong>In adults, baricitinib, a Janus kinase (JAK)1/JAK2 inhibitor, is the first globally approved treatment for severe alopecia areata (AA). Its efficacy and safety were established in phase III trials, but real-life evidence remains limited.</p><p><strong>Objective: </strong>Our aim was to evaluate the real-life safety profile of baricitinib over 48 weeks in a clinical setting.</p><p><strong>Methods: </strong>A prospective observational study was conducted on 87 adult patients with severe AA at the University Hospital of Turin. Patients were treated with baricitinib at doses of 2 or 4 mg daily and were evaluated at baseline, 12, 24, 36, and 48 weeks. Adverse events (AEs) were carefully monitored, and disease severity was measured using the Severity of Alopecia Tool (SALT) score.</p><p><strong>Results: </strong>The cohort consisted of 71% females, with a mean age of 42 years and a mean baseline SALT score of 76.9. Baricitinib was generally well tolerated, with 20% of patients reporting AEs. The most common AEs were hypercholesterolemia (17%), hypertriglyceridemia (9.2%), and upper respiratory tract infections (5%). Two patients discontinued treatment due to neutropenia and recurrent infections. Most AEs were mild and manageable.</p><p><strong>Conclusion: </strong>Baricitinib shows a favorable safety profile in real-life clinical settings, aligning with findings from controlled clinical trials. The results support its use in routine clinical practice, though larger prospective studies are needed for further confirmation.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tolerability of Low-Dose Oral Minoxidil in Patients With Systemic Lupus Erythematosus: A Retrospective Cohort Study.","authors":"Devyn Zaminski, Lina Alhanshali, Jerry Shapiro, Avrom S Caplan, Alisa N Femia, Kristen Lo Sicco, Daniel R Mazori","doi":"10.1111/ijd.17734","DOIUrl":"https://doi.org/10.1111/ijd.17734","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early Biologic Therapy in Young Psoriasis Patients: Evaluating the Step-Down Approach.","authors":"Hinpetch Daungsupawong, Viroj Wiwanitkit","doi":"10.1111/ijd.17757","DOIUrl":"https://doi.org/10.1111/ijd.17757","url":null,"abstract":"","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blaschkoid Alopecia.","authors":"Gautham Sasi, Kethireddi Susmitha Divya, Guruprasad Patnala, Sudhir Babu Karri","doi":"10.1111/ijd.17724","DOIUrl":"https://doi.org/10.1111/ijd.17724","url":null,"abstract":"<p><p>A 20-year-old man presented with progressive hair loss on the scalp, which initially appeared as a localized patch over the vertex and subsequently extended in a curvilinear pattern, affecting the sides and back of the scalp.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence-Based Recommendations for Managing Atopic Dermatitis in Pediatric Patients: A Systematic Review and Meta-Analysis From the Pediatric Dermatology Special Interest Group of IADVL.","authors":"Rahul Mahajan, Rashmi Sarkar, Maitreyee Panda, Bhumesh Kumar Katakam, Jigna Padhiyar, Thiruveedhula Haritha, Liza Mohapatra, Nibedita Patro, Rita Vora, Shazia Shah, Sudarshan P Gaurkar, Krina Bharat Patel, Vinutha Rangappa","doi":"10.1111/ijd.17723","DOIUrl":"https://doi.org/10.1111/ijd.17723","url":null,"abstract":"<p><strong>Background: </strong>Atopic dermatitis (AD) is the most common inflammatory skin disease in the pediatric age group, affecting 15%-20% of children globally. Initial treatment modes include hydration, occlusive topical medicines, antimicrobial treatment, phototherapy, and systemic immune suppressants in the case of severe to moderate refractory AD. However, there is a lack of head-to-head studies on the choice of topical and systemic therapies for moderate to severe AD in the pediatric age group.</p><p><strong>Objective: </strong>This systematic review aimed to determine the efficacy and safety of topical and systemic treatments for moderate-to-severe AD in the pediatric age group.</p><p><strong>Method: </strong>A systematic review was performed following the Preferred Reporting Items for Systemic Reviews and Meta-Analyses (PRISMA) guidelines. A search of articles was done from PubMed and Google Scholar from 1975 to 2023.</p><p><strong>Results: </strong>We found a total of 1114 possible clinical trials. Of these, 68 articles fulfilled the eligibility criteria. Thirty-four articles discussed topical therapies, which included corticosteroids, calcineurin inhibitors, and emollients, and 34 articles were about systemic therapies, consisting of cyclosporine, dupilumab, upadacitinib, thymopentin, omalizumab, antihistamines, probiotics, and others. Out of 68 studies, 41 were randomized controlled trials.</p><p><strong>Conclusion: </strong>Based on the study results, we conclude that topical steroids and calcineurin inhibitors are effective and safe in mild to moderate pediatric AD. It was also demonstrated that while systemic monotherapy with dupilumab (in age groups younger than 6 months) and JAK inhibitors (like abrocitinib and upadacitinib in those younger than 12 years) is highly effective in rapidly reducing severity scores, their high cost and limited availability restrict their use in countries like India. In such settings, cyclosporine (and sometimes oral prednisolone in tapering doses over 2 weeks) is still recommended as a first-line therapy in severe AD while planning for steroid-sparing agents.</p>","PeriodicalId":13950,"journal":{"name":"International Journal of Dermatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143648333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}