International journal of clinical and experimental pathology最新文献_第9页

New PLAG1-fusion transcripts in the spectrum of pediatric fibrotic, lipofibrotic, and mature lipomatous tumors. 新的plag1融合转录物在儿童纤维化、脂肪纤维化和成熟脂肪瘤肿瘤的谱。

IF 1.4

International journal of clinical and experimental pathology Pub Date : 2022-10-15 eCollection Date: 2022-01-01

Bernhard Theis, Ilmi Alhussami, Elke Kämmerer, Karim Kentouche, Christian Vokuhl, Nikolaus Gassler, Kathrin Katenkamp

引用次数: 0

Clinicopathologic characteristics of low-grade thyroid-like nasopharyngeal papillary adenocarcinoma: a case report. 低级别甲状腺样鼻咽乳头状腺癌的临床病理特征1例。

IF 1.4

International journal of clinical and experimental pathology Pub Date : 2022-10-15 eCollection Date: 2022-01-01

Haoyue Hu, Lang Long, Xue Fan, Jun He

引用次数: 0

Role of macrophages in progression of colorectal cancer: a contrast with the traditional paradigm. 巨噬细胞在结直肠癌进展中的作用：与传统模式的对比。

IF 1.1

International journal of clinical and experimental pathology Pub Date : 2022-10-15 eCollection Date: 2022-01-01

Aleksei S Konstantinov, Olga V Kovaleva, Daria V Samoilova, Ksenya V Shelekhova

{"title":"Role of macrophages in progression of colorectal cancer: a contrast with the traditional paradigm.","authors":"Aleksei S Konstantinov, Olga V Kovaleva, Daria V Samoilova, Ksenya V Shelekhova","doi":"","DOIUrl":"","url":null,"abstract":"The phenotype of tumor-associated macrophages may be critical for tumor immunity, angiogenesis, and clinical disease outcome. Here, we elucidated the prognostic significance of the neovasculature and macrophages in colorectal cancer. We analyzed the effect of M2 macrophage density on the clinical behavior of 151 primary colorectal carcinomas using CD206 as a marker for type 2 macrophages. Triple immunohistochemical staining (ERG, SMA, and podoplanin) was used for microvessel evaluation. We found that M2 macrophages in colorectal cancer did not have a direct association with metastatic behavior. However, high numbers of CD206 tumor-associated macrophages correlated positively with recurrence-free interval duration (P=0.005). Fewer macrophages in the tumor microenvironment resulted in insufficient coverage of newly formed vessels by pericytes (P=0.011), and a high number of pericyte-impaired microvessels correlated with metastatic behavior (P<0.001). These results suggested that type 2 macrophages had a role in limiting the metastatic process by affecting vascular maturity and normalization. These findings contribute to understanding complex interactions in the tumor microenvironment and the clinical behavior of colorectal cancer.","PeriodicalId":13943,"journal":{"name":"International journal of clinical and experimental pathology","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2022-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638838/pdf/ijcep0015-0403.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40476474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dysregulation of long non-coding RNA SNHG12 alters the viability, apoptosis, and autophagy of prostate cancer cells by regulating miR-195/CCNE1 axis [Retraction]. 长链非编码RNA SNHG12的失调通过调节miR-195/CCNE1轴改变前列腺癌细胞的活力、凋亡和自噬[撤回]。

IF 1.4

International journal of clinical and experimental pathology Pub Date : 2022-10-15 eCollection Date: 2022-01-01

引用次数: 0

The role of immunohistochemistry in the assessment of classical Hodgkin lymphoma microenvironment. 免疫组织化学在经典霍奇金淋巴瘤微环境评估中的作用。

IF 1.4

International journal of clinical and experimental pathology Pub Date : 2022-10-15 eCollection Date: 2022-01-01

Dominique Fonseca Rodrigues Lacet, Cristiano Claudino Oliveira

{"title":"The role of immunohistochemistry in the assessment of classical Hodgkin lymphoma microenvironment.","authors":"Dominique Fonseca Rodrigues Lacet, Cristiano Claudino Oliveira","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Classical Hodgkin lymphoma (CHL) has a unique cellular composition, containing a minority of neoplastic cells - Hodgkin and Reed-Sternberg (HRS) cells - in an inflammatory background. Investigations into this microenvironment have been given special importance in scientific hematopathology, playing an important role in elucidating its composition and its relationship to the prognosis of patients.Objective: To investigate microenvironment tumor markers in CHL, in order to analyze their interactions with clinical-morphological aspects of interest in onco-hematopathology.Methods: This retrospective study analyzed 184 patients with a pathologic diagnosis of CHL. Clinical data were reviewed from medical records. A morphological and immunophenotypic study with CD20, CD30, CD15, PAX-5, CD3, CD4, CD8, CD68, CD34, CD138 and PD-1 were performed. The data were tabulated and p value less than 0.05 was considered significant.Results: The time-to-cure was shorter in CD20+ patients, especially in those with more than 25% positivity (P=0.0183). The time-to-cure (P=0.0309) and the death (P=0.016) rates were shorter in PD-1 negative patients. Among patients with the presence of plasma cells in the microenvironment, those with lower numbers tend to be cured earlier (P=0.0374). Higher vascular density is associated with lower frequency of B symptoms (P=0.036) and presence of disease recurrence (P=0.004).Conclusions: The microenvironment is certainly the setting of increasingly robust studies and the findings of this work highlight non-neoplastic B lymphocytes, plasma cells, PD-1 lymphocytes, and vascular density, related to prognosis of CHL patients.","PeriodicalId":13943,"journal":{"name":"International journal of clinical and experimental pathology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2022-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9638837/pdf/ijcep0015-0412.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40476473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diffuse large B-cell lymphoma: morphologic and immunohistochemical analysis of bone marrow for staging, with emphasis on lymphoid aggregates. 弥漫性大b细胞淋巴瘤:骨髓形态学和免疫组织化学分析的分期，重点是淋巴样聚集体。

IF 1.4

International journal of clinical and experimental pathology Pub Date : 2022-09-15 eCollection Date: 2022-01-01

Vinicius C Nóbrega, Maria A C Domingues, Lígia Niero-Melo, Cristiano C Oliveira

{"title":"Diffuse large B-cell lymphoma: morphologic and immunohistochemical analysis of bone marrow for staging, with emphasis on lymphoid aggregates.","authors":"Vinicius C Nóbrega, Maria A C Domingues, Lígia Niero-Melo, Cristiano C Oliveira","doi":"","DOIUrl":"","url":null,"abstract":"Diffuse large B-Cell lymphoma (DLBCL) may infiltrate bone marrow (BM) and evaluation of BM plays an important role in DLBCL staging. This study used BM samples from DLBCL patients for staging and analyzed the use of immunohistochemistry in the diagnostic management of these cases by the pathologist. Patients with DLBCL submitted to BM biopsy/aspiration for staging were studied according to clinical aspects, morphologic aspects, and expression of CD20 and CD3. The characteristics of lymphoid aggregates in the bone marrow and the power of histopathological diagnosis were studied, with immunohistochemistry as the gold standard for the decision of a neoplastic infiltration definition. An isolated morphological analysis showed low sensitivity (42.9%) for lymphoma detection in BM, which is disadvantageous. The median of three lymphoid aggregates in the BM (p-value = 0.02) and the presence of increased reticulin fibers (grade 2) in the lymphoid aggregate (p-value = 0.01) had significant associations with neoplastic infiltration. A morphological analysis must be accompanied by an immunohistochemical analysis in all cases, or when this is not possible, in cases with two or more lymphoid aggregates or an increase of reticulin within them.","PeriodicalId":13943,"journal":{"name":"International journal of clinical and experimental pathology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2022-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547993/pdf/ijcep0015-0345.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33537215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypoglycemic and hypolipidemic effects of Garcinia cambogia extracts in streptozotocin-nicotinamide induced diabetic rat model. 黄藤提取物对链脲佐菌素-烟酰胺诱导的糖尿病大鼠模型的降血糖和降血脂作用。

IF 1.4

International journal of clinical and experimental pathology Pub Date : 2022-09-15 eCollection Date: 2022-01-01

Prathvi Shetty, Mohandas Rai, Arun Ravindran, H N Gopalakrishna, Vinitha Ramanath Pai, Bhuvanesh Sukhlal Kalal

{"title":"Hypoglycemic and hypolipidemic effects of Garcinia cambogia extracts in streptozotocin-nicotinamide induced diabetic rat model.","authors":"Prathvi Shetty, Mohandas Rai, Arun Ravindran, H N Gopalakrishna, Vinitha Ramanath Pai, Bhuvanesh Sukhlal Kalal","doi":"","DOIUrl":"","url":null,"abstract":"Background and objectives: Diabetes mellitus, a global health problem, is associated with metabolic complications such as hyperglycemia, hyperlipidemia, hypertension, cardiovascular diseases, and loss of vision. The present study evaluated the antidiabetic and antihyperlipidemic effects of ethanol extract of Garcinia cambogia (L.) N. Robson (G. cambogia) fruit rind in a streptozotocin-nicotinamide induced diabetic Wistar Rat model.Materials and methods: Streptozotocin-nicotinamide was injected intraperitoneally to induce diabetes in Wistar rats. Five groups of rats (n=6) - normal control, diabetic, diabetic treated with G. cambogia at 400 mg/kg and 800 mg/kg body weight, and diabetic treated with metformin at 500 mg/kg body weight, were studied. Blood samples were collected after three weeks of treatment. Random blood glucose (RBG), Serum total cholesterol levels (TCL), serum total triglyceride levels (TGL), high-density lipoprotein levels, and body weight were measured.Results: Although G. cambogia treatment did not have any antidiabetic activity (p>0.05) rind in the streptozotocin-nicotinamide induced diabetic Wistar Rat model, it decreased the serum TCL, and body weight significantly (P<0.05).Conclusions: Ethanolic extract of G. cambogia fruit rind possesses anti-obesity activity and significantly reduces total cholesterol but does not have antidiabetic activity.","PeriodicalId":13943,"journal":{"name":"International journal of clinical and experimental pathology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2022-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547994/pdf/ijcep0015-0380.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33537216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression and significance of CDX2, FXR, and TGR5 in esophageal cancer. CDX2、FXR、TGR5在食管癌中的表达及意义

IF 1.4

International journal of clinical and experimental pathology Pub Date : 2022-09-15 eCollection Date: 2022-01-01

Hongying Zhang, Xiaodong Qu, Na Wang, Lifeng Zhang, Ting Yuan, Miao Shi, Nina Sun, Donghong Yuan, Hanbing Ning, Mengyun Zhao, Yongxi Wang, Zhen Ni, Chuan Han, Yongquan Shi

{"title":"Expression and significance of CDX2, FXR, and TGR5 in esophageal cancer.","authors":"Hongying Zhang, Xiaodong Qu, Na Wang, Lifeng Zhang, Ting Yuan, Miao Shi, Nina Sun, Donghong Yuan, Hanbing Ning, Mengyun Zhao, Yongxi Wang, Zhen Ni, Chuan Han, Yongquan Shi","doi":"","DOIUrl":"","url":null,"abstract":"This study explored the expression and significance of three critical morphogenesis genes in normal esophagus, reflux esophagitis (RE), Barrett's esophagus (BE), esophageal adenocarcinoma (EA), and esophageal squamous cell carcinoma (ESCC). Esophageal tissue samples and tissue microarrays were used. CDX2, FXR, and TGR5 protein expression were measured by immunohistochemistry in normal esophageal, RE, BE, EA, and ESCC tissues. All 3 proteins had markedly changed expression during the progression of EA. The expressions of CDX2 and FXR were positively correlated in EA. In addition, TGR5 expression was positively correlated with CDX2 in RE and BE. The expressions of CDX2 and FXR were also positively correlated in ESCC. Although CDX2, FXR, and TGR5 were upregulated in ESCC, these factors might not be markers for the prognosis of ESCC. These results suggested that CDX2, FXR, and TGR5 might play different roles in EA and ESCC. They may represent novel therapeutic targets for patients with these cancers.","PeriodicalId":13943,"journal":{"name":"International journal of clinical and experimental pathology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2022-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547995/pdf/ijcep0015-0354.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33537217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obesity influence on bladder inflammation and cancer: a cystitis model. 肥胖对膀胱炎症和癌症的影响:膀胱炎模型。

IF 1.4

International journal of clinical and experimental pathology Pub Date : 2022-09-15 eCollection Date: 2022-01-01

Cristiano Trindade de Andrade, Guilherme Zweig Rocha, Marina Zamuner, Rodolfo Borges Dos Reis, Leonardo Oliveira Reis

{"title":"Obesity influence on bladder inflammation and cancer: a cystitis model.","authors":"Cristiano Trindade de Andrade, Guilherme Zweig Rocha, Marina Zamuner, Rodolfo Borges Dos Reis, Leonardo Oliveira Reis","doi":"","DOIUrl":"","url":null,"abstract":"Background: Recently, the role of subclinical inflammation in obesity has gained prominence. An association between obesity and chronic inflammation has been observed in several studies that show a relationship between increased morbidity and high Body Mass Index (BMI). This study aims to compare inflammatory pathways in obese (by high-fat diet) and non-obese mice after exposure to an intravesical carcinogen in a cystitis model.Methods: We divided 16 female, 7 week old mice into two groups: 1) CONTROL: standard diet, and 2) OBESE: high fat diet for 8 weeks. Both groups underwent a protocol for N-Nitroso-N-methylurea (MNU) pro-inflammatory bladder instillation. Bladder was analyzed by histopathology and western blotting for proteins of the inflammatory pathway (JNK, NFκB, c-JUN, IKK), and immunohistochemistry (proliferation and apoptosis).Results: While mice eating standard diet showed minimal histologic alteration in 4 of 5 (80%) bladder tissues, those eating a high fat diet showed moderate (60%) and intense (40%) chronic active inflammation with dysplasia foci, increased proliferation, apoptosis and inflammatory pathway activation with increased NFκB, and also IKKβ, JNK, and c-JUN phosphorylation in the urothelium.Conclusion: A high-fat diet causes increased urothelial proliferation, apoptosis, and NFκB expression with cystitis exacerbation and dysplasia. Together, these results suggest that obesity induced by a high-fat diet increases the inflammatory pathway in the bladder with possible pre-malignant alterations.","PeriodicalId":13943,"journal":{"name":"International journal of clinical and experimental pathology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2022-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547991/pdf/ijcep0015-0373.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33537214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic utility of immunohistochemical markers alpha methyl acyl coA racemase (AMACR) and Ets related gene (ERG) in prostate cancer. 免疫组织化学标记α甲基酰基辅酶a消旋酶(AMACR)和Ets相关基因(ERG)在前列腺癌中的诊断价值

IF 1.4

International journal of clinical and experimental pathology Pub Date : 2022-09-15 eCollection Date: 2022-01-01

Norton Stephen, Bhawana A Badhe

{"title":"Diagnostic utility of immunohistochemical markers alpha methyl acyl coA racemase (AMACR) and Ets related gene (ERG) in prostate cancer.","authors":"Norton Stephen, Bhawana A Badhe","doi":"","DOIUrl":"","url":null,"abstract":"Objectives: To study the sensitivity and specificity of IHC markers AMACR and ERG in prostatic adenocarcinoma.Methods: The study was a prospective one and samples were collected from August 2014 to June 2016. A total of 186 samples were obtained from the Department of Urology, in which 112 of these were benign prostatic hyperplasia (BPH), and 71 were prostatic adenocarcinoma. The adenocarcinoma cases were evaluated by two histopathologists, and appropriate Gleason score was given according to the modified ISUP Gleason grading system (2016). IHC markers AMACR & ERG were performed on the adenocarcinoma cases and their sensitivity and specificity were calculated.Results: AMACR was a highly sensitive and specific marker for detecting prostatic carcinoma with a sensitivity and specificity of 95.8% and 96.5% respectively. ERG was a very specific marker with poor sensitivity in detecting prostate cancer. The sensitivity and specificity of ERG were 35.2% and 100% respectively. ERG expression decreased with increasing Gleason grade, PSA level, and tumour volume, which was statistically significant while the association of AMACR with Gleason grade or with tumor volume was not significant.Conclusion: ERG is a marker of early prostatic carcinogenesis and tumors may be positive or negative subtypes. Special histomorphologic features like perineural invasion, glomerulations, and intraluminal blue mucin were also studied. AMACR was a highly sensitive marker for detecting prostatic adenocarcinoma, while ERG was highly specific.","PeriodicalId":13943,"journal":{"name":"International journal of clinical and experimental pathology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2022-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547992/pdf/ijcep0015-0364.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33537218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0