International journal of clinical and experimental pathology最新文献

{"title":"Diffuse large B-cell lymphoma: morphologic and immunohistochemical analysis of bone marrow for staging, with emphasis on lymphoid aggregates.","authors":"Vinicius C Nóbrega,&nbsp;Maria A C Domingues,&nbsp;Lígia Niero-Melo,&nbsp;Cristiano C Oliveira","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Diffuse large B-Cell lymphoma (DLBCL) may infiltrate bone marrow (BM) and evaluation of BM plays an important role in DLBCL staging. This study used BM samples from DLBCL patients for staging and analyzed the use of immunohistochemistry in the diagnostic management of these cases by the pathologist. Patients with DLBCL submitted to BM biopsy/aspiration for staging were studied according to clinical aspects, morphologic aspects, and expression of CD20 and CD3. The characteristics of lymphoid aggregates in the bone marrow and the power of histopathological diagnosis were studied, with immunohistochemistry as the gold standard for the decision of a neoplastic infiltration definition. An isolated morphological analysis showed low sensitivity (42.9%) for lymphoma detection in BM, which is disadvantageous. The median of three lymphoid aggregates in the BM (<i>p</i>-value = 0.02) and the presence of increased reticulin fibers (grade 2) in the lymphoid aggregate (<i>p</i>-value = 0.01) had significant associations with neoplastic infiltration. A morphological analysis must be accompanied by an immunohistochemical analysis in all cases, or when this is not possible, in cases with two or more lymphoid aggregates or an increase of reticulin within them.</p>","PeriodicalId":13943,"journal":{"name":"International journal of clinical and experimental pathology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2022-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547993/pdf/ijcep0015-0345.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33537215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoglycemic and hypolipidemic effects of Garcinia cambogia extracts in streptozotocin-nicotinamide induced diabetic rat model.","authors":"Prathvi Shetty,&nbsp;Mohandas Rai,&nbsp;Arun Ravindran,&nbsp;H N Gopalakrishna,&nbsp;Vinitha Ramanath Pai,&nbsp;Bhuvanesh Sukhlal Kalal","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background and objectives: </strong>Diabetes mellitus, a global health problem, is associated with metabolic complications such as hyperglycemia, hyperlipidemia, hypertension, cardiovascular diseases, and loss of vision. The present study evaluated the antidiabetic and antihyperlipidemic effects of ethanol extract of <i>Garcinia cambogia</i> (L.) N. Robson (<i>G. cambogia</i>) fruit rind in a streptozotocin-nicotinamide induced diabetic Wistar Rat model.</p><p><strong>Materials and methods: </strong>Streptozotocin-nicotinamide was injected intraperitoneally to induce diabetes in Wistar rats. Five groups of rats (n=6) - normal control, diabetic, diabetic treated with <i>G. cambogia</i> at 400 mg/kg and 800 mg/kg body weight, and diabetic treated with metformin at 500 mg/kg body weight, were studied. Blood samples were collected after three weeks of treatment. Random blood glucose (RBG), Serum total cholesterol levels (TCL), serum total triglyceride levels (TGL), high-density lipoprotein levels, and body weight were measured.</p><p><strong>Results: </strong>Although <i>G. cambogia</i> treatment did not have any antidiabetic activity (p>0.05) rind in the streptozotocin-nicotinamide induced diabetic Wistar Rat model, it decreased the serum TCL, and body weight significantly (P<0.05).</p><p><strong>Conclusions: </strong>Ethanolic extract of <i>G. cambogia</i> fruit rind possesses anti-obesity activity and significantly reduces total cholesterol but does not have antidiabetic activity.</p>","PeriodicalId":13943,"journal":{"name":"International journal of clinical and experimental pathology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2022-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547994/pdf/ijcep0015-0380.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33537216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression and significance of CDX2, FXR, and TGR5 in esophageal cancer.","authors":"Hongying Zhang,&nbsp;Xiaodong Qu,&nbsp;Na Wang,&nbsp;Lifeng Zhang,&nbsp;Ting Yuan,&nbsp;Miao Shi,&nbsp;Nina Sun,&nbsp;Donghong Yuan,&nbsp;Hanbing Ning,&nbsp;Mengyun Zhao,&nbsp;Yongxi Wang,&nbsp;Zhen Ni,&nbsp;Chuan Han,&nbsp;Yongquan Shi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This study explored the expression and significance of three critical morphogenesis genes in normal esophagus, reflux esophagitis (RE), Barrett's esophagus (BE), esophageal adenocarcinoma (EA), and esophageal squamous cell carcinoma (ESCC). Esophageal tissue samples and tissue microarrays were used. CDX2, FXR, and TGR5 protein expression were measured by immunohistochemistry in normal esophageal, RE, BE, EA, and ESCC tissues. All 3 proteins had markedly changed expression during the progression of EA. The expressions of CDX2 and FXR were positively correlated in EA. In addition, TGR5 expression was positively correlated with CDX2 in RE and BE. The expressions of CDX2 and FXR were also positively correlated in ESCC. Although CDX2, FXR, and TGR5 were upregulated in ESCC, these factors might not be markers for the prognosis of ESCC. These results suggested that CDX2, FXR, and TGR5 might play different roles in EA and ESCC. They may represent novel therapeutic targets for patients with these cancers.</p>","PeriodicalId":13943,"journal":{"name":"International journal of clinical and experimental pathology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2022-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547995/pdf/ijcep0015-0354.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33537217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obesity influence on bladder inflammation and cancer: a cystitis model.","authors":"Cristiano Trindade de Andrade,&nbsp;Guilherme Zweig Rocha,&nbsp;Marina Zamuner,&nbsp;Rodolfo Borges Dos Reis,&nbsp;Leonardo Oliveira Reis","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Recently, the role of subclinical inflammation in obesity has gained prominence. An association between obesity and chronic inflammation has been observed in several studies that show a relationship between increased morbidity and high Body Mass Index (BMI). This study aims to compare inflammatory pathways in obese (by high-fat diet) and non-obese mice after exposure to an intravesical carcinogen in a cystitis model.</p><p><strong>Methods: </strong>We divided 16 female, 7 week old mice into two groups: 1) CONTROL: standard diet, and 2) OBESE: high fat diet for 8 weeks. Both groups underwent a protocol for <i>N</i>-Nitroso-<i>N</i>-methylurea (MNU) pro-inflammatory bladder instillation. Bladder was analyzed by histopathology and western blotting for proteins of the inflammatory pathway (JNK, NFκB, c-JUN, IKK), and immunohistochemistry (proliferation and apoptosis).</p><p><strong>Results: </strong>While mice eating standard diet showed minimal histologic alteration in 4 of 5 (80%) bladder tissues, those eating a high fat diet showed moderate (60%) and intense (40%) chronic active inflammation with dysplasia foci, increased proliferation, apoptosis and inflammatory pathway activation with increased NFκB, and also IKKβ, JNK, and c-JUN phosphorylation in the urothelium.</p><p><strong>Conclusion: </strong>A high-fat diet causes increased urothelial proliferation, apoptosis, and NFκB expression with cystitis exacerbation and dysplasia. Together, these results suggest that obesity induced by a high-fat diet increases the inflammatory pathway in the bladder with possible pre-malignant alterations.</p>","PeriodicalId":13943,"journal":{"name":"International journal of clinical and experimental pathology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2022-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547991/pdf/ijcep0015-0373.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33537214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic utility of immunohistochemical markers alpha methyl acyl coA racemase (AMACR) and Ets related gene (ERG) in prostate cancer.","authors":"Norton Stephen,&nbsp;Bhawana A Badhe","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objectives: </strong>To study the sensitivity and specificity of IHC markers AMACR and ERG in prostatic adenocarcinoma.</p><p><strong>Methods: </strong>The study was a prospective one and samples were collected from August 2014 to June 2016. A total of 186 samples were obtained from the Department of Urology, in which 112 of these were benign prostatic hyperplasia (BPH), and 71 were prostatic adenocarcinoma. The adenocarcinoma cases were evaluated by two histopathologists, and appropriate Gleason score was given according to the modified ISUP Gleason grading system (2016). IHC markers AMACR & ERG were performed on the adenocarcinoma cases and their sensitivity and specificity were calculated.</p><p><strong>Results: </strong>AMACR was a highly sensitive and specific marker for detecting prostatic carcinoma with a sensitivity and specificity of 95.8% and 96.5% respectively. ERG was a very specific marker with poor sensitivity in detecting prostate cancer. The sensitivity and specificity of ERG were 35.2% and 100% respectively. ERG expression decreased with increasing Gleason grade, PSA level, and tumour volume, which was statistically significant while the association of AMACR with Gleason grade or with tumor volume was not significant.</p><p><strong>Conclusion: </strong>ERG is a marker of early prostatic carcinogenesis and tumors may be positive or negative subtypes. Special histomorphologic features like perineural invasion, glomerulations, and intraluminal blue mucin were also studied. AMACR was a highly sensitive marker for detecting prostatic adenocarcinoma, while ERG was highly specific.</p>","PeriodicalId":13943,"journal":{"name":"International journal of clinical and experimental pathology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2022-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547992/pdf/ijcep0015-0364.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33537218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel pyroptosis-related gene signature for predicting laryngeal carcinoma prognosis.","authors":"Haopeng Zhang,&nbsp;Lihua Wang,&nbsp;Ziming Yin,&nbsp;Lin Ji,&nbsp;Yu Guo","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Pyroptosis, a newly-defined mode of cell death related to inflammation, is closely related to cancers but has not yet been studied in laryngeal carcinoma (LC). We investigated pyroptosis in LC and constructed a prognostic model. Using RNA sequencing data, we identified differentially expressed genes (DEGs) in LC and normal tissues to construct a prognostic risk model. The model's accuracy and independent prognostic value were evaluated using survival- and receiver operating characteristic (ROC)- curves; and univariate and multivariate Cox regression analyses, respectively. Gene Expression Omnibus (GEO) data was utilized as a model validation set. Differential analysis revealed 37 DEGs, and consistent clustering showed that pyroptosis-related genes could predict LC prognosis. Six genes (CHMP7, GSDME, GZMB, CASP9, IL6, and NLRP1) were obtained by Lasso Cox regression analysis to construct a prognostic model. The high-risk group had a poor prognosis with areas under the ROC curve at 1-, 3-, and 5-years of 0.619, 0.692, and 0.656, respectively. Univariate and multivariate Cox analyses showed that the risk score was an independent prognostic factor. Enrichment analysis of GO and KEGG pathways revealed that differentially expressed genes may be related to infection, T cell differentiation, immunity, and inflammation. It was further found that the low survival rate of the high-risk group may be related to the significant reduction of immune cell infiltration and immune function. With the bioinformatic method, six genes related to pyroptosis affecting LC prognosis were screened and a prognostic risk model was constructed, which laid a foundation for pyroptosis study in LC.</p>","PeriodicalId":13943,"journal":{"name":"International journal of clinical and experimental pathology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441861/pdf/ijcep0015-0301.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40358841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrointestinal mucormycosis in the pediatric age group: an evolving disease.","authors":"Nidhi Mahajan,&nbsp;Niyaz Ahmed Khan,&nbsp;Arti Khatri,&nbsp;Shafqat Bano,&nbsp;Chabbi Ranu Gupta,&nbsp;Mamta Sengar,&nbsp;Karnika Saigal,&nbsp;Arpita Chattopadhyay,&nbsp;Natasha Gupta","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Mucormycosis is a devastating opportunistic fungal infection resulting in significant mortality, especially in pediatric patients with predisposing risk factors.</p><p><strong>Materials & methods: </strong>Biopsies and surgical specimens reported and proven as Mucormycosis in children under 12 years of age were retrieved from the records for three years (January 2018 to January 2021). Complete data, predisposing factors, treatment, and clinical outcome were recorded.</p><p><strong>Results: </strong>15 cases were identified, ranging from 9 days to 5 years. The male-female ratio was 3:1; three children were preterm. Fourteen children were diagnosed with gastrointestinal Mucormycosis (14/15), and one had palatal and sinusoidal involvement. Abdominal pain with distention was the most typical complaint. On microscopy, biopsies and surgical specimens showed extensive liquefactive necrosis with broad aseptate fungal hyphae. An intraoperative diagnosis was rendered in two cases. All neonates underwent exploratory laparotomy with surgical debridement and were administered Liposomal Amphotericin B. However, only two neonates survived out of the fifteen cases, one with disease limited to the appendix and pouch colon. The others succumbed to the disease despite antifungal therapy and surgical debridement. Thus, the overall mortality in the current study was calculated to be 86%, with neonatal mortality of 75%.</p><p><strong>Conclusion: </strong>Gastrointestinal involvement is more common in neonates and infants with a male preponderance. The diagnosis relies on direct microscopy, histopathology, and fungal culture. Intraoperative tissue may be sent in all suspected cases for direct microscopic examination for rapid diagnosis and treatment.</p>","PeriodicalId":13943,"journal":{"name":"International journal of clinical and experimental pathology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441857/pdf/ijcep0015-0323.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40358844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reactive hyperplasia of vascular pericytes in meningioma: immunohistochemical and ultrastructural studies of two cases.","authors":"Masayuki Shintaku,&nbsp;Makoto Ohta,&nbsp;Hideo Chihara","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>An isolated proliferation of pericytes is a unique vascular reaction seen almost exclusively in the stroma of secretory meningioma. We report the results of immunohistochemical and ultrastructural studies of a pericytic proliferation that was found in two cases of meningioma (a secretory meningioma of the sphenoid ridge and a parasagittal atypical meningioma showing predominantly fibroblastic features). Pericytes had hyperchromatic nuclei and scant cytoplasm, and showed stratification or formed small clusters within the walls of small blood vessels. They occasionally showed close contact with pseudopsammoma bodies in secretory meningioma. Pericytes showed immunoreactivity for α-smooth muscle actin but were not immunoreactive for desmin. They also exhibited characteristic ultrastructural features of pericytes, including the presence of microfilaments and abundant pinocytotic vesicles, and investment by the basal lamina. This isolated pericytic proliferation is likely a peculiar response of the vascular wall, probably induced by some cytokines secreted from neoplastic meningothelial cells. The close contact of proliferating pericytes with pseudopsammoma bodies suggests a close pathogenetic association between them. The occurrence of pericytic proliferation that was found in our second case (atypical meningioma with predominantly fibroblastic features) is exceptional and has not been documented to date.</p>","PeriodicalId":13943,"journal":{"name":"International journal of clinical and experimental pathology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441860/pdf/ijcep0015-0316.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40358843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extremely intricate labyrinthine structures: an electron microscopic observation of peculiar invaginations of the plasma membrane found in secretory meningioma.","authors":"Masayuki Shintaku","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Large, extremely intricate labyrinthine structures were observed during an electron microscopic examination of a secretory meningioma that originated in the sphenoid ridge of a 73-year-old man. In many neoplastic cells, these labyrinthine structures formed round-shaped regions within the cytoplasm, and profiles indicated their internal structure consisted of numerous thin fragments of cytoplasm and intervening flocculent material. These labyrinthine structures did not exhibit apparent topographic association with pseudopsammoma bodies, and direct communication with the extracellular space by very thin channels was rarely observed. The structures resembled the \"intracytoplasmic lumina\" commonly seen in epithelial neoplasms; but they did not appear to be true \"intracytoplasmic\" closed structures but rather deep and elaborate invaginations of the plasma membrane into the cytoplasm. These structures are distinct from pseudopsammoma bodies and might represent another expression of the epithelial properties of neoplastic cells in this subtype of meningioma. Although their pathogenesis or significance remain unknown, these structures may significantly increase the surface area of neoplastic cells and facilitate the uptake of extracellular material.</p>","PeriodicalId":13943,"journal":{"name":"International journal of clinical and experimental pathology","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441856/pdf/ijcep0015-0338.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40358846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ovarian steroid cell tumor associated with von Hippel-Lindau syndrome: a report of two cases and literature review.","authors":"Yulan Gong,&nbsp;Suad Taraif,&nbsp;Iryna Mazur,&nbsp;Amandeep Aneja,&nbsp;Min Huang,&nbsp;Debra L Somers,&nbsp;Jian J Fu","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Steroid cell tumor (SCT) is a rare sex cord-stromal tumor accounting for only 0.1% of ovarian tumors. Steroid cell tumor, not otherwise specified (SCT, NOS) is of uncertain lineage and is the most common among the three subtypes of SCT. Patients often present with endocrine abnormalities. Von Hippel-Lindau (VHL) syndrome is an autosomal dominant disorder resulting from inactivating gene deletions, frameshifts, and missense mutations of the VHL gene. VHL syndrome can involve multiple organs and clinically is subclassified into type 1 and type 2 based on the risk of pheochromocytoma (PCC). The association of VHL syndrome with genital tract tumors is rare, and here we report two cases of SCT, NOS in patients with VHL disease. The first case is a 19-year old female with VHL and prior resection of bilateral cerebellar hemangioblastomas. During the radiological surveillance, she was found to have multiple small enhancing foci in the cerebellar hemispheres and a stable small enhancing focus in the T6 cord with associated edema, likely reflecting a small hemangioblastoma. She had long history of irregular menses and ultrasound of pelvis found a large right ovarian mass. Cystectomy specimen showed a 6.4 cm well-circumscribed lesion with yellow cut surface. Histologic examination and immunohistochemical staining confirmed the diagnosis of SCT, NOS. The second patient is a 39-year-old female with VHL, previous surgery for retinal hemangioblastomatosis and cerebellar hemangioblastoma, history of abnormal uterine bleeding and elevated testosterone. CT of abdomen and pelvis revealed bilateral multiple cystic and solid renal lesions and a large left ovarian complex cyst. Bilateral partial nephrectomy showed multiple renal cysts and clear cell renal cell carcinomas (RCCs). Left salpingo-oophorectomy showed a 7 cm lesion with yellow-orange cut surface and features consistent with SCT, NOS. Review of the previously reported VHL SCT cases (not including the current two cases) indicated a probable link between VHL syndrome and SCT.</p>","PeriodicalId":13943,"journal":{"name":"International journal of clinical and experimental pathology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9441858/pdf/ijcep0015-0332.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40358842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}