International journal of clinical and experimental pathology最新文献_第10页

MicroRNA-126 acts as a tumor suppressor in glioma cells by targeting insulin receptor substrate 1 (IRS-1) [Retraction]. MicroRNA-126通过靶向胰岛素受体底物1 (IRS-1)在胶质瘤细胞中起肿瘤抑制作用[撤回]。

IF 1.4

International journal of clinical and experimental pathology Pub Date : 2022-08-15 eCollection Date: 2022-01-01

引用次数: 0

Intraligamentous synovial osteochondroma of the ligamentum teres: a series of 14 cases. 韧带内滑膜骨软骨瘤:附14例报告。

IF 1.4

International journal of clinical and experimental pathology Pub Date : 2022-07-15 eCollection Date: 2022-01-01

Rana M Ajabnoor, David A Quinzi, Emily Carmody, Brendan F Boyce

{"title":"Intraligamentous synovial osteochondroma of the ligamentum teres: a series of 14 cases.","authors":"Rana M Ajabnoor, David A Quinzi, Emily Carmody, Brendan F Boyce","doi":"","DOIUrl":"","url":null,"abstract":"Background: The ligamentum teres (LT) is covered by synovium. It acts as a stabilizer of the hip and as such it has been compared to the ACL of the knee joint. Pathologic changes occur in the LT with aging and osteoarthritis (OA), including degeneration, occasional chondroid metaplasia, and synovial chondromatosis are well-recognized in the literature. However, there are no reports of intraligamentous synovial osteochondroma occuring in the LT.Methods: We reviewed the pathology reports of 542 osteoarthritic femoral arthroplasty specimens between January 2016 and December 2018. The LT was examined histologically in 55 cases because it was abnormal on gross examination.Results: A single synovial osteochondroma, ranging in size from 0.4-1.7 cm in diameter, was present in the body of the LT in 14 cases (9 males; 5 females, aged 34 to 81 years), representing 2.6% of 542 arthroplasty cases. Ten of the osteochondromas had bone marrow fat without hematopoietic elements, 1 had hematopoietic elements, and 3 had no marrow among the bony trabeculae. Radiographically, all cases had moderate to severe osteoarthritis with no mention of an abnormality of LT.Conclusion: To our knowledge, this is the first report of intraligamentous synovial osteochondroma in the LT in osteoarthritis patients undergoing hip arthroplasty. It provides further support for microscopic examination of arthroplasty specimens for histologic abnormalities. Further prospective study is needed to determine if this lesion contributes adversely to the development or progression of osteoarthritis and if it is a reactive or neoplastic process.","PeriodicalId":13943,"journal":{"name":"International journal of clinical and experimental pathology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2022-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360587/pdf/ijcep0015-0282.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40685509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression and prognostic potential of TMEM204: a pan-cancer analysis. TMEM204的表达和预后潜力:一项泛癌症分析。

IF 1.4

International journal of clinical and experimental pathology Pub Date : 2022-07-15 eCollection Date: 2022-01-01

Zicheng Zhen, Minghao Li, Muyan Zhong, Jiaqi Liu, Wendu Huang, Liqun Ye

{"title":"Expression and prognostic potential of TMEM204: a pan-cancer analysis.","authors":"Zicheng Zhen, Minghao Li, Muyan Zhong, Jiaqi Liu, Wendu Huang, Liqun Ye","doi":"","DOIUrl":"","url":null,"abstract":"TMEM204 (Transmembrane Protein 204) is a member of the TMEM family that regulates cell function and angiogenesis. Previous studies showed that TMEM204 is related to pancreatic cancer, but its roles in other cancers remain unknown. To reveal this relationship, we conducted a pan-cancer analysis by several online databases. The expression of TMEM204 was analyzed by Oncomine and Tumor Immune Estimation Resource2.0 (TIMER2.0). The prognostic potential of TMEM204 was evaluated by the GEPIA2, UALCAN, and Oncolnc. The methylation level of gene expression was analyzed by UALCAN, and the relationship between cancer and immune invasion was displayed by TIMER2.0. The Protein-Protein Interactions Network and functional analysis of TMEM204 and its related genes were conducted by STRING and Webgestalt. We found that TMEM204 expression was up-regulated and correlated with prognosis in multiple cancers. In liver hepatocellular carcinoma (LIHC), high TMEM204 expression was associated with a good prognosis, and with high infiltrating levels of CD8+ T and CD4+ T cells, macrophages, neutrophils, and myeloid dendritic cells. In addition, the methylation level in LIHC was higher than in normal tissues. p53 signaling pathway and Fanconi anemia pathway were implicated by KEGG pathway analysis. These results indicate that TMEM204 is associated with the prognosis, methylation, and immune invasion of cancers, especially LIHC. TMEM204 may act as a prognostic marker of LIHC and its role in other cancers should be studied.","PeriodicalId":13943,"journal":{"name":"International journal of clinical and experimental pathology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2022-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360586/pdf/ijcep0015-0258.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40685506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunohistochemical analysis of sex hormone receptors in squamous changes of the urothelium. 泌尿系鳞状上皮变化中性激素受体的免疫组化分析。

IF 1.1

International journal of clinical and experimental pathology Pub Date : 2022-07-15 eCollection Date: 2022-01-01

Julia B Seitz, Josef Högel, Markus Eckstein, Verena Lieb, Bernd Wullich, Arndt Hartmann, Ralf J Rieker

{"title":"Immunohistochemical analysis of sex hormone receptors in squamous changes of the urothelium.","authors":"Julia B Seitz, Josef Högel, Markus Eckstein, Verena Lieb, Bernd Wullich, Arndt Hartmann, Ralf J Rieker","doi":"","DOIUrl":"","url":null,"abstract":"Objective: Squamous cell transformation of the urinary bladder urothelium has various causes, symptoms, and few treatment options. The aim of this study was to analyze and compare the expression of sex hormone receptors in non-keratinized and keratinized squamous metaplasia (NKSM, KSM), squamous cell carcinoma (SCC), and healthy urothelium with regard to possible therapeutic approaches.Methods: Biopsies from 26 patients with urothelial NKSM, KSM, and SCC were analyzed retrospectively. Tissue microarrays (TMA) of formalin-fixed paraffin-embedded (FFPE) bladder biopsies were stained with hematoxylin and eosin followed by immunohistochemical analysis with specific antibodies against estrogen, progesterone, and androgen receptors (ER, PR, AR) and assessment using the immunoreactive score. Statistical evaluations included the Wilcoxon signed-rank test and the Wilcoxon rank-sum test in the form of permutation tests.Results: Of the 15 women and 11 men included in this explorative study, 17 had metaplasia: 15 (six men, nine women) had NKSM and two KSM (both men). A total of nine patients (three men, six women) had keratinized SCC or urothelial carcinoma with squamous differentiation. The comparison between normal urothelial cells and metaplasia showed a significantly stronger expression in the metaplastic tissue (P=0.0374). The invasive carcinoma showed significantly less PR than the extracellular matrix of the healthy urothelium (P=0.0026). Expression of AR was nearly absent in healthy and metaplastic urothelium.Conclusion: There appears to be an association between squamous metaplasia of the bladder mucosa and sex steroid hormone receptor expression, especially estrogen receptors. Topical hormone therapy should be considered.","PeriodicalId":13943,"journal":{"name":"International journal of clinical and experimental pathology","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2022-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360584/pdf/ijcep0015-0272.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40685507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transient atypical lymphoplasmacytic proliferation of the endometrium associated with pyometra: a case report. 子宫内膜短暂性非典型淋巴浆细胞增生伴脓膜增生1例。

IF 1.4

International journal of clinical and experimental pathology Pub Date : 2022-07-15 eCollection Date: 2022-01-01

Tomoyuki Otani, Kosuke Murakami, Masatomo Kimura, Mitsuru Matsuki, Takao Satou, Noriomi Matsumura, Akihiko Ito

{"title":"Transient atypical lymphoplasmacytic proliferation of the endometrium associated with pyometra: a case report.","authors":"Tomoyuki Otani, Kosuke Murakami, Masatomo Kimura, Mitsuru Matsuki, Takao Satou, Noriomi Matsumura, Akihiko Ito","doi":"","DOIUrl":"","url":null,"abstract":"Plasmablastic lymphoma is a mature B-cell neoplasm with plasmablastic differentiation, often associated with human immunodeficiency virus (HIV) infection and other forms of immunosuppression. Although it is usually an aggressive disease, spontaneous regression has been seen in a few cases. Plasmablastic lymphoma of the uterus is rare. We report a case of atypical lymphoplasmacytic proliferation resembling plasmablastic lymphoma associated with pyometra that disappeared completely as the pyometra resolved. A 76-year-old HIV-negative woman presented with abnormal vaginal bleeding. Ultrasound and MRI findings were consistent with pyometra diagnosis. Endometrial biopsy revealed large plasmablastoid cells with abundant cytoplasm and prominent nucleoli proliferating in the endometrium. Immunohistochemistry showed that large cells stained positive for CD138, CD79a, and MUM1, and negative for CD20, PAX5, CD3, and CD5. Ki67 labelled at least 80% of the large cells. Epstein-Barr virus was detected in a small number of cells. The histologic picture was highly indicative of lymphoma, especially plasmablastic lymphoma, though the clinical context was unusual. As the pyometra was treated and resolved, the intrauterine abnormality disappeared completely. The patient has been well after 16 months with no sign of recurrent disease. This case underscores the sometimes blurry distinction between benign inflammation and lymphoma.","PeriodicalId":13943,"journal":{"name":"International journal of clinical and experimental pathology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2022-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360585/pdf/ijcep0015-0296.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40685508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic ovarian torsion after vaginal hysterectomy: a case with metastatic serous ovarian cancer. 阴道子宫切除术后慢性卵巢扭转一例转移性浆液性卵巢癌。

IF 1.4

International journal of clinical and experimental pathology Pub Date : 2022-07-15 eCollection Date: 2022-01-01

Ünzüle Korkmaz, Özer Birge, Mehmet Sait Bakır, Saliha Sağnıç, Tayup Simsek

引用次数: 0

Overexpression of Karyopherin α2 in small cell carcinoma of the cervix correlates with poor prognosis. 核粘蛋白α2在宫颈小细胞癌中的过表达与预后不良相关。

IF 1.4

International journal of clinical and experimental pathology Pub Date : 2022-06-15 eCollection Date: 2022-01-01

Ling-Min Liao, Zhen-Bang Gu, Ming Fang, Gong-Ji Yao, Long Huang

{"title":"Overexpression of Karyopherin α2 in small cell carcinoma of the cervix correlates with poor prognosis.","authors":"Ling-Min Liao, Zhen-Bang Gu, Ming Fang, Gong-Ji Yao, Long Huang","doi":"","DOIUrl":"","url":null,"abstract":"Background: Cervical small cell carcinoma (SCCC) is uncommon and little is known about its molecular markers. Karyopherin α2 (KPNA2) has been demonstrated in a variety of malignancies. Our objective was to determine whether the KPNA2 level is predictive of clinical outcome in patients with SCCC.Methods: We detected KPNA2 expression by immunohistochemistry in SCCC tumors from 62 patients. The staining results were evaluated by H-score. The correlation among KPNA2 expression level, clinical characteristics, and prognosis was analyzed.Results: KPNA2 expression was detected in tumor tissue from 55 patients with SCCC (55/62, 89%). High KPNA2 expression correlated significantly with International Federation of Gynecology and Obstetrics staging (P=0.035), tumor size (P=0.019), poorer overall survival (OS) (P=0.008), and poorer disease-free survival (P=0.004) compared to low KPNA2 expression. Multivariate analysis showed that KPNA2 expression level (P=0.037) and tumor size (P=0.046) were independent prognostic factors of OS.Conclusions: KPNA2 may be a molecular marker and indicator of prognosis in SCCC.","PeriodicalId":13943,"journal":{"name":"International journal of clinical and experimental pathology","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253809/pdf/ijcep0015-0241.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40565629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nipple adenoma with ipsilateral Spitz nevus in a 26-year-old female: a case report. 乳头腺瘤伴同侧斯皮兹痣1例，26岁女性。

IF 1.4

International journal of clinical and experimental pathology Pub Date : 2022-06-15 eCollection Date: 2022-01-01

Xiaofeng Hu, Zhongxin Lu

引用次数: 0

Serum testosterone level and semen quality in male patients with sickle cell disease in outpatient department of Chhattisgarh: a case-control study. 恰蒂斯加尔邦门诊部镰状细胞病男性患者的血清睾酮水平和精液质量：一项病例对照研究。

IF 1.1

International journal of clinical and experimental pathology Pub Date : 2022-06-15 eCollection Date: 2022-01-01

Vinita Singh, Sabah Siddiqui, Nighat Hussain, Rachita Nanda, Amit Bugalia, Sarita Agrawal

{"title":"Serum testosterone level and semen quality in male patients with sickle cell disease in outpatient department of Chhattisgarh: a case-control study.","authors":"Vinita Singh, Sabah Siddiqui, Nighat Hussain, Rachita Nanda, Amit Bugalia, Sarita Agrawal","doi":"","DOIUrl":"","url":null,"abstract":"Introduction: Infertility issues in men with sickle cell disease (SCD) have been studied more frequently than those in women. Semen analysis of men with SCD often shows sperm abnormalities in up to 91%. No such study has been conducted in India so far, and Chhattisgarh being a state with a high incidence of male infertility as well as SCD, this study holds significance.Objectives: 1. To identify whether male patients attending All India Institute of Medical Sciences Outpatient Department with SCD have abnormal testosterone and/or poor semen quality. 2. Counseling of infertile male patients with SCD regarding future childbearing, prognosis, fertility preservation, and management options.Methods: This study was an age-matched case-control study; 58 participants of age between 18-45 years were assigned in each group.Results: The sperm count was higher in HbSS, while volume and pH were greater in HbAA. However, no significant difference (P>0.05) was found in total motility or progressive motility. A highly significant difference (P<0.001) was observed in pH, sperm count, total motility, and normal morphology. There was a significant difference (P=0.005) in volume. The values of the HbSS subjects were higher than the standard reference values. The values of the HbAA subjects were higher than the standard reference value. However, no significant difference (P>0.05) was found in sperm count or vitality.Conclusion: Men in Chhattisgarh with SCD do not suffer from any reproductive disorders such as delayed sexual maturity, low serum testosterone, poor semen quality, or hypogonadism.","PeriodicalId":13943,"journal":{"name":"International journal of clinical and experimental pathology","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2022-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9253810/pdf/ijcep0015-0247.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40565627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Implications of thyroid transcription factor-1 gene methylation in carcinogenesis of interstitial pneumonia-related non-terminal respiratory unit lung adenocarcinoma. 甲状腺转录因子-1基因甲基化在间质性肺炎相关非末端呼吸单元肺腺癌癌变中的影响

IF 1.1

International journal of clinical and experimental pathology Pub Date : 2022-03-15 eCollection Date: 2022-01-01

Koji Okudela, Takehisa Suzuki, Toshiaki Kataoka, Mai Matsumura, Chihiro Koike, Tomohisa Baba, Hiromasa Arai, Tae Iwasawa, Misaki Sugiyama, Motoki Sekiya, Hideaki Mitsui, Hideya Kitamura, Tamiko Takemura, Takashi Ogura, Kenichi Ohashi

{"title":"Implications of thyroid transcription factor-1 gene methylation in carcinogenesis of interstitial pneumonia-related non-terminal respiratory unit lung adenocarcinoma.","authors":"Koji Okudela, Takehisa Suzuki, Toshiaki Kataoka, Mai Matsumura, Chihiro Koike, Tomohisa Baba, Hiromasa Arai, Tae Iwasawa, Misaki Sugiyama, Motoki Sekiya, Hideaki Mitsui, Hideya Kitamura, Tamiko Takemura, Takashi Ogura, Kenichi Ohashi","doi":"","DOIUrl":"","url":null,"abstract":"The present study aimed to elucidate the mechanisms underlying the histogenesis of interstitial pneumonia (IP)-related lung adenocarcinoma (LADC). We focused on the methylation of thyroid transcription factor 1 (TTF-1). The TTF-1 locus was highly methylated in IP-LADCs compared to non-IP-LADCs. Among the IP-LADCs, the non-terminal respiratory unit (TRU) LADCs showed marked hypermethylation in CpG sites in a particular intragenic region. This region was also found to be highly methylated in the IP lungs. The hierarchical dendrogram based on methylation levels divided the IP lungs into three different clusters. One of them showed a methylation profile similar to that of non-TRU LADCs. The non-TRU LADCs developed from this cluster with a significantly higher frequency. Moreover, bronchiolar metaplasia lining honeycomb/cystic lesions in IP lungs, IP-related non-TRU LADCs, and bronchiolar epithelia in healthy lungs were separately collected by microdissection and examined for methylation. Bronchiolar metaplasia showed hypermethylation, but bronchiolar epithelia did not. The methylation patterns in bronchiolar metaplasia were similar to those in non-TRU LADCs. In summary, a particular region of TTF-1 was highly methylated in IP-related non-TRU LADCs and bronchiolar metaplasia, supporting the theory that IP-related non-TRU LADCs may develop from bronchiolar metaplasia lining honeycomb/cystic lesions.","PeriodicalId":13943,"journal":{"name":"International journal of clinical and experimental pathology","volume":null,"pages":null},"PeriodicalIF":1.1,"publicationDate":"2022-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8986470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142055484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0