Clinicopathologic characteristics of neuroendocrine tumors with assessment by digital image analysis for Ki-67 index with a focus on the gastroenteropancreatic tract: a single-center study.

IF 1.1 Q4 ONCOLOGY
International journal of clinical and experimental pathology Pub Date : 2023-09-15 eCollection Date: 2023-01-01
Ji Hyun Park, Su-Jin Shin, Nara Jeon, Beom Jin Lim
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引用次数: 0

Abstract

Objectives: Neuroendocrine tumors (NETs) are a heterogeneous group of tumors that arise at various sites throughout the body. The gastroenteropancreatic (GEP) tract is the most common site of NETs. We investigated the clinicopathologic features of patients with GEP-NETs and the utility of digital image analysis, which was compared to eyeball estimation, a conventional method used to determine the Ki-67 labeling index.

Methods: The clinicopathologic data of GEP-NET patients at Gangnam Severance Hospital from January 2008 to October 2019 were retrospectively analyzed. Each case was reclassified according to the 2019 World Health Organization classification system, to which the classification of grade 3 was added. Comparisons between eyeball estimation and the digital image analysis method for Ki-67 index assessment were performed by calculating Cohen's kappa (k) coefficient.

Results: In total, 345 patients with GEP-NETs were enrolled. The mean age was 49.3 (range 13-79) years, with more male (61.1%) than female patients. The primary tumor sites were the rectum (70.1%), pancreas (12.5%), stomach (6.7%), and duodenum (5.8%). Overall, 298 (86.4%), 35 (10.1%), 2 (0.6%), and 10 (2.9%) patients exhibited grade 1, 2, and 3 and neuroendocrine carcinoma, respectively. Statistical analysis revealed that age > 50 years, tumor size > 2 cm, and presence of lymphovascular invasion, nodal metastasis, and distant metastasis were significantly associated with short overall survival. Additionally, 283 patients underwent digital image analysis of the Ki-67 index, and substantial agreement was found between the two methods (κ value: 0.765).

Conclusions: Eyeball estimation revealed non-inferior results compared with digital image analysis. Further research is needed to evaluate the possibility of using digital image analysis as an alternative analysis method.

神经内分泌肿瘤的临床病理特征与Ki-67指数的数字图像分析评估,重点关注胃肠胰道:一项单中心研究。
目的:神经内分泌肿瘤(NETs)是一组异质性肿瘤,发生在全身不同部位。胃肠胰道是NETs最常见的部位。我们研究了GEP-NETs患者的临床病理特征和数字图像分析的实用性,并将其与眼球估计(一种用于确定Ki-67标记指数的传统方法)进行了比较。方法:回顾性分析2008年1月至2019年10月江南Severance医院GEP-NET患者的临床病理资料。每个病例都根据2019年世界卫生组织的分类系统进行了重新分类,其中增加了3级分类。通过计算Cohen’s kappa(k)系数对Ki-67指数评估的眼球估计和数字图像分析方法进行比较。结果:共有345名GEP NETs患者入选。平均年龄49.3岁(13-79岁),男性患者(61.1%)多于女性患者。主要肿瘤部位为直肠(70.1%)、胰腺(12.5%)、胃(6.7%)和十二指肠(5.8%)。总的来说,298名(86.4%)、35名(10.1%)、2名(0.6%)和10名(2.9%)患者分别表现为1、2和3级神经内分泌癌。统计分析显示,年龄>50岁,肿瘤大小>2cm,淋巴管浸润、淋巴结转移和远处转移与总生存期短显著相关。此外,283名患者接受了Ki-67指数的数字图像分析,发现两种方法之间基本一致(κ值:0.765)。结论:与数字图像分析相比,眼球估计显示的结果并不差。需要进一步的研究来评估使用数字图像分析作为替代分析方法的可能性。
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来源期刊
自引率
0.00%
发文量
42
审稿时长
1 months
期刊介绍: The International Journal of Clinical and Experimental Pathology (IJCEP, ISSN 1936-2625) is a peer reviewed, open access online journal. It was founded in 2008 by an international group of academic pathologists and scientists who are devoted to the scientific exploration of human disease and the rapid dissemination of original data. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal. Unlike most other open access online journals, IJCEP will keep all the traditional features of paper print that we are all familiar with, such as continuous volume and issue numbers, as well as continuous page numbers to keep our warm feelings towards an academic journal.
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