International Journal of Cancer Therapy and Oncology最新文献

{"title":"Evaluation of Eclipse 3D plans using an independent treatment planning system","authors":"Anil kumar Ayyalasomayajula, K. Ayyangar, Srinivas Vuppu, A. R. Rani, P. V. L. Narayana, A. D. P. Rao","doi":"10.14319/IJCTO.51.25","DOIUrl":"https://doi.org/10.14319/IJCTO.51.25","url":null,"abstract":"Purpose: The goal of the current investigation was to compare complex 3D conformal plans generated on Eclipse™ treatment planning system (TPS) with independent dose calculations from radiation oncology planning system (ROPS™) TPS used as a secondary quality assurance check. Methods: Fifteen cancer patients that were treated with complex conformal treatment plans with cobalt and linac beams, using Eclipse TPS, were selected for this study. The structure sets, treatment beam data and prescription information were exported from the Eclipse TPS using DICOM-RT export. Using custom software, these data were imported into ROPS TPS. Independent dose calculation on the ROPS planning system using Clarkson summation algorithm was done. The dose volume histograms (DVH) from both planning systems were extracted and analyzed using custom software. Dose assessment was accomplished by defining criteria based on gross tumor volume (GTV) dose coverage, dose homogeneity and mean dose. For organs at risk (OAR) other than GTV, the main dose parameters were, mean dose and percentage of volume receiving 95% of prescription dose. Results: For the GTV, all 15 cases met the criteria set for the mean dose and dose homogeneity index. However, breast cases were found to have deviation in the percentage volume receiving the 95% of prescription dose. Conclusion: Using the criteria set for plan acceptance, all the 15 clinical cases were evaluated. Except for breast tangent plans, all plans passed all the criteria set. The large deviation for breast tangent plans was attributed to differences in dose calculation algorithms.","PeriodicalId":13931,"journal":{"name":"International Journal of Cancer Therapy and Oncology","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78378888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The efficacy of the Quercetin analogue LY294002 in immortalized cancer cell lines is related to the oxygenic and metabolic status of cells","authors":"H. Townley","doi":"10.14319/IJCTO.51.14","DOIUrl":"https://doi.org/10.14319/IJCTO.51.14","url":null,"abstract":"Purpose: LY294002, a promising drug for chemotherapy, suppresses the activity of Phosphatidylinositol 3-Kinase (PI3K) which is pivotal to a number of processes such as proliferation, metabolism, and apoptosis. The compound has, however, been seen to have very variable efficacy in vivo . Methods: Proliferation and viability of two immortalized cells with divergent bioenergetic profiles was determined using crystal violet staining, and the 3-(4, 5-dimethylthiazol-2yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay. Oxygen consumption rates were determined using MitoXpress-Xtra probes, and lactate generation was assessed with pH-Xtra probe and BM-lactate strips. Immunoblotting was performed with phospho-Akt-Ser 473 and Akt-pan primary antibodies. Results: U87 cells were shown to have a glycolytic metabolism, whereas RD cells exhibited a more aerobic metabolism. In both lines, hypoxia was shown to increase lactate production, and LY294002 reduced lactate production. The drug decreased cell proliferation and viability under all conditions, but the effect was greatest in U87 cells under normoxic conditions. Conclusion: Metabolic analysis showed a link between a glycolytic cell status and LY294002 induced cell death. However, in both cell lines the drug was also less effective under hypoxic conditions, as would be found in a tumour in vivo . Furthermore, in the presence of LY294002 the phosphorylation status of Akt, a target of PI3K, was found to be related to both the mechanism of cell respiration, and the oxygenic status of the cells.","PeriodicalId":13931,"journal":{"name":"International Journal of Cancer Therapy and Oncology","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82848558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of ArcCHECK SNC Machine QA tool for Modern Linear Accelerator","authors":"V. Mhatre, P. Patwe","doi":"10.14319/ijcto.51.11","DOIUrl":"https://doi.org/10.14319/ijcto.51.11","url":null,"abstract":"Purpose: ArcCHECK SNC Machine QA tool is used to test geometric and delivery aspects of linear accelerator. Methods: In this study we evaluated the performance of this tool. For each item analyzed by the tool, wherever possible, tests across the same time period using portal dosimetry were also evaluated. Machine QA feature allows user to perform quality assurance tests using ArcCHECK phantom. Following tests can be performed 1) Gantry Speed, Rotation and Angle 2) MLC/Collimator 3) Beam Profile Flatness and Symmetry. Data was collected on true BEAM STx for a year. All plans were created for 6 and 10 MV beams as per the SNC patient user manual in Eclipse v.13. Results: The Gantry speed was 3.9 deg/sec with speed maximum deviation around 0.3 deg/sec. The Gantry Isocenter for arc delivery was 0.9 mm and static delivery was 0.4 mm which was well consistent with MPC (0.4 mm). The average maximum percent positive and negative diff was found to be 1.9%, -0.25% and average maximum distance positive and negative diff was 0.4 mm, -0.3 mm for MLC/Collimator QA. The average gamma error at 1% 1 mm criteria was 1.4% using portal Dosimetry for 6 MV. The Flatness for Arc delivery was 1.8% and Symmetry for Y was 0.8% and X was 1.8%. Conclusion: ArcCHECK SNC Machine QA tool is useful for quality assurance of modern linear accelerators as it tests both geometric and delivery aspects. This test can be incorporated in the regular quality assurance protocol for VMAT delivery.","PeriodicalId":13931,"journal":{"name":"International Journal of Cancer Therapy and Oncology","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87259360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The advantages of collimator optimization for intensity modulated radiation therapy","authors":"Brian E Doozan, Farrah Mohamed, E. Nourishirazi, S. Pella, T. Leventouri","doi":"10.14319/ijcto.51.7","DOIUrl":"https://doi.org/10.14319/ijcto.51.7","url":null,"abstract":"Purpose: The goal of this study was to improve dosimetry for pelvic, head and neck and other cancers with aspherical planning target volumes (PTV) using collimator optimization for intensity modulated radiation therapy (IMRT). Methods: A retroactive study on the effects of collimator optimization of 20 patients was done by comparing collimator angles from optimized plans in Eclipse version 11.0. Keeping all other parameters equal, plans were created with four collimator techniques: CA 0 , all fields have collimators set to 0°, CA­ E , using the Eclipse collimator optimization, CA A­, minimizing the area of the jaws around the PTV, and CA X , minimizing the x-jaw gap. The minimum area and the minimum x-jaw angles were found by evaluating each field beam’s eye view of the PTV with ImageJ and finding the desired parameters with a custom script. The evaluation of the plans included the monitor units (MU), the maximum dose of the plan, the maximum dose to organs at risk (OAR), the conformity index (CI) and the number of split fields. Results : Compared to the CA 0 plans, the monitor units decreased on average by 6% for the CA X with a p-value of 0.01 from an ANOVA test. The average maximum dose stayed within 1.1% between all four methods with the lowest being CA X . The maximum dose to the most at risk organ was best spared by the CA A , which decreased by 0.62% from the CA 0 . Minimizing the x-jaws significantly reduced the number of split field from 61 to 37. Conclusion: In every field tested the CA X optimization produced as good or superior results than the other three techniques. For aspherical PTVs, CA X on average reduced the number of split fields, the maximum dose, minimized the dose to the surrounding OAR, and reduced the MU all while achieving the same control of the PTV.","PeriodicalId":13931,"journal":{"name":"International Journal of Cancer Therapy and Oncology","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74015558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preferred treatment position between supine and prone for pelvic radiation therapy; quantification of the intrafractional body motion component by 3D surface imaging system","authors":"Hui Zhao, V. Sarkar, Long Huang, Brian Wang, P. Rassiah‐Szegedi, Y. Huang, M. Szegedi, V. Gonzalez, B. Salter","doi":"10.14319/IJCTO.51.8","DOIUrl":"https://doi.org/10.14319/IJCTO.51.8","url":null,"abstract":"Purpose: We investigated the preferred treatment position between supine and prone during pelvic radiation treatment using real time tracking data from AlignRT. Our findings will provide valuable information regarding the role of intrafractional body motion in answering the question of prone versus supine position for pelvis radiation. Methods: Ten patients receiving pelvic radiation were enrolled in this study. For each patient, two simulation helical CT scans were performed, one in supine and one in prone position. Body surface contours were automatically generated and then exported to the AlignRT system as reference images. AlignRT continuous patient body motion tracking (1.5 to 2 minutes) was performed for both positions for each patient once per week for five weeks. The equivalent patient body motion along three principle directions was calculated from the six degree of freedom real time patient displacements data. The maximum and the standard deviation (STD) of equivalent patient body motion were calculated, so as the average of maximum and STD of equivalent patient motion over five fractions. These were then compared between supine and prone orientations. Results: A correlation was observed between the intrafractional body motion and large BMI. For overweight/obese patients, the intrafractional body motion was smaller for the supine position in both vertical and longitudinal directions. For normal range BMI patients, we observed no clear advantage for either supine or prone position in both vertical and longitudinal directions. In lateral direction, the intrafractional motion did not have statistically difference between two positions. Conclusion: Our study shows that the amount of intrafractional body motion between supine and prone orientation is correlated with patient BMI. Overweight/obese patients experienced significantly less overall body motion in supine orientation. The preferred treatment position for normal BMI patients was seen to be individually variable.","PeriodicalId":13931,"journal":{"name":"International Journal of Cancer Therapy and Oncology","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75200524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multileaf-collimator daily quality assurance of Vero4DRT system: our one-year experience","authors":"H. Miura, S. Ozawa, S. Tsuda, K. Yamada, Y. Nagata","doi":"10.14319/IJCTO.51.12","DOIUrl":"https://doi.org/10.14319/IJCTO.51.12","url":null,"abstract":"Purpose: We assessed the daily quality assurance (QA) of multi-leaf collimator (MLC) using the Vero4DRT system. Methods: As part of daily MLC QA, the irradiation field was set to 100 × 150 mm 2 with a gantry angle of 0 o. Only the leaf positioning error values only were displayed. We developed an in-house program to easily acquire these values using an open source optical character recognition engine. This test was implemented between 24 August 2015 and 23 August 2016. Results: The maximum leaf positioning error was 0.40 mm in both banks. In addition, the maximum deviation was 0.10 mm in both banks. The average and standard deviation for left and right banks were 0.19 mm ± 0.11 mm and 0.15 mm ± 0.09 mm, respectively. In our one-year measurement, the leaf positioning error was less than 0.50 mm. Therefore, if the leaf position error for daily MLC QA exceeded 0.50 mm, then an external intervention is required. Conclusion: The daily MLC QA of our one-year evaluation of the Vero4DRT system demonstrates an excellent leaf accuracy and reproducibility, thereby giving confidence in the quality of the treatment.","PeriodicalId":13931,"journal":{"name":"International Journal of Cancer Therapy and Oncology","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81407933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical implementation of IMRT step and shoot with simultaneous integrated boost for breast cancer: A dosimetric comparison of planning techniques","authors":"U. Nastasi, L. Gianusso, F. Monte, A. Cannizzaro, P. Rovea","doi":"10.14319/ijcto.51.9","DOIUrl":"https://doi.org/10.14319/ijcto.51.9","url":null,"abstract":"Purpose: Radiotherapy post-lumpectomy with two coplanar tangent beams is the standard treatment for women with early stage breast cancer. Despite the use of wedges as tissue compensators, the resultant plans often contains a significant dose gradient and 'hot spots' in excess of 15% or more of prescribed dose. In recent years a field-in-field (FIF) dose-compensation technique, which use two standard tangent fields and one or two (rarely three) small beams within these, was developed. It allows to obtain a more uniform dose throughout the target volume in the majority of cases but not in all. This study presents our experience to develop optimal intensity modulated radiation therapy (IMRT) techniques to be applied clinically in those cases where the traditional technique with two tangent fields or its variant field in field (FIF) are unable to achieve a satisfactory planning target volumes (PTVs) coverage and dose objectives to the organs at risk (OARs). Methods: We investigated two pure IMRT plans (named 3F-IMRT and 4F-IMRT) and a hybrid one (H-IMRT). Treatment plans were performed for 7 left-sided and 4 right-sided breasts using simultaneously integrated boost (SIB) planned technique with inverse optimization. Results were compared with those obtained with FIF technique. Dose prescribed was 45 Gy/20 fractions to the breast and 50 Gy /20 fractions to the lumpectomy cavity delivered in 5 fr/week. Dose–volume histograms were generated and parameters as target dose coverage, conformity and homogeneity as well as OARs dose distribution were analyzed. Finally the secondary cancer risk to contralateral breast due to radiation was evaluated as a further parameter for the choice of the optimal plan. Results: Compared to the FIF, the three IMRT plans provided the same target coverage and a better dose conformation, but a worst dose homogeneity of the boost target. The volume of the OARs, receiving higher doses than 15 Gy was reduced but was increased the volume receiving low doses. This causes the increase of the risk of radiation induced cancer, especially for the contralateral breast. For this organ, the highest value of the excess absolute risk (EAR) was associated to the 4F-IMRT, while the lower, to the FIF. Conclusion: The intensity-modulated radiation therapy techniques 5F-IMRT and 4F-IMRT were the best to be applied clinically in those cases, where the traditional technique of irradiation of the breast is unable to achieve the PTVs coverage and dose objectives to the OARs. However, all the IMRT techniques showed an increased volume of healthy tissues receiving low doses, so they should not be used in extensive manner and in particular should be avoided in the cases of young women due to the excess of risk to develop a secondary cancer.","PeriodicalId":13931,"journal":{"name":"International Journal of Cancer Therapy and Oncology","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90256212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The bootstrap method to improve statistical analysis of dosimetric data for radiotherapy outcomes","authors":"A. Chaikh, J. Bresciani, J. Balosso","doi":"10.14319/IJCTO.51.2","DOIUrl":"https://doi.org/10.14319/IJCTO.51.2","url":null,"abstract":"Purpose: The purpose of this study is to validate a new technique in radiotherapy, the medical physicist needs to evaluate the dosimetric benefit and the risk of toxicity before integrating it in the clinical use. Methods: We validate a sound decision tool based on bootstrap method to help the radio oncologist and the medical physicist to usefully analyze the dosimetric data obtained from small-sized samples, with few patients. Statistical investigation principles are presented in the framework of a clinical example based on 36 patients with 6 different cancer sites treated with radiotherapy. For each patient, two treatment plans were generated. In plan 1, the dose was calculated using Modified Batho's (MB) density correction method integrated with pencil beam convolution (PBC) as type (a) algorithm. In plan 2, the dose was calculated using Anisotropic Analytical Algorithm (AAA) as type (b) algorithm. The delivered doses in monitor units (MUs) were compared using the two plans. Then, the bootstrap method was applied to the original data set to assess the dose differences and evaluate the impact of sample size on the 95% confidence interval (95%.CI). Shapiro-Wilks and Wilcoxon signed-rank tests were used to assess the normality of the data and determine the p-value. In addition, Spearman’s rank test was used to calculate the correlation coefficient between the doses calculated with both algorithms. Results: A significant difference was observed between AAA and MB for all tested radiation sites. Spearman’s test indicated a good correlation between the doses calculated with both methods. The bootstrap simulation with 1000 random samplings can be used for small populations with n = 10 and provides a true estimation. Conclusion: one must be cautious when implementing this method for radiotherapy: the data should be representative of the real variations of the cases and the cases should be as homogeneous as possible to avoid bias of over/under estimation of the results.","PeriodicalId":13931,"journal":{"name":"International Journal of Cancer Therapy and Oncology","volume":"11 1","pages":"512"},"PeriodicalIF":0.0,"publicationDate":"2017-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89267531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stability assessment of radiation isocenter with the gimbaled linac system","authors":"H. Miura, S. Ozawa, S. Tsuda, K. Yamada, Y. Nagata","doi":"10.14319/ijcto.51.13","DOIUrl":"https://doi.org/10.14319/ijcto.51.13","url":null,"abstract":"Purpose: We report the results of our year-long radiation isocenter accuracy verification for daily quality assurance (QA) implementation on a Vero4DRT system. Methods: The radiation isocenter was calculated using a cube phantom with a steel ball of diameter 10 mm fixed to the center of the phantom. A single photon beam was set with a field size of 100 × 100 mm 2 . Coincidence of the centroid of the steel ball at kiloVolt X-ray imaging isocenter and megaVolt beam radiation isocenter at each gantry and ring angle was tested. This procedure was performed for gantry angles of 0°, 90°, 180°, and 270°, and ring angles of 0°, 20°, and 340°. The centroid of the steel ball and the center of the radiation field were calculated to analyze the radiation isocenter error. This analysis was automatically calculated using the Daily Check tool in the Vero4DRT system. This QA was implemented between 24 August 2015 and 23 August 2016. Results: The average and standard deviation for pan and tilt directions were 0.12 ± 0.10 mm and -0.20 ± 0.13 mm, respectively. The maximum radiation isocenter accuracy error was 0.50 mm in both directions. Conclusion: The radiation isocenter alignment for the one year duration of the experiment was performed with high accuracy.","PeriodicalId":13931,"journal":{"name":"International Journal of Cancer Therapy and Oncology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89571413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gamma Putty shielding effect in megavoltage photon beam","authors":"Aime M. Gloi","doi":"10.14319/IJCTO.51.5","DOIUrl":"https://doi.org/10.14319/IJCTO.51.5","url":null,"abstract":"Purpose: Traditionally, lead and Cerrobend have been employed for field shaping in radiation therapy. Lately, another shielding material called Gamma Putty has emerged. The objective of this report is to examine its dosimetric and shielding characteristics in megavoltage photon beam. Methods: All measurements were carried out in a dual energy linac. Data were collected using a calibrated ionization chamber. Percent transmission, linear attenuation, and field size dependence were evaluated for open square fields (4 × 4 cm 2 to 10 × 10 cm 2 ) defined by collimator jaws and for different Gamma Putty thicknesses (t = 0, 0.3, 0.5, 1.0, 1.5, 2.0, and 2.5 cm) at 6 and 18 MV photon beams. The measurements were performed both in air using appropriate acrylic buildup cap and in solid water. Results: The Gamma Putty tray factor (GPTF) increased steadily with field size for both 6 and 18 MV. It was characterized by a half value thickness (HVT) of 2.513 ± 0.101 and 2.855 ± 0.024 cm for 6 and 18 MV, respectively. The reduction in surface dose was about 6%, 14.5%, 22%, 36.37%, and 54% for 6 MV and 2.75 %, 9.36 %, 16.25 %, 28.95 %, and 44.47 % for 18 MV for Gamma Putty thicknesses of 0.3, 0.5, 1.0, 1.5, 2.0, and 2.5 cm. Conclusion: The result of Gamma Putty shielding on the photon beam output increases with thickness, beam energy, and field size. Therefore, clinical use of Gamma Putty tray factors should be tailored for all thicknesses, beam energies, and field sizes.","PeriodicalId":13931,"journal":{"name":"International Journal of Cancer Therapy and Oncology","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90729516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}