International Journal of Contemporary Medical Research [IJCMR]最新文献_第2页

Role of Immunohistochemistry in Diagnosis and Subtyping of Acute Leukemia using Selected IHC Markers in a Resource Limited Setting 在资源有限的情况下，免疫组织化学在使用免疫组化标记物诊断和分型急性白血病中的作用

International Journal of Contemporary Medical Research [IJCMR] Pub Date : 2020-06-01 DOI: 10.21276/ijcmr.2020.7.6.15

S. Pant, R. Misra

{"title":"Role of Immunohistochemistry in Diagnosis and Subtyping of Acute Leukemia using Selected IHC Markers in a Resource Limited Setting","authors":"S. Pant, R. Misra","doi":"10.21276/ijcmr.2020.7.6.15","DOIUrl":"https://doi.org/10.21276/ijcmr.2020.7.6.15","url":null,"abstract":"Introduction: In resource limited settings where genetic studies and flow cytometry were not routinely done or available, morphology is primarily used for diagnosis and subtyping of acute leukemias with use of ancillary tests like cytochemistry and immunohistochemistry in selected cases for a more accurate and definitive diagnosis. This study was done to assess the role of immunohistochemistry in diagnosis and subtyping of acute leukemias in resource poor setting using selected IHC markers and to find diagnostic accuracy of morphologic diagnosis. Material and methods: The study was done on 45 selected cases of acute leukemia. Immunohistochemistry was done on all cases for typing and confirmation of diagnosis after morphological examination of peripheral blood smears and all three bone marrow preparations.A limited panel of IHC markers were used including Anti MPO, Anti CD3, Anti CD20, Anti CD22, Anti TdT, Anti CD117, Anti CD15 and Anti CD68(KP1) for immunohistochemistry. Results: The accuracy of morphological diagnosis in cases of AML and ALL in the study was 84.09% and 82.22% respectively. By intercalating immunohistochemical studies with morphological examination almost all cases of acute leukemia can be diagnosed and subclassified, and diagnostic accuracy is increased as compared to morphological examination alone. Conclusion: Though morphology remains the gold standard for paraffin embedded bone marrow trephines,immunohistochemical staining has became an integral part of diagnostic workup in cases of hematologic malignancies in limited resource settings.","PeriodicalId":13918,"journal":{"name":"International Journal of Contemporary Medical Research [IJCMR]","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80493542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Paratubal Atypical Proliferative Serous Tumour in a Young Adolescent Female - A Diagnostic Dilemma 一个年轻的青春期女性的输卵管旁非典型增生性浆液性肿瘤-诊断困境

International Journal of Contemporary Medical Research [IJCMR] Pub Date : 2020-03-01 DOI: 10.21276/ijcmr.2020.7.3.34

M. Garg, N. Kaur, Kanwardeep Kaur, Amrinder Kaur, C. Chandrika

引用次数: 0

Osseous Metaplasia in Leiomyoma: Case Report with Literature Review 平滑肌瘤骨性化生1例并文献复习

International Journal of Contemporary Medical Research [IJCMR] Pub Date : 2020-03-01 DOI: 10.21276/ijcmr.2020.7.3.33

P. Kaur, M. Garg, Veerpal Kaur, M. Monika, Ira Moudgil

引用次数: 1

Role and Clinical efficacy of Subconjunctival Injection Bevacizumab in Nonsurgical Management of Pterygium 结膜下注射贝伐单抗在非手术治疗翼状胬肉中的作用及临床疗效

International Journal of Contemporary Medical Research [IJCMR] Pub Date : 2020-03-01 DOI: 10.21276/ijcmr.2020.7.3.40

S. Gaur, Vivek Sharma

{"title":"Role and Clinical efficacy of Subconjunctival Injection Bevacizumab in Nonsurgical Management of Pterygium","authors":"S. Gaur, Vivek Sharma","doi":"10.21276/ijcmr.2020.7.3.40","DOIUrl":"https://doi.org/10.21276/ijcmr.2020.7.3.40","url":null,"abstract":"Introduction: Pterygium progression and recurrence is a common complication. In various studies conducted on role of subconjunctival depot injection of bevacizumab, nothing has been standardized with regards to dosage and its frequency. The study was done with aim to assess role and clinical efficacy of subconjunctival injection of bevacizumab as a non surgical treatment modality for pterygium. Material and Methods: 80 cases of pterygium were included in this study. Study was done over a period of 12 months from December 2018 to November 2019 at a tertiary care ophthalmic centre of Northern India. In this study, three doses of 2.5 mg of bevacizumab were administered sub-conjunctivally at monthly interval under topical anaesthesia on Outdoor Patient Department basis. Standard aseptic measures were observed. Results: Cases were followed up next day after each injection and thereafter on monthly basis for three months and finally after 06 months of first injection. Progression of pterygium was noted in 8 cases. Subconjunctival haemorrhage was noted in 41 cases. Conjunctival cyst was seen in three cases which were punctured in OPD, however recurrence was noted after one month in one case. No rise in Intra Ocular Pressure (IOP) was noted. Conclusions: Subconjunctival injection of bevacizumab is useful in treatment of patients with pterygium without local or systemic adverse effects.","PeriodicalId":13918,"journal":{"name":"International Journal of Contemporary Medical Research [IJCMR]","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84286027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eccrine Spiradenoma

International Journal of Contemporary Medical Research [IJCMR] Pub Date : 2020-02-01 DOI: 10.21276/ijcmr.2020.7.2.7

M. Murali Krishna, Y. S. Sarma, M. Srihari Babu

引用次数: 0

Results of Surgical treatment of Nonunion of Humeral Shaft Fracture with Dynamic Compression Plate and Cancellous Bone Grafting 动力加压钢板加松质骨植骨治疗肱骨骨干骨折不愈合的疗效

International Journal of Contemporary Medical Research [IJCMR] Pub Date : 2020-02-01 DOI: 10.21276/ijcmr.2020.7.2.36

A. Bhat, Suhail Wani, Javed Ahmad Nabir

{"title":"Results of Surgical treatment of Nonunion of Humeral Shaft Fracture with Dynamic Compression Plate and Cancellous Bone Grafting","authors":"A. Bhat, Suhail Wani, Javed Ahmad Nabir","doi":"10.21276/ijcmr.2020.7.2.36","DOIUrl":"https://doi.org/10.21276/ijcmr.2020.7.2.36","url":null,"abstract":"Introduction: Nonunion of humeral fractures after conservative or surgical treatment represents a disabling condition for the patient and a challenge for the surgeon. Study aimed to evaluate the outcome of treatment of humeral shaft nonunions with dynamic compression plate and cancellous bone graft. Material and Methods: This study was conducted at Department of Orthopaedics, GMC Srinagar from June 2016 to December 2019. Twenty patients were operated over this period. Trauma was the cause of injury in majority of the patients. Nonunion was atrophic in 80% and hypertrophic in 20% of the individuals. All the patients had closed fracture at presentation, and 70% had received previous treatment from traditional bone setters and 30% had failure of the conservative cast management. Results: The average time to union was 18 weeks. Treatment previously from traditional bone setters significantly affected the time to fracture union (p<0.05). All fractures united successfully. Conclusion: we concluded that treatment with dynamic compression plating and cancellous bone grafting remains an effective treatment option for nonunion of humeral shaft.","PeriodicalId":13918,"journal":{"name":"International Journal of Contemporary Medical Research [IJCMR]","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79980313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Three Methods of Dressings for Split Thickness Skin Graft Donor Site - Non Woven Dressing Impregnated with Amorphous Hydrogel, Amorphous Hydrogel with Colloidal Silver and Conventional Paraffin Gauze Dressing 非晶态水凝胶浸渍无纺布敷料、非晶态水凝胶胶体银敷料和常规石蜡纱布敷料三种敷料方法的比较

International Journal of Contemporary Medical Research [IJCMR] Pub Date : 2019-12-01 DOI: 10.21276/ijcmr.2019.6.12.36

A. Kujur, N. D’souza

{"title":"Comparison of Three Methods of Dressings for Split Thickness Skin Graft Donor Site - Non Woven Dressing Impregnated with Amorphous Hydrogel, Amorphous Hydrogel with Colloidal Silver and Conventional Paraffin Gauze Dressing","authors":"A. Kujur, N. D’souza","doi":"10.21276/ijcmr.2019.6.12.36","DOIUrl":"https://doi.org/10.21276/ijcmr.2019.6.12.36","url":null,"abstract":"Introduction: Skin grafting is a common reconstructive technique done in plastic surgery. Management of split skin graft donor sites are targeted at promoting faster healing, minimizing pain and complications. A vast number of dressing options for donor sites are available. Search for a better dressing method continues. Aim of this study was to determine the best method of dressing the donor site among three different methods with respect to the rate of healing, pain, exudates and infection. Material and methods: Institutional ethical clearance and patient consent was obtained prior to start of the study. Based on investigator’s previous clinical experience, sample size of 75 was arrived at with a power of 80%. Patients were randomly divided into 3 groups by Graph Pad quick calc computing provided by statistician. Group Adressings with conventional paraffin gauze. Group B-dressings with non woven dressings impregnated with amorphous hydrogel. Group Cdressings with amorphous hydrogel with colloidal silver and paraffin gauze. Statistical analysis was done by Anova and Kruskal Wallis Test. Results: Median healing percentage was 98%, 96% and 99% in groups A, B, C respectively on 8th post operative day. This difference was statistically significant (P=0.033). Pain score on post op day 3 was lower in group C (P=0.08). Two patients had infection one in group b and one in group c, which was not statistically significant. Conclusion: Patients undergoing dressings with amorphous hydrogel with colloidal silver and paraffin gauze had faster healing and experienced lower pain.","PeriodicalId":13918,"journal":{"name":"International Journal of Contemporary Medical Research [IJCMR]","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81205208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Seroprevalence of Transfusion Transmissible Infections among Blood Donors at a Tertiary Care Teaching Hospital in Central India 印度中部一家三级护理教学医院献血者输血传播感染的血清患病率

International Journal of Contemporary Medical Research [IJCMR] Pub Date : 2019-12-01 DOI: 10.21276/ijcmr.2019.6.12.34

A. Varma, Garima Malpani, S. Kosta, K. Malukani, Bela Sarda, Avinash Raghuvanshi

{"title":"Seroprevalence of Transfusion Transmissible Infections among Blood Donors at a Tertiary Care Teaching Hospital in Central India","authors":"A. Varma, Garima Malpani, S. Kosta, K. Malukani, Bela Sarda, Avinash Raghuvanshi","doi":"10.21276/ijcmr.2019.6.12.34","DOIUrl":"https://doi.org/10.21276/ijcmr.2019.6.12.34","url":null,"abstract":"Introduction: Blood transfusion is both a life saving measure in many medical and surgical emergencies and a source of transfusion transmitted infections. So a provision for strict criteria in recruitment and deferral of blood donors may improve safe transfusion practice. The present study was conducted to estimate the prevalence of transfusion transmitted infections in voluntary and replacement donors at a tertiary care teaching hospital in Indore, Madhya Pradesh,Central India. Material and Methods: The present study was a 4 year retrospective study from 2015 to 2018. Data was analyzed from blood bank records,pertaining to all donors who were screened for HBsAg, Hepatitis C virus and HIV by using appropriate methods. Results: A total of 45,704 Voluntary & replacement donors were screened out of which 44,663 (97.72%) were males & 1041 (2.27%) were females. The overall seroprevalence of HBV & HCV was 1.29% & 0.072% respectively, while the prevalence of HIV was 0.076%.The prevalence rate was highest for HBV followed by HIV and HCV in decreasing order. The overall seroprevalence of various TTI’s among the studied donors was 1.43%. Conclusion: Blood is still one of the main sources of transmission of infections like HIV, Hepatitis B and Hepatitis C. Extensive donor selection and screening procedures will help in improving the blood safety.","PeriodicalId":13918,"journal":{"name":"International Journal of Contemporary Medical Research [IJCMR]","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84814830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of Perioperative Complications Following Radical Cystectomy – Our Experience in a South Indian Tertiary Urology Centre 根治性膀胱切除术后围手术期并发症分析-我们在南印度三级泌尿外科中心的经验

International Journal of Contemporary Medical Research [IJCMR] Pub Date : 2019-11-01 DOI: 10.21276/ijcmr.2019.6.11.22

Raghuveer Pedamallu

{"title":"Analysis of Perioperative Complications Following Radical Cystectomy – Our Experience in a South Indian Tertiary Urology Centre","authors":"Raghuveer Pedamallu","doi":"10.21276/ijcmr.2019.6.11.22","DOIUrl":"https://doi.org/10.21276/ijcmr.2019.6.11.22","url":null,"abstract":"Introduction: Bladder cancer is one of the common urological malignancy. The aim of this study was to analyze perioperative complications and mortality in our institute following radical cystectomy and urinary diversion. Material and methods: Thirty four patients presented with muscle invasive bladder cancer for radical cystectomy to urology department between August 2009 and December 2011 was included in the study. Results: Patients mean age was 56.9 Years. There was higher percentage of Male patients compared to Female patients with ratio of 4.6:1 and most of the patients had ASA score <= 2.0. Mean operating time and length of hospital stay was 4.2 hours and 10.2 days respectively. Perioperative complications was observed in 32.35% of patient cohort and perioperative mortality rate of 2.94%. The most frequent complications were ileus (6 patients) followed by wound infection / wound dehiscence (4 patients). No preoperative factors predicted complications were found except for age. Conclusion: In our study, age was the only preoperative factors predicted complication and mortality rate. With proper selection of patients, and preoperative evaluation, surgical technique and better postoperative care, Radical cystectomy with urinary diversion can be safely done in selected patients with acceptable morbidity and mortality.","PeriodicalId":13918,"journal":{"name":"International Journal of Contemporary Medical Research [IJCMR]","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77809772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anemia in Type 2 Diabetes Mellitus in Absence of Renal Insufficiency 无肾功能不全的2型糖尿病患者贫血

International Journal of Contemporary Medical Research [IJCMR] Pub Date : 2019-11-01 DOI: 10.21276/ijcmr.2019.6.11.26

Jaya Pathak, Varoon J. Vadodariya, A. Jhala, Deesha Bhojwani, Niravkumar Brahmbhatt

{"title":"Anemia in Type 2 Diabetes Mellitus in Absence of Renal Insufficiency","authors":"Jaya Pathak, Varoon J. Vadodariya, A. Jhala, Deesha Bhojwani, Niravkumar Brahmbhatt","doi":"10.21276/ijcmr.2019.6.11.26","DOIUrl":"https://doi.org/10.21276/ijcmr.2019.6.11.26","url":null,"abstract":"Introduction: Diabetes Mellitus is associated with many complications such as microvascular, macrovascular and non vascular. Presence of anemia in diabetes is due to the disease itself rather than usual causes of anemia. Apart from causing usual symptoms, anemia also increases the risk of cardiovascular disease in diabetics. Here, we have conducted a study to compare the presence of anemia in patients with Diabetes, with that in healthy population. Material and Methods: A case-control study was conducted in a tertiary care hospital setting in Vadodara,Gujarat. A total of 120 patients were enrolled, of which 60 were cases who had Diabetes Mellitus type 2 and 60 were healthy controls, matched for age and gender. A detailed clinical history and examination was done for both cases and controls. Blood investigations in form of a complete hemogram, thin peripheral smear, blood sugar and serum creatinine was done. Only individuals with normal serum creatinine levels were included in the study. Comparison was done between the two groups for the presence of anemia, in absence of renal involvement. Results: Anemia was more prevelant in patients with Type 2 Diabetes Mellitus when compared to controls (Odds Ratio = 2.04, P < 0.05). On comparing the anemic cases and controls in both genders, the Odds ratio for males and females was 2.14 and 2.04 respectively with P < 0.05. Conclusion: Patients with diabetes mellitus type 2 are at a higher risk of suffering from anemia irrespective of their renal function.","PeriodicalId":13918,"journal":{"name":"International Journal of Contemporary Medical Research [IJCMR]","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83097619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4