International journal of clinical and experimental medicine最新文献_第5页

Parathyroid adenoma causing a spontaneous cervical and mediastinal massive hematoma. 甲状旁腺腺瘤导致自发性颈部和纵隔大面积血肿。

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International journal of clinical and experimental medicine Pub Date : 2015-11-15 eCollection Date: 2015-01-01

Cheng Zhao, Xiurong Wang, Hui Wei, Guifeng Ma

引用次数: 0

One center experience in China. 中国一个中心的经验。

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International journal of clinical and experimental medicine Pub Date : 2015-11-15 eCollection Date: 2015-01-01

Yunpeng Ling, Xi Liu, Yu Chen, Shenglong Chen, Xinxin Jin, Suixin Dong, Feng Wan

{"title":"One center experience in China.","authors":"Yunpeng Ling, Xi Liu, Yu Chen, Shenglong Chen, Xinxin Jin, Suixin Dong, Feng Wan","doi":"","DOIUrl":"","url":null,"abstract":"Objective: To investigate the outcomes and prognostic factors for patients with coronary artery disease and low left ventricular ejection fraction (LVEF≤40%) undergoing off-pump coronary artery bypass grafting OPCAB).Methods: From 2001 to 2004, 71 patients with low EF undergoing OPCABG in our hospital, the mean age is 65.0±9.0 years (from 37 to 81), 49 males and 16 females, the mean EF was 33.8±5.0%. Regular follow-up evaluation was completed. Draw the Kaplan-Meier survival curves, Use the log-rank test and Cox regression model to find out the factors that affect the long-term result.Results: 71 low LVEF patients, 6 patients died perioperative, 63 patients discharged successfully, the follow-up time was 64.9±30.4 months. 6 patients lost of follow up, 19 patients died during follow-up including 10 patients (15.9%) who had cardiac-related death. The survival rate at 1, 3, 5 and 8 years was 95.1%, 93.3%, 86.3%, 77.7%, respectively. Univariate analysis shows EF≤30% and acute myocardial infarction within 30 days are risk factors for the long-term survival (P<0.05). Cox regression analysis showed that EF≤30% (RR=6.446, P<0.05) and acute myocardial infarction within 30 days (RR=5.993, P<0.05) are two independent risk factors for the cardiac-related death after discharge.Conclusions: The patients with low eject fraction ventricular have satisfactory outcomes after OPCAB. LVEF≤30% and acute myocardial infarction within 30 days are two independent risk factors that affect the long-term outcome.","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 11","pages":"21477-81"},"PeriodicalIF":0.1,"publicationDate":"2015-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140193729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictive potential role of GSTs gene polymorphisms in the treatment outcome of advanced non-small cell lung cancer patients. GSTs 基因多态性对晚期非小细胞肺癌患者治疗效果的潜在预测作用。

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International journal of clinical and experimental medicine Pub Date : 2015-11-15 eCollection Date: 2015-01-01

Kaixiong Liu, Qichang Lin, Haibo Ding, Yongxu Jin, Gongping Chen

{"title":"Predictive potential role of GSTs gene polymorphisms in the treatment outcome of advanced non-small cell lung cancer patients.","authors":"Kaixiong Liu, Qichang Lin, Haibo Ding, Yongxu Jin, Gongping Chen","doi":"","DOIUrl":"","url":null,"abstract":"This study aimed to investigate the possible association between GSTP1, GSTM1, and GSTT1 polymorphisms and treatment outcome of advanced NSCLC. Between October 2009 and October 2011, a total of 308 patients of NSCLC on stage IIIA, IIIB or IV, treated with cisplatin-based chemotherapy were included. Polymerase chain reaction-restriction fragment length polymorphism was used to genotype the GSTP1 and GSTM1, and GSTT1 polymorphisms. We found that the IIe/Val and Val/Val genotypes of GSTP1 showed more CR+PR to chemotherapy in advanced NSCLC when compared with IIe/IIe genotype, and the Ors (95% CI) were 0.37 (0.18-0.71) and 0.15 (0.07-0.38). The IIe/Val and Val/Val genotypes of GSTP1 were associated with longer overall survival of advanced NSCLC when compared with the IIe/IIe genotype (For IIe/Val vs IIe/IIe, 37.63 ± 2.01 months vs 30.25 ± 2.06 months; for Val/Val vs IIe/IIe, 39.84 ± 3.36 months vs 30.25 ± 2.06 months). In the Cox proportional hazards model, the IIe/Val and Val/Val genotypes significantly decreased risk of death from all causes in patients with advanced NSCLC, and the HRs (95% CIs) were 0.51 (0.28-0.94) and 0.35 (0.16-0.78), respectively. We found that the GSTP1 polymorphisms might affect the clinical outcome of patients with advanced NSCLC, and our results could help us to facilitate therapeutic decision for individualized therapy. ","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 11","pages":"20918-24"},"PeriodicalIF":0.1,"publicationDate":"2015-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723864/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140193731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The anti-ulcerative colitis effects of Annona squamosa Linn. leaf aqueous extract in experimental animal model. 在实验动物模型中研究乌鳢叶水提取物抗溃疡性结肠炎的作用

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International journal of clinical and experimental medicine Pub Date : 2015-11-15 eCollection Date: 2015-01-01

Rasha Ym Ibrahim, Amal I Hassan, Eithar K Al-Adham

{"title":"The anti-ulcerative colitis effects of Annona squamosa Linn. leaf aqueous extract in experimental animal model.","authors":"Rasha Ym Ibrahim, Amal I Hassan, Eithar K Al-Adham","doi":"","DOIUrl":"","url":null,"abstract":"This study aimed to evaluate the anti-inflammatory effects of Annona squamosa (A. squamosa) leaf aqueous extract against acetic acid induced colitis in rats with a trial to explore its use for the treatment of colon inflammation. Sprague Dawley rats weighing 180-200 g were used in this study. Treatment with A. squamosa extract at dose 300 mg/kg for 4 weeks counteracted acetic acid induced ulcerative colitis by a significant decrease (P<0.05) of colonic tissue of malondialdehyde (MDA) and significant increases of catalase (CAT), glutathione (GSH) and glutathione peroxidase (Gpx) compared to ulcerative colitis control group. Furthermore, induction of oxidative stress was observed in the colonic tissue through the levels of 8-hydroxy-2'-deoxyguanosine (8-OHdG) which significant increase in colonic tissue DNA by acetic acid. Moreover AA induced significant increase in serum interleukin-10 (IL10), tumor necrosis factor-α (TNF-α), transforming growth factor (TGF 1β), and C reactive protein (CRP) as compared to the control group. On the contrary, our results showed AA induced significant decrease of vascular endothelial growth factor (VEGF) and thyroid hormones triiodothyronin and thyroxin (T3 & T4) in installed group with AA as compared to control which significantly improved after treatment with A. squamosa leaf extract. Histopathological observation in our study confirmed the biochemical study. Thus, therapeutic method offer a sign to analyze further the effectiveness of A. squamosa as a unique agent for alleviating colitis. ","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 11","pages":"21861-70"},"PeriodicalIF":0.1,"publicationDate":"2015-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4724002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140193732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum osteocalcin levels are inversely associated with the presence of nonalcoholic fatty liver disease in patients with coronary artery disease. 血清骨钙素水平与冠状动脉疾病患者非酒精性脂肪肝的存在呈负相关。

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International journal of clinical and experimental medicine Pub Date : 2015-11-15 DOI: 10.1016/S0168-8227(16)31276-1

Jing Du, X. Pan, Zhigang Lu, Mei-fang Gao, Xiang Hu, Xueli Zhang, Y. Bao, W. Jia

引用次数: 13

Radial versus femoral artery access for percutaneous coronary angiography and intervention: a systematic review and meta-analysis of randomized controlled trials in Chinese population. 经皮冠状动脉造影和介入治疗的桡动脉与股动脉入路：中国人群随机对照试验的系统回顾和荟萃分析。

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International journal of clinical and experimental medicine Pub Date : 2015-10-15 eCollection Date: 2015-01-01

Peng Liu, Xue Liang Gao, Bei Fang Li, Xue Zhi Ding, Zi Hao Wang, Yan Ping Dang, Yang Gui Liu, Yun Fu Li

{"title":"Radial versus femoral artery access for percutaneous coronary angiography and intervention: a systematic review and meta-analysis of randomized controlled trials in Chinese population.","authors":"Peng Liu, Xue Liang Gao, Bei Fang Li, Xue Zhi Ding, Zi Hao Wang, Yan Ping Dang, Yang Gui Liu, Yun Fu Li","doi":"","DOIUrl":"","url":null,"abstract":"To compare the feasibility, efficiency and safety of coronary angiography (CAG) and interventional procedures between the radial and femoral catheterization approaches in Chinese population using systematic review and meta-analysis, we conducted a search of the studies comparing radial and femoral catheterization approaches in patients underwent either CAG or percutaneous coronary intervention (PCI) in Chinese population. Fixed-effect relative risk (RR) for the primary end points and the second end points were compared between the two approaches. A total of 27 studies (n=8,749 patients) were finally included in the analysis. The success rate of radial approach was slightly lower than that of femoral approach in patients receiving CAG (P=0.004), but similar in patients receiving a further PCI treatment (P=0.11). The risk of major adverse cardiovascular events (MACEs) was similar between two approaches (P=0.27). Radial catheterization had a significantly lower rate of puncture site complications (P<0.00001), but a lower rate of puncture success rate (P=0.02). In patients with acute myocardial infarction (AMI), there was no difference in neither the risk of MACEs nor PCI success rate between two approaches (P=0.23 and 0.45, respectively), but a board line decrease of puncture success rate was observed in radial catheterization group (P=0.04). There were no significant differences in the volumes of contrast media, X-ray exposure time and operation time between the two approaches (all P>0.05). Thus, we concluded that radial approach is a safe method for CAG or PCI compared to traditional femoral approach in Chinese population due to their similar success rate of the procedure and risk of MACEs, and a decreased risk of puncture site complications. ","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 10","pages":"17151-66"},"PeriodicalIF":0.1,"publicationDate":"2015-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140193700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Absence of non-alcoholic fatty liver disease in the presence of insulin resistance is a strong predictor for colorectal carcinoma. 在存在胰岛素抵抗的情况下，不存在非酒精性脂肪肝是预测结直肠癌的一个强有力的指标。

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International journal of clinical and experimental medicine Pub Date : 2015-10-15 eCollection Date: 2015-01-01

Sebahat Basyigit, Metin Uzman, Ayse Kefeli, Ferdane Pirincci Sapmaz, Abdullah Ozgür Yeniova, Yasar Nazligul, Zeliha Asiltürk

{"title":"Absence of non-alcoholic fatty liver disease in the presence of insulin resistance is a strong predictor for colorectal carcinoma.","authors":"Sebahat Basyigit, Metin Uzman, Ayse Kefeli, Ferdane Pirincci Sapmaz, Abdullah Ozgür Yeniova, Yasar Nazligul, Zeliha Asiltürk","doi":"","DOIUrl":"","url":null,"abstract":"Background: Colorectal carcinoma (CRC) and non-alcoholic fatty liver disease (NAFLD) share common risk factors. Insulin resistance (IR) has an important role in both diseases. It has been speculated that the prevalence of colorectal neoplasms might be increased in patients with NAFLD. However, It is unclear whether NAFLD is an actual risk factor or any association is incidental coexistance due to the role of IR in both disease. We aimed to assess the risk for CRC in patients with NAFLD in relation to IR.Method: This study was designed prospectively and cross-sectionally. We determined NAFLD by ultrasonography and measured IR by the homeostatic model of assessment-insulin resistance model.Results: The prevalences of CRC and adenoma were shown to be significantly higher in patients with IR (respectively; P: 0.005, P: 0.008). But prevalence of CRC was found to be significantly lower in subjects with NAFLD (P: 0.001). On multivariate logistic regression analysis, the risks of colorectal adenoma and carcinoma were significantly associated with the presence of IR (respectively; OR: 2.338, 95% CI: 1.080-4.993, P: 0.003 and : 5.023, 95% CI: 1.789-9.789, P: 0.001). The risk for CRC was significantly associated with the absence of NAFLD (OR: 7.380, 95% CI: 3.069-7.961, P: 0.010). The absence of NAFLD in the presence of IR was associated with significantly high risk for CRC (OR: 5.218, 95% CI: 1.538-7.448, P: 0.017).Conclusion: The risk of CRC can increased in subjects with IR but without NAFLD. The absence of NAFLD in the presence of IR may predict the CRC.","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 10","pages":"18601-10"},"PeriodicalIF":0.1,"publicationDate":"2015-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141083091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Administration time-dependent effects of combination therapy on ambulatory blood pressure in hypertensive subjects. 联合治疗对高血压患者动态血压的给药时间依赖性影响。

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International journal of clinical and experimental medicine Pub Date : 2015-10-15 eCollection Date: 2015-01-01

Weizhong Huangfu, Peilin Duan, Dingcheng Xiang, Ruiying Gao

{"title":"Administration time-dependent effects of combination therapy on ambulatory blood pressure in hypertensive subjects.","authors":"Weizhong Huangfu, Peilin Duan, Dingcheng Xiang, Ruiying Gao","doi":"","DOIUrl":"","url":null,"abstract":"The aim of this study was to explore the influence of combination therapy in different administration time on antihypertensive efficacy and blood pressure variability in patients with essential hypertension. A total of 86 patients with stage II to III essential hypertension were randomly divided into 4 groups: taking indapamide and losartan potassium together in the morning or in the evening 2 to 4 hours before sleep, indapamide in the morning and losartan potassium in the evening, losartan potassium in the morning and indapamide in the evening. Ambulatory blood pressure monitoring was performed before and 12 weeks after the medication. The result showed that statistically significant reductions from baseline of systolic blood pressure/diastolic blood pressure occurred in all treatment groups. There was no significant difference of the reductions or SI among the four groups, neither the rate of decline of BP in the night or the circadian rhythm. In group B, the numbers of rapid rise in BP in the morning hours were significantly less after the medication, while not in the other groups. It is concluded that independent of the administration time, both once-daily treatment and component-based dual therapy had significant antihypertensive effect, but the night taken-together combination resulted in reductions of BP, SI and morning blood pressure peak that may have advantages over the other combinations, without the increased incidence of hypotension at night. Medicines should be taken 2 to 4 hours before sleep. ","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 10","pages":"19156-61"},"PeriodicalIF":0.1,"publicationDate":"2015-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71435109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of cytokine expressions in acute myocardial infarction and stable angina stages of coronary artery disease. 冠心病急性心肌梗死和稳定型心绞痛阶段细胞因子表达的比较。

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International journal of clinical and experimental medicine Pub Date : 2015-10-15 eCollection Date: 2015-01-01

Wenwen Yan, Siwan Wen, Lemin Wang, Qianglin Duan, Lin Ding

{"title":"Comparison of cytokine expressions in acute myocardial infarction and stable angina stages of coronary artery disease.","authors":"Wenwen Yan, Siwan Wen, Lemin Wang, Qianglin Duan, Lin Ding","doi":"","DOIUrl":"","url":null,"abstract":"Objective: To investigate the differential gene expression of cytokines and compare their impacts on the immune functions among the acute myocardial infarction patients (AMI), the stable angina patients (SA) and the controls.Methods: 20 patients with AMI, 20 patients with SA and 20 healthy volunteers were recruited into the study. Whole human genome microarray analysis was used to detect the gene expression differences in interferons, interleukins, chemokines, tumor necrosis factors and associated receptors in peripheral blood mononuclear cells (PBMCs) among three groups.Results: Compared with SA patients and the controls respectively, in AMI patients, IFNα2, IFNαR1, IFNαR2, IFNγR1, IFNγR2, L1β, IL16, IL18, Cxcl1, Cxcl2, Cxcl6, CxcR2, CxcR4, LIGHT, TNFR1, LT-βR, CD137, TRAILR, and TWEAKR mRNA expressions were significantly up-regulated (P<0.05), while Ccl5, Ccl24, Ccl28, CcR5, TWEAK, CD40, CD27, and BAFFR mRNA expressions were significantly down-regulated (P<0.05). But, there was no significant difference in cytokine expression between the SA patients and the controls.Conclusion: In AMI patients, mRNA expression levels of cytokines were imbalanced, indicating the dysfunction of the immune system. Together with no significant change of cytokines was observed between the SA and controls, showing the different cytokine related immune activity in the AMI and SA patients.","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 10","pages":"18082-9"},"PeriodicalIF":0.1,"publicationDate":"2015-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141081239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison between nitroglycerin and remifentanil in acute hypervolemic hemodilution combined with controlled hypotension during intracranial aneurysm surgery. 比较硝酸甘油和瑞芬太尼在颅内动脉瘤手术急性高血容量血液稀释合并控制性低血压中的作用。

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International journal of clinical and experimental medicine Pub Date : 2015-10-15 eCollection Date: 2015-01-01

Xuekang Zhang, Qian Hu, Zhiyi Liu, Haijin Huang, Qin Zhang, Hanying Dai

{"title":"Comparison between nitroglycerin and remifentanil in acute hypervolemic hemodilution combined with controlled hypotension during intracranial aneurysm surgery.","authors":"Xuekang Zhang, Qian Hu, Zhiyi Liu, Haijin Huang, Qin Zhang, Hanying Dai","doi":"","DOIUrl":"","url":null,"abstract":"Allogenetic transfusion has long been considered to be a relatively safe and extremely effective blood transfusion treatment. However, acute hypervolemic hemodilution (AHH) combined with the remifentanil-induced controlled hypotension (CH) have rarely been examined. Herein, 40 intracranial aneurysm surgery patients were randomly divided into nitroglycerin group (A group, n=20) and remifentanil group (B group, n=20). During intracranial aneurysm surgery, MAP, HR, Hb, and Hct were recorded. SjvO2, PjvO2, SaO2, PaO2 were measured, and CaO2, Da-jvO2, CjvO2, CERO2, VADL were calculated. In addition, The venous blood samples were collected for determining PT, TT, APTT, FBG, VIII, VWF and electrolytes. The results show that HR in nitroglycerin group dramatically accelerated and HR in remifentanil group slowed at 30 minutes after hypotension and 5 minutes after aneurysm occlusion (P<0.01) after hypotension. Compared with A group, the SjvO2 and CjvO2 of B group increased significantly and the Da-jvO2 and CERO2 decreased significantly at T3, T4. In addition, There were no significant differences between after AHH and before AHH in two groups (P>0.05) on TT, PT, APTT, FIB, VIII, VWF, Na(+), Cl(-), K(+), Ca(2+). These results suggest that AHH combined with remifentanil-based CH significantly lowered cerebral metabolic rate of oxygen and had effects on blood coagulation without clinical hemorrhagic signs increased and had important clinical significance for blood conservation. ","PeriodicalId":13892,"journal":{"name":"International journal of clinical and experimental medicine","volume":"8 10","pages":"19353-9"},"PeriodicalIF":0.1,"publicationDate":"2015-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141081263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0