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Corrigendum to "mTOR aggravated CD4+ T cell pyroptosis by regulating the PPARγ-Nrf2 pathway in sepsis" [Int. Immunopharmacol. 140 (2024) 112822]. "mTOR通过调节脓毒症中的PPARγ-Nrf2通路加重CD4+ T细胞的热毒症"[Int. Immunopharmacol. 140 (2024) 112822]的更正。
IF 4.8 2区 医学
International immunopharmacology Pub Date : 2024-12-25 Epub Date: 2024-10-15 DOI: 10.1016/j.intimp.2024.113389
Guoyu Zhao, Yawen Xie, Xianli Lei, Ran Guo, Na Cui
{"title":"Corrigendum to \"mTOR aggravated CD4<sup>+</sup> T cell pyroptosis by regulating the PPARγ-Nrf2 pathway in sepsis\" [Int. Immunopharmacol. 140 (2024) 112822].","authors":"Guoyu Zhao, Yawen Xie, Xianli Lei, Ran Guo, Na Cui","doi":"10.1016/j.intimp.2024.113389","DOIUrl":"10.1016/j.intimp.2024.113389","url":null,"abstract":"","PeriodicalId":13859,"journal":{"name":"International immunopharmacology","volume":" ","pages":"113389"},"PeriodicalIF":4.8,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142464598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to "Timing, initiation and function: An in-depth exploration of the interaction network among neutrophil extracellular traps related genes in acute pancreatitis" [Int. Immunopharmacol. 141 (2024) 112923]. 对 "时间、起始和功能：深入探讨急性胰腺炎中嗜中性粒细胞胞外捕获相关基因之间的相互作用网络" [Int. Immunopharmacol.
IF 4.8 2区 医学
International immunopharmacology Pub Date : 2024-12-25 Epub Date: 2024-10-22 DOI: 10.1016/j.intimp.2024.113443
Haoyu Zhang, Zheng Wang, Jie Li, Yuchen Jia, Fei Li
{"title":"Corrigendum to \"Timing, initiation and function: An in-depth exploration of the interaction network among neutrophil extracellular traps related genes in acute pancreatitis\" [Int. Immunopharmacol. 141 (2024) 112923].","authors":"Haoyu Zhang, Zheng Wang, Jie Li, Yuchen Jia, Fei Li","doi":"10.1016/j.intimp.2024.113443","DOIUrl":"10.1016/j.intimp.2024.113443","url":null,"abstract":"","PeriodicalId":13859,"journal":{"name":"International immunopharmacology","volume":" ","pages":"113443"},"PeriodicalIF":4.8,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to "Role of glucose metabolism reprogramming in keratinocytes in the link between psoriasis and metabolic syndrome" [Int. Immunopharmacol. 139 (2024) 112704]. 更正："角朊细胞葡萄糖代谢重编程在牛皮癣与代谢综合征之间的联系中的作用" [Int. Immunopharmacol. 139 (2024) 112704]。
IF 4.8 2区 医学
International immunopharmacology Pub Date : 2024-12-25 Epub Date: 2024-10-15 DOI: 10.1016/j.intimp.2024.113384
Liang Yan, Wenqiu Wang, Yuxin Qiu, Chongli Yu, Rui Wang, Chengxin Li
{"title":"Corrigendum to \"Role of glucose metabolism reprogramming in keratinocytes in the link between psoriasis and metabolic syndrome\" [Int. Immunopharmacol. 139 (2024) 112704].","authors":"Liang Yan, Wenqiu Wang, Yuxin Qiu, Chongli Yu, Rui Wang, Chengxin Li","doi":"10.1016/j.intimp.2024.113384","DOIUrl":"10.1016/j.intimp.2024.113384","url":null,"abstract":"","PeriodicalId":13859,"journal":{"name":"International immunopharmacology","volume":" ","pages":"113384"},"PeriodicalIF":4.8,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142464599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to "Forecasting of Oxidant/Antioxidant levels of COVID-19 patients by using Expert models with biomarkers used in the Diagnosis/Prognosis of COVID-19" [Int. Immunopharmacol. 100 (2021) 108127]. 对 "利用用于 COVID-19 诊断/预后的生物标志物专家模型预测 COVID-19 患者的氧化剂/抗氧化剂水平 "的更正 [Int. Immunopharmacol. 100 (2021) 108127]。
IF 4.8 2区 医学
International immunopharmacology Pub Date : 2024-12-25 Epub Date: 2024-11-22 DOI: 10.1016/j.intimp.2024.113650
Mehmet Tahir Huyut, Zübeyir Huyut
{"title":"Corrigendum to \"Forecasting of Oxidant/Antioxidant levels of COVID-19 patients by using Expert models with biomarkers used in the Diagnosis/Prognosis of COVID-19\" [Int. Immunopharmacol. 100 (2021) 108127].","authors":"Mehmet Tahir Huyut, Zübeyir Huyut","doi":"10.1016/j.intimp.2024.113650","DOIUrl":"10.1016/j.intimp.2024.113650","url":null,"abstract":"","PeriodicalId":13859,"journal":{"name":"International immunopharmacology","volume":" ","pages":"113650"},"PeriodicalIF":4.8,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to "Combined diosmin and bisoprolol attenuate cobalt chloride-induced cardiotoxicity and endothelial dysfunction through modulating miR-143-3P/MAPK/MCP-1, ERK5/CXCR4, Orai-1/STIM-1 signaling pathways" [Int. Immunopharmacol. 140 (2024) 112777]. 通过调节 miR-143-3P/MAPK/MCP-1、ERK5/CXCR4、Orai-1/STIM-1 信号通路，联合地奥司明和比索洛尔减轻氯化钴诱导的心脏毒性和内皮功能障碍》[Int. Immunopharmacol.
IF 4.8 2区 医学
International immunopharmacology Pub Date : 2024-12-25 Epub Date: 2024-11-20 DOI: 10.1016/j.intimp.2024.113557
Ehab A M El-Shoura, Ahmed A N Mohamed, Ahmed M Atwa, Esraa A Salem, Souty M Z Sharkawi, Hend Mostafa Selim, Aya Ibrahim Elberri, El-Sayed Gawesh, Yasmine H Ahmed, Omnia A M Abd El-Ghafar
{"title":"Corrigendum to \"Combined diosmin and bisoprolol attenuate cobalt chloride-induced cardiotoxicity and endothelial dysfunction through modulating miR-143-3P/MAPK/MCP-1, ERK5/CXCR4, Orai-1/STIM-1 signaling pathways\" [Int. Immunopharmacol. 140 (2024) 112777].","authors":"Ehab A M El-Shoura, Ahmed A N Mohamed, Ahmed M Atwa, Esraa A Salem, Souty M Z Sharkawi, Hend Mostafa Selim, Aya Ibrahim Elberri, El-Sayed Gawesh, Yasmine H Ahmed, Omnia A M Abd El-Ghafar","doi":"10.1016/j.intimp.2024.113557","DOIUrl":"10.1016/j.intimp.2024.113557","url":null,"abstract":"","PeriodicalId":13859,"journal":{"name":"International immunopharmacology","volume":" ","pages":"113557"},"PeriodicalIF":4.8,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to "Distinct disease-modifying therapies are associated with different blood immune cell profiles in people with relapsing-remitting multiple sclerosis" [Int. Immunopharmacol. 131 (2024) 111826]. 对 "不同的疾病修饰疗法与复发缓解型多发性硬化症患者不同的血液免疫细胞特征有关 "的更正 [Int. Immunopharmacol. 131 (2024) 111826]。
IF 4.8 2区 医学
International immunopharmacology Pub Date : 2024-12-25 Epub Date: 2024-11-04 DOI: 10.1016/j.intimp.2024.113555
João Canto-Gomes, Daniela Boleixa, Catarina Teixeira, Ana Martins da Silva, Inés González-Suárez, João Cerqueira, Margarida Correia-Neves, Claudia Nobrega
{"title":"Corrigendum to \"Distinct disease-modifying therapies are associated with different blood immune cell profiles in people with relapsing-remitting multiple sclerosis\" [Int. Immunopharmacol. 131 (2024) 111826].","authors":"João Canto-Gomes, Daniela Boleixa, Catarina Teixeira, Ana Martins da Silva, Inés González-Suárez, João Cerqueira, Margarida Correia-Neves, Claudia Nobrega","doi":"10.1016/j.intimp.2024.113555","DOIUrl":"10.1016/j.intimp.2024.113555","url":null,"abstract":"","PeriodicalId":13859,"journal":{"name":"International immunopharmacology","volume":" ","pages":"113555"},"PeriodicalIF":4.8,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroprotective effects of gypenosides on LPS-induced anxiety and depression-like behaviors. 吉贝苷对 LPS 诱导的焦虑和抑郁样行为的神经保护作用
IF 4.8 2区 医学
International immunopharmacology Pub Date : 2024-12-25 Epub Date: 2024-10-16 DOI: 10.1016/j.intimp.2024.113367
Mei Guo, Wen-Jing Pei, Liming Liu, Kexuan Chen, Yong Cheng, Xiang-Lan Piao
{"title":"Neuroprotective effects of gypenosides on LPS-induced anxiety and depression-like behaviors.","authors":"Mei Guo, Wen-Jing Pei, Liming Liu, Kexuan Chen, Yong Cheng, Xiang-Lan Piao","doi":"10.1016/j.intimp.2024.113367","DOIUrl":"10.1016/j.intimp.2024.113367","url":null,"abstract":"<p><strong>Aim: </strong>Depression, a prevalent mental disorder, significantly impairs the quality of life and social functioning. Targeting neuroinflammation is a promising therapeutic approach, highlighting the need for natural neuroprotective agents. Gypenosides (Gyp) from Gynostemma pentaphyllum exhibit anxiolytic and antidepressant effects, yet the underlying mechanisms remain unclear. We investigated whether Gyp, isolated and purified by our laboratory, can exert neuroprotective effects by modulating neuroinflammation in the hippocampus and prefrontal cortex (PFC) of mice with LPS-induced anxiety and depression, thereby ameliorating behavioral phenotypes.</p><p><strong>Methods: </strong>LPS (1 mg/kg, i.p.) was used to induce anxiety and depression-like behaviors. Gyp was administered at 50, 100, or 200 mg/kg in pretreatment, with fluoxetine hydrochloride (Flu) as a positive control, for 10 consecutive days.</p><p><strong>Results: </strong>Gyp, especially at 100 mg/kg, significantly ameliorated LPS-induced anxiety and depression in mice, normalizing cytokine expression in the hippocampus and PFC, with IL-1β showing the most pronounced regulation (Hippocampus: Ratio<sub>Gyp-100/LPS</sub> = 30.73 %, PFC: Ratio<sub>Gyp-100/LPS</sub> = 55.89 %). Gyp also reversed LPS-induced neuronal loss and necrosis, reduced glial cell activation, and prevented the transition of microglia to the M1 phenotype. Mechanistically, Gyp suppressed the activation of the NLRP3 inflammasome in the PFC, and modulated hippocampal synaptic protein loss, thereby mediating neuroinflammation.</p><p><strong>Conclusions: </strong>Gyp improved anxiety and depression in LPS-induced mice, which may be achieved by balancing systemic inflammatory levels, regulating glial cell activation and phenotypic polarization, regulating hippocampal synaptic plasticity, and suppressing the NLRP3/Caspase-1/ASC signaling pathway in the PFC.</p>","PeriodicalId":13859,"journal":{"name":"International immunopharmacology","volume":"143 Pt 1","pages":"113367"},"PeriodicalIF":4.8,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142464601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to "Combined sulforaphane and β-sitosterol mitigate against olanzapine-induced metabolic disorders in rats: Insights on FOXO, PI3K/AKT, JAK/STAT3, and MAPK signaling pathways" [Int. Immunopharmacol. 140 (2024) 112904]. 对 "联合使用莱菔素和β-谷甾醇可减轻奥氮平诱导的大鼠代谢紊乱：FOXO、PI3K/AKT、JAK/STAT3 和 MAPK 信号通路的启示" [Int. Immunopharmacol.
IF 4.8 2区 医学
International immunopharmacology Pub Date : 2024-12-25 Epub Date: 2024-11-08 DOI: 10.1016/j.intimp.2024.113556
Ehab A M El-Shoura, Lobna A Abdelzaher, Nesreen I Mahmoud, Omar A Farghaly, Mostafa Sabry, Mary Girgis Shahataa, Esraa A Salem, Hebatallah M Saad, Omnya Elhussieny, Magy R Kozman, Ahmed M Atwa
{"title":"Corrigendum to \"Combined sulforaphane and β-sitosterol mitigate against olanzapine-induced metabolic disorders in rats: Insights on FOXO, PI3K/AKT, JAK/STAT3, and MAPK signaling pathways\" [Int. Immunopharmacol. 140 (2024) 112904].","authors":"Ehab A M El-Shoura, Lobna A Abdelzaher, Nesreen I Mahmoud, Omar A Farghaly, Mostafa Sabry, Mary Girgis Shahataa, Esraa A Salem, Hebatallah M Saad, Omnya Elhussieny, Magy R Kozman, Ahmed M Atwa","doi":"10.1016/j.intimp.2024.113556","DOIUrl":"10.1016/j.intimp.2024.113556","url":null,"abstract":"","PeriodicalId":13859,"journal":{"name":"International immunopharmacology","volume":" ","pages":"113556"},"PeriodicalIF":4.8,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Macrophage-derived exosomal miR-2137 regulates pyroptosis in LPS-induced acute lung injury. 巨噬细胞源性外泌体 miR-2137 在 LPS 诱导的急性肺损伤中调控脓毒症。
IF 4.8 2区 医学
International immunopharmacology Pub Date : 2024-12-25 Epub Date: 2024-11-16 DOI: 10.1016/j.intimp.2024.113549
Cong Ye, Xiaodong Yang, Lin Zhu, Guilin Chang, Yu Hu, Weixi Wang
{"title":"Macrophage-derived exosomal miR-2137 regulates pyroptosis in LPS-induced acute lung injury.","authors":"Cong Ye, Xiaodong Yang, Lin Zhu, Guilin Chang, Yu Hu, Weixi Wang","doi":"10.1016/j.intimp.2024.113549","DOIUrl":"10.1016/j.intimp.2024.113549","url":null,"abstract":"<p><strong>Background: </strong>Alveolar macrophages (AMs) play a predominant role in acute lung injury (ALI). However, the role of macrophage-derived exosomal miRNAs in lipopolysaccharide (LPS)-induced ALI has not been determined.</p><p><strong>Methods: </strong>We previously reported that exosomes in the bronchoalveolar lavage fluid (BALF) of mice with ALI were derived predominantly from macrophages. Exosomal small RNA sequencing was conducted to identify the miRNA profiles. Exosomes derived from LPS-induced macrophages (LPS-exos) were intravenously administered to C57BL/6J mice, after which lung injury and pyroptosis were assessed. LPS-exos were cultured with alveolar epithelial cells (AECs) to further validate the results of the animal studies.</p><p><strong>Results: </strong>LPS-exos promoted lung inflammation and pyroptosis in vivo and in vitro. MiR-2137 was significantly upregulated in both LPS-exos and in MLE-12 cells. LPS-exos reduced cell viability, promoted the expression of LDH and inflammatory cytokines, and exacerbated vacuolization in MLE-12 cells. The administration of miR-2137 mimics and LPS-treated exosomes further strengthened these effects and enhanced pyroptosis mediated by NLRP3, Caspase1, ASC, and GSDMD. MiR-2137 mediated the effects of LPS-exos by targeting Wnt9a in AECs. In addition, the miR-2137 inhibitor markedly decreased the severity of LPS-exo-induced histological lesions, inflammation and pyroptosis in the lung.</p><p><strong>Conclusion: </strong>Exosomal miR-2137 derived from AMs contributes to LPS-induced ALI by inducing AEC pyroptosis through the targeting of Wnt9a to activate the Wnt signaling pathway. This study revealed that AMs and AECs interact in ALI, providing novel strategies for ALI treatment.</p>","PeriodicalId":13859,"journal":{"name":"International immunopharmacology","volume":"143 Pt 3","pages":"113549"},"PeriodicalIF":4.8,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to "Integrative analysis of anoikis-related genes prognostic signature with immunotherapy and identification of CDKN3 as a key oncogene in lung adenocarcinoma" [ Int. Immunopharmacol. 143 (2024) 113282]. 对 "免疫疗法与anoikis相关基因预后特征的整合分析以及CDKN3作为肺腺癌关键癌基因的鉴定"[ Int. Immunopharmacol.
IF 4.8 2区 医学
International immunopharmacology Pub Date : 2024-12-25 Epub Date: 2024-11-22 DOI: 10.1016/j.intimp.2024.113584
Haotian Qin, Qichang Wang, Juan Xu, Hui Zeng, Jixian Liu, Fei Yu, Jun Yang
{"title":"Corrigendum to \"Integrative analysis of anoikis-related genes prognostic signature with immunotherapy and identification of CDKN3 as a key oncogene in lung adenocarcinoma\" [ Int. Immunopharmacol. 143 (2024) 113282].","authors":"Haotian Qin, Qichang Wang, Juan Xu, Hui Zeng, Jixian Liu, Fei Yu, Jun Yang","doi":"10.1016/j.intimp.2024.113584","DOIUrl":"10.1016/j.intimp.2024.113584","url":null,"abstract":"","PeriodicalId":13859,"journal":{"name":"International immunopharmacology","volume":" ","pages":"113584"},"PeriodicalIF":4.8,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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