International Journal of ChemTech Research最新文献_第2页

Microwave assisted Synthesis and Antimicrobial Activity ofSubstituted Pyrrolidinone derivatives 取代吡咯烷酮衍生物的微波辅助合成及抗菌活性研究

International Journal of ChemTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijctr.2019.130128

M. K. Swamy, N. Venkatesh, M. Swapna, P. V. Rao

引用次数: 2

Thermodynamic Studies of Complexes of AmlodipineBesylate with Ni2+, Mg2+, Co2+ and Ca2+ cations in pure and inmixed binary solvent systems at 303.15, 313.15 and 323.15K by Conductometric Method 用电导法研究氨氯地松酯与Ni2+、Mg2+、Co2+和Ca2+离子在纯和混合二元溶剂体系中在303.15、313.15和323.15K下配合物的热力学

International Journal of ChemTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijctr.2019.130125

Dhruvi. R. Mehta, Raviprakash S. Chandra, M. Maisuria

{"title":"Thermodynamic Studies of Complexes of Amlodipine\u0000Besylate with Ni2+, Mg2+, Co2+ and Ca2+ cations in pure and in\u0000mixed binary solvent systems at 303.15, 313.15 and 323.15\u0000K by Conductometric Method","authors":"Dhruvi. R. Mehta, Raviprakash S. Chandra, M. Maisuria","doi":"10.20902/ijctr.2019.130125","DOIUrl":"https://doi.org/10.20902/ijctr.2019.130125","url":null,"abstract":"The present work relates to the complexation reaction between Amlodipine Besylate[AML] with Ni 2+ , Mg 2+ , Co 2+ and Ca 2+ cation in dimethylsulfoxide (DMSO), pure methanol (MeOH) and their binary mixtures(DMSO-MeOH and DMSO-Water) by conductometric method. The conductance data show that the stoichiometry of the complexes formed between AML with Ni 2+ , Mg 2+ , Co 2+ and Ca 2+ cation in pure DMSO, pure MeOHas well as in the binary solvent mixtures was 1:1. The stability of AML complexes with Ni 2+ , Mg 2+ , Co 2+ and Ca 2+ metal ion was observed to be sensitive to the nature of the solvent system. In case of DMSO-Water binary solvent systems there was a linear change in LogKf values but in case of DMSO-MeOH binary solvent systems non linear change in LogKf values observed.The negative values of ΔG 0 show that the reaction is spontaneous and ability of the AML ligand to form stable complexes. However, the result shows positive value of ΔH 0 which indicates that enthalpy is not driving force for the formation of the complexes. Furthermore, the positive value of ΔS 0 indicates that entropy is a driving force for the complexation. The values of ΔH 0 and ΔS 0 for formation of the complexes were obtained from temperature dependence of the stability constants.","PeriodicalId":13853,"journal":{"name":"International Journal of ChemTech Research","volume":"49 1","pages":"206-216"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86843589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Silico Anti- HIV Analysis of FTIR identified Bioactivecompounds present in Vitex altissima Land Vitex leucoxylon L 白荆和白荆中生物活性化合物的红外光谱分析

International Journal of ChemTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijctr.2019.130312

C. Masi, S. Naganathan, A. Natarajan, Vivek Pazhamalai, M. Tafesse

{"title":"In Silico Anti- HIV Analysis of FTIR identified Bioactive\u0000compounds present in Vitex altissima L\u0000and Vitex leucoxylon L","authors":"C. Masi, S. Naganathan, A. Natarajan, Vivek Pazhamalai, M. Tafesse","doi":"10.20902/ijctr.2019.130312","DOIUrl":"https://doi.org/10.20902/ijctr.2019.130312","url":null,"abstract":"The knowledge of the traditional plants in India is a collection over millennia by our ancient people. The Siddha System of Medicine (Traditional Tamil System of medicine) is the foremost of all other medical systems in the world which provide service to the humanity for more than 5000 years in combating diseases and also in maintaining its physical, mental and moral health. Vitex species were used in siddha for its anti- viral activity for several years. However, the present study deals with the Human Immunodeficiency Virus because of its complexity and killing effects. FTIR analysis of Vitex altissima L and Vitex leucoxylon L revealed the presence of 21 and 17 bioactive compounds respectively. These compounds were analysed further for its binding affinity mechanism against one of the virulence causing protein, reverse transcriptase (target protein) of Human Immunodeficiency Virus (HIV) by using molecular docking and bioinformatics tools. Interaction rate was determined between bioactive compounds against the protein target based on binding free energy requirements. Molecular docking was also made to the commercially available drugs (Zidovudine, Stavudine, and Nevirapine) against the target protein. By comparing the results between bioactive compounds in the Vitex species and the commercially available drugs, it was clear that the bioactive compounds were much more effective than the commercially available drugs, thereby suitable for the treatment of AIDS. Hence, this study will form the basis for promoting therapeutic lead molecules from the traditional plants which restore the tradition and also eliminates the harmful side effects.","PeriodicalId":13853,"journal":{"name":"International Journal of ChemTech Research","volume":"28 1","pages":"149-165"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83585073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spectrophotometric determination of Clinidipine, Efavirenz,Prazosin drugs by using Folin-Ciocalteu Reagent 福林- ciocalteu试剂分光光度法测定克林地平、依非韦伦、普拉唑类药物的含量

International Journal of ChemTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijctr.2019.130318

Naveen Reddy Pailla, Bhaskar Kuthati

引用次数: 0

Development & Validation of HPLC method for simultaneousestimation of Drotaverine & Omeprazole HPLC法同时测定氯他弗林和奥美拉唑的方法建立与验证

International Journal of ChemTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijctr.2019.130101

Zaheer Shaikh, A. Ahad, S. Patel, M. Farooqui

引用次数: 0

Review on the Bioactivities of Quercetin 槲皮素生物活性研究进展

International Journal of ChemTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijctr.2019.130315

Shabana, R. C. Jaysree, R. N

{"title":"Review on the Bioactivities of Quercetin","authors":"Shabana, R. C. Jaysree, R. N","doi":"10.20902/ijctr.2019.130315","DOIUrl":"https://doi.org/10.20902/ijctr.2019.130315","url":null,"abstract":"Quercetin, the most active bioflavonoid which is produced as a secondary metabolite by plants, is a polyphenol with a wide spectrum of bioactivities. This bioflavonoid is the ―nature‘s biological response modifier‖ as it interferes with the various allergens and other reactive compounds. Apple, oranges, tomatoes, onions, black tea and green tea are good sources of quercetin and it is also available commercially. After absorption in the small intestine and colon, quercetin conjugates with glucuronic acid and binds to albumin and passes to liver and benefits the body by its various bioactivities. Quercetin‘s antioxidant activity enhances the radical scavenging activity and metal chelation of the ions but the prooxidant activity depends on its high concentration. Further, quercetin interferes with the formation of leukotrienes from arachidonic acid showing its anti-inflammatory effect. A combined effect of quercetin and bromelain effectively suppresses the allergic reactions and the excessive inflammation resulting from bruising and tissue damage. The mutualistic effect of vitamin C and quercetin protects each other from getting oxidized. A direct relationship was also found to exist between quercetin's antiviral activity and enhancement of cyclic adenosine monophosphate (cAMP), which is a second messenger involved in many biological processes. Quercetin helps in down regulation of mutant gene p53 and inhibits the growth of cancerous cells by putting a check at G1 phase. This also controls the surpassing of the normal regulatory growth by the tumor cells and inhibits the production of heat shock proteins and thus showing its anticancer properties. Owing to the potential pharmaceutical properties of quercetin, the bioactivities, principle uses and mechanisms involved in the treatment of various diseases were reviewed in this paper. In addition, safety issues involved in the partake of quercetin by humans have also been discussed.","PeriodicalId":13853,"journal":{"name":"International Journal of ChemTech Research","volume":"56 1","pages":"181-194"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91035726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic Effect of Trisodium citrate (TSC) on the InhibitionEfficiency of Sargassum swartzii (SS) -Zn2+ System on MildSteel in Aqueous Environment 柠檬酸三钠(TSC)对水环境中马尾藻(SS) -Zn2+体系对软钢的协同抑制作用

International Journal of ChemTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijctr.2019.130403

S. Manimegalai

{"title":"Synergistic Effect of Trisodium citrate (TSC) on the Inhibition\u0000Efficiency of Sargassum swartzii (SS) -Zn2+ System on Mild\u0000Steel in Aqueous Environment","authors":"S. Manimegalai","doi":"10.20902/ijctr.2019.130403","DOIUrl":"https://doi.org/10.20902/ijctr.2019.130403","url":null,"abstract":"The aquatic plant kingdom is a treasure of potential bioactive compounds. Aquatic plants contain some organic compounds that provide definite physiological actions on the human body. In the present study deals with the synergistic effect of Trisodium citrate (TSC)on the inhibition efficiency of methanolic extract of Sargassum swartzii (SS) and Zn 2+ system on mild steel in aqueous environment. The corrosion monitoring techniques adopted in the study were weight-loss methods, electrochemical measurements, FT-IR and surface morphological techniques namely SEM and EDX. It has proved the formulation consisting of 100 ppm of Zn 2+ , 120 ppm of SS and 100 ppm of TSC has 95.77% IE. The high performance of SS Zn 2+ TSC system could be due to synergistic effect that covers a wide surface coverage area on the metal surface and thus retarding the corrosion. Polarization study reveals that this formulation functions as a mixed inhibitor. AC impedance spectra suggest the presence of protective film on the metal surface. FT-IR spectra reveals that the protective film consists of Fe 2+ -SS complex, Fe 2+ -TSC complex and Zn (OH)2. SEM and EDX provide a pictorial representation on the nature of surface film in the absence and presence of inhibitors. Thus, it concluded that Sargassum swartzii Zn 2+ TSC inhibitor system acted as a good inhibitor in aqueous medium.","PeriodicalId":13853,"journal":{"name":"International Journal of ChemTech Research","volume":"219 1","pages":"347-356"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89374173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analytical Method Development and Stability Studies forEstimation of Oseltamivir In Bulk and Capsules Using RPHPLC 奥司他韦散装和胶囊分析方法的建立及稳定性研究

International Journal of ChemTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijctr.2019.130113

L SivaSankerReddy, B. Ishaq, G. Mounica

{"title":"Analytical Method Development and Stability Studies for\u0000Estimation of Oseltamivir In Bulk and Capsules Using RPHPLC","authors":"L SivaSankerReddy, B. Ishaq, G. Mounica","doi":"10.20902/ijctr.2019.130113","DOIUrl":"https://doi.org/10.20902/ijctr.2019.130113","url":null,"abstract":"A simple and reproducible method of isocratic reverse phase liquid chromatography (RP-LC) was developed for the quantitative determination of oseltamivir phosphate in bulk drug and capsules, used to treat antiviral (influenza). The proposed RP-HPLC method uses X terra C18, 4.6 mm, 150 mm 4.6 mm i.d. column (at room temperature), using 0.1% octa-sulfonic acid: acetonitrile 30: 70 v / v, effluent flow rate (1.0 ml / min) and UV detection at 237 nm for oseltamivir analysis. The method was validated according to the ICH guidelines in terms of specificity, linearity, precision and accuracy. The retention time for oseltamivir was 2.31 min. The recovery determinations allowed the calculation of a confidence interval from 99.79 to 101.30% with a relative standard deviation value of 0.5%. LOD and LOQ were estimated at 2.98 and 9.98 µg/mL respectively. The validated method was successfully applied to the determination of oseltamivir in dosage form in capsules (Tamiflu 75 mg, Roche). Oseltamivir was exposed to conditions of acid, basic, oxidative and thermal stress and the stressed samples were analyzed with the proposed method. The chromatographic peak purity results indicated the absence of elution peaks with the main oseltamivir peak, which demonstrated the specificity of the test method for estimating oseltamivir in the presence of degradation products. This method has advantages that include a short execution time, a simple and rapid sample preparation which makes this method used for routine oseltamivir analysis in quality control laboratories.","PeriodicalId":13853,"journal":{"name":"International Journal of ChemTech Research","volume":"1 1","pages":"107-116"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89761346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Physico–Chemical analysis of groundwater quality near thesalt-pans of Thoothukudi Districts, Tamilnadu, India 印度泰米尔纳德邦Thoothukudi地区盐田附近地下水质量的物理化学分析

International Journal of ChemTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijctr.2019.130306

J. Vincent, C. Lekha, Bagavathi, B. Vijaya, Bhuvaneshwari, G. Lakshmi

引用次数: 0

Synthesis and Characterization of Co(II) and Ni(II)complexes of Schiff base derived from Ninhydrin and Valine 茚三酮和缬氨酸衍生的希夫碱Co(II)和Ni(II)配合物的合成与表征

International Journal of ChemTech Research Pub Date : 2020-01-01 DOI: 10.20902/ijctr.2019.130324

Bekele Yirga, A. Chimdi, P. Arasu

{"title":"Synthesis and Characterization of Co(II) and Ni(II)\u0000complexes of Schiff base derived from Ninhydrin and Valine","authors":"Bekele Yirga, A. Chimdi, P. Arasu","doi":"10.20902/ijctr.2019.130324","DOIUrl":"https://doi.org/10.20902/ijctr.2019.130324","url":null,"abstract":"In this study, Complexes of Co (II) and Ni (II) ions with Ruhmann’s purple (ligand) were successfully synthesized and characterized. The complexes of NiL2and CoL2were synthesized by using template condensation synthesis method and characterized by melting point, solubility, elemental analysis, and molar conductance, and magnetic susceptibility, infrared and electronic spectral studies. The complexes, NiL2and CoL2 are soluble in ethanol, partially soluble in Diethyl ether and chloroform and insoluble in hexane and petroleum ether. The complexes, NiL2and CoL2 neither melt nor decompose up to 420 0 C. The molar conductance of NiL2and CoL2 was 42 Scm 2 /mol and 46Scm 2 /mol in respectively. The molar magnetic susceptibility of two complexes was 1.74 BM for NiL2 and 2.76 BM for CoL2. The metal to ligand ratio of both metal complexes was 1:2; both metal complexes are non-electrolytes in ethanol and are paramagnetic at 21 0 C. Based on the spectral data and other analytical data, monobasic ONO donor behavior of the ligand (Ruhmann’s purple) generates octahedral geometry for the pink-green colored Ni (II) complex and green colored Co (II) complex.","PeriodicalId":13853,"journal":{"name":"International Journal of ChemTech Research","volume":"18-19 1","pages":"265-273"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89495690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0