International Journal of Drug Delivery Technology最新文献

{"title":"Formulation and In-vitro Evaluation of Two Layers Tablet for Dual Release of a Model Drug","authors":"Mushtaq J Mohammed, W. Ali","doi":"10.25258/ijddt.13.1.08","DOIUrl":"https://doi.org/10.25258/ijddt.13.1.08","url":null,"abstract":"Objective: Glimepiride is a third-generation sulfonylurea medication that has been used to treat type 2 diabetes (T2D) mellitus. It is class II drug according to the biopharmaceutical classifi cation system (BCS) characterized with its low solubility and high permeability. Due to the drug’s weak water solubility, its bioavailability is restricted by its dissolving rate. This study aimed to develop a bilayer tablet of glimepiride with one layer for immediate release (IR), a dose of 2 mg, a second layer for sustained release (SR), and a 4 mg dose Immediate release layer included solid dispersion of glimepiride . Methods: Glimepiride solid dispersions were prepared utilizing four water-soluble carriers (poloxamer 188, polyethylene glycol (PEG6000), Kollicoat IR and soluplus) by solvent evaporation and fusion techniques at 1:1, 1:2, and 1:4 ratios and evaluated in 0.1 N of HCL buff er pH 1.2 with 1% of sodium lauryl sulphate (SLS) for 2 hours. utilizing a USP-II paddle-type dissolution apparatus containing 900 mL dissolution medium kept at 37 ± 0.5℃ and 50 rpm. The sustained release layer of glimepiride bilayer tablet was prepared using various polymers, including HPMC K15, HPMC K4, xanthan gum, carbopol 934 and ethyl cellulose at 1:1, 1:2,1:3 ratios and combination of polymers in phosphate buff er pH 6.8 for 12 hours. The prepared solid dispersion of immediate release were evaluated by X-ray powder diff raction (PXRD), and fourier transform infrared spectroscopy for selected SD9. The FTIR spectroscopy analysis for selected formula (F24) of sustained layer, angle of repose, Hausner’s ratio and Carr’s Index were used to evaluate the fl owability and compressibility of the formulation powders during the pre-compression investigations, while, thickness, hardness, weight variation, friability, drug content, for prepared tablets. Results: The results revealed that SD9 at ratio (1:4 glimepiride: soluplus) was the optimal formula since 94% of drug released at 2 hours for immediate layer formula 24, which included ethylcellulose polymer in a 1:1 ratio in the sustained layer of the tablet, was chosen as the optimal formula out of another formula (F1–F28), This formula demonstrated acceptable sustained properties of the glimepiride over the course of 12 hours. and approximately 96% of the medication was released. Conclusion: This study succussed in designing bilayer tablets containing glimepiride solid dispersion formulation in the fi rst immediate release layer and untreated pure drug formulation in the second layer for sustaining the release of the drug for a specifi c period of time to be used as the eff ective treatment of type II diabetes mellitus.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45022414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Infl ammatory Bowel Disease and Tumor Necrosis Factor-863 C/A Polymorphism in Iraq","authors":"Sali E Hussian, W. S. Mahood","doi":"10.25258/ijddt.13.1.12","DOIUrl":"https://doi.org/10.25258/ijddt.13.1.12","url":null,"abstract":"Background: The underlying causes of infl ammatory bowel disease (IBD) are unknown, but they are thought to be a combination of genetics, environmental factors, abnormal immune responses, and disruption of the gut microbiota. This study aims to investigate the eff ect of tumor necrosis factor-alpha (TNF-α) -863 C/A(rs 1800630) single nucleotide polymorphism (SNP) in infl ammatory bowel patients and it is relation with the patient’s clinical characteristics. Methods: The study was conducted on 74 blood samples from patients of IBD including 47 patients with ulcerative colitis (UC) and 27 patients with Crohn’s disease (CD) in addition to 20 blood samples apparently healthy individuals, TNF-α-863 C>A genotype was screened by PCR and Sanger sequencing techniques. Results: The results showed that the homozygous CC genotype frequency was the higher genotype frequency in 45/60 (75%) for IBD patients with less than 50 years ages compared with 7/14 (50%) the IBD patients with more than 50 years, signifi cant high association OD (CI): 2.75 (1.38–4.08), The allelic C frequency in ulcerative colitis (UC) patients was (0.83) and signifi cantly higher than the A allele frequency (0.17) and it may act as risk factor infl ammatory disease. The homozygous CC genotype of the TNF-α-863 gene was 9/27 (70.37%) in CD patients compared with 6/20 (30%) in the control group with high signifi cant diff erences (p ≤ 0.01, OR=1.00). Signifi cant diff erences also applied for the heterozygous CA genotype in -863 SNP,it was 8/27 (29.62%) compared with the control group 14/20 (70%) the odds ratio (2.62), while the homozygous AA genotype frequency showed no signifi cant association with CD (p -1.00). Conclusion: The frequency of homozygous CC genotype of the TNF-α-863 gene was higer in CD patients than in the control group with signifi cant diff erences. Signifi cant diff erences also applied for the heterozygous CA genotype while the three genotypes (CC, CA and AA) of the TNF-α-863 gene showed non-signifi cant diff erences in ulcerative patients in comparison with the control.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43356998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of NSAIDS and Oral Hypoglycemic Agent on Leukemia and Lymphoma Cell Lines","authors":"K. Khaleel, Abeer A Ahmed, Maeda H. Mohammad, A. A. Fadhe","doi":"10.25258/ijddt.13.1.19","DOIUrl":"https://doi.org/10.25258/ijddt.13.1.19","url":null,"abstract":"Cancer is regarded as global burden and a serious health challenge. Its occurrences increased due to population aging and the prevalence of risk factors. This study investigated the eff ect of metformin and aspirin on two cell lines SR (diff use large B cell lymphoma) and NB4 (promyelocytic leukemia). The eff ect of metformin as monotherapy on SR was 28.43% viable, while on NB4, only 44.4% were viable. However, the eff ect of aspirin on SR and NB4 cell lines were decreased; the percentage of cell viability were 27.2 and 41.2%, respectively. In conclusion, there is signifi cant eff ect of metformin and aspirin on SR cell line and only mild eff ect on NB4. These may be useful drugs in old diabetic patients with diff use large B cell lymphoma that may reduce the chemotherapy dose","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47659780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, Characterization and Biological Activity of Azo Dye Derived from 2-methoxyaniline and its Complexes","authors":"H. Mohammed, Saif D K Alzamili","doi":"10.25258/ijddt.13.1.63","DOIUrl":"https://doi.org/10.25258/ijddt.13.1.63","url":null,"abstract":"The azo ligand of guanine namely 8-[2-methoxyphenylazo]-guanine (MPAG) was prepared and characterized by elemental analysis, mass spectroscopy, 1H-NMR, FTIR and UV-vis spectroscopies. The Cu(II) and Zn(II) complexes of MPAG ligand were prepared under mole ratio equal to 2:1 as MPAG ligand to metal ions and characterized by 1H-NMR, FTIR, UV-vis, XRD powder and mass spectroscopies and elemental analysis, magnetic susceptibility as well as molar conductance. The solvents did not have a signifi cant eff ect on the NAPAG ligand, and the MPAG ligand exhibited potential changes under diff erent pH values. The MPAG ligand may be utilized as a colorimetric sensor for the particles of Co2+, Ni2+, Cu2+ and Zn in watery solutions. The MPAG ligand is tridentate and the complexes are electrolyte and octahedral.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44854514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-Alzhimer Activity of Bay Leaves in Scopolamine-induced Rat Model","authors":"Sonali G. Banpure, V. Chopade, P. Chaudhari, P. Ingale","doi":"10.25258/ijddt.13.1.3","DOIUrl":"https://doi.org/10.25258/ijddt.13.1.3","url":null,"abstract":"Indian spices always play a great role in Ayurveda and Indian medicine. So, analyzing these plants for their unknown and specialized activity is great. Nearly all the spices have some activity on the brain and CNS. Bay leaves are one of the most common culinary spices from day to day life of Indians. In this study, we have studied bay leaves for their anti-Alzheimer activity which depends on the inhibition of acetylcholine esterase and butyrylcholinesterase. For this study, fi rstly bay leaf oil was extracted by hydrodistillation. Further phytoconstituent like alpha-pinene, terpineol, 1,8-cineol, sabinene, and methyl eugenol were isolated and purifi ed by using TLC, HPLC, and column chromatography followed by fractional distillation. These isolated phytoconstituents were evaluated for their acetylcholinesterase and butyrylcholinesterase inhibition activity in scopolamine-induced rats. This study used galanthamine as a reference, and compared the anti-alzheimer activity of all isolated phytoconstituents.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46919176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of Antibiotic-resistant Bacteria Isolated from Children with Urinary Tract Infection","authors":"A. H. Al-Wandawy, L. Zwain, Murad R Wali","doi":"10.25258/ijddt.13.1.23","DOIUrl":"https://doi.org/10.25258/ijddt.13.1.23","url":null,"abstract":"Urine samples 96 to 100 were collected from patients (children) with urinary tract infections (UTIs) from Azadi Hospital in Kirkuk province, Iraq, where included (76 males and 120 females) with ages ranging from (≥ one-15) years old, for period from 1/1/2022 to 26/4/2022. The study included isolation and identifi cation depending on macroscopic, microscopic and defi nite with API 20e and API Staphylococcus. Moreover, all isolates were tested for resistance to 23 antibiotics. 55 bacterial isolations were obtained and E. coli had the highest rate of 27 (49.09%) followed by Klebsiella spp. with 14 (25.45%) and each of the bacteria, Staphylococcus aureus, Proteus spp., Citrobacter spp., Enterobacter spp., Pseudomonas spp. and Morganella morganii they reached 4(7.27%), 5(9.09%), 1(1.81%), 2 (3.63%), 1(1.81%) and 1(1.81%), respectively. Result showed enterobacteriaceae higher resistance to amoxicillin-clavulanate (100%). E. coli had the highest rate and were resistance 100% to tobramycin, penicillin and amoicillin, followed by amoxicillin-clavulanate and ampicillin (96.29 and 91.66), respectively. At the same time (Doxycycline, Ceftazidime, Tetracycline, Cefepime, Trimethoprim, Cefotaxime) were (88.88, 88, 85.71, 84, 83.33, 81.81%), respectively. At the same time, Pseudomonas spp. were resistant to (Ampicillin, Cefotaxime, Morganella morgani, and Erythromycin) 100% and S. aureus were resistant to (Amoxicillin-clavulanate, Cefotetan, Cefepime, Erythromycin, Norfl oxacin, Tetracycline, Cefotaxime, Morganella morgani, Amikacin) 100%.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45121591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rheological and Thermal Behavior of Choline-based Deep Eutectic Ionic Liquid and its Impact on a Poorly Soluble Drug Model","authors":"Rafif Raad, Nidhal K. Maraie, Ayad M. R. Raauf","doi":"10.25258/ijddt.13.1.13","DOIUrl":"https://doi.org/10.25258/ijddt.13.1.13","url":null,"abstract":"Objective: This study was conducted to prepare a deep eutectic ionic liquid based on choline chloride and malonic acid (Maline) in diff erent molar ratios and evaluate the maline properties to designate the best ratio for solubilizing risperidone, a poorly soluble drug model. Method: Malines were prepared using choline chloride and malonic acid in 1:0.8, 1:0.9 and 1:1 molar ratios. The characterization of malines involved pH rating, rheological test and thermal behavior using DSC. In addition to estimating the interactions that occur between the choline chloride and malonic acid to form the malines theoretically using the computational prediction program Mercury and experimentally by 1H-NMR and FTIR. Results: This study shows that all malines (M1-M3) represents an acidic pH and high viscosity with a non-newtonian behavior (shear thinning property ) at low temperature while a Newtonian behavior (shear rate-independent) at high temperatures. In malines (M1-M3) thermograms, the absence of pure compounds melting point peaks with a glass transition temperature at -14○C that confi rms the DES property. FTIR and 1H-NMR results represent a hydrogen bond formation between choline chloride and malonic acid and further between maline and risperidone which is similar to the computational prediction. Maline (M1) with molar ratio of 1:1 had a preferable solubilizing eff ect on risperidone reaching 20.5 mg/mL, while in (M2) (1:0.9) reaches 13.6 mg/mL, and in (M3) reaches 11.9 mg/mL. Conclusion: Maline (M1) was chosen as the optimum molar ratio to form a deep eutectic ionic liquid that successfully enhances risperidone solubility and boosts its bioavailability.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47489367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights of In-silico Neurotoxicity Studies of Glucuronolactone, Taurine and Gluconolactone Correlating the Induced Neuronal Alteration in Rat Pups","authors":"Revathi Boyina, S. Dodoala, Sumalatha Gindi, P. M, P. K. Desu","doi":"10.25258/ijddt.13.1.06","DOIUrl":"https://doi.org/10.25258/ijddt.13.1.06","url":null,"abstract":"Background: Signifi cant concentrations of food additives found in energy drinks have the potential to be neurotoxic and promote oxidative stress, among other negative consequences. Pregnant rats were split up into six groups for the current study. Group 1 received vehicle, CAF standard (25 mg/kg p.o.), groups 3-6 received GLUR (5 mg/kg p.o.), TAU (8 mg/kg p.o.), GLU (84 mg/kg p.o.), and combinations of the three chosen food additives (CF), respectively. From prenatal day 3 through postnatal day 15, certain food additives were administered to pregnant rats at signifi cant doses. After parturition on PND 21, behavioral changes were assessed using the Rotarod, active avoidance, and elevated plus maze tests. On PND 30, 45, and 60, rat brain tissue had its acetylcholine and epinephrine levels evaluated. Further, on days 30 and 60, brain tissue was assessed for the presence of oxidative stress markers such as lipid peroxidation, catalase, superoxide dismutase, and glutathione peroxidase. Finally, histopathological studies were carried out in brain hippocampal region. Further in-silico studies were carried out on selected receptors. Results: Rat pups fed with food additives showed a signifi cant (p < 0.001) change in behavior, including memory, cognition, and motor activity. Increased lipid peroxidation and decreased anti-oxidant enzymes were signifi cant in TAU and CF groups. Further in-silico studies were carried out, where GLUR showed high binding affi nity to specifi c receptor targets, GABA A and NMDA1 receptors, and specifi c enzyme targets MAO A and MAO B neurotransmitter metabolic enzymes compared to caff eine hinted the decrease in neurotransmitters as in-vivo studies. Conclusion: The current fi ndings support the hypothesis that the chosen dose and mix of food additives altered rat pups’ neurobehavioral and neurotransmitter profi les.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48630850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eco-friendly Analytical Method for Estimation for Benzodiazepine Drug in Pure and Pharmaceuticals Formulations by Oxidative Coupling Reaction with Phenylephrine Hydrochloride","authors":"Aseel M. Aljeboree, Shaimaa M. Essa, F. Dawood, M. S. Ali, A. Alkaim","doi":"10.25258/ijddt.13.1.51","DOIUrl":"https://doi.org/10.25258/ijddt.13.1.51","url":null,"abstract":"A simple, fast, sensitive and selective spectrophotometric method has been developed based on the oxidative coupling reaction process, which depends on the determination of clonazepam (CZP) drug using an oxidizing agent sodium periodate (NaIO4) in the presence of a reagent, phenylephrine hydrochloride (PH-HCL), that uses the pink color of CZP at a wavelength of 495 nm. Where several factors aff ecting the color intensity and absorbance were studied, including the eff ect of color stability time, eff ect of the volume of the reagent, the eff ect of the volume of the oxidizing agent, order of addition and temperature. The calibration curve found to obey Lambert beer at range concentration (2–20 mg/L), while the limit of detection (LoD) (8. 9*10-2), limit of quantitation (LoQ) (2.6*10-2) and molar absorbance is 1.4 × 102 liters mol-1cm-1. The method was applied to pharmaceutical preparations (Tablet) and was found to characterize the best precision and accuracy. The standard methods not need any control of temperature and also not aff ected by interferences and henceforth successfully utilized to determine CZP in pharmaceutical preparations","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45016371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using of Nano-poly Chitosan Cephalexin Drug to Inhibit Spread Cancer Cells","authors":"Aliaa H Abbas, Mohammad N. Al-Baiati","doi":"10.25258/ijddt.13.1.05","DOIUrl":"https://doi.org/10.25258/ijddt.13.1.05","url":null,"abstract":"In our work, a natural chitosan nano polymer was synthesized and characterized by fourier transform infrared (FTIR), proton nuclear magnetic resonance (1H-NMR), atomic force microscopy (AFM), transmission electron microscope (TEM) and X-ray diff raction (XRD) techniques. Then the nano-chitosan was linked with cephalexin drug, which FTIR characterized, and 1H-NMR techniques. The biological activity of the nano-chitosan- cephalexin drug was studied by measured cell line breast cancer. Where it showed a high rate in preventing the spread of breast cancer.","PeriodicalId":13851,"journal":{"name":"International Journal of Drug Delivery Technology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41415896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}