International Journal of Antimicrobial Agents最新文献

{"title":"Misassignment of patients in meta-analysis of polymyxin B","authors":"Alexandre P. Zavascki","doi":"10.1016/j.ijantimicag.2024.107362","DOIUrl":"10.1016/j.ijantimicag.2024.107362","url":null,"abstract":"","PeriodicalId":13818,"journal":{"name":"International Journal of Antimicrobial Agents","volume":"64 6","pages":"Article 107362"},"PeriodicalIF":4.9,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of rifampicin combination therapy for orthopaedic implant-related infections: A systematic review and meta-analysis","authors":"Naomi Kobayashi ,&nbsp;Kazuhiko Matsushita ,&nbsp;Emi Kamono ,&nbsp;Hiroshi Matsumoto ,&nbsp;Natsumi Saka ,&nbsp;Katsufumi Uchiyama ,&nbsp;Kai Suzuki ,&nbsp;Yui Akiyama ,&nbsp;Hiroyuki Onuma ,&nbsp;Koji Yamada","doi":"10.1016/j.ijantimicag.2024.107359","DOIUrl":"10.1016/j.ijantimicag.2024.107359","url":null,"abstract":"<div><h3>Background</h3><div>In vitro, animal, and clinical comparative studies have revealed that combinations of rifampicin with antibacterial agents are effective in the treatment of biofilm-associated infections. This study aimed to assess the effectiveness of rifampicin combination therapies compared with monotherapies without rifampicin in patients with orthopaedic implant-related infections.</div></div><div><h3>Materials and Methods</h3><div>The clinical literature was comprehensively searched for studies assessing the effectiveness of rifampicin combination therapy in patients with orthopaedic implant-related infection. Identified studies were screened based on the Preferred Reporting Items for Systematic Reviews and Meta-analyses flow diagram. The primary outcome was the cure rate and the secondary outcome was the incidence of adverse events. Subgroup analyses were performed based on causative organisms, antibacterial agents, and types of surgical intervention.</div></div><div><h3>Results</h3><div>Twenty-seven studies were identified, including two randomized controlled trials (RCTs) and 25 cohort studies. Rifampicin combinations were associated with significantly higher cure rates than monotherapies in cohort studies, but not in RCTs. Subgroup analyses showed that rifampicin combinations were effective in patients infected with <em>Cutibacterium</em> and <em>Staphylococcus</em> spp.; in patients who underwent debridement, antibiotics, implant retention procedures; and in patients with one-stage revision. Moreover, combinations of rifampicin and fluoroquinolones were more effective than fluoroquinolones alone, while combinating rifampicin with other antibacterial agents showed no significant benefit. Combination treatment did not significantly affect adverse events in either RCTs or observational studies. Risk of bias assessment and summary of findings showed that the certainty of evidence for both RCTs and observational studies was very low.</div></div><div><h3>Conclusions</h3><div>This systematic review and meta-analysis confirmed the potential effectiveness of rifampicin combination therapy for the cure of orthopaedic implant-related infection in some circumstances, although the certainty and quality of evidence were very low.</div></div>","PeriodicalId":13818,"journal":{"name":"International Journal of Antimicrobial Agents","volume":"64 6","pages":"Article 107359"},"PeriodicalIF":4.9,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142464588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emergence of extensively-drug-resistant hypervirulent Acinetobacter baumannii isolated from patients with bacteraemia: bacterial phenotype and virulence analysis","authors":"Pek Kee Chen ,&nbsp;Chia-Ying Liu ,&nbsp;Han-Yueh Kuo ,&nbsp;Yi-Tzu Lee ,&nbsp;Yu-Han Liu ,&nbsp;Yen-Zhen Zhang ,&nbsp;Cheng-Yen Kao","doi":"10.1016/j.ijantimicag.2024.107358","DOIUrl":"10.1016/j.ijantimicag.2024.107358","url":null,"abstract":"<div><h3>Objectives</h3><div>Individuals infected with extensively-drug-resistant (XDR) <em>Acinetobacter baumannii</em> are difficult to cure and have a high mortality rate. This study compared the genomic and phenotypic differences between XDR and non-multi-drug-resistant (MDR) <em>A. baumannii</em>, and further characterized hypervirulent XDR <em>A. baumannii</em>.</div></div><div><h3>Methods</h3><div>In total, 1403 acinetobacter isolates were collected from patients with bacteraemia between 1997 and 2015. Antimicrobial susceptibility tests were performed to categorize isolates into non-MDR, MDR and XDR groups. The presence of selected virulence-associated genes was determined by polymerase chain reaction. Bacterial phenotypes, including iron acquisition, biofilm formation, capsule production, and virulence to larvae and mice, were determined.</div></div><div><h3>Results</h3><div>Multi-locus sequence typing revealed a high prevalence of sequence type (ST) 2 (81.6%) and ST129 (18.4%) among 49 XDR isolates, and the STs of 18 non-MDR isolates were more diverse. Virulence-associated phenotypic assays showed that XDR isolates had higher iron acquisition ability, greater capsule production, and virulence to <em>Galleria mellonella</em> larvae. However, their ability to form biofilm was lower compared with that of non-MDR isolates. XDR isolates were more likely to have virulence genes (<em>tonB, hemO, abaI</em> and <em>ptk</em>), while non-MDR isolates were more likely to have <em>pld</em> and <em>ompA</em> genes. Twenty-one XDR isolates that had a &lt;20% larvae survival rate after 7 days post-infection were defined as hypervirulent XDR isolates. Among them, isolates 1677 (ST129) and 929-1 (ST2) caused the death of all infected mice within 2 days.</div></div><div><h3>Conclusion</h3><div>Some subpopulations of highly-drug-resistant ST2 isolates exhibit high virulence. As such, it is of utmost importance to continue monitoring the spread of hypervirulent XDR <em>A. baumannii</em> isolates.</div></div>","PeriodicalId":13818,"journal":{"name":"International Journal of Antimicrobial Agents","volume":"64 6","pages":"Article 107358"},"PeriodicalIF":4.9,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142464589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thrice is nice: Thrice weekly versus daily ertapenem in patients on haemodialysis","authors":"Surafel G. Mulugeta ,&nbsp;Andrew Mannino ,&nbsp;Nada Aref ,&nbsp;Vince Procopio ,&nbsp;Suzette Gendjar ,&nbsp;Shaina Vincent","doi":"10.1016/j.ijantimicag.2024.107355","DOIUrl":"10.1016/j.ijantimicag.2024.107355","url":null,"abstract":"","PeriodicalId":13818,"journal":{"name":"International Journal of Antimicrobial Agents","volume":"64 6","pages":"Article 107355"},"PeriodicalIF":4.9,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacodynamic Target Attainment at Infection Site During Treatment of Post-Neurosurgical Ventriculitis Caused by Carbapenem-Resistant Klebsiella pneumoniae with Ceftazidime–Avibactam–Based Regimens: a case report","authors":"Yinru Chen ,&nbsp;Wanzhen Li ,&nbsp;Xiaofen Liu ,&nbsp;Yan Chen ,&nbsp;Jing Zhang ,&nbsp;Nanyang Li ,&nbsp;Lei Yang","doi":"10.1016/j.ijantimicag.2024.107356","DOIUrl":"10.1016/j.ijantimicag.2024.107356","url":null,"abstract":"<div><div>A patient developed a post-neurosurgical ventriculitis with carbapenem-resistant <em>Klebsiella pneumoniae</em> and mold, initially treated with ceftazidime/avibactam and voriconazole. A <em>Klebsiella pneumoniae</em> carbapenemase mutation led to therapy adjustment to ceftazidime/avibactam and polymyxin B, achieving cure. Pharmacokinetic/pharmacodynamic analysis highlights effective ceftazidime/avibactam brain penetration and bacterial clearance efficacy.</div></div>","PeriodicalId":13818,"journal":{"name":"International Journal of Antimicrobial Agents","volume":"64 6","pages":"Article 107356"},"PeriodicalIF":4.9,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutralizing chimeric anti-F1 monoclonal antibody against Yersinia pestis infection","authors":"Xi Wang ,&nbsp;Qing Xie ,&nbsp;Ying Huang,&nbsp;Jiansheng Lu,&nbsp;Lei Chen,&nbsp;Jiazheng Guo,&nbsp;Yujia Jiang,&nbsp;Qinglin Kang,&nbsp;Xinrui Yu,&nbsp;Wei Zhang,&nbsp;Meng Lv,&nbsp;Lingfei Hu,&nbsp;Rong Wang,&nbsp;Zhixin Yang,&nbsp;Tao Zheng","doi":"10.1016/j.ijantimicag.2024.107354","DOIUrl":"10.1016/j.ijantimicag.2024.107354","url":null,"abstract":"<div><div>Drug-resistant <em>Yersinia pestis</em> (<em>Y. pestis)</em> poses a threat to the use of antibiotics to treat <em>Y. pestis</em> infections. Passive immunization with neutralizing monoclonal antibodies (mAbs) is considered an effective approach for the treatment of infectious diseases. In this study, a murine single-chain fragment variable (scFv) phage antibody library targeting the F1 antigen was constructed and screened. Therapeutic intravenous injection of 400 μg chimeric mAb S1 through tail veins provided complete protection against <em>Y. pestis</em> 201 challenge in a pneumonic plague mouse model. Timely antibody treatment eliminated the bacteria and reduced lung inflammation. These data suggest that chimeric mAb S1 is a candidate treatment for <em>Y. pestis</em> infection that warrants further study.</div></div>","PeriodicalId":13818,"journal":{"name":"International Journal of Antimicrobial Agents","volume":"64 6","pages":"Article 107354"},"PeriodicalIF":4.9,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravenous combined with aerosolised polymyxins vs intravenous polymyxins monotherapy for ventilator-associated pneumonia: A systematic review and meta-analysis","authors":"Ran Tong ,&nbsp;Xinlei Zou ,&nbsp;Xinge Shi ,&nbsp;Xiaojuan Zhang ,&nbsp;Xiang Li ,&nbsp;Shaohua Liu ,&nbsp;Xiaoguang Duan ,&nbsp;Bin Han ,&nbsp;Haixu Wang ,&nbsp;Ruifang Zhang ,&nbsp;Limin Sun ,&nbsp;Yu Kong ,&nbsp;Fen Zhang ,&nbsp;Mingyu Ma ,&nbsp;Xianfei Ding ,&nbsp;Tongwen Sun","doi":"10.1016/j.ijantimicag.2024.107357","DOIUrl":"10.1016/j.ijantimicag.2024.107357","url":null,"abstract":"<div><div>Polymyxins were applied via different administration routes to treat ventilator-associated pneumonia (VAP) caused by carbapenem-resistant Gram-negative bacteria (CR-GNB). The potential benefits of aerosolised polymyxins as adjunctive treatment for patients are contradictory. This review assessed the safety and efficacy of intravenous (IV) combined with aerosolised polymyxins vs IV polymyxins monotherapy in patients with VAP caused by CR-GNB. Two reviewers independently evaluated and extracted data from PubMed, Embase, Cochrane library and Web of Science. The primary outcome was all-cause mortality and secondary outcomes included clinical cure rate, clinical improvement rate, microbiological eradication rate and nephrotoxicity. Differences for dichotomous outcomes were expressed as odds ratios (ORs) with 95% confidence intervals (CIs). Eleven eligible studies were included. The results showed that compared with IV polymyxins monotherapy, IV plus aerosolised polymyxins therapy significantly reduced all-cause mortality rate (OR = 0.75, 95% CI 0.57–0.99, <em>P</em> = 0.045) and improved clinical improvement rate (OR = 1.62, 95% CI 1.02–2.60, <em>P</em> = 0.043) and microbial eradication rate (OR = 2.07, 95% CI 1.40–3.05, <em>P</em> = 0.000). However, there were no significant differences in terms of clinical cure rate (OR = 1.59, 95% CI 0.96–2.63, <em>P</em> = 0.072) and nephrotoxicity (OR = 1.14, 95% CI 0.80–1.63, <em>P</em> = 0.467) for IV plus aerosolised polymyxins therapy. Subgroup analysis revealed that the clinical improvement rate was significantly improved in case-control studies. Aerosolised polymyxins may be a useful adjunct to IV polymyxins for patients with CR-GNB VAP.</div></div>","PeriodicalId":13818,"journal":{"name":"International Journal of Antimicrobial Agents","volume":"64 6","pages":"Article 107357"},"PeriodicalIF":4.9,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating an Outbreak of Extensively Drug-Resistant Acinetobacter baumannii in a Tertiary Healthcare Centre in Lebanon Using Next-Generation Sequencing","authors":"Fatima I. Darwiche ,&nbsp;Hadi M. Hussein ,&nbsp;Souad Bou Harb ,&nbsp;Sarah Nahhal ,&nbsp;Abdallah Kurdi ,&nbsp;Ahmad Sleiman ,&nbsp;Lama Hamadeh ,&nbsp;Sara Barada ,&nbsp;Jose-Rita Gerges ,&nbsp;George F. Araj ,&nbsp;Nada Kara Zahreddine ,&nbsp;Ahmad Ibrahim ,&nbsp;Zeina Kanafani ,&nbsp;Rami Mahfouz ,&nbsp;Souha S. Kanj ,&nbsp;Ghassan M. Matar ,&nbsp;Antoine G. Abou Fayad","doi":"10.1016/j.ijantimicag.2024.107353","DOIUrl":"10.1016/j.ijantimicag.2024.107353","url":null,"abstract":"<div><div>The frequent occurrence of <em>Acinetobacter baumannii</em> in hospital settings and the elevated rate of antimicrobial resistance in this pathogen represent a serious clinical and public health threat worldwide, and particularly in Lebanon where outbreak surveillance and control are still insufficient. Whole-genome sequencing (WGS) is a fast and reliable tool to study outbreaks at the molecular level and obtain actionable knowledge, leading to better control measures. A total of 59 <em>A. baumannii</em> isolates were collected from intensive care unit (ICU) patients (57 isolates) and from the hospital environment (2 isolates) between August 2022 and May 2023, antimicrobial susceptibility testing (AST) was performed and gDNA was subjected to WGS. Analysis was performed to reveal the sequence types (ST), the relatedness to strains that caused other outbreaks and the arsenal of resistance genes harboured by these bacteria. Of 59 isolates, 85% were categorised as extensively drug-resistant (XDR), 13.6% as multidrug-resistant (MDR) and 1.7% as pan-drug-resistant. All isolates belonged to international clone (IC)2, of which the majority were of ST2 (91.5%). The isolates clustered well with those of a previous outbreak in the same hospital. In addition, isolates from hospitals in Lebanon clustered well together and some clustered with those originating from other countries. The observed genetic relatedness between the current isolates and those from the previous outbreaks underscores the importance of strict surveillance to limit the threat of outbreaks. Moreover, the clustering of isolates from Lebanon with others from distant countries proves the necessity to further investigate the international spread of drug-resistant pathogens and the implementation of control strategies.</div></div>","PeriodicalId":13818,"journal":{"name":"International Journal of Antimicrobial Agents","volume":"64 5","pages":"Article 107353"},"PeriodicalIF":4.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142371768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Title Page & Editorial Board","authors":"","doi":"10.1016/S0924-8579(24)00263-2","DOIUrl":"10.1016/S0924-8579(24)00263-2","url":null,"abstract":"","PeriodicalId":13818,"journal":{"name":"International Journal of Antimicrobial Agents","volume":"64 4","pages":"Article 107347"},"PeriodicalIF":4.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142358915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vivo Emergence of Ceftazidime/Avibactam, Cefiderocol and Aztreonam/Avibactam Cross-Resistance in a Patient With KPC-Producing Klebsiella pneumoniae Infection After Cefiderocol-Based Treatment","authors":"Gabriele Bianco ,&nbsp;Matteo Boattini ,&nbsp;Sara Comini ,&nbsp;Davide Gibellini ,&nbsp;Paolo Gaibani","doi":"10.1016/j.ijantimicag.2024.107343","DOIUrl":"10.1016/j.ijantimicag.2024.107343","url":null,"abstract":"","PeriodicalId":13818,"journal":{"name":"International Journal of Antimicrobial Agents","volume":"64 5","pages":"Article 107343"},"PeriodicalIF":4.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142371767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}