International Journal of Bioscience, Biochemistry and Bioinformatics最新文献_第3页

Influence of abiotic and biotic factors on seasonal abundance of brinjal shoot and fruit borer, Leucinodes orbonalis Guenee 非生物和生物因素对茄子芽和果螟季节丰度的影响

International Journal of Bioscience, Biochemistry and Bioinformatics Pub Date : 2022-01-01 DOI: 10.33545/26646536.2022.v4.i1a.37

R. K. Nayak, A. Hussain, K. Prajapat, M. Gurjar

引用次数: 0

The Influence of Novel Coronavirus on Human Body System 新型冠状病毒对人体系统的影响

International Journal of Bioscience, Biochemistry and Bioinformatics Pub Date : 2022-01-01 DOI: 10.17706/ijbbb.2022.12.2.39-42

Ruolin Liu

引用次数: 0

The Use of iPSC-Derived Liver Organoids as an Exclusive Toxicity Testing Tool 利用ipsc衍生的肝类器官作为独家毒性测试工具

International Journal of Bioscience, Biochemistry and Bioinformatics Pub Date : 2022-01-01 DOI: 10.17706/ijbbb.2022.12.1.1-13

X. Ji

{"title":"The Use of iPSC-Derived Liver Organoids as an Exclusive Toxicity Testing Tool","authors":"X. Ji","doi":"10.17706/ijbbb.2022.12.1.1-13","DOIUrl":"https://doi.org/10.17706/ijbbb.2022.12.1.1-13","url":null,"abstract":"Drug-induced liver injury (DILI) remains a primary reason for drug withdrawal from the market, often after large amounts of money have been invested and patients put at risk in clinical trials. In dealing with DILI, the current 2D models are not sufficient in predicting DILI, thereby resulting in DILI discovered in clinical trials and postmarket surveillance. In recent decades, organoid technology has gained much attention and interest. The self-organizing and self-renewing features of organoids has led to their application in disease modeling, regenerative and personalized medicine, as well as in toxicity testing. The emergence of organoid technology challenges current in vitro and in vivo toxicity testing models as it overcomes several drawbacks two dimensional (2D) traditional models face. This review discusses the use of induced human pluripotent stem cells (iPSC) to make liver organoids specifically. Among many sources to make liver organoids, iPSCs are the least invasive and can ensure reproducible productions of liver organoids which better recapitulates the human liver in vivo. This paper, in particular, looks at the potential of iPSC-derived liver organoids as an exclusive tool for liver toxicity testing, including liver organoid construction, functionality, hepatic biomarkers measured, commercial availability, and challenges.","PeriodicalId":13816,"journal":{"name":"International Journal of Bioscience, Biochemistry and Bioinformatics","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79523112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk of Using Traditional Herbal Medicine against COVID-19 使用传统草药对抗COVID-19的风险

International Journal of Bioscience, Biochemistry and Bioinformatics Pub Date : 2022-01-01 DOI: 10.17706/ijbbb.2022.12.1.14-21

Rui Zhao

引用次数: 0

Gene Regulatory Network of Secondary Cell Wall Biosynthesis during VND7 Induced de novo Xylem Formation VND7诱导新生木质部形成过程中次生细胞壁生物合成的基因调控网络

International Journal of Bioscience, Biochemistry and Bioinformatics Pub Date : 2021-10-01 DOI: 10.17706/ijbbb.2021.11.4.74-81

Haonan Tong, Hao Chen, Cranos M. Williams

{"title":"Gene Regulatory Network of Secondary Cell Wall Biosynthesis during VND7 Induced de novo Xylem Formation","authors":"Haonan Tong, Hao Chen, Cranos M. Williams","doi":"10.17706/ijbbb.2021.11.4.74-81","DOIUrl":"https://doi.org/10.17706/ijbbb.2021.11.4.74-81","url":null,"abstract":"Accumulation of -omics data allows us to analyze the coordination and cooperation of multiple genes involved in different biological processes. Gene regulatory networks (GRNs) are used to characterize the regulatory relationships between transcription factors and downstream genes involved in different biological processes. The secondary cell wall (SCW) formation is involved with many important biological processes in plants, such as stress defense, mechanical reinforcement, and the transportation of water and nutrients. We construct GRNs based on the time-series data of VND7-induced de novo SCW formation using multiple algorithms, and then evaluate each GRN model based on the MYB46 experimental validated regulation data. From the optimal GRN model, we not only identify 8 TFs that have been previously demonstrated as the master regulators of SCW formation, but also show 6 novel SCW regulators which include EGL3, DREB19, TCP14, BZIP61, RGA2, and a zinc-finger type TF. From further in silico annotation of the downstream genes that are regulated by these TFs, we find the shared transcriptional program between the SCW formation and the processes of photosynthesis and drought response. Overall, our work suggests a pipeline for reconstructing and analyzing GRN to pinpoint gene functions in biological processes.","PeriodicalId":13816,"journal":{"name":"International Journal of Bioscience, Biochemistry and Bioinformatics","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73179912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Optimization of Nitrogen Sources and Carbon Source for Recombinant Omega-3 Fatty Acid-Containing Biomass Production 重组含Omega-3脂肪酸生物质生产的氮源和碳源优化

International Journal of Bioscience, Biochemistry and Bioinformatics Pub Date : 2021-10-01 DOI: 10.17706/ijbbb.2021.11.4.82-88

Le Thi Tuyet Trinh, M. Ketudat-Cairns, Chotika Gosalawit, A. Boontawan

引用次数: 0

Application of Liquid Chromatography-Mass Spectrometry-Based Metabolomics in Cell Culture, Drug Study, and Diseases 基于液相色谱-质谱的代谢组学在细胞培养、药物研究和疾病中的应用

International Journal of Bioscience, Biochemistry and Bioinformatics Pub Date : 2021-04-01 DOI: 10.17706/IJBBB.2021.11.2.34-39

R. Huang

引用次数: 1

Cell Type Specific Gene Interaction between Microbiota and Antidepressant Drugs 微生物群与抗抑郁药物的细胞类型特异性基因相互作用

International Journal of Bioscience, Biochemistry and Bioinformatics Pub Date : 2021-04-01 DOI: 10.17706/IJBBB.2021.11.2.14-21

Chutian Guo

引用次数: 1

Computational Identification of Novel Missense Variants in Coding Regions of Genes Associated with Intellectual Disability 与智力残疾相关的基因编码区新型错义变异的计算鉴定

International Journal of Bioscience, Biochemistry and Bioinformatics Pub Date : 2021-04-01 DOI: 10.17706/IJBBB.2021.11.2.22-33

Anna Liu, Junmeng Yang, Tina Yuan, Yongsheng Bai

{"title":"Computational Identification of Novel Missense Variants in Coding Regions of Genes Associated with Intellectual Disability","authors":"Anna Liu, Junmeng Yang, Tina Yuan, Yongsheng Bai","doi":"10.17706/IJBBB.2021.11.2.22-33","DOIUrl":"https://doi.org/10.17706/IJBBB.2021.11.2.22-33","url":null,"abstract":"Single nucleotide variants (SNVs) are mutations in the DNA sequence of a gene that are responsible for a variety of genetic disorders. Exonic variants located in the coding region of a gene can be especially harmful to an organism when they alter the biological functions of proteins. In this study, we performed multiple functional annotations and sequence alignments to assess the impact of SNVs in coding regions of genes associated with intellectual disability (ID). Through bioinformatics analysis, we identified three significant motifs in the coding region of ACTB, PTPN11, and GNAO1 prioritized by our pipeline. Detailed examination of these three genes revealed that eight variant coordinates were located in the three motifs, two of which from ACTB are reported to be pathogenic by MISCAST and three from GNAO1 are reported likely pathogenic according to clinical significance from National Center for Biotechnology Information (NCBI). In particular, we discovered two novel SNVs located at chr16:56370698 and chr16:56370711 in GNAO1 that are highly likely to be pathogenic and possibly associated with ID. Overall, our results revealed the pathogenic roles of SNVs within coding regions of ID candidate genes. Future work is to automate this process through developing a bioinformatics software that can identify novel SNVs in coding regions responsible for various human diseases.","PeriodicalId":13816,"journal":{"name":"International Journal of Bioscience, Biochemistry and Bioinformatics","volume":"37 1","pages":"22-33"},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84092705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antioxidant activity of fruits of Cerasus vulgaris Mill. species in the area of Nakhchivan Autonomous Republic 寻常樱果实抗氧化活性的研究。纳希切万自治共和国地区的一种

International Journal of Bioscience, Biochemistry and Bioinformatics Pub Date : 2021-01-01 DOI: 10.33545/26646536.2021.v3.i1a.22

Rahimova S A, B. R, Ganbarli A A

引用次数: 0