Cell Type Specific Gene Interaction between Microbiota and Antidepressant Drugs

Abstract

Major depression is one of the typical psychiatric diseases. When psychiatric disease occurs, the function of brain cells may be influenced by some intestinal microbiota, which provides a pathway for the development of antidepressant drugs. The research on the correlation between microbiota and antidepressant has become a key issue in the treatment of major depression. This work explores the cell type specific gene interaction between microbiota and antidepressant drugs and isolates some potentially important genes that can be targets of further investigation in the mechanisms of how depressive related behaviours occur and act. Our analysis provides a deeper demonstration of the interaction between antidepressant and microbiota compared to original study, by means of an effective genetic matrix and PLS model.