Integrative Cancer Therapies最新文献

{"title":"Methodological Concerns Regarding the Systematic Review and Meta-Analysis of Acupuncture and Moxibustion for NSCLC.","authors":"Bofei Shu, Bangjiang Fang","doi":"10.1177/15347354261455883","DOIUrl":"10.1177/15347354261455883","url":null,"abstract":"","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"25 ","pages":"15347354261455883"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13219959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148042274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reporting Quality of Randomized Controlled Trials Published in <i>Integrative Cancer Therapies</i>: Evaluation Against CONSORT 2010 and Perspectives for CONSORT 2025.","authors":"Geliang Yang, Shuting Guo, Feng Wen, Xu Han, Huiqing Zhang","doi":"10.1177/15347354261464521","DOIUrl":"10.1177/15347354261464521","url":null,"abstract":"<p><p>Consolidated Standards of Reporting Trials (CONSORT) 2025 Statement was issued in April 2025, however, no dedicated CONSORT extension currently exists for integrative oncology. It is therefore essential to provide practical recommendations, grounded in the CONSORT 2025 Statement and in an analysis of randomized controlled trials (RCT) reporting quality against CONSORT 2010, to guide future RCTs. This study presents a literature-based analysis of RCTs published in <i>Integrative Cancer Therapies</i> between 2010 and 2025, describing study characteristics and overall weighted adherence to CONSORT 2010 of 72 included RCTs. The annual number of publications exhibited an overall upward trend over the past 15 years; overall weighted adherence to CONSORT 2010 across the 72 studies was 67.9%, and the mean per-manuscript adherence was 67.2%. Drawing on this analysis and the CONSORT 2025 update, several specific measures are proposed to improve the reporting quality of RCTs in integrative oncology.</p>","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"25 ","pages":"15347354261464521"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13305783/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148301710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Retrospective Assessment of Symptom Reduction With Group Acupuncture at an NCI-Designated Comprehensive Cancer Center.","authors":"Maria Grosso Zelaya, Moshelle Borjigin, Reza Lahiji, Gloria Fung, Anna Bausum, Margarite Melikian, Almira Catic, Ryan Suk, Kevin Kalinsky, Viraj A Master","doi":"10.1177/15347354261482145","DOIUrl":"10.1177/15347354261482145","url":null,"abstract":"<p><p>Acupuncture is increasingly integrated into oncology care as a nonpharmacologic strategy for managing cancer- and treatment-related symptoms. However, specific symptom responses remain incompletely characterized. This study retrospectively evaluated changes in individual symptoms following completion of a structured group acupuncture regimen at an NCI-designated comprehensive cancer center. Patients treated at our Integrative Oncology and Survivorship Program between 2023 and 2025 who completed ≥8 acupuncture sessions and pre- and post-treatment Measure Yourself Concerns and Wellbeing (MYCaW) questionnaires were included. Patients identified and rated their two most bothersome symptoms on a 0-6 Likert scale. Symptoms were categorized into 20 domains. Pre-to-post changes were assessed using Wilcoxon signed-rank tests. Among 723 patients (median age 60 years; 78.8% female; 36.0% Black), breast cancer was the most common diagnosis (52.8%). Reported symptoms included peripheral neuropathy (n=293), generalized pain (n=245), fatigue (n=120), hot flashes (n=96), and insomnia (n=83), with a median severity score of 5. Significant improvements were observed across all domains (p<0.05) except depression and urinary incontinence (p = 0.057). Large effect sizes (<i>r</i>≥0.8) were noted for upper gastrointestinal symptoms (r = -0.86), radiation-related changes (r = -0.80), lower gastrointestinal symptoms (r = -0.79), and oral-salivary gland symptoms (r = -0.79). High-prevalence symptoms, including neuropathy (<i>Mdn</i>: 5 vs 4, p<0.001), pain (5 vs 3, p<0.001), fatigue (5 vs 3, p<0.001), hot flashes (5 vs 3, p<0.001), and insomnia (5 vs 4, p<0.001), demonstrated substantial improvement. Completion of a structured group acupuncture regimen was associated with broad improvements in all but two patient-identified symptoms. Controlled studies are warranted to further define acupuncture's role in comprehensive oncology symptom management.</p>","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"25 ","pages":"15347354261482145"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety of Acupuncture Using Semi-Permanent Needles in a Pediatric Cancer Unit: A Retrospective Study.","authors":"Esther Martínez García, Iolanda Jordan, Maria Betina Nishishinya Aquino, Cristina López de San Roman Fernández, Sara Perez-Jaume, Andrés Morales-La Madrid, Carles Fernández-Jané, Ofelia Cruz Martínez","doi":"10.1177/15347354261439141","DOIUrl":"10.1177/15347354261439141","url":null,"abstract":"<p><strong>Objective: </strong>To determine the safety of semi-permanent needles alone or combined with filiform needles in patients treated within a pediatric oncology unit during antineoplastic therapy.</p><p><strong>Methods: </strong>A retrospective review of electronic medical records at the Pediatric Cancer Center Barcelona of Hospital Sant Joan de Déu, Spain. Data were collected from September 1, 2019, to September 30, 2021, including all oncology patients treated with semi-permanent needles at the integrative pediatric oncology unit. The primary outcome was the safety of acupuncture in pediatric cancer patients, specifically assessing infection and bleeding risks, considering sequential levels of neutropenia and thrombocytopenia.</p><p><strong>Results: </strong>A total of 196 patients (59.2% boys, 40.8% girls) underwent acupuncture. The median age at first treatment was 11.82 years (range: 0.2-34.0 years). The median number of treatments per patient was 4 (range: 1-44), totaling 1107 acupuncture sessions. Of these, 370 (33.4%) were performed in patients with neutropenia and 305 (27.6%) in patients with thrombocytopenia. A total of 9360 semi-permanent needles and 5125 filiform needles were used. No cases of sepsis, local infections, or skin irritation were reported within 72 hours post-removal. One self-limited adverse event-a superficial ear hematoma in a patient with grade 4 thrombocytopenia-was observed, which resolved spontaneously without complications.</p><p><strong>Conclusion: </strong>Semi-permanent needle therapy, alone or combined with filiform needles, is a safe acupuncture modality when used within pediatric oncology settings, including care contexts that encompass a small number of adolescents and young adults. This study supports the feasibility of incorporating semi-permanent needles into integrative oncology protocols within pediatric oncology practice.</p><p><strong>Registration number: </strong>ClinicalTrials.gov (NCT05585463).</p>","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"25 ","pages":"15347354261439141"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13187391/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147972251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence of Patients With Breast Carcinoma and Gynecologic Genital Carcinoma in the Use of Integrative Therapy Recommendations.","authors":"Milena Beierlein, Carolin C Hack, Anna-Katharin Theuser, Katharina Au, Lena Brueckner, Matthias W Beckmann, Katharina Seitz","doi":"10.1177/15347354261483630","DOIUrl":"10.1177/15347354261483630","url":null,"abstract":"<p><p>BackgroundThis study aimed to evaluate differences in adherence to integrative therapy recommendations provided by the Consultation Service for Integrative Medicine (SIM) at the Women's Clinic of the University Hospital Erlangen, Germany, across patient subgroups. The study sought to identify opportunities for further optimization and refinement of the integrative care program.MethodsIn this cross-sectional study, data of 120 women who visited the SIM consultancy were collected at the first presentation (Baseline) and after 3 to 6 months of therapy (Follow-Up) using standardized questionnaires. The adherence variable was defined as the proportion of integrative therapy methods implemented for at least four weeks of the total number of therapy recommendations received per patient. Differences in patient-reported adherence to integrative therapies among cohorts defined by demographic characteristics, lifestyle factors, and tumor-related characteristics were evaluated using independent-samples t-tests and analyses of variance (ANOVA).ResultsThere was no significant difference in adherence with Integrative therapy recommendations in cohorts based on age, education, Body-mass-index (BMI), tumor localization and treatment modality. Factors significantly associated with lower adherence, were low physical activity, defined as self-reported absence of regular exercise, compared with patients reporting approximately 1 hour or 2-4 hours of exercise per week, and presence of distant metastases.ConclusionAdherence with SIM recommendations was significantly lower among patients with low physical activity levels, as well as among patients with distant metastatic disease. This shows that the treatment concepts of the SIM need to be adapted more individually and, in particular, body-based treatments need to be reviewed in order to make them accessible for patients with poorer physical condition.</p>","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"25 ","pages":"15347354261483630"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13583315/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148976657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Acupuncture for Loss of Appetite in Advanced Lung Cancer Undergoing Immunotherapy: Protocol of a Randomized Controlled Trial.","authors":"Jiarong Fan, Ying Zhan, He Chen, Yuanjie Sun, Jiufei Fang, Yixing Xu, Zhishun Liu","doi":"10.1177/15347354261499341","DOIUrl":"https://doi.org/10.1177/15347354261499341","url":null,"abstract":"<p><p>BackgroundLoss of appetite (LOA) is a highly prevalent and distressing symptom in advanced lung cancer, leading to malnutrition, poorer treatment tolerance, and reduced quality of life. Although acupuncture may help manage cancer-related symptoms, its effect on LOA in patients receiving immunotherapy is unclear. This study aims to assess the efficacy and safety of acupuncture for alleviating LOA in this population.MethodsThis multicenter, randomized, double-blind, sham-controlled trial will enroll 80 eligible patients with advanced lung cancer undergoing immunotherapy who experience LOA, defined as a Visual Analogue Scale (VAS) score ≥30 mm. Participants will be randomly assigned to either true acupuncture or sham acupuncture in a 1:1 ratio, administered over 24 sessions within a 12-week period. The primary outcome is the LOA response rate at week 12. Secondary outcomes include changes in LOA severity, nutritional and hematologic markers, patient-reported measures (appetite/cachexia, disease symptoms, psychological distress, and sleep), and tumor response. Safety and blinding success will also be assessed. Data will be analyzed using SPSS 20.0 and R software.DiscussionTo our knowledge, this is the first rigorously designed trial evaluating acupuncture for LOA in advanced lung cancer patients undergoing immunotherapy. The findings may inform integrative supportive care strategies for this patient population.</p>","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"25 ","pages":"15347354261499341"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149244077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Definition Dilemma of Fuzheng-Based Therapy in NSCLC Systematic Reviews and a Proposal for a Dual-Anchor Model.","authors":"Xiaoyu Han, Yujin Liu","doi":"10.1177/15347354251414648","DOIUrl":"10.1177/15347354251414648","url":null,"abstract":"","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"25 ","pages":"15347354251414648"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12876638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146118903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Efficacy of Chinese Medicine on Postoperative Rehabilitation of Non-Small Cell Lung Cancer (NSCLC), a Randomized Controlled Study\".","authors":"Xiaojie Zhou, Junlei Chen, Yuying Li, Yin Fu","doi":"10.1177/15347354261420552","DOIUrl":"10.1177/15347354261420552","url":null,"abstract":"","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"25 ","pages":"15347354261420552"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12876640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146124900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction: The Efficacy of Internet-Based Cognitive Behavioral Therapy for Patients With Breast Cancer: A Systematic Review and Meta-Analysis.","authors":"","doi":"10.1177/15347354261468411","DOIUrl":"10.1177/15347354261468411","url":null,"abstract":"","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"25 ","pages":"15347354261468411"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13428818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148648516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination Therapy of <i>Sini Decoction</i> and Cyclophosphamide Inhibits Tumor Growth in an Orthotopic Lung Cancer Model.","authors":"Dacheng Pang, Shuo Zhang, Tian Tian, Tong Wang","doi":"10.1177/15347354261450965","DOIUrl":"10.1177/15347354261450965","url":null,"abstract":"<p><strong>Background: </strong>Lung cancer represents a frequently seen respiratory system malignancy. <i>Sini Decoction</i> combined with cyclophosphamide is demonstrated to remarkably extend survival and improve quality of life of these patients; however, the associated anti-tumor mechanisms are largely unexplored.</p><p><strong>Objective: </strong>The present work focused on investigating the inhibition of tumor cells by <i>Sini Decoction</i> plus cyclophosphamide within the orthotopic lung cancer model and exploring the mechanisms in terms of exosome-based tumor hypoxic microenvironment modulation.</p><p><strong>Methods: </strong>A549-luc2-tdT-2 cells were implanted in left lung of nude mice for establishing the orthotopic lung cancer xenograft model. After 5 days, bioluminescence imaging was conducted for model validation. Mice were later randomized as 4 groups: model, <i>Sini Decoction</i>, cyclophosphamide, as well as <i>Sini Decoction</i> plus cyclophosphamide. Bioluminescence imaging was conducted to assess anti-tumor effects. Enzyme-linked immunosorbent assay (ELISA) was performed for measuring liver and kidney function indicators (ALT, AST, Cr) in serum. Additionally, RT-qPCR and immunohistochemistry were carried out for detecting hypoxia-related factor levels (HIF-1α, VEGF, PDGF-β) within lung tissue. Additionally, characterizations of the separated exosomes were completed with transmission electron microscopy, BCA protein assay, nanoparticle tracking analysis, and Western blotting. Exosomal miR-20a-5p was chosen based on TargetScan database for analysis, while RT-qPCR was completed for validation.</p><p><strong>Results: </strong><i>Sini Decoction</i> plus cyclophosphamide dramatically suppressed tumor growth within the orthotopic lung cancer model while ameliorating hepatorenal toxicities, as evidenced by serum liver and kidney function indicators and bioluminescence imaging. Meanwhile, immunohistochemistry showed that the combination therapy markedly downregulated HIF-1α expression in lung tissue and suppressed the expression of its downstream target genes VEGF and PDGF-β, which was also confirmed by RT-qPCR. Additionally, bioinformatic analysis suggested that tumor-derived exosomal miR-20a-5p could target HIF-1α. Isolation and RT-qPCR analysis of lung tissue-derived exosomes demonstrated that the combination therapy significantly downregulated the expression of exosomal miR-20a-5p.</p><p><strong>Conclusion: </strong>This study indicates that the combination of <i>Sini Decoction</i> and cyclophosphamide can effectively inhibit lung cancer growth and alleviate hepatorenal toxicity. The mechanism may be associated with the amelioration of the tumor hypoxic microenvironment, inhibition of the HIF-1α-mediated tumor hypoxia signaling pathway, and regulation of exosomal miR-20a-5p expression.</p>","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"25 ","pages":"15347354261450965"},"PeriodicalIF":3.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13187382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147972211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}