Jennifer Brunet, Julia Hussien, Anne Pitman, Amanda Wurz, Ellen Conte, Nadia Polskaia, Dugald Seely
{"title":"瑜伽疗法作为一种干预措施，可改善成人癌症治疗后的患者报告结果：采用单受试者实验设计的试验的初步结果。","authors":"Jennifer Brunet, Julia Hussien, Anne Pitman, Amanda Wurz, Ellen Conte, Nadia Polskaia, Dugald Seely","doi":"10.1177/15347354241233517","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Cancer is a chronic condition associated with a substantial symptom burden, which can impair recovery after treatment. Investigating interventions with potential to improve self-reported disease and/or treatment effects-known as patient-reported outcomes (PROs)-is paramount to inform cancer care. The objective of this study was to evaluate the effects of a yoga therapy (YT) intervention on key PROs (ie, cancer-related fatigue, anxiety, cognitive function, depression, stress, quality of life [QoL]) among adults after treatment for cancer.</p><p><strong>Methods: </strong>Data from 20 adults (<i>M</i><sub>age</sub> = 55.74 years, 85% female; <i>M</i><sub>time since diagnosis</sub> = 2.83 years) who had completed treatment for cancer were analyzed for this study. In this single-subject exploratory experimental study, the YT intervention comprised a 1:1 YT session (ie, 1 participant with 1 yoga therapist) followed by 6 weekly small (ie, 2-3 participants) group YT sessions. Group sessions were facilitated by the same yoga therapist who delivered participants' 1:1 session to ensure an in-depth personalized approach. PROs were assessed before (ie, pre-intervention) and after the 1:1 YT session (ie, during the intervention), as well as after the last group YT session (ie, post-intervention). Hierarchical linear modeling was used to analyze the data.</p><p><strong>Results: </strong>Participants showed improvements in cancer-related fatigue, state anxiety, trait anxiety, perceived cognitive impairments, impacts of perceived cognitive impairments on QoL, and 1 dimension of QoL (ie, functional wellbeing) over time. Notably, cancer-related fatigue and state anxiety increased immediately after the 1:1 session, but showed greater improvements over time afterward (ie, during the intervention phase). No changes were observed for the remaining PROs.</p><p><strong>Conclusion: </strong>Although results require confirmation in future trials, this study highlights the importance of continuing to investigate YT as an intervention to enhance important PROs (ie, cancer-related fatigue and state anxiety) after treatment for cancer. More research is needed to identify additional beneficial effects and factors that influence participants' responses to 1:1 and group YT (ie, moderators and mediators).</p><p><strong>Registration number: </strong>ISRCTN64763228.</p><p><strong>Date of registration: </strong>December 12, 2021. This trial was registered retrospectively.</p><p><strong>Url of trial registry record: </strong>https://www.isrctn.com/ISRCTN64763228.</p><p><strong>Published protocol: </strong>Brunet, J., Wurz, A., Hussien, J., Pitman, A., Conte, E., Ennis, J. K., . . . & Seely, D. (2022). Exploring the Effects of Yoga Therapy on Heart Rate Variability and Patient-Reported Outcomes After Cancer Treatment: A Study Protocol. <i>Integrative Cancer Therapies</i>, <i>21</i>, 15347354221075576.</p>","PeriodicalId":13734,"journal":{"name":"Integrative Cancer Therapies","volume":"23 ","pages":"15347354241233517"},"PeriodicalIF":2.9000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10893844/pdf/","citationCount":"0","resultStr":"{\"title\":\"Yoga Therapy as an Intervention to Improve Patient-Reported Outcomes Among Adults After Treatment for Cancer: Preliminary Findings From a Trial Using Single-Subject Experimental Design.\",\"authors\":\"Jennifer Brunet, Julia Hussien, Anne Pitman, Amanda Wurz, Ellen Conte, Nadia Polskaia, Dugald Seely\",\"doi\":\"10.1177/15347354241233517\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Cancer is a chronic condition associated with a substantial symptom burden, which can impair recovery after treatment. Investigating interventions with potential to improve self-reported disease and/or treatment effects-known as patient-reported outcomes (PROs)-is paramount to inform cancer care. The objective of this study was to evaluate the effects of a yoga therapy (YT) intervention on key PROs (ie, cancer-related fatigue, anxiety, cognitive function, depression, stress, quality of life [QoL]) among adults after treatment for cancer.</p><p><strong>Methods: </strong>Data from 20 adults (<i>M</i><sub>age</sub> = 55.74 years, 85% female; <i>M</i><sub>time since diagnosis</sub> = 2.83 years) who had completed treatment for cancer were analyzed for this study. In this single-subject exploratory experimental study, the YT intervention comprised a 1:1 YT session (ie, 1 participant with 1 yoga therapist) followed by 6 weekly small (ie, 2-3 participants) group YT sessions. Group sessions were facilitated by the same yoga therapist who delivered participants' 1:1 session to ensure an in-depth personalized approach. PROs were assessed before (ie, pre-intervention) and after the 1:1 YT session (ie, during the intervention), as well as after the last group YT session (ie, post-intervention). Hierarchical linear modeling was used to analyze the data.</p><p><strong>Results: </strong>Participants showed improvements in cancer-related fatigue, state anxiety, trait anxiety, perceived cognitive impairments, impacts of perceived cognitive impairments on QoL, and 1 dimension of QoL (ie, functional wellbeing) over time. Notably, cancer-related fatigue and state anxiety increased immediately after the 1:1 session, but showed greater improvements over time afterward (ie, during the intervention phase). No changes were observed for the remaining PROs.</p><p><strong>Conclusion: </strong>Although results require confirmation in future trials, this study highlights the importance of continuing to investigate YT as an intervention to enhance important PROs (ie, cancer-related fatigue and state anxiety) after treatment for cancer. More research is needed to identify additional beneficial effects and factors that influence participants' responses to 1:1 and group YT (ie, moderators and mediators).</p><p><strong>Registration number: </strong>ISRCTN64763228.</p><p><strong>Date of registration: </strong>December 12, 2021. This trial was registered retrospectively.</p><p><strong>Url of trial registry record: </strong>https://www.isrctn.com/ISRCTN64763228.</p><p><strong>Published protocol: </strong>Brunet, J., Wurz, A., Hussien, J., Pitman, A., Conte, E., Ennis, J. K., . . . & Seely, D. (2022). Exploring the Effects of Yoga Therapy on Heart Rate Variability and Patient-Reported Outcomes After Cancer Treatment: A Study Protocol. <i>Integrative Cancer Therapies</i>, <i>21</i>, 15347354221075576.</p>\",\"PeriodicalId\":13734,\"journal\":{\"name\":\"Integrative Cancer Therapies\",\"volume\":\"23 \",\"pages\":\"15347354241233517\"},\"PeriodicalIF\":2.9000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10893844/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Integrative Cancer Therapies\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/15347354241233517\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"INTEGRATIVE & COMPLEMENTARY MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Integrative Cancer Therapies","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/15347354241233517","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"INTEGRATIVE & COMPLEMENTARY MEDICINE","Score":null,"Total":0}
引用次数: 0
摘要
背景：癌症是一种慢性疾病，伴随着严重的症状负担，会影响治疗后的恢复。调查有可能改善自我报告的疾病和/或治疗效果的干预措施--即患者报告的结果（PROs）--对于癌症护理至关重要。本研究旨在评估瑜伽疗法（YT）干预对成人癌症治疗后主要PROs（即癌症相关疲劳、焦虑、认知功能、抑郁、压力、生活质量[QoL]）的影响：本研究分析了 20 名已完成癌症治疗的成年人（年龄 = 55.74 岁，85% 为女性；确诊时间 = 2.83 年）的数据。在这项单受试者探索性实验研究中，瑜伽治疗干预包括 1:1 的瑜伽治疗课程（即 1 名参与者与 1 名瑜伽治疗师），随后是每周 6 次的小型（即 2-3 名参与者）瑜伽治疗小组课程。小组课程由提供 1:1 课程的同一位瑜伽治疗师主持，以确保采用深入的个性化方法。在 1:1 YT 课程之前（即干预前）和之后（即干预期间），以及最后一次小组 YT 课程之后（即干预后），对 PROs 进行了评估。采用层次线性模型对数据进行分析：随着时间的推移，参与者在癌症相关疲劳、状态焦虑、特质焦虑、感知认知障碍、感知认知障碍对 QoL 的影响以及 QoL 的一个维度（即功能健康）方面均有所改善。值得注意的是，癌症相关疲劳和状态焦虑在 1:1 治疗后立即增加，但随着时间的推移（即在干预阶段）有了更大的改善。结论：尽管结果需要在未来的试验中得到证实，但我们认为癌症相关的疲劳和焦虑状态随着时间的推移（即在干预阶段）会得到更大的改善：尽管结果需要在未来的试验中得到证实，但这项研究强调了继续研究 YT 作为一种干预措施来提高癌症治疗后重要的 PROs（即癌症相关疲劳和状态焦虑）的重要性。还需要进行更多的研究，以确定更多的有益效果以及影响参与者对1:1和小组YT反应的因素（即调节因子和中介因子）：注册日期：2021 年 12 月 12 日。本试验为回顾性登记。试验登记记录网址：https://www.isrctn.com/ISRCTN64763228.Published protocol：Brunet, J., Wurz, A., Hussien, J., Pitman, A., Conte, E., Ennis, J. K., ... & Seely, D. (2022)。探索瑜伽疗法对癌症治疗后心率变异性和患者报告结果的影响：研究方案。癌症综合疗法》，21，15347354221075576。
Yoga Therapy as an Intervention to Improve Patient-Reported Outcomes Among Adults After Treatment for Cancer: Preliminary Findings From a Trial Using Single-Subject Experimental Design.
Background: Cancer is a chronic condition associated with a substantial symptom burden, which can impair recovery after treatment. Investigating interventions with potential to improve self-reported disease and/or treatment effects-known as patient-reported outcomes (PROs)-is paramount to inform cancer care. The objective of this study was to evaluate the effects of a yoga therapy (YT) intervention on key PROs (ie, cancer-related fatigue, anxiety, cognitive function, depression, stress, quality of life [QoL]) among adults after treatment for cancer.
Methods: Data from 20 adults (Mage = 55.74 years, 85% female; Mtime since diagnosis = 2.83 years) who had completed treatment for cancer were analyzed for this study. In this single-subject exploratory experimental study, the YT intervention comprised a 1:1 YT session (ie, 1 participant with 1 yoga therapist) followed by 6 weekly small (ie, 2-3 participants) group YT sessions. Group sessions were facilitated by the same yoga therapist who delivered participants' 1:1 session to ensure an in-depth personalized approach. PROs were assessed before (ie, pre-intervention) and after the 1:1 YT session (ie, during the intervention), as well as after the last group YT session (ie, post-intervention). Hierarchical linear modeling was used to analyze the data.
Results: Participants showed improvements in cancer-related fatigue, state anxiety, trait anxiety, perceived cognitive impairments, impacts of perceived cognitive impairments on QoL, and 1 dimension of QoL (ie, functional wellbeing) over time. Notably, cancer-related fatigue and state anxiety increased immediately after the 1:1 session, but showed greater improvements over time afterward (ie, during the intervention phase). No changes were observed for the remaining PROs.
Conclusion: Although results require confirmation in future trials, this study highlights the importance of continuing to investigate YT as an intervention to enhance important PROs (ie, cancer-related fatigue and state anxiety) after treatment for cancer. More research is needed to identify additional beneficial effects and factors that influence participants' responses to 1:1 and group YT (ie, moderators and mediators).
Registration number: ISRCTN64763228.
Date of registration: December 12, 2021. This trial was registered retrospectively.
Url of trial registry record: https://www.isrctn.com/ISRCTN64763228.
Published protocol: Brunet, J., Wurz, A., Hussien, J., Pitman, A., Conte, E., Ennis, J. K., . . . & Seely, D. (2022). Exploring the Effects of Yoga Therapy on Heart Rate Variability and Patient-Reported Outcomes After Cancer Treatment: A Study Protocol. Integrative Cancer Therapies, 21, 15347354221075576.
期刊介绍：
ICT is the first journal to spearhead and focus on a new and growing movement in cancer treatment. The journal emphasizes scientific understanding of alternative medicine and traditional medicine therapies, and their responsible integration with conventional health care. Integrative care includes therapeutic interventions in diet, lifestyle, exercise, stress care, and nutritional supplements, as well as experimental vaccines, chrono-chemotherapy, and other advanced treatments. Contributors are leading oncologists, researchers, nurses, and health-care professionals.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
