Haematology Journal of Bangladesh最新文献

{"title":"Outcome of Diffuse Large B-Cell Lymphoma with First-line Chemotherapy","authors":"Zulfia Zinat Chowdhury, Tamanna Bahar, Shaila Rahman, Salina Haque, A. Islam, M. E. Ali, Md. Mahbubur Rahman","doi":"10.37545/HAEMATOLJBD202156","DOIUrl":"https://doi.org/10.37545/HAEMATOLJBD202156","url":null,"abstract":"Background: Diffuse Large B-Cell Lymphoma (DLBCL), most common Non-Hodgkin Lymphoma (NHL) variety, is an aggressive, fast-growing form comprising up to 40% of all cases globally. Objective: To observe the treatment outcome of different subtypes of Diffuse Large B-Cell Lymphoma (DLBCL) after first-line chemotherapy and also the association with IHC, presenting age, sex, and IPI score with outcome. Methodology: This is a retrospective data analysis included all DLBCL patients registered in the department of Haematology of National Institute of Cancer Research and Hospital (NICRH) between July 2016 to June 2019. Results: Total 188 cases were included in this study and mean age was 48 years with a Standard deviation of 15 years with Male (69.1%) predominance. We divide the cases into three different entities of DLBCL [Germinal Centre B-cell like (GCB), Non-GCB and others (NOS) among them Non-GCB variety was the prevalent (47.3%) one. After first line   chemotherapy 52.1% complete remission with 7% death was observed in overall outcome. There was no significant difference in outcome among different types of DLBCL after chemotherapy based on Han’s algorithm. Rituximab with CHOP has significantly better outcome than CHOP alone arm (p: 0.021). Conclusion: This limited database study of NICRH will help to ascertain the outcome of DLBCL after first-line chemotherapy in Bangladesh.","PeriodicalId":137283,"journal":{"name":"Haematology Journal of Bangladesh","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126198793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of Haemophilia Patients: A One-Year Experience from A Tertiary Care Hospital in Bangladesh","authors":"M. Miah, Md. Abdur Rafi, Md. Kamrul Hasan","doi":"10.37545/HAEMATOLJBD202058","DOIUrl":"https://doi.org/10.37545/HAEMATOLJBD202058","url":null,"abstract":"Haemophilia is one of the most common bleeding disorders globally. Though the prevalence of haemophilia in Bangladesh according to the ‘World Haemophilia Registry’ is ten per million people, the original prevalence would be much higher. There is lack of evidence about the socio-demographic and clinical characteristics of these patients. The objective of the present study was characterization of the haemophilia patients according their socio-demographic condition as well as their disease and treatment related profiles. All the patients who visited the haematology department of Rajshahi Medical College Hospital (RMCH) from May 1, 2019 to April 30, 2020 diagnosed as haemophilia were included in the study. Socio-demographic and clinical data from 74 haemophilia patients were analysed. Among them 72 patients were male. More than two-thirds of the patients were from rural area and belonged to lower socioeconomic status. Total 72 out of 74 patients were suffering from haemophilia A. Severity of the disease was mild 34%, moderate 63% and severe 3%. More than 86% patients reported target joint of bleeding and 78% of them had bleeding in last six months. A total of 73% patients received treatment within past six months of the current visit and all of them received factor concentrates. More than 94% patients received treatment on demand. Under the shed of findings of the present study it is recommended that a funded haemophilia management program and optimum use of prophylactic therapy is necessary to improve the quality of life as well as increase life expectancy of the patients.","PeriodicalId":137283,"journal":{"name":"Haematology Journal of Bangladesh","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122138026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EBV Associated Post-Transplant Lymphoproliferative Disorder Complicated with Haemophagocytic Lymphohistiocytosis After Allogeneic Stem Cell Transplant: A Rare Complication with Fatal Outcome","authors":"Tangia Muquith","doi":"10.37545/HAEMATOLJBD202064","DOIUrl":"https://doi.org/10.37545/HAEMATOLJBD202064","url":null,"abstract":"Epstein –Barr virus related post-transplant lymphoproliferative disorder is a fatal and life-threatening complication because of immunocompromised state.1 Haemophagocytic lymphohistiocytosis is a sign of poor outcome in EBV associated PTLD after allogeneic stem cell transplantation. It is particularly common when in vivo T cell depletion strategies have been applied.2 In both situations, post-transplant lymphoproliferative disorder and Haemophagocytic lymphohistiocytosis, infection with EBV is the key mechanism. Here I present a case of 29 years old female with acute myeloid leukaemia after second allogeneic stem cell transplant, who developed PTLD complicated with Haemophagocytic lymphohistiocytosis secondary to Epstein – Barr virus (EBV) infection. Patient was treated with chemo immunotherapy and responded but ultimately died after 100 days of transplant. The association of HLH and EBV related PTLD is rare and data on outcome of these patients are limited with very high mortality.","PeriodicalId":137283,"journal":{"name":"Haematology Journal of Bangladesh","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131505130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 and Our Haematology Practice","authors":"A. Saleh","doi":"10.37545/HAEMATOLJBD202068","DOIUrl":"https://doi.org/10.37545/HAEMATOLJBD202068","url":null,"abstract":"","PeriodicalId":137283,"journal":{"name":"Haematology Journal of Bangladesh","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128395658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demographic and Treatment Status of Thalassaemia Patients in a Tertiary Hospital in Bangladesh","authors":"Md Jamal Uddin Tanin, F. Jeenia, F. Ahamed, M. Abrar","doi":"10.37545/HAEMATOLJBD20201","DOIUrl":"https://doi.org/10.37545/HAEMATOLJBD20201","url":null,"abstract":"Introduction: Thalassaemia is now effectively treated with adequate blood transfusion and iron chelation. The disease process itself and iron overload from blood transfusions together produce multiple complications. Objective: Due to increased life expectancy of thalassaemia patients it is important to point out demographic profiles and clinical history related factors that may vary due to numerous causes. Therefore, objective of this study may lead to know the obstacles to access treatment and to find solutions to prevent complications in our socioeconomic background. Methodology: Three clinical types of thalassaemia were assessed in Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. Total 109 subjects with thalassaemia were included in the study according to the inclusion criteria. They were distributed as thalassaemia major (33 subjects), thalassaemia intermedia (34 subjects) and thalassaemia minor (42 subjects). The patients were asked questions regarding demographic status and some clinical histories through a questionnaire. After compilation of the data statistical analysis was done accordingly. Results: The mean age of the subjects in years were 22.7 in thalassaemia major, 22.09 in thalassaemia intermedia and 22.5 in thalassaemia minor with nearly equal gender distributions. Students constituted 27.27% among thalassaemia major, 32.35% among thalassaemia intermedia and 30.95% among thalassaemia minor. The participants were educated up to primary level by 51.52% in thalassaemia major, 47.06 % in thalassaemia intermedia and 57.14 % in thalassaemia minor. Most of the subjects were Muslims and over 75% of the subjects came from outside the Dhaka the city. The mean number of life time transfusions were 105.33 in the patients of thalassaemia major, 33.85 in the intermedia and 0.76 in the minor. Iron chelation were done in 48.48% of thalassaemia major and 17.64% of thalassaemia intermedia at some point of their treatment.  Splenectomy was done in 5 (15.15%) of thalassaemia major and 2 (5.8%) in thalassaemia intermedia patients. Before enrolment in the study 9.09% thalassaemia major, 50% intermedia and 83% minor subjects never visited haematologists or haematology OPD. Conclusion: Most of the subjects were at their working age and students and had to take treatment from inter-district facilities. Majority of the patients with thalassaemia intermedia and minor never consulted haematologists. Transfusion frequency was high with inadequate iron chelation.","PeriodicalId":137283,"journal":{"name":"Haematology Journal of Bangladesh","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125981819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone Marrow Transplant and Bangladesh Perspective","authors":"A. Saleh","doi":"10.37545/haematoljbd202053","DOIUrl":"https://doi.org/10.37545/haematoljbd202053","url":null,"abstract":"Availability of donors is the major concern for allogeneic SCT in which success mostly depends. Full matched HLA siblings are the most preferred donors but roughly it matches in around 30% cases. For the remaining majority cases we must depend on alternative sources like currently popular haplo-identical donors, cord blood or unrelated donors. Worldwide leading donor registries are: Australasian Bone Marrow Transplant Recipient Registry (ABMTRR), Centre for International Blood and Marrow Transplant Research (CIBMTR), the Austrian Registry (ASCTR), the Czech BMT Registry, the French Registry (SFGM), the German Registry (DRST), the Italian Registry (GITMO), the Dutch Registry (HOVON), the Spanish BMT Registry (GETH), the Swiss Registry (SBST), the Turkish BMT Registry and the British Registry (BSBMT) and Eurocord1. To arrange a cord unit or unrelated donor from these registries is exceedingly difficult in terms of logistics and costly as well. To overcome this obstacle, we need to establish a national marrow registry through which many donors could be available.","PeriodicalId":137283,"journal":{"name":"Haematology Journal of Bangladesh","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114650852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency of Hypothyroidism in Transfusion Dependent Thalassaemia Patients at a Tertiary Care Hospital","authors":"Khaza Amirul Islam, M. S. Azam, Nishat Mahzabin, Md. Rafiquzzaman Khan, Md Salahuddin Shah, M. Aziz","doi":"10.37545/haematoljbd202049","DOIUrl":"https://doi.org/10.37545/haematoljbd202049","url":null,"abstract":"The aim of the study was to determine the frequency of hypothyroidism in transfusion dependent thalassaemia patients. A total of 64 transfusion dependent thalassaemia (TDT) patients were included in this cross-sectional study from April, 2018 to September, 2019 according to selection criteria. Thyroid hormone status was assessed by estimation of serum FT4 and serum TSH. Body iron load was estimated by serum ferritin level. The study sample consisted of 43 male and 21 female TDT patients, with a mean age of 25.5 years. Total 28% patients were found hypothyroid, 11% were overt hypothyroid and 17% were subclinical hypothyroid. Mean serum ferritin level was 2462.6 ng/ml. Significant correlation was not found between serum TSH and Serum ferritin level (p = 0.055). Total unit of transfusion (p=0.001) and duration of transfusion therapy (p=0.003) were significantly associated with development of hypothyroidism.","PeriodicalId":137283,"journal":{"name":"Haematology Journal of Bangladesh","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129600720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Socio-Demographic Pattern of Beta Thalassaemia in Bangladesh","authors":"A. Masud, M. Hasan, S. Sinha, K. Islam, M. J. Rahman","doi":"10.37545/haematoljbd202046","DOIUrl":"https://doi.org/10.37545/haematoljbd202046","url":null,"abstract":"Beta thalassaemia is one of the most prevalent haemolytic disorders worldwide which poses serious economic burden to the society. Study on clinical and demographic pattern of this disorder will help the concern authorities to figure out the problem. This cross-sectional descriptive study was carried out to determine the socio-demographic and clinical characteristics as well as to find out the existence of other co-morbidities among the ?-thalassaemic patients (n-101). The study was carried out at the Department of Haematology, Bangabandhu Sheikh Mujib Medical University (BSMMU) from June 2010 to January 2011. Data were collected from 3 tertiary care hospitals of Dhaka city. Almost all the patients were young, age ranged from 10 to 32 years with the mean age of 16. Male to female ratio was almost equal (52.5:47.5) and 80% of the respondents were Muslims. Forty-five (45%) percent of patients were illiterate and 37% respondents had primary education only. Almost 90% were unmarried and majority had a family of 6-8 members. Forty-seven percent (47%) of patients had monthly income 5000-7000 BDT and 56% of the respondents were unemployed. The major clinical features were pallor (72.3%), palpitation (60%), and breathlessness (52.5%). The haemoglobin (Hb) concentration ranged from 7gm/dl to 12gm/dl and 57% patients had an Hb concentration of 8 gm/dl. Sixty percent of the respondents had jaundice with majority had enlarged spleen (86%) and some had enlarged liver too (23%). Ninety percent (90%) respondents had co-morbidities among which arrhythmia is more prevalent (54%).","PeriodicalId":137283,"journal":{"name":"Haematology Journal of Bangladesh","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121329827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Advances in Haematology","authors":"M. Rahman","doi":"10.37545/haematoljbd202051","DOIUrl":"https://doi.org/10.37545/haematoljbd202051","url":null,"abstract":"The advent of different techniques as well as different randomized clinical trial has led to many advances in the discipline of haematology. Recently in the year of 2019 and 2020, new advances have been observed both in the diagnosis and management of haematological disorders.","PeriodicalId":137283,"journal":{"name":"Haematology Journal of Bangladesh","volume":"73 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125016104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Congenital Langerhans Cell Histiocytosis Presenting as Neonatal Papulovesicular Eruption","authors":"F. Begum, A. Islam, A. A. Rahman, Momena Begum","doi":"10.37545/HAEMATOLJBD201757","DOIUrl":"https://doi.org/10.37545/HAEMATOLJBD201757","url":null,"abstract":"Congenital self-healingLangerhans cell histiocytosis (CSHLCH) is a rare type of Langerhans Cell Histiocytosis, presenting at birth or during the neonatal period. It is usually characterized by the eruption of multiple, discrete, red-brown papules or nodules which may increase in size and number during the first few weeks of life with spontaneous regression.Congenital LCH has rarely been reported to present as a papulovesicular eruption at birth. Here we describe a male baby presenting   with papulovesicular eruption at birth who rapidly developed pulmonary infiltrates and multiple osteolytic lesions in skull and long bones after spontaneous regression of cutaneous lesion.","PeriodicalId":137283,"journal":{"name":"Haematology Journal of Bangladesh","volume":"88 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126200862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}